protein and amino acid metabolism in copd PDF
Preview protein and amino acid metabolism in copd
R e n a t UITNODIGING e J o n k Voor het bijwonen e r — van de openbare P verdediging van het R proefschrift O T E IN Protein and amino A acid metabolism N D in COPD A New insights using M I stable tracer N O methodology A C ID door M E T Renate Jonker A B O Woensdag L IS 13 september 2017 M om 10.00 uur I N C In de Aula van de O Universiteit Maastricht P D Minderbroedersberg 4-6 — te Maastricht N www.promotiewijzer.nl/ ew aula-um in s ig Aansluitend bent u h ts van harte welkom op u s PROTEIN AND AMINO ACID de receptie in g s ta METABOLISM IN COPD Paranimfen ble Miranda Jonker t Gerdien Ligthart-Melis r a New insights using stable c e r m tracer methodology e Renate Jonker t h Omring 13 o d 1702 NB o lo Heerhugowaard g [email protected] y Renate Jonker 14752_RJonker_13,5_OMS.indd 1 07-08-17 14:29 14752_RJonker_13,5_OMS.indd 2 07-08-17 14:29 PPRROOTTEEIINN AANNDD AAMMIINNOO AACCIIDD MMEETTAABBOOLLIISSMM IINN CCOOPPDD NNeeww iinnssiigghhttss uussiinngg ssttaabbllee ttrraacceerr mmeetthhooddoollooggyy RReennaattee JJoonnkkeerr 14752_RJonker_BW.indd 1 09-08-17 10:48 PROTEIN AND AMINO ACID METABOLISM IN COPD The studies presented in this thesis were performed at the Center for Transla- New insights using stable tracer methodology tional Research in Aging & Longevity (CTRAL) at the Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA, and the Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Lit- tle Rock, AR, USA. Financial support was received from the National Heart, Lung and Blood Institute (RO1HL095903), National Center for Research Resources (S10RR027047, 1UL1RR029884), ESPEN Research Fellowship, and UAMS Re- PROEFSCHRIFT search Endowment Fund. ter verkrijging van de graad van doctor aan de Universiteit Maastricht, ISBN 978-94-6299-643-4 op gezag van de Rector Magnificus, Prof. dr. Rianne M. Letschert volgens het besluit van het College van Decanen, Cover: J. Jonker in het openbaar te verdedigen Printing: Ridderprint BV, the Netherlands op woensdag 13 september 2017 om 10.00 uur Printing and distribution of this thesis was financially supported by Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabo- lism, Chiesi Pharmaceuticals BV, Fresenius Kabi Nederland BV, Nutricia Re- search, Cambridge Isotope Laboratories Inc, and Nestlé Health Science. door B B Renate Jonker H B B B B B Copyright © 2017 R Jonker, Maastricht H B All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval H Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy system, or trBansmitted in any form or by anyB means, electronic, mechanical, pho- tocopying, recording or otherwise, without prior written permission of the cor- B B responding jHournals or the author. B B B B B B B H B 14752_RJonker_BW.indd 2 09-08-17 10:48 B B H Where Nutrition Becomes Therapy H Where Nutrition Becomes Therapy B B Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy PROTEIN AND AMINO ACID METABOLISM IN COPD The studies presented in this thesis were performed at the Center for Transla- New insights using stable tracer methodology tional Research in Aging & Longevity (CTRAL) at the Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA, and the Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Lit- tle Rock, AR, USA. Financial support was received from the National Heart, Lung and Blood Institute (RO1HL095903), National Center for Research Resources (S10RR027047, 1UL1RR029884), ESPEN Research Fellowship, and UAMS Re- PROEFSCHRIFT search Endowment Fund. ter verkrijging van de graad van doctor aan de Universiteit Maastricht, ISBN 978-94-6299-643-4 op gezag van de Rector Magnificus, Prof. dr. Rianne M. Letschert volgens het besluit van het College van Decanen, Cover: J. Jonker in het openbaar te verdedigen Printing: Ridderprint BV, the Netherlands op woensdag 13 september 2017 om 10.00 uur Printing and distribution of this thesis was financially supported by Maastricht University, NUTRIM School of Nutrition and Translational Research in Metabo- lism, Chiesi Pharmaceuticals BV, Fresenius Kabi Nederland BV, Nutricia Re- search, Cambridge Isotope Laboratories Inc, and Nestlé Health Science. door B B Renate Jonker H B B B B B Copyright © 2017 R Jonker, Maastricht H B All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval H Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy system, or trBansmitted in any form or by anyB means, electronic, mechanical, pho- tocopying, recording or otherwise, without prior written permission of the cor- B B responding jHournals or the author. B B B B B B B H B 14752_RJonker_BW.indd 3 09-08-17 10:48 B B H Where Nutrition Becomes Therapy H Where Nutrition Becomes Therapy B B Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy Promotoren Prof. dr. Annemie M.W.J. Schols Prof. dr. Nicolaas E.P. Deutz Copromotor Dr. Mariëlle P.K.J. Engelen Beoordelingscommissie Prof. dr. Emiel F.M. Wouters (voorzitter) Prof. dr. Luc J.C. van Loon Prof. dr. Steven W.M. Olde Damink Dr. ir. Peter J.M. Weijs (Vrije Universiteit Amsterdam) Prof. dr. Robert R. Wolfe (University of Arkansas for Medical Sciences) Aan: mijn ouders 14752_RJonker_BW.indd 4 09-08-17 10:48 Promotoren Prof. dr. Annemie M.W.J. Schols Prof. dr. Nicolaas E.P. Deutz Copromotor Dr. Mariëlle P.K.J. Engelen Beoordelingscommissie Prof. dr. Emiel F.M. Wouters (voorzitter) Prof. dr. Luc J.C. van Loon Prof. dr. Steven W.M. Olde Damink Dr. ir. Peter J.M. Weijs (Vrije Universiteit Amsterdam) Prof. dr. Robert R. Wolfe (University of Arkansas for Medical Sciences) Aan: mijn ouders 14752_RJonker_BW.indd 5 09-08-17 10:48 TABLE OF CONTENTS PART 5 General Discussion Chapter 9 General discussion 249 PART 1 General Introduction & Aims Chapter 1 General introduction & aims 11 PART 6 Summary Summary 273 PART 2 Protein & Amino Acid Supplementation Samenvatting 279 Chapter 2 Hydrolyzed casein and whey protein meals comparably 33 stimulate net whole-body protein synthesis in COPD pa- tients with nutritional depletion without an additional PART 7 Appendices effect of leucine co-ingestion Valorisation 289 Chapter 3 Effectiveness of essential amino acid supplementation in 59 Dankwoord 295 stimulating whole body net protein anabolism is compa- rable between COPD patients and healthy older adults Publications & awards 299 Chapter 4 Whole body protein anabolism in COPD patients or 89 Curriculum Vitae 301 healthy older adults is not enhanced by the addition of either carbohydrates or leucine to a serving of protein PART 3 Aspects of the Protein Anabolic Response to Feeding Chapter 5 Preserved protein anabolic threshold and capacity as es- 123 timated by a novel stable tracer approach suggests no anabolic resistance and/or increased requirements in weight stable COPD patients Chapter 6 A critical evaluation of the anabolic response after bolus 151 or continuous feeding in healthy older adults and COPD patients PART 4 Alterations in the Metabolism of Individual Amino Acids Chapter 7 Alterations in whole body arginine metabolism in 191 chronic obstructive pulmonary disease Chapter 8 Comprehensive metabolic flux analysis in patients with 215 chronic obstructive pulmonary disease 14752_RJonker_BW.indd 6 09-08-17 10:48 TABLE OF CONTENTS PART 5 General Discussion Chapter 9 General discussion 249 PART 1 General Introduction & Aims Chapter 1 General introduction & aims 11 PART 6 Summary Summary 273 PART 2 Protein & Amino Acid Supplementation Samenvatting 279 Chapter 2 Hydrolyzed casein and whey protein meals comparably 33 stimulate net whole-body protein synthesis in COPD pa- tients with nutritional depletion without an additional PART 7 Appendices effect of leucine co-ingestion Valorisation 289 Chapter 3 Effectiveness of essential amino acid supplementation in 59 Dankwoord 295 stimulating whole body net protein anabolism is compa- rable between COPD patients and healthy older adults Publications & awards 299 Chapter 4 Whole body protein anabolism in COPD patients or 89 Curriculum Vitae 301 healthy older adults is not enhanced by the addition of either carbohydrates or leucine to a serving of protein PART 3 Aspects of the Protein Anabolic Response to Feeding Chapter 5 Preserved protein anabolic threshold and capacity as es- 123 timated by a novel stable tracer approach suggests no anabolic resistance and/or increased requirements in weight stable COPD patients Chapter 6 A critical evaluation of the anabolic response after bolus 151 or continuous feeding in healthy older adults and COPD patients PART 4 Alterations in the Metabolism of Individual Amino Acids Chapter 7 Alterations in whole body arginine metabolism in 191 chronic obstructive pulmonary disease Chapter 8 Comprehensive metabolic flux analysis in patients with 215 chronic obstructive pulmonary disease 14752_RJonker_BW.indd 7 09-08-17 10:48 1 PART 2 PROTEIN & AMINO ACID SUPPLEMENTATION 14752_RJonker_BW.indd 8 09-08-17 10:48
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