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Proteases: Potential Role in Health and Disease PDF

575 Pages·1984·16.665 MB·English
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PROTEASES Potential Role in Health and Disease ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo NICHOLAS R. DI LUZIO, Tulane University School of Medicine EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, Rockland Research Institute RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 159 OXYGEN TRANSPORT TO TISSUE-IV Edited by Haim I. Bicher and Duane F. Bruley Volume 160 PORPHYRIN PHOTOSENSITIZATION Edited by David Kessel and Thomas J. Dougherty Volume 161 MYOCARDIAL INJURY Edited by John J. Spitzer Volume 162 HOST DEFENSES TO INTRACELLULAR PATHOGENS Edited by Toby K. Eisenstein, Paul Actor, and Herman Friedman Volume 163 FOLYL AND ANTIFOLYL POLYGLUTAMATES Edited by I. David Goldman, Joseph R. Bertino, and Bruce A. Chabner Volume 164 THROMBOSIS AND CARDIOVASCULAR DISEASES Edited by Antonio Strano Volume 165 PURINE METABOLISM IN MAN-IV Edited by Chris H. M. M. De Bruyn, H. Anne Simmonds, and Mathias M. Muller Volume 166 BIOLOGICAL RESPONSE MODIFIERS IN HUMAN ONCOLOGY AND IMMUNOLOGY Edited by Thomas Klein, Steven Specter, Herman Friedman, and Andor Szentivanyi Volume 167 PROTEASES: Potential Role in Health and Disease Edited by Walter H. Hod and August Heidland A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. PROTEASES Potential Role in Health and Disease Editedhy Walter H. Horl and August Heidland University of Wiirzburg Wiirzburg, Federal Republic of Germany PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging in Publication Data International Symposium on Proteases: Potential Role in Health and Disease (1982: Wiirzburg, Germany) Proteases, potential role in health and disease. (Advances in experimental medicine and biology; v. 167) "Proceedings of the International Symposium on Proteases: Potential Role in Health and Disease, held October 17-20, 1982, in Wiirzburg, Federal Republic of Germany" Verso t.p. Includes bibliographical references and index. \. Proteolytic enzymes-Congresses. 2. Proteolytic enzyme inhibitors-Congresses. I. HorJ, Walter H. II. Heidiand, August. III. Series. [DNLM: \. Protease inhibitors Congresses. 2. Peptide hydrolases-Congresses. WI AD559 v.167 / QU 136 I615p 1982] QP609.P78I57 1982 599'.019256 83-19186 ISBN-13: 978-1-4615-9357-7 e-ISBN-13: 978-1-4615-9355-3 001: 10.1007/978-1-4615-9355-3 Proceedings of the International Symposium on Proteases: Potential Role in Health and Disease, held October 17-20, 1982, in Wiirzburg, Federal Republic of Germany © 1984 Plenum Press, New York A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 Softcover reprint of the hardcover 1s t edition 1984 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher TO OUR WIVES Ursula Horl Gundula Heidland AND TO OUR CHILDREN PREFACE We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October 17-20, 1982. The topics discussed included those dealing with the physi ology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-kinin system, complement and the coagulation system, the function of proteases in the kidney and the intestinal tract as well as the role of proteases in lung diseases, pancreatitis, arthritis and hypercatabolic states (multiple trauma, septicemia, acute renal failure). The papers presented answered many questions, but raised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortunately impossible in this volume to in clude the extended, lively and extremely stimulating discussions which were enjoyed by the participants during the conference. The meeting has provided a unique framework for close inter action between scientists from various disciplines, including bio chemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pulmonology and nephrology. We would like to express our thanks and appreciation for all those who have stimulated, encouraged and supported us to hold this symposium in WUrzburg. This endeavor could not have been possible without the generous financial support of the Paul-Martini Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg). Bellco GmbH (Freiburg), Boehringer GmbH (Ingelheim), Boehringer GmbH (Mannheim), Byk Gulden GmbH (Konstanz), Ciba-Geigy (Wehr), Cyanamid GmbH (Wolfratshausen), Deutsche Abbott GmbH (Wiesbaden), Diamed GmbH (KBln), Fresenius AG (Oberursel), Gambro KG (MUnchen), Hoechst AG (Frankfurt), von Heyden GmbH (MUnchen), Mack (Iller tissen), Madaus & Co. (Koln), MSD Sharp & Dohme (MUnchen), Merck (Darmstadt), Nordmark-Werke GmbH (Uetersen), Pfizer GmbH (Karls ruhe), Pfrimmer & Co. GmbH (Erlangen), Pharmacodex (MUnchen), San- viii PREFACE doz AG (NUrnberg), Schering AG (Berlin), Travenol GmbH (MUnchen), Wellcome GmbH (Burgwedel), Verein zur Bekampfung der Hochdruck und Nierenkrankheiten (WUrzburg). We also are indebted to Mrs. I. Hevendehl, Miss M. Eiring and Mrs. A. Dempwolff for their invaluable assistance and help in the organization of the meeting. It is a pleasure to acknowledge the excellent secretarial assistance of Monika Eiring for preparing the manuscripts. Walter H. Horl August Heidland CONTENTS PHYSIOLOGY AND PATHOPHYSIOLOGY OF PROTEASES AND THEIR INHIBITORS Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes ........•.......................... 1 K. Havemann and M. Gramse Regulation of Protease Activity 21 M. Steinbuch Human Kininogens and Their Function in the Kallikrein- Kinin Systems ..................•........................ 41 W. Muller-Esterl and H. Fritz Possible Involvement of Kinins in Muscle Energy Metabolism .......•....•................................. 63 G. Dietze, E. Maerker, C. Lodri, R. Schifman, M. Wicklmayr, R. Geiger, E. Fink, I. Boettger, H. Fritz, and H. Mehnert Structure and Function of Natural Inhibitors as Antagonists of Proteinase Activities .................... 73 H. Tschesche Oxidation of Alpha-i-Proteinase Inhibitor: Significance for Pathobiology .................•......... 89 J. Travis, K. Beatty, and N. Matheson In Vivo Significance of Kinetic Constants of Macromolecular Proteinase Inhibitors .................... 97 J. G. Bieth On the Multiplicity of Cellular Elastases and their Inefficient Control by Natural Inhibitors ............... 111 W. Hornebeck, D. Brechemier, M. P. Jacob, C. Frances, and L. Robert ix x CONTENTS Proteases - Proteases Inhibitors: a Local Cellular Information System ...•.......•....•...•....•.•• 121 H. Heine PROTEASES AND HORMONES Regulatory Proteolysis during Corticosteroid Hormone Action ........•.•.......•.........•............. 129 M. K. Agarwal Proteases in Hormone Production and Metabolism ..••....•••..... 141 w. A. Hsueh Precursor Processing and Metabolism of Parathyroid Hormone: Regulation by Calcium .....•.••.•....••.•..•..•..•.•.••..•.••..•.... 153 J. A. Fischer Processing and Degradation of Met-Enkephalin by Peptidase Associated with Rat Brain Cortical Synaptosomes •.....•..••••...•.•..........•.••.. 165 W. Demmer and K. Brand PROTEASES IN KIDNEY AND INTESTINAL TRACT Characterization and Clinical Significance of Membrane Bound Proteases from Human Kidney Cortex •....••••.....•.•..•...•••.•••.•.••...••.•. 179 J. E. Scherberich, C. Gauhl, G. Heinert, W. Mondorf, and W. Schoeppe Recent Advances in Protease Research using Synthetic Substrates ••....•.....•........•.•...•..•.•••• 191 R. Gossrau, Z. Lojda, R. E. Smith, and P. Sinha Kinetic Characterization of Brush Border Membrane Proteases in Relationship to Mucosal Architecture by Section Biochemistry ••.•••••••...••••••. 209 S. Gutschmidt, R. Hoper, and R. Gossrau Fluorescence Detection of Proteases with AFC, AMC and MNA Peptides using Isoelectric Focusing .••.•.••.•.••.•••.•..•••..••.••••....••.•.•..•.• 219 P. Sinha, R. Gossrau, R. E. Smith, and z. Lojda CONTENTS xi PROTEASES AND BLOOD SYSTEM Pathophysiology of the Interaction between Complement and Non-Complement Proteases •...•...................•....•..........•..... 227 U. E. Nydegger and S. Suter Interactions between the Alternative Complement Pathway and Proteases of the Coagulation System ......•.....•.••........••...• 235 M. D. Kazatchkine and M.-H. Jouvin The Calcium-Dependent Neutral Protease of Human Blood Platelets: a Comparison of its Effe~ts on the Receptors for von Willebrand Factor and for the Fc-Fragment Derived from IgG •.•....•.•....•........•... 241 M. O. Spycher, U. E. Nydegger, and E. F. Luescher Alpha-2-Plasmin Inhibitor Inactivation by Human Granulocyte Elastase .•.•.....•...•............... 253 M. Gramse, K. Havemann, and R. Egbring Heparin and Plasma Proteinase Inhibitors: Influence of Heparin on the Inhibition of Thrombin bya2Macroglobulin ......................... 263 P. Lambin, F. Pochon, and M. Steinbuch The Involvement of Plasmatic and Fibrinolytic Systems in Idiopathic Glomerulo- nephritis (GN) ...•..•...•...•........•.•..•..•....•.•.. 273 K. Andrassy, E. Ritz, and R. Waldherr The Effect of Aprotinin on Platelet Function, Blood Coagulation and Blood Lactate Level in Total Hip Replacement - a Double Blind Clinical Trial............................ 287 S. Haas, R. Ketterl, A. Sternberger, P. Wendt, H.-M. Fritsche, H. Kienzle, F. Lechner, and G. B1Umel PROTEASES AND LUNG Interaction of Granulocyte Proteases with Inhibitors in Pulmonary Diseases .....•..........•...... 299 K. Ohlsson, U. Fryksmark, M. Ohlsson, and H. Tegner

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