Proteases: Potential Role in Health and Disease

575 Pages·1984·16.67 MB·English

by  Klaus Havemann

PROTEASES
Potential Role in Health and Disease
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
NICHOLAS R. DI LUZIO, Tulane University School of Medicine
EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, Rockland Research Institute
RODOLFO PAOLETTI, University of Milan
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PROTEASES: Potential Role in Health and Disease
Edited by Walter H. Hod and August Heidland
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PROTEASES
Potential Role in Health and Disease
Editedhy
Walter H. Horl
and
August Heidland
University of Wiirzburg
Wiirzburg, Federal Republic of Germany
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Symposium on Proteases: Potential Role in Health and Disease (1982:
Wiirzburg, Germany)
Proteases, potential role in health and disease.
(Advances in experimental medicine and biology; v. 167)
"Proceedings of the International Symposium on Proteases: Potential Role in Health
and Disease, held October 17-20, 1982, in Wiirzburg, Federal Republic of Germany"
Verso t.p.
Includes bibliographical references and index.
\. Proteolytic enzymes-Congresses. 2. Proteolytic enzyme inhibitors-Congresses.
I. HorJ, Walter H. II. Heidiand, August. III. Series. [DNLM: \. Protease inhibitors
Congresses. 2. Peptide hydrolases-Congresses. WI AD559 v.167 / QU 136 I615p
1982]
QP609.P78I57 1982 599'.019256 83-19186
ISBN-13: 978-1-4615-9357-7 e-ISBN-13: 978-1-4615-9355-3
001: 10.1007/978-1-4615-9355-3
Proceedings of the International Symposium on Proteases: Potential Role in Health
and Disease, held October 17-20, 1982, in Wiirzburg, Federal Republic of Germany
© 1984 Plenum Press, New York
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
Softcover reprint of the hardcover 1s t edition 1984
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
TO OUR WIVES
Ursula Horl
Gundula Heidland
AND TO OUR CHILDREN
PREFACE
We are pleased to present to our readers the Proceedings of
the International Symposium "Proteases: Potential Role in Health
and Disease" which was held in WUrzburg (FRG) during October 17-20,
1982.
The topics discussed included those dealing with the physi
ology and pathophysiology of proteases and their inhibitors, the
interactions of proteases and hormones, the kallikrein-kinin system,
complement and the coagulation system, the function of proteases in
the kidney and the intestinal tract as well as the role of proteases
in lung diseases, pancreatitis, arthritis and hypercatabolic states
(multiple trauma, septicemia, acute renal failure). The papers
presented answered many questions, but raised many more concerning
the significance of proteases and their inhibitors in clinical
medicine. It was unfortunately impossible in this volume to in
clude the extended, lively and extremely stimulating discussions
which were enjoyed by the participants during the conference.
The meeting has provided a unique framework for close inter
action between scientists from various disciplines, including bio
chemistry, physiology, surgery, anaesthesiology, endocrinology,
hematology, pulmonology and nephrology.
We would like to express our thanks and appreciation for all
those who have stimulated, encouraged and supported us to hold
this symposium in WUrzburg. This endeavor could not have been
possible without the generous financial support of the Paul-Martini
Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg).
Bellco GmbH (Freiburg), Boehringer GmbH (Ingelheim), Boehringer
GmbH (Mannheim), Byk Gulden GmbH (Konstanz), Ciba-Geigy (Wehr),
Cyanamid GmbH (Wolfratshausen), Deutsche Abbott GmbH (Wiesbaden),
Diamed GmbH (KBln), Fresenius AG (Oberursel), Gambro KG (MUnchen),
Hoechst AG (Frankfurt), von Heyden GmbH (MUnchen), Mack (Iller
tissen), Madaus & Co. (Koln), MSD Sharp & Dohme (MUnchen), Merck
(Darmstadt), Nordmark-Werke GmbH (Uetersen), Pfizer GmbH (Karls
ruhe), Pfrimmer & Co. GmbH (Erlangen), Pharmacodex (MUnchen), San-
viii PREFACE
doz AG (NUrnberg), Schering AG (Berlin), Travenol GmbH (MUnchen),
Wellcome GmbH (Burgwedel), Verein zur Bekampfung der Hochdruck
und Nierenkrankheiten (WUrzburg).
We also are indebted to Mrs. I. Hevendehl, Miss M. Eiring and
Mrs. A. Dempwolff for their invaluable assistance and help in the
organization of the meeting. It is a pleasure to acknowledge the
excellent secretarial assistance of Monika Eiring for preparing
the manuscripts.
Walter H. Horl
August Heidland
CONTENTS
PHYSIOLOGY AND PATHOPHYSIOLOGY OF PROTEASES
AND THEIR INHIBITORS
Physiology and Pathophysiology of Neutral Proteinases
of Human Granulocytes ........•.......................... 1
K. Havemann and M. Gramse
Regulation of Protease Activity 21
M. Steinbuch
Human Kininogens and Their Function in the Kallikrein-
Kinin Systems ..................•........................ 41
W. Muller-Esterl and H. Fritz
Possible Involvement of Kinins in Muscle Energy
Metabolism .......•....•................................. 63
G. Dietze, E. Maerker, C. Lodri, R. Schifman,
M. Wicklmayr, R. Geiger, E. Fink, I. Boettger,
H. Fritz, and H. Mehnert
Structure and Function of Natural Inhibitors as
Antagonists of Proteinase Activities .................... 73
H. Tschesche
Oxidation of Alpha-i-Proteinase Inhibitor:
Significance for Pathobiology .................•......... 89
J. Travis, K. Beatty, and N. Matheson
In Vivo Significance of Kinetic Constants of
Macromolecular Proteinase Inhibitors .................... 97
J. G. Bieth
On the Multiplicity of Cellular Elastases and their
Inefficient Control by Natural Inhibitors ............... 111
W. Hornebeck, D. Brechemier, M. P. Jacob,
C. Frances, and L. Robert
ix
x CONTENTS
Proteases - Proteases Inhibitors: a Local
Cellular Information System ...•.......•....•...•....•.•• 121
H. Heine
PROTEASES AND HORMONES
Regulatory Proteolysis during Corticosteroid
Hormone Action ........•.•.......•.........•............. 129
M. K. Agarwal
Proteases in Hormone Production and Metabolism ..••....•••..... 141
w.
A. Hsueh
Precursor Processing and Metabolism of
Parathyroid Hormone: Regulation
by Calcium .....•.••.•....••.•..•..•..•.•.••..•.••..•.... 153
J. A. Fischer
Processing and Degradation of Met-Enkephalin
by Peptidase Associated with Rat Brain
Cortical Synaptosomes •.....•..••••...•.•..........•.••.. 165
W. Demmer and K. Brand
PROTEASES IN KIDNEY AND INTESTINAL TRACT
Characterization and Clinical Significance of
Membrane Bound Proteases from Human
Kidney Cortex •....••••.....•.•..•...•••.•••.•.••...••.•. 179
J. E. Scherberich, C. Gauhl, G. Heinert,
W. Mondorf, and W. Schoeppe
Recent Advances in Protease Research using
Synthetic Substrates ••....•.....•........•.•...•..•.•••• 191
R. Gossrau, Z. Lojda, R. E. Smith, and
P. Sinha
Kinetic Characterization of Brush Border Membrane
Proteases in Relationship to Mucosal
Architecture by Section Biochemistry ••.•••••••...••••••. 209
S. Gutschmidt, R. Hoper, and R. Gossrau
Fluorescence Detection of Proteases with AFC,
AMC and MNA Peptides using Isoelectric
Focusing .••.•.••.•.••.•••.•..•••..••.••••....••.•.•..•.• 219
P. Sinha, R. Gossrau, R. E. Smith, and
z. Lojda
CONTENTS xi
PROTEASES AND BLOOD SYSTEM
Pathophysiology of the Interaction between
Complement and Non-Complement
Proteases •...•...................•....•..........•..... 227
U. E. Nydegger and S. Suter
Interactions between the Alternative
Complement Pathway and Proteases
of the Coagulation System ......•.....•.••........••...• 235
M. D. Kazatchkine and M.-H. Jouvin
The Calcium-Dependent Neutral Protease of
Human Blood Platelets: a Comparison
of its Effe~ts on the Receptors for
von Willebrand Factor and for the
Fc-Fragment Derived from IgG •.•....•.•....•........•... 241
M. O. Spycher, U. E. Nydegger, and
E. F. Luescher
Alpha-2-Plasmin Inhibitor Inactivation by
Human Granulocyte Elastase .•.•.....•...•............... 253
M. Gramse, K. Havemann, and R. Egbring
Heparin and Plasma Proteinase Inhibitors:
Influence of Heparin on the Inhibition
of Thrombin bya2Macroglobulin ......................... 263
P. Lambin, F. Pochon, and M. Steinbuch
The Involvement of Plasmatic and Fibrinolytic
Systems in Idiopathic Glomerulo-
nephritis (GN) ...•..•...•...•........•.•..•..•....•.•.. 273
K. Andrassy, E. Ritz, and R. Waldherr
The Effect of Aprotinin on Platelet Function,
Blood Coagulation and Blood Lactate
Level in Total Hip Replacement - a
Double Blind Clinical Trial............................ 287
S. Haas, R. Ketterl, A. Sternberger,
P. Wendt, H.-M. Fritsche, H. Kienzle,
F. Lechner, and G. B1Umel
PROTEASES AND LUNG
Interaction of Granulocyte Proteases with
Inhibitors in Pulmonary Diseases .....•..........•...... 299
K. Ohlsson, U. Fryksmark, M. Ohlsson,
and H. Tegner