Table Of Content

Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 425-428 © 1998 Harcourt Brace & Co. Ltd Subject Index A Catfish, detection of 8-epi PGF;,, in extract from epidermal secretion, 325 Acetylsalicylic acid (ASA) see Aspirin Cervical intraepithelial and infiltrating lesions, fatty acid Airway hyperresponsiveness compositions free fatty acid profiles, 253 asthma, effects of thromboxane A, antagonist, 185 saturated and unsaturated fatty acid profiles, 259 effect of DP-1904, 407 Anti-oxidants, peptic ulcer disease, 401 total fatty acid profiles, 247 Aorta Coronary artery occlusions, preservation of myocardial compliance, effect of fish oil supplementation: role of metabolism with retrograde coronary sinus perfusion and endothelium, 335 iloprost, 169 ectopic calcification, reduction with n-3 fatty acid Coronary heart disease, long-term inhibition of thromboxane supplementation, 221 production by acetylsalicylic acid, 17 Arachidonic acid (AA) Cyclooxygenase, rabbit platelets, effects of nitric oxide and comparative anti-mitotic effects of lithium gamma-linolenate, peroxynitrite, 95 gamma-linolenic acid and arachidonic acid on transformed Cyclooxygenase-2 expression in gastric mucosa, induction in Helicobacter pylori infection, 313 and embryonic cells, 285 effect of evening primrose oil in nerve from diabetic rat, Cytokines, effect of gamma-linolenic acid, 273 195 | D effects of nitric oxide and peroxynitrite on 12-lipoxygenase and cyclooxygenase, 95 metabolism in pulmonary artery smooth muscle cells, effect D-002, anti-inflammatory activity, 235 of IL-1B and TNFa, 71 Desmoglein, inhibition of expression by eicosatrienoic acid in Arachidonylethanolamide interaction with CB, and CB, squamous cell carcinoma in vitro, 371 cannabinoid receptors, 111 Dexamethasone Aspirin, long-term inhibition of thromboxane production in effect on leukotriene synthesis in DMSO-stimulated HL-60 coronary heart disease patients, 17 cells, 385 Asthma, effects of thromboxane A, antagonist on airway regulation of prostaglandin H synthase-2 via NF-kB pathway, 63 hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils, 185 Diabetes mellitus effect of evening primrose oil on arachidonic acid in nerve, 195 | B fatty acid composition of phospholipids and neutral lipds from small arteries and veins, 363 Beeswax, anti-inflammatory activity of D-002 from, 235 fatty acid intake and tissue concentration in pregnancy, 209 non-insulin-dependent, effect of nitric oxide on placental Bladder, role of prostaglandins, 415 Borage oil, dietary, effects on fatty acid composition in plasma, prostanoid production in late pregnancy, 299 liver and vascular tissue in hypertensive rats, 1 1 in vivo effect of 8-epi PGF,,, on retinal circulation, 349 Diet | Cc borage oil, effects on fatty acid composition in plasma, liver and vascular tissue in hypertensive rats, 11 E-cadherin, inhibition of expression by eicosatrienoic acid in effect of high linoleic acid diet on oxidative stress and nitric squamous cell carcinoma in vitro, 371 oxide metabolism, 229 effect on metabolism of EPA and GLA in erythrocyte Calcification, ectopic, rat aortas and kidneys, reduction with n-3 fatty acid supplementation, 221 membrane and plasma, 27 Calcium fatty acid intake and tissue concentration in omnivores, vegetarians and diabetics, 209 effect of Helicobacter pylori fatty acid cis 9,10- methyleneoctadecanoic acid on CA**, 119 lipids, effect on y-glutamyl transferase-positive foci during phosphatidic acid effects on cytosolic calcium and hepatocarcinogenesis in rats, 83 restricted, effect on metabolism of glucose in uteri of proliferation in osteoblastic cells, 101 Cannabinoid receptors: arachidonylethanolamide interaction immature rats: influence of indomethacin and with CB, and CB, receptors, 111 nordihydroguaiaretic acid, 175 Carcinogenesis Docosahexaenoic acid synthesis, Y-79 retinoblastoma cells, cervical, fatty acid compositions effect of loss of A6-desaturase activity, 293 free fatty acid profiles, 253 Doxosahexaenoic acid, attenuation of oxidant-mediated saturated and unsaturated fatty acid profiles, 259 endothelial cell injury, 127 DP-1904, effects on airway hyperresponsiveness and infiltration total fatty acid profiles, 247 of inflammatory cells in guinea pigs, 407 effect of dietary lipid on y-glutamy] transferase-positive foci during hepatocarcinogenesis, 83 effect of evening primrose oil and fish oils on two stage skin E carcinogenesis, 155 Carcinoma, squamous cell, eicosatrienoic acid inhibition of Ear, effect of lipo-proprostaglandin E, on inner ear expression of E-cadherin and desmoglein, 371 microciruclatory thrombosis, 203 426 Subject index Eiconasoids Gammaz-linolenic acid (GLA) dienoic, levels in mice fed menhaden oil and juniper oil diets comparative anti-mitotic effects of lithium gamma-linolenate, in response to intraperitoneal lethal dose of LPS, 89 gamma-linolenic acid and arachidonic acid on transformed profile in cultured human pulmonary artery smooth muscle and embryonic cells, 285 cells treated with IL-1B and TNFa, 71 effect on cytokine levels, 273 Eicosanoids, relationship with endothelins in vasculature effect of diet on metabolism in erythrocyte membrane and (review), 1 plasma, 27 Eicosapentaenoic acid (EPA), effect of diet on metabolism in Gastric acid, secretion in parietal cells, effect of Helicobacter erythrocyte membrane and plasma, 27 pylori fatty acid cis 9,10-methyleneoctadecanoic acid, 119 Eicosatrienoic acid, inhibition of expression of E-cadherin and Gastric injury, effect of dietary linoleate/o-linolenate balance, 317 desmoglein in squamous cell carcinoma in vitro, 371 Gastric mucins, glycosylation, effects of PGE, amd PGE Endothelial cells, attenuation of oxidant-mediated injury with derivatives, 49 docosahexaenoic acid: role of intracellular iron, 127 Gastric mucosa, Helicobacter pylori infection induction of Endothelin peptides, role in intestinal ischemia-perfusion injury, cyclooxygenase-2 expression, 313 279 GLA see Gamma-linolenic acid Endothelin-1, role in hypoxic pulmonary vasoconstriction, 137 Glucose metabolism in uteri of immature rats, effect of Endothelins restricted diet, 175 relations with eicosanoids in vasculature (review), 1 Glycosylation relationship with nitric oxide in intestinal ischemia/ gastric mucins, effects of PGE, and PGE derivatives, 49 reperfusion injury, 379 role of N-glycosylation in ligand binding of prostaglandin E, EPA see Eicosapentaenoic acid receptor EP;,, investigated by site-directed mutagenesis, 265 Erythrocytes, fatty acid composition, relationship with plasma | H | insulin, 191 Evening primrose oil effect on arachidonoyl-containing molecular species in nerve Helicobacter pylori fatty acid cis 9,10-methyleneoctadecanoic from diabetic rats, 195 acid, effect on Ca’*, protein kinase C and gastric acid effect on cytokine levels, 273 secretion in parietal cells, 119 effect on two stage skin carcinogenesis in mice, 155 Helicobacter pylori infection, induction of cyclooxygenase-2 expression in gastric mucosa, 313 | EF Henoch--Schénlein purpura, pathogenesis, role of free oxygen radicals and prostanoids, 181 Fatty acids Hepatocarcinogenesis, effect of dietary lipid on y-glutamyl dietary intake and tissue concentration in omnivore, transferase-positive foci, 83 vegetarian and diabetic pregnancy, 209 Hypertension, effects of dietary borage oil on fatty acid effect of dietary linoleate/o-linolenate balance on gastric composition in plasma, liver and vascular tissue, 11 injury in rats, 317 Hypoxic pulmonary vasoconstriction, role of endothelin-1, effects of dietary borage oil on composition in plasma, liver prostanoids and ATP-dependent potassium channels, 137 and vascular tissue in hypertensive rats, 11 erythrocyte, plasma insulin and, 191 essential cell membranes and plasma of patients with primary Iloprost, preservation of myocardial metabolism in acute Sjogren’s syndrome, 239 coronary artery occlusions, 169 peptic ulcer disease, 401 Indomethacin, influence on glucose metabolism in uteri of reduction of ectopic calcification of rat aortas and kidneys immature rats, 175 with n-3 fatty acid supplementation, 221 Inflammation: anti-inflammatory activity of D-002 from incorporation of [1-'*C]20:3 n-6 and [1-'*C]20:3 n-6 into beeswax, 235 nuclear lipids from rat liver cells, 39 Insulin, plasma, relationship with erythrocyte fatty acid intraepithelial and infiltrating lesions of cervix composition, 191 free fatty acid profiles, 253 Interleukin-1f (IL-1) saturated and unsaturated fatty acid profiles, 259 effect on arachidonic acid metabolism in pulmonary artery total fatty acid profiles, 247 smooth muscle cells, 71 polyunsaturated regulation of prostaglandin H synthase-2 via NF-kB pathway, diabetic small arteries and veins, 363 63 effect of n-3 and n-6 fatty acids on murine mesenchymal Interleukin-6 (IL-6) levels in mice fed menhaden oil and juniper tumour development, 341 oil diets in response to intraperitoneal lethal dose of LPS, 89 polyunsaturated long-chain Interleukin-10 (IL-10) levels in mice fed menhaden oil and effect of linoleic acid on w-3 status, 329 juniper oil diets in response to intraperitoneal lethal dose of influence on oxidation of low density lipoprotein, 143 LPS, 89 Fish oils Ischemia-reperfusion injury, intestinal effect of supplementation on aortic compliance in rats: role of nitric oxide and endothelin relationship, 389 endothelium, 335 role of endogenous endothelin peptides, 279 effect on two stage skin carcinogenesis in mice, 155 Isradipine, effect on arterial low density lipoprotein retention, 305 Free oxygen radicals, role in pathogenesis of Henoch--Sch6énlein purpura, 181 | J | G J Juniper oil diet, effect on production of TNF-a and levels of dienoic eicosanoids, IL-6 and IL-10, 89 Gamma-glutamy] transferase-positive foci in hepatocarcinogenesis, effect of dietary lipid, 83 K a Gamma-linolenate: comparative anti-mitotic effects of lithium gammaz-linolenate, gamma-linolenic acid and arachidonic Kidneys, ectopic calcification, reduction with n-3 fatty acid acid on transformed and embryonic cells, 285 supplementation, 221 Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 425-428 © 1998 Harcourt Brace & Co. Ltd Subject index 427 | L | P Leukaemia, HL-60 cells, effect of dexamethasone on leukotriene Peptic ulcer, oxidant stress, anti-oxidants, nitric oxide and synthesis in DMSO-stimulated cells, 385 essential fatty acids in, 401 Leukotriene synthesis in DMSO-stimulated HL-60 cells, effect of Peroxynitrite, effects on 12-lipoxygenase and cyclooxygenase dexamethasone, 385 metabolism of arachidonic acid in rabbit platelets, 95 Linoleate/o-linolenate, dietary balance, effect on gastric injury Phosphatidic acid, effects on cytosolic calcium and proliferation in rats, 317 in osteoblastic cells, 101 Linoleic acid Phospholipids from diabetic small arteries and veins, fatty acid effect of high linoleic acid diet on oxidative stress and nitric composition, 363 oxide metabolism, 229 Potassium channels, ATP-dependent, role in hypoxic pulmonary effect on long-chain polyunsaturated fatty acid w-3 status, vasoconstriction, 137 329 Pregnancy Lipids effect of nitric oxide on placental prostanoid production in dietary, effect on y-glutamy]l transferase-positive foci during late pregnant non-insulin-dependent diabetic rat, 299 hepatocarcinogenesis in rats, 83 fatty acid intake and tissue concentration in omnivores, neutral, from diabetic small arteries and veins, fatty acid vegetarians and diabetics, 209 composition, 363 relationship between mouse uterine contractility, nitric oxide nuclear, incorporation of [1-'*C]20:3 n-6 and [1-"*C]20:3 n-6 and prostaglandin production, 163 from rat liver cells, 39 Prolactin, modulation of rat liver lipid metabolism, 395 prolactin modulation of liver lipid metabolism, 395 Prostaglandin E (PGE) Lipoprotein interaction between nitric oxide and prostaglandin E low density, influence of long-chain polyunsaturated fatty pathways in rat smooth muscle myometrial cells, 357 acids on oxidation, 143 synthetic derivatives, effects on glycosylation of pig gastric low density arterial, effect of isradipine on retention, 305 mucins, 49 12-Lipoxygenase, rabbit platelets, effects of nitric oxide and Prostaglandin E, (PGE,), effect on inner ear microcirculatory peroxynitrite, 95 thrombosis, 203 Prostaglandin E, (PGE,), effects on glycosylation of pig gastric | M mucins, 49 Prostaglandin E, receptor, EP;,, subtype, role of N-glycosylation Menhaden oil diet, effect on production of TNF-a and levels of in ligand binding investigated by site-directed mutagenesis, dienoic eicosanoids, IL-6 and IL-10, 89 265 Mesenchymal murine tumour development, effect of n-3 and n- Prostaglandin F,,, (PGF2,) 6 polyunsaturated fatty acids, 341 detection of 8-epi PGF,,, in extract from epidermal secretion of Mucins, gastric see Gastric mucins catfish, 325 Myocardial metabolism, preservation in acute coronary artery in vivo effect 8-epi PGF,,, on retinal circulation in diabetic and occlusions, 169 non-diabetic rats, 349 Myometrial cells, smooth muscle, interaction between nitric Prostaglandin H synthase-2 (PGHS-2), regulation of gene oxide and prostaglandin E pathways, 357 expression by interleukin-1f and dexamethasone via NF-kB pathway, 63 | N Prostaglandins agonists, use of semi-automated robotic radioimmunoassay to Nephrocalcinosis, reduction with n-3 fatty acid measure CAMP generated by activation of DP-, EPU2u- and supplementation, 221 IP-prostaglandin receptors, 77 Nitric oxide relationship between mouse uterine contractility, nitric oxide effect on placental prostanoid production from late pregnant and prostaglandin production in early pregnancy, 163 non-insulin-dependent diabetic rat, 299 role in urinary bladder, 415 effects on 12-lipoxygenase and cyclooxygenase metabolism of Prostanoids arachidonic acid in rabbit platelets, 95 placental production from late pregnant non-insulin- interaction between nitric oxide and prostaglandin E dependent diabetic rat, effect of nitric oxide, 299 pathways in rat smooth muscle myometrial cells, 357 role in hypoxic pulmonary vasoconstriction, 137 metabolism, effect of high linoleic acid diet, 229 role in pathogenesis of Henoch--Sch6nlein purpura, 181 peptic ulcer disease, 401 Protein kinase C, effect of Helicobacter pylori fatty acid cis 9,10- relationship between mouse uterine contractility, nitric oxide methyleneoctadecanoic acid, 119 and prostaglandin production in early pregnancy, 163 L R + relationship with endothelin in intestinal ischemia/reperfusion injury, 379 Nitric oxide synthase inhibitors, effects on isolated uteri of Radioimmunoassay, semi-automated robotic, measurement of fasting rats, 23 cAMP generated by activation of DP-, EP,- and IP- Non-steroidal anti-inflammatory drugs (NSAIDs), systematic prostaglandin receptors, 77 pharmacological approach to characterization, 55 Retinal circulation, in vivo effect of 8-epi PGF,,, in diabetic and Nordihydroguaiaretic acid, influence on metabolism of glucose non-diabetic rats, 349 in uteri of immature rats, 175 Retinoblastoma, Y-79 cells, effect of loss of A6-desaturase NSAIDs see Non-steroidal anti-inflammatory drugs activity on docosahexaenoic acid synthesis, 293 ri s | Oxidant injury, endothelial cells, attenuation with Seratrodast: effects on airway hyperresponsiveness, exhaled nitric docosahexaenoic acid: role of intracellular iron, 127 oxide, and induced sputum eosinophils in asthmatics, 185 Oxidant stress, peptic ulcer disease, 401 Sjdgren’s syndrome, essential fatty acid status in cell Oxidative stress, effect of high linoleic acid diet, 229 membranes and plasma, 239 © 1998 Harcourt Brace & Co. Ltd Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 425-428 428 Subject index [ T production in mice fed menhaden oil and juniper oil diets in response to intraperitoneal lethal dose of LPS, 89 Thrombosis, inner ear, effect of lipo-proprostaglandin E,, U AS-103, 203 Thromboxane, long-term inhibition of production by acetylsalicylic acid in coronary heart disease patients, 17 Uterus Thromboxane A, antagonist (TXA,), effects on airway effects of inhibitors of nitric oxide synthase on isolated uteri hyperresponsiveness, exhaled nitric oxide, and induced of fasting rats, 23 sputum eosinophils in asthmatics, 185 relationship between mouse uterine contractility, nitric Tumorigenesis oxide and prostaglandin production in early pregnancy, mesenchymal murine tumours, effect of n-3 and n-6 163 polyunsaturated fatty acids, 341 | see also Carcinogenesis V Tumour necrosis factor-o (TNF-a) effect on arachidonic acid metabolism in pulmonary artery Vegetarians, fatty acid intake and tissue concentration in pregnancy, 209 smooth muscle cells, 71 Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 425-428 © 1998 Harcourt Brace & Co. Ltd Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 429-431 © 1998 Harcourt Brace & Co. Ltd Author Index Dohi, D., 317 Doormaal, JJ. van, 329 Abramovich, D.R., 209 du Plessis, DJ., 273 Aizawa, H., 185 Du, S.-H., 143 Akk6k, N., 181 Du, XJ., 335 Aktan, A.O., 379 Durakbasa, C.U., 379 Al-Hassan, J.M., 325 Dursun, A., 279 Albertini, M., 1, 137 Dziak, R., 101 Ali, M., 325 Dzurik, R., 17 Anadol, A.Z., 279 Arruzazabala, M.L., 235 Ashton, J., 209 Asmussen, K., 239 Eichberg, J., 195 Eisenblatter, R., 49 Engelbrecht, A.M., 247, 253, 259 Engler, M.B., 11 Barotto, N.N., 341 Engler, M.M., 11 Basu, S., 229 Enss, M.-L., 49 Bayram, O., 279 Erbas, D., 181 Beil, W., 49, 119 Ercan, S., 279 Berglund, B.A., 111 Eynard, A.R., 341, 371 Beron de Astrada, M., 163 Bianchi, P., 285 Biberoglu, G., 181 Bilsel, A.S., 379 Finkelberg, A.B., 175 Birincioglu, L., 169 Fitscha, P., 305 Birkholz, C., 119 Forse, R.A., 89 Boquet, M., 163 Fujimoto, Y., 95 Boring, D.L., 111 Fujita, T., 95 Brenner, R.R., 39 Fukuyama, S., 185 Brouwer, D.AJ., 329 | Brum-Fernandes, AJ. de, 55 Buyan, N., 181 Gajdo§, M., 17 Gimeno, M., 299 Gimeno, M.A.F., 163 Campso, M.L., 23 Gimeno, M.A.F.de, 357 Carbajal, D., 235 Goldraij, A., 23, 175 Carpio, L.C., 101 Gomez Dumm, I.N.T. de, 395 Casalino-Matsuda, S.M., 23 Gonzalez, E., 299 Cebral, E., 163 Gonzalez, E.T., 357 Chavali, S.R., 89 Goya, R.G., 395 Chen, H.W., 83 Griffin, B.W., 77 Chin-Dusting, J.P.F., 335 Grubb, D., 209 Claassen, N., 221 Gunawan, E.S., 313 Claire, M., 363 | Clement, M.G., 1, 137 Clifton, P.M., 191 Cloete, F., 247, 253, 259 Haggarty, P., 209 Coetzer, H., 221 Haklar, G., 379 Crider, J.Y., 77 Hamasaki, Y., 385 Hara, N., 185 Hart, C.M., 127 Hasanoglu, E., 181 Dagli, T.E., 379 Hayasaki, R., 385 Daniellan, PJ., 209 Hedrich, HJ., 49 Dart, A.M., 335 Heim, H.-K., 49 Das, U.N., 155, 401 Hettema, Y., 329 Denault, J.-B., 55 Hokamura, K., 203 Deneuville, M., 363 Hori, M., 313 Dirks, J., 273 Horrobin, D.F., 239 430 Author index Howlett, A.C., 111 Muro, E., 385 Huang, C., 265 Muskiet, F.AJ., 329 Mutanen, M., 229 | | Ichimaru, T., 385 Nakamura, N., 203 Igal, R.A., 395 Inoue, H., 185 Nakano, H., 185 Iscan, Z., 169 Nakashima, M., 203 Itoh, M., 317 Naval, J., 293 Nestel, PJ., 191 ae Novaro, V., 299 Jawerbaum, A., 299 Jeremy, J.Y., 415 Ober, M.D., 127 Jiang, W.G., 371 Joh, T., 317 Ogawa, K., 95 O'Grady, J., 305 Jovanovska, V., 335 Okuyama, H., 317 Oxholm, P., 239 Oz, E., 181 Katircioglu, S.F., 169 Kawano, S., 313 Khan, M.A., 415 Pace-Asciak, C.R., 325 Kincaid, J.C., 195 Panzer, A., 285 Kingwell, B.A., 335 Peterson, R.G., 195 Kita, M., 385 Pineiro, A., 293 Ko, JJ., 83 Kobayashi, I., 385 Koto, H., 185 Kritz, H., 305 Rademeyer, C., 221 Krivosikova, Z., 17 Ramesh, G., 155 Kruger, M.C., 221 Rudolph, I., 357 Kuruvilla, R., 195 Sakuma, S., 95 Lagarde, M., 349 Saritas, Z., 169 Lakin, V., 209 Sawaoka, H., 313 Lanfri-Aguilar, N., 175 Schlemmer, C.K., 221 Lecomte, M., 349, 363 Sebekova, K., 17 Leduc, R., 55 Seegers, J.C., 285 Lii, C.K., 83 Sewing, K.-F., 49, 119 Linares, J.A., 23 Sharif, N.A., 77 Lopez, C.B., 341 Sinner, D., 299 Lora, M., 55 Sinzinger, H., 305 Lottering, M.-L., 285 Smuts, C.M., 221 Louw, L., 247, 253, 259 Spinnler Benadé, AJ., 27 Spustova, V., 17 Stark, J.H., 285 Sun, W., 313 McNeill, G., 209 Swanevelder, S., 27 Magraner, J., 235 | Makriyannis, A., 111 Manjari, V., 401 Mansel, R-E., 371 Tagano, S., 95 Marzo, I., 293 Tai, H.-H., 63, 265 Mas, R., 235 Takami, M., 407 Matsuba, S., 317 Takashima, T., 203 Matsumoto, K., 185 Takeyama, H., 317 Matsuo, M., 385 Thomas, D.R., 143 Michoud, E., 349 Thompson, C.S., 415 Mikhailidis, D.P., 415 Thomson, M., 325 Miyazaki, S., 385 Tsuji, M., 313 Moffat, C.F., 209 Tsuji, S., 313 Molina, V., 235 Tsukada, W., 407 Morgan, RJ., 415 Turpeinen, A.M., 229 Morgenthal, J.C., 27 Motta, A., 163 Motta, A.B., 357 Mouni, H., 379 Ulus, A.T., 169 Mumtaz, F.H., 415 Umemura, K., 203 Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 429-431 © 1998 Harcourt Brace & Co. Ltd Author index 431 | Wiernsperger, N., 349, 363 Wiik, A., 239 Valdés, S., 235 Wilken, G.H., 111 Valentich, M.A., 341 van Aswegen, C.H., 273 | van Doormaal, JJ ., 329 van Jaarsveld, L., 221 Xu, S.X., 77 van Rooyen, J., 27 Ves Losada, A., 39 | | Yamak, B., 169 Yamamoto, S., 385 Wagner, S., 49, 119 Yoshida, M., 71, 185 Wander, R.C., 143 Yuksel, M., 379 Wang, Z., 63 Watanabe, K., 71 | Watanabe, M., 203 Watanabe, S., 317 Zaitsu, M., 385 Weeks, C.E., 89 Zhong, W.W., 89 Wen, F.Q., 71 © 1998 Harcourt Brace & Co. Ltd Prostaglandins, Leukotrienes and Essential Fatty Acids (1998) 59(6), 429-431