Prostaglandins in Cancer Research

285 Pages·1987·17.023 MB·English

by  B. Samuelsson, C. Serhan (auth.), Professor Dr. Enrico Garaci, Professor Dr. Rodolfo Paoletti, Dr. M. Gabriella Santoro (eds.)

Proceedings in Life Sciences
Prostaglandins
in Cancer Research
Edited by
E. Garaci R. Paoletti M.G. Santoro
With 113 Figures
Springer- Verlag
Berlin Heidelberg New York
London Paris Tokyo
Professor Dr. ENRICO GARACI
Department of Experimental Medicine
II University of Rome
Via O. Raimondo
00173 Rome, Italy
Professor Dr. RODOLFO PAOLETII
Institute of Pharmacological Sciences
University of Milan
Via Balzaretti 9
20133 Milan, Italy
Dr. M. GABRIELLA SANTORO
Institute of Experimental Medicine, CNR
II University of Rome
Via O. Raimondo
00173 Rome, Italy
ISBN-13:978-3-642-71906-6 e-ISBN-13:978-3-642-71904-2
DOl: 10.1007/978-3-642-71904-2
This work is subject to copyright. All rights are reserved, whether the whole or part of the
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© Springer-Verlag Berlin Heidelberg 1987
Softcover reprint of the hardcover 1st edition 1987
The use of registered names, trademarks, etc. in this publication does not imply, even in the
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2131/3130-543210
Preface
Arachidonic acid metabolites are known to playa regulatory role in a
number of biological systems, in which they function as microenviron
mental hormones and intracellular signal mediators. One of the most
exciting areas of research of these compounds is the one that studies
the relationship between prostaglandins and tumor cell growth and
function.
In the last few years there has been an extraordinary evolution of
data on prostaglandins (and related compounds) and cancer. This vol
ume is based on papers presented at the 1986 International Confer
ence on Prostaglandins and Cancer organized by the Italian National
Research Council and the II University of Rome, and held in Rome,
Italy, in June, 1986. This Conference brought together oncologists
and specialists in the areas of prostaglandin chemistry, biochemistry,
pharmacology, physiology, cellular and molecular biology to overview
the actual state of knowledge on the role of eicosanoids in cancer and
to focus on the key questions that need to be answered. The picture
that comes out of this book describes a very complicated network of
interactions between arachidonic acid metabolites and different as
pects of the complex phenomenon "cancer".
Eicosanoids participate in carcinogenesis initiation and promotion,
and their relationship with tumor promoters and growth factors is well
established.
During cancer growth, different prostaglandins can have different
roles in the regulation of cell proliferation and differentiation and in
metastasis formation; meanwhile evidence is accumulating for a pos
sible use of some of these compounds as antineoplastic agents.
Another aspect of eicosanoids and cancer research is the prominent
role that these compounds have acquired as immunomodulators, a
role that is rendered more interesting by the discovery that the deli
cate balance in the synthesis of arachidonic acid metabolites can be
abruptly altered by overproduction of some prostaglandins by tumor
tissue.
Finally, even though very little is known on the molecular biology
of prostaglandins, the fIrst data on their effect on gene expression and
VI Preface
protein synthesis machinery have now been described. This volume
will be of interest to researchers and clinicians involved in biochemis
try. cell biology. pharmacology. immunology. virology and oncology.
and we hope that it will serve to stimulate further study in this still
new but fascinating field of research.
Spring 1987 The Editors
Contents
Introductory Lectures
On the Formation and Biological Role of Leukotrienes and
Lipoxins
B. Samuelsson and C. Serhan (With 2 Figures). . . . . . . . . . . . . 3
Anti-Inflammatory Drugs and the Arachidonic Acid Cascade
J.R. Vane (With 2 Figures) . . . . . . . . . . . . . . . . . . . . . . . .. 12
Carcinogenesis
Icosanoids, Chromosome Damage and Cancer
1. Emerit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 29
The Arachidonate Cascade and Mouse Skin Tumor Promotion
S.M. Fischer (With 5 Figures). . . . . . . . . . . . . . . . . . . . . . .. 35
Modulation of the Conversion Stage of Multistep CarCinogenesis
in Mouse Skin by Eicosanoids
G. Ffustenberger, M. Gschwendt, H. Hagedorn, and F. Marks
(With 6 Figures) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 48
Tumor Promoters, Growth Factors and Arachidonic Acid
Metabolism
L. Levine (With 7 Figures). . . . . . . . . . . . . . . . . . . . . . . . .. 62
Cellular and Molecular Mechanisms of PG Action
Prostaglandins and Calcium Metabolism in Cancer
R.S. Bockman, N. Hickok, and B. Rapuano (With 1 Figure). . .. 77
Cellular Uptake and Nuclear Accumulation of Prostaglandin A
and J, a Mechanism of Prostaglandin-Induced Growth Inhibition
S. Narumiya, K. Ohno, M. Fukushima, and M. Fujiwara
(With 12 Figures) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 86
VIII Contents
Involvement of Protein Synthesis in the Antiproliferative and
the Antiviral Action of Prostaglandins
M.G. Santoro (With 8 Figures) ..................... " 97
The Mechanism of Prostaglandin Inhibition on the Cell Cycle
M. Hughes-Fulford (With 7 Figures) . . . . . . . . . . . . . . . . . . . 115
Interferon-Induced Modifications of the Fatty Acid Side Chains
of Cell Membrane Phospholipids
K.A. Chandrabose and S. Agarwal (With 9 Figures) ......... 129
Cell Proliferation and Differentiation
Prostaglandin Production by Tumors
B.M. Jaffe and M.G. Santoro ........................ 141
Regulation by Prostaglandins of Differentiation of Mouse
Myeloid Leukemia Ml Cells
M. Horumi, Y. Honma, T. Kasukabe, J. Okabe-Kado, and
K. Takenaga ................................... 151
The Role of Prostaglandins and Other Arachidonic Acid
Metabolites in the Differentiation of HL-60
T.R. Breitman (With 9 Figures) ...................... 161
Analysis of Platelet, Tumor Cell and Endothelial Cell
Interactions in Vivo and in Vitro
K.V. Honn, D.G. Menter, B.W. Steinert, J.D. Taylor,
J.M. Onoda, and BF. Sloane (With 7 Figures) ............. 172
Prostaglandins and Cancer: Clinical Approaches
T.J.Powles ................................... 184
Immunomodulation
Leukotrienes and Prostaglandins Mutually Govern the Antitumor
Potential of Macrophages
I.L. Bonta and S. Ben-Efraim (With 5 Figures) ............ 193
Prostaglandins and Leukotrienes in the T -Helper and
T -Suppressor Cell System
J.M. Bailey and M. Fletcher-Cieutat (With 6 Figures) ........ 202
The Effect of Prostaglandins on the Intracellular Signal
Transmission and Regulation of T-Cell Functions
W. Droge, M. Wolf, and S. Mihm (With 6 Figures) .......... 216
Contents IX
Eicosanoids and Gamma Interferon
B.A. Torres, J.K. Russell, and H.M. Johnson (With 3 Figures) .. 227
Role of Prostaglandins, Interleukin-l , Interferon-r and
Anti-Inflammatory Compounds in the Regulation of Thymocyte
Proliferation
M. Papiernik and F. Homo-Delarche (With 7 Figures) ........ 235
Prostaglandins in Immunotherapy of Cancer
C. Favalli, A. Mastino, and E. Garaci (With 3 Figures) ........ 245
Brief Reports
The Effects of Eicosanoid Inhibitors on Tumor Cell Arachidonic
Acid (and Metabolite) Uptake, Release and Metabolism
J.R. Dunn II, D.W. Ohannesian, S. Tefend, D. Malick, A. Kendall,
J.D. Taylor, B.F. Sloane, and K.V. Honn (With 3 Figures) ..... 257
PGAs Inhibit in Vitro Infection with HTLV-I in Human Cord
Blood Lymphocytes During Long-Term Culture
C. D'Onofrio, E. Bonmassar, E. Garaci, and M.G. Santoro
(With 2 Figures) ............................... , 261
Differential Effect of Mitomycin C on Prostaglandin E2 and
Thromboxane in Human Cells
M.L. Foegh and PW. Ramwell (With 1 Figure) ............ 265
Tamoxifen Has Little Effect on Cyclo-Oxygenase but Can
Inhibit 5-Lipoxygenase
LF. Stamford, LA. Tavares, P.B. Melhuish, N. Mascolo,
J .A. Brown, S. Morgan, and A. Bennett ................. 269
Differential Induction of Macrophage Prostaglandin E2
Secretion and Suppressor Activity by Lewis Lung Carcinoma
Variants
M.R. Young and M. Newby. . . . . . . . . . . . . . . . . . . . . . . . . 273
Prostaglandin E2, a Seminal Constituent, Facilitates the
Replication of Acquired Immune Deficiency Syndrome (AIDS)
Virus in Vitro
R. Ueno, S. Kuno, and O. Hayaishi (With 2 Figures) ......... 277
Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Contributors
You will fmd the addresses at the beginning of the respective contributions
Agarwal, S. 129 Levine, 1. 62
Bailey, J.M. 202 Malick, D. 257
Ben-Efraim, S. 193 Marks,F.48
Bennett, A. 269 Mascolo, N. 269
Bockman, R.S. 77 Mastino, A. 245
Bonmassar, E. 261 Melhuish, P .B. 269
Bonta,I.1. 193 Menter, D.G. 172
Breitman, T.R. 161 Mihm,S.216
Brown, J.A. 269 Morgan, S. 269
Chandrabose,K.A. 129 Narumiya, S. 86
D'Onofrio, C. 261 Newby, M. 273
Droge, W. 216 Ohannesian, D.W. 257
Dunn II, J.R. 257 Ohno,K. 86
Emerit, I. 29 Okabe-Kado,J. 151
Favalll, C. 245 Onoda, J.M. 172
Fischer, S.M. 35 Papiemik, M. 235
Fletcher-Cieutat, M. 202 Powles, T.J. 184
Foegh,M.1. 265 Ramwell,P.W. 265
Fujiwara, M. 86 Rapuano, B. 77
Fukushima, M. 86 Russell, J .K. 227
FUrstenberger, G. 48 Samuelsson, B. 3
Garaci, E. 245, 261 Santoro, M.G. 97,141,261
Gschwendt, M. 48 Serhan,C. 3
Hagedom,H. 48 Sloane, B.F. 172,257
Hayaishi, O. 277 Stamford, I.F. 269
Hickok, N. 77 Steinert, B.W. 172
Homo-Delarche, F. 235 Takenaga, K. 151
Honma, Y. 151 Tavares, I.A. 269
Honn,K.V. 172,257 Taylor, J.D. 172,257
Hozumi,M. 151 Tefend, S. 257
Hughes-Fulford, M. 115 Torres, B.A. 227
Jaffe, B.M. 141 Ueno,R. 277
Johnson, H.M. 227 Vane, J.R. 12
Kasukabe, T. 151 Wolf,M. 216
Kendall, A. 257 Young, M.R. 273
Kuno,S. 277
Introductory Lectures