Progress in Neurobiology 1991: Vol 36 Index & Table of Contents

21 Pages·1991·4.3 MB·English

Progress 1n
Neurobiology
VOLUME 36
Editors:
G. A. KERKUT
Department of Physiology and Biochemistry,
University of Southampton
J. W. PHILLIS
Department of Physiology,
Wayne State University
©
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PROGRESS IN
NEUROBIOLOGY
An International Review Journal
Editors
G. A. Kerkut
Department of Physiology and Biochemistry, University of Southampton, England
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J. W. Phillis
Department of Physiology, Wayne State University, U.S.A.
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CONTENTS
DEVELOPMENT OF SUBSTANCE P (SP)-CONTAINING CELLS IN THE CENTRAL
NERVOUS SYSTEM: CONSEQUENCES OF NEUROTRANSMITTER CO-LOCALIZATION
G. M. JONAKAITT, L. NI, P. D.W ALKER and R. P. HART, Department of Biological Sciences, Rutgers
University, Newark, U.S.A.
ROLE OF CCK IN REGULATION OF FOOD INTAKE
A. J. SILVER and J. E. MORLEY, Division of Geriatrics, St. Louis University School of Medicine, St.
Louis, MO 63104, U.S.A.
GABA RECEPTOR MECHANISMS IN THE CENTRAL NERVOUS SYSTEM
L. SIVILOTTI and A. NISTRI, Department of Pharmacology, St. Bartholomew’s Hospital Medical
College, Charterhouse Square, London ECIM 6BQ, U.K.
THE REGULATION OF QUANTAL SIZE
W. VAN DER KLOOT, Departments of Physiology and Biophysics and of Pharmacological Sciences,
Health Science Center, Stony Brook, NY 11794, U.S.A.
NEUROPHYSIOLOGY AND NEUROPHARMACOLOGY OF HYPOTHALAMIC
MAGNOCELLULAR NEURONS SECRETING VASOPRESSIN AND OXYTOCIN
L. P. RENAUD* and C. W. BOURQUE, *Neurology Division, Neurosciences Unit, Ottawa Civic
Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada. {McGill Center for Research in
Neuroscience, Montreal General Hospital, Montreal, Quebec, Canada
MECHANISMS THAT MAY UNDERLIE THE BEHAVIOURAL EFFECTS OF ETHANOL
H. J. LITTLE, Pharmacology Department, The Medical School, University Walk, Bristol BS8 ITD,
U.K.
MONOAMINE SYSTEMS IN THE CEREBRAL CORTEX: EVIDENCE FOR ANATOMICAL
SPECIFICITY
G. C. PAPADOPOULOS* and J. G.P ARNAVELASf, *Laboratory of Anatomy, Veterinary School,
University of Thessaloniki, Greece. fDepartment of Anatomy and Development Biology, University
College, London, U.K.
CLASSICAL (PAVLOVIAN) CONDITIONING MODELS OF AGE-RELATED CHANGES IN
ASSOCIATIVE LEARNING AND THEIR NEUROBIOLOGICAL SUBSTRATES
D. A. POWELL*f, S. L.B UCHANAN* and L. L.H ERNANDEZ}, *Neuroscience Laboratory, Wm
Jennings Bryan Dorn VA Medical Center, Columbia, SC 29201, U.S.A. Department of Psychology,
University of South Carolina, Columbia, U.S.A. {Department of Neuropsychiatry and Behavioral
Science, University of South Carolina School of Medicine, Columbia, SC 29208, U.S.A.
ON THE INTERPRETATION OF ASYMMETRIES OF POSTURE AND LOCOMOTION
PRODUCED WITH DOPAMINE AGONISTS IN ANIMALS WITH UNILATERAL DEPLETION
OF STRIATAL DOPAMINE
R. MILLER* and R. J. BENINGER¢ , *Department of Anatomy and Neuroscience Centre, University
of Otago Medical School, PO Box 913, New Zealand. {Department of Psychology, Queens University,
Kingston, Ontario, Canada
TACRINE: A PHARMACOLOGICAL REVIEW
S. E. FREEMAN and R. M. DAWSON, Materials Research Laboratory (MRL)—DSTO, PO Box 50,
Melbourne, Australia
FRACTAL AND CHAOTIC DYNAMICS IN NERVOUS SYSTEMS
C. C. KING, Department of Mathematics and Statistics, University of Auckland, Auckland, New
Zealand
THE MODULAR CEREBELLUM
R. HAWKES* and C. GRAVEL, *Department of Anatomy and Neuroscience Research Group,
Faculty of Medicine, University of Calgary, Alberta, Canada. fInstitut de Recherche Clinique, Montreal,
Canada
iv CONTENTS
THE ELECTROPHYSIOLOGY OF ADENOSINE IN THE MAMMALIAN CENTRAL NERVOUS
SYSTEM
R. W. GREENE* and H. L. HAAS7, *Harvard Medical School and Brockton Veterans Administration,
MA 02401, U.S.A. {Johannes Gutenburg-Universitat, Mainz, F.R.G.
INSULIN RECEPTORS IN THE CENTRAL NERVOUS SYSTEM: LOCALIZATION,
SIGNALLING MECHANISMS AND FUNCTIONAL ASPECTS
J. W. UNGER*, J. N. LIVINGSTON}# and A. M. MOSS{, *Department of Anatomy, University of
Munich, Pettenkoferstrasse 11, D-8000 Miinchen 2, F.R.G. {Department of Medicine, Endocrinology
Unit, and {Department of Neurology, University of Rochester, 601 Elmwood Avenue, Rochester, NY
14642, U.S.A.
THE PEDUNCULOPONTINE NUCLEUS
E. GARCIA-RILL, University of Arkansas for Medical Sciences, 4301 W. Markham, Little Rock, AR
72205-7199, U.S.A.
CENTRAL SYNAPTIC TRANSMISSION: STUDIES AT THE CONNECTION BETWEEN
PRIMARY AFFERENT FIBRES AND DORSAL SPINOCEREBELLAR TRACT (DSCT)
NEURONES IN CLARKE’S COLUMN OF THE SPINAL CORD
B. WALMSLEY, Neural Research Laboratory, School of Anatomy, University of New South Wales, PO
Box |, Kensington, Australia
THE NEUROLEPTIC MALIGNANT SYNDROME
W. DICKEY, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
QUANTITATIVE STUDIES ON THE MAMMALIAN CEREBELLUM
R. J. HARVEY and R. M. A. NAPPER, Department of Anatomy and Neuroscience Centre, University
of Otago Medical School, PO Box 913, Dunedin, New Zealand
MODULATION OF OXYTOCIN AND VASOPRESSIN RELEASE AT THE LEVEL OF THE
NEUROHYPOPHYSIS
N. FALKE, Sektion Elektronenmikroskopie, Universitat Ulm, Postfach 4066, D-7900 Ulm, F.R.G.
ASPECTS OF VERTEBRATE NEURONAL VOLTAGE-ACTIVATED CALCIUM CURRENTS
AND THEIR REGULATION
R. H. SCOTT*, H. A. PEARSON? and A. C. DOLPHIN‘, *Department of Physiology, St. George’s
Hospital Medical School, Cranmer Terrace, Tooting, London SW17 ORE, U.K. {Department of
Pharmacology, Royal Free Hospital of Medicine, Rowland Hill Street, London NW3 2PF, U.K.
Acetylcholine ionic selectivity 43
age-related decline in nucleus basalis 219 y-Aminobutyric acid B receptors 53
effect on magnocellular neurosecretory -Aminobutyric acid transmission
neurons 137 autoregulation 55
packaging into vesicles 103, 108 brainstem nuclei 77
quanta cerebellum 75
role in neural lobe 479 ethanol effects 174
tacrine effects on release of 268 hippocampus 58
Acetylcholinesterase nucleus accumbens 75
in cerebellum 314 olfactory bulb 68
development 321 olfactory cortex and neocortex 64
inhibition by tacrine 259 septal nuclei 70
Action potentials, neurosecretory cells 134 spinal cord 77
Adaptive resonance theory 292 striatum 73
Adenosine substantia nigra 74
electrophysiology 337 thalamus 71
epilepsy and hypoxia 338 Aminooxyacetic acid, effect on ethanol action 175
inhibition of evoked synaptic potentials 334 Aminoquinolines, gMEPPs 107
mediators of electrophysiological effects 335 Amphetamine
postsynaptic effects 330 induced rotation 236
Adenosine-3’ ,5’-monophosphate stereotypy 249
interaction with Ca2+ channels 509 Amygdala central nucleus, age-related changes in
role in electrophysiological effects of adenosine associative learning 217
336 Analgesia, pedunculopontine nucleus 371
Adenosine receptor subtypes, Angiotensin, effect on neurosecretory
electrophysiology 335 neurons 149, 476
Ca2+-Adenosine triphosphatase, effect of ethanol Antibodies, effect on neuronal Ca2+ channel
on calcium flux 181 function 501
Adrenaline, quantal size 113 Apomorphine, effect on rotatory behaviour 235
Adrenergic receptors, in neurohypophysis 478 Arachidonic acid, interaction with Ca2+ channels
Afterhyperpolarization 210
hippocampus 220 Argiotoxin 636 500
hypothalamic magnocellular neurons 134 Arousal, pedunculopontine nucleus 370, 374
Age, food intake 25 Associative learning, age-related changes 201-228
Aging, changes in associative learning 201-228 Asymmetries, dopamine, posture and locomotion
classical conditioning operations 202 229-256
humans 213, 222 Atriopeptins, effect on magnocellular
neurobiological substrates 215 neurosecretory neurons 150
non-human animals 207, 222 Atrotoxin, interaction with Ca2+ channels 501
Agranular prefrontal cortex, age-related changes in Attention, pedunculopontine nucleus 374
associative learning 217 Autism 375
Alpha responding 215 Autonomic responses
Alphaxalone, effect on GABA channels 52 age-related changes in associative learning 210
Alzheimer’s disease, tacrine 259, 269, 271 role of insulin 355
Amantidine, treatment of neuroleptic malignant
syndrome 430
y-Aminobutyric acid Baclofen, GABAg receptors 53
effect on Ca2+ channels 504 Barbiturates
effect on magnocellular neurosecretory effect on GABA receptors 39, 43, 51
neurons 144 interaction with Ca2+ channels 503
effect on neurohypophysial hormone release 479 Bay 8644, interaction with Ca2+ channels 184,
effect of tacrine on release of 269 186, 499
y-Aminobutyric acid/benzodiazepine receptor Behaviour
complex, effect of ethanol 173 dopamine and asymmetries of posture and
-Aminobutyric acid receptor, central visual locomotion 229-256
pathway 57 effects of ethanol, mechanisms 171-194
y-Aminobutyric acid A receptors Benzodiazepines, binding to GABA receptor
binding sites 37 complex 39, 43, 52
biochemical pliarmacology 36 Benzodiazepine/GABA receptor complex, effect of
Cl- channels 47, 49 ethanol 173
Cl- flux measurements 41 Benzodiazepine receptor inverse agonists, effect on
conductance of gated ion channel 44 effect of ethanol 176
INDEX
Bicuculline 39, 50 Chaotic and fractal dynamics 279-308
Biogenic amines, effect on magnocellular concepts and techniques 280
neurosecretory neurons 137 diversity of non-linear characteristics 294
Blood-brain barrier, insulin 344 encephalogram 301
Bombesin, effect on food intake 27 excitable cells 297
Botulinium toxins, gMEPPs 106 fractal extension to quantum level 304
Brainstem, insulin receptors 346 modelling of neural systems 290, 299
Brainstem nuclei, GABAergic transmission 77 olfactory bulb 299
Bromocriptine, treatment of neuroleptic malignant Chay-Rinzel model of the chaotic neuron 297
syndrome 429 Chirikov map 288
Bulimia nervosa 29 Chlordiazepoxide, ethanol interaction 178
t-Butylbicyclophosphorothionate, binding in Chloride, GABA-induced flux, effect of ethanol
brain 41 175, 176
Butyrylcholinesterase, inhibition by tacrine 259 Chloride channel, GABA, receptor 43, 47, 49, 57
Chloride flux, GABA, receptor activity 41
Chlorpromazine, neuroleptic malignant syndrome
426
Caffeine, effect on adenosine evoked Cholecystokinin
excitation 337 effect on neurosecretory neurons 146, 476
Calcineurin 496 role in regulation of food intake 23-34
Calcium Choline acetyltransferase, in SON neurons 137
dependent potassium current, effect of Cholinesterase
adenosine 332 Alzheimer’s disease 271
effect of ethanol on movement of 180 inhibition by tacrine 259
flux in hippocampus, age and conditioning Cholinoceptive pontine inhibitory area 376
defects 220 Circumventricular organs, insulin receptors 344,
homeostasis in neurons 486 353
Calcium channels 180 CL 218872, binding in brain 40
effect of ethanol 183 Clarke’s column 391
effect of tacrine 265 afferent input to DSCT neurons 392
Calcium channel ligands 497 morphology of DSCT neurons 392
Calcium currents 485-520 morphology of primary afferent boutons 397
baclofen-induced depression 54 ultrastructural studies of collaterals 395
classification 493 ultrastructure of synaptic boutons 397
effect of adenosine 332 Classical conditioning
electrophysiological methods 488 age-related changes in humans 213, 222
functional aspects 511 age-related changes in non-human animals 207
inactivation and rundown 495 controls for non-associative influences on
pharmacology 496 performance 214
regulation by neurotransmitters and experimental operations 202
neuromodulators 503 hippocampus 219
second messenger systems link receptors 506 neurobiological substrates for age-related
Catatonia 431 deficits 215
Catecholamines Climbing fibres, compartments, cerebellum 315,
in neuroleptic malignant syndrome 426 323
effect on oxytocin and vasopressin release 478 Coma, pedunculopontine nucleus 376
Caudate nucleus, age-related changes in associative Compartmentation and connectivity in cerebellum
learning 216 315, 322
Cerebellum 309-327, 437-463 w-Conotoxin, effect on Ca2+ channels 494, 500
age-related changes 217 Contralateral sensory attractiveness,
compartmentation/connectivity 315, 322 dopamine 243
corticonuclear projection 317 Contralateral syndrome 232
development 318 Corticonuclear projection 317
electron microscopy 443 Corticosteroids, quantal size 120
GABAergic transmission 75 Corticotropin releasing factor 376
granule cell density 443, 453, 457 effect on oxytocin and vasopressin release 477
insulin receptors 346 Cysteine sulfinic acid decarboxylase, in cerebellum
levels of organization 318 StS: 315
light microscopy 440 Cytochrome oxidase, in cerebellum 314
molecular markers of compartmentation 310
parallel fibres 455, 457
pf-P synapses 255 D600, interaction with Ca2+ channels 498
Purkinje cell number and density 440, 453, 456 Dantrolene, treatment of neuroleptic malignant
stereological methods 447 syndrome 429
synapse area per Purkinje cell 456 Deconvolution, EPSP amplitude fluctuations 412
synaptic components in molecular layer 454 Dendritic tree 295
volumes 450, 456 Denervation supersensitivity to dopamine 241
Cerebrospinal fluid, insulin in 344 Depolarizing afterpotentials 135
Depression, pedunculopontine nucleus 376 Familial infantile myasthenia 121
Development Feeding behaviour
brain insulin receptors 355 brain insulin receptors 355
cerebellum 318 role of cholecystokinin 23-34
substance P-containing neurons 1-21 Fetus, substance P-containing neurons 2
Diabetes mellitus, brain insulin receptors 356 FG7142, effect on behavioural actions of
Diazepam, binding site in brain 39, 40 ethanol 176
Dihydropicrotoxinin, binding in brain 41 Fluspiriline, effect on Ca2+ channels 503
Dihydropyridines Fractal dynamics 283
binding in brain, effect of ethanol 184 excitable cells 297
interaction with Ca2+ channels 497 in a voltage-dependent K+ channel 298
Dopamine quantum level 304
abnormalities in neuroleptic malignant Freeman-Skarda model of the olfactory bulb 299
syndrome 426 Funnel web spider toxin, interaction with Ca2+
behavioural actions in striatum 231, 242 channels 500
denervation supersensitivity 241
effect of tacrine on release of 269
effect on neurosecretory neurons 139, 478 Galanin
involvement in learning and memory, age-related in magnocellular neurosecretory neurons 150
changes 216, 218 effect on neurohypophysial hormone release 476
regional differences in striatal function 232 Gastric emptying, role of cholecystokinin 26, 29
Dopamine agonists Gastrins, effect on oxytocin and vasopressin
stereotypy 249 release 476
turning behaviours 235 Gastrointestinal peptides, food intake 23
Dopamine antagonists, effect on apomorphine- Giant miniatures 104
induced rotation 239 Globus pallidus, GABAergic transmission 73
Dopamine receptors, rotatory behaviour 237, 244 Glucagon, effect on food intake 27
Dorsal spinocerebellar tract neurones Glucocorticoids, aging and learning 221
afferent input to 392 Glucose, role of cholecystokinin in homeostasis 25
morphology 392 Glutamate
physiology 405 binding in brain, effect of ethanol 187
quantal transmission at group 1 afferent effect on magnocellular neurosecretory
connection 412 neurons 143
Dynorphin(1-8), effect on oxytocin release from Glutamate decarboxylase, in cerebellum 314
neurosecretosomes 473 Glutamate receptors, dorsal spinocerebellar tract
Dynorphin-related peptides, in neurons 407
neurohypophysis 466 Glycine, effect on magnocellular neurosecretory
neurons 144
Glycolate psychotomimetic drugs, interaction with
Edge-walking 243 tacrine 258
Eicosanoids, effect on oxytocin and vasopressin G-protein
release 477 GABAsg receptors 54
Electroconvulsive therapy, neuroleptic malignant interaction with Ca2+ channels 499, 506
syndrome 430 role in electrophysiological effects of adenosine
Electroencephalogram, experimental chaos in 301 336
Embryo, substance P-containing neurons 2 Granule cells
Enkephalins density 443, 453, 457
effect on oxytocin release from GABAergic transmission 63
neurosecretosomes 473 particle counting 447
in magnocellular neurons 151 Guanosine-3’ ,5'-monophosphate, interaction with
in neurohypophysis 469 Ca*+ channels 509
Ependyma, insulin receptors 353
Epidermal growth factor, in brain 354
Epilepsy Haloperidol
pedunculopontine nucleus 375 effect on apomorphine-induced rotation 239
role of adenosine 338 neuroleptic malignant syndrome 426
Ethanol, behavioural effects 171-194 Hausdorff dimension 282
cell calcium 180 Heart rate, conditioned response 203, 206, 210,
excitatory amino acid transmission 187 223
GABA/benzodiazepine receptor complex 173 Heatstroke, neuroleptic-induced 431
tolerance and dependence 176, 179, 183, 186 Hemicholinium-3, effect on MEPP 109
withdrawal 178, 185, 188 Heparin, interaction with Ca2+ channels 503
Excitable cells, chaos and fractal dynamics 297 Hippocampus
Excitatory amino acids, effect on magnocellular age-related changes in associative learning 219
neurosecretory neurons 142 GABAergic transmission 58
Excitatory amino acid transmission, effect of Histamine, effect on magnocellular neurosecretory
ethanol 187 neurons 138
Eyeblink conditioned response 203, 207, 213, 223 Hopf bifurcation 286, 287
viii
Hopfield nets 290, 292 synaptic inputs 135
Horseshoes 287, 288 Malignant hyperthermia 426, 430
6-Hydroxydopamine, effect on motor control 231, Mandelbrot set 285
233 McCulloch-Pits neurons, mathematical modelling
5-Hydroxytryptamine 291
containing cells in medullary raphe, co-location Medullary raphe, 5-HT and substance P cells
with substance P 12 in 12
innervation in cerebral cortex 196 Melanocyte-stimulating hormone, effect on oxytocin
effect on magnocellular neurosecretory and vasopressin release 477
neurons 142 Memory
effect of tacrine on release of 269 adaptive resonance theory 293
Hyperpolarizing afterpotential 134 aging 201, 207
Hypothalamus, magnocellular neurons 131-169 Menthol, effect on Ca?+ channels 503
Hypoxia, role of adenosine 339 Mesencephalic locomotor region 367
N-Methyl-D-aspartate receptors
effect of ethanol 187, 188
Inhibin-related peptides, in magnocellular effect of tacrine 267
neurons 152 Methylxanthines, effect on adenosine evoked
Inhibitory amino acids, effect on magnocellular excitation 337
neurosecretory neurons 144 Metoclopramide, neuroleptic malignant syndrome
Inositol phospholipid, interaction with Ca2+ 427
channels 510 Miniature end-plate current 94
Insulin channel opening times 100
action in brain 354 sites of generation 101
effect on MEPP size 114 Miniature end-plate potential, quantal size 95,
origin in CNS 344
Insulin-like growth factor-1 receptor, in brain 345, MK 801 187, 188
354 Monoaminergic cortical systems, anatomical
Insulin receptors in brain 343-362 specificity 195-200
biochemistry 345 Monstrosities, quantal size 104, 123
disease state 355 Morphine
function 354 effect on magnocellular neurosecretory
identification 344 neurons 151
localization 345 tacrine interaction 257
signalling mechanisms 353 Mossy fibres, cerebellum, compartments 316, 323
Interleukin-18, effect on oxytocin and vasopressin Motilin, in cerebellum 313
release 477 Muscarinic receptors, tacrine interaction 263
Interneurones, GABAergic transmission 64, 68 Muscimol 38, 49
Ion channels, tacrine interactions 265 effect on magnocellular neurosecretory
Ipsilateral motor control 233, 244 neurons 144
Julia sets 283, 287 Narcolepsy 373
Neocortex, GABAergic transmission 64
Nerve agent poisoning, tacrine as an antidote 262
Kolmogorov entropy 282 Neural nets, mathematical models 291
Neurohypophysis, modulation of oxytocin and
vasopressin release 465-484
L-364,718, effect on food intake 30 Neuroleptic malignent syndrome
Lambert-Eaton myasthenic syndrome 501 causative drugs 426
Laterodorsal tegmental nucleus 364 clinical features 428
Learning, aging 201, 207 differential diagnosis 430
Leptinotarsin 501 incidence 428
Liapunov exponent 281, 284 pathogenesis 425
Lithium, role in neuroleptic malignant syndrome patients at risk 427
427 rechallenge with neuroleptic agents 431
Locomotion treatment 429
dopamine agonists and asymmetries 229-256 Neuromuscular junction, quantal size 94
pedunculopontine nucleus 366 Neurons
LY 171555, induced rotation 237, 238 calcium channels 493
calcium homeostasis 486
diversity of non-linear characteristics 294
Magnocellular neurosecretory neurons insulin receptors 346
amino acids 142 Neuropeptide Y, effect on magnocellular
biogenic amines 137 neurosecretory neurons 147
identification 132 Neurosecretory neurons 131-169
intrinsic properties 133 Neurosecretosomes
peptides 146 opioid binding sites 470
oxytocin and vasopressin release 470 Pain, pedunculopontine nucleus 371
Neurotransmitters Pancreatitis, cholecystokinin 25
regulation of Ca2+ channels 503 Parallel fibre to Purkinje cell synapses 449, 455,
release, multiple feedback links 296 458
effect of tacrine on release and uptake of 268 Paraventricular nuclei, neurosecretory
Nictitating membrane, conditioned response 203, neurons 132
207, 215, 223 Parkinson’s disease, striatum and motor
Nimodipine, aging and learning 221 control 233
Nitrendipine, interaction with Ca2+ channels 499 Pedunculopontine nucleus 363-389
Noradrenaline anatomy and physiology 364
age-related learning deficits 218 development 368
Alzheimer’s disease 271 locomotion 366
effect of tacrine on release of 270 model 378
effect on Ca2+ channels 505 pathophysiology 373
effect on magnocellular neurosecretory rhythmic functions 369
neurons 140 Penicillin, effect on GABA-induced currents 50
innervation in cerebral cortex 196 Peptides, effect on magnocellular neurosecretory
quantal size 113 neurons 146
Noradrenaline receptors, in neurohypophysis 478 Pergolide, induced rotation 237, 240
5’-Nucleotidase, in cerebellum 313 Phencyclidine receptor, effect of tacrine 267
Nucleus accumbens Phenothiazines, neuroleptic malignant syndrome
dopamine and locomotor activity 233 6
GABAergic transmission 75 Phenytoin, effect on Ca2+ channels 503
Nucleus basalis, effect of aging 219 Phospholipase A2, interaction with Ca?+
channels 510
Phospholipase C, interaction with Ca2+ channels
510
Phosphotyrosine, in brain, insulin receptor 353
Obesity, brain insulin receptors 356 Physostigmine, treatment of Alzheimer’s
1-Octanol, effect on Ca2+ channels 503 disease 271
Olfactory bulb Picrotoxin, binding in brain 41, 50
Freeman-Skarda model 299 Pirenzepine, binding in brain, effect of tacrine 263
GABAergic transmission 68 Pitrazepin 39
Olfactory cortex, GABAergic transmission 64 Pituicytes 466
Opiates, cholecystokinin interaction 25 opioid binding sites 470
Opioid peptides, effect on magnocellular PN 200-110 185, 186
neurosecretory neurons 151 Polyamine toxins, interaction with Ca2+ channels
Opioid peptides in neurohypophysis 500
binding sites 469 Posture, dopamine agonists and asymmetries
effect on oxytocin and vasopressin release 470 229-256
localization 466 Potassium, effect on quantal size 116
role 474 Potassium channel
«-Opioid receptors, in neurohypophysis 469 effect of tacrine 265
Optic tectum, GABA receptor in 57 fractal dynamics in 298
Organophosphorus compounds, tacrine as an Potassium conductance
antidote 262 adenosine effects 330, 332
Oxytocin, modulation of release 465 baclofen-induced activation 54
angiotensin 476 Power spectrum 282
catecholamines 478 Preprotackykinin 11, 17
cholecystokinins 476 Probabilistic quantal models 414
corticotropin releasing factor 477 Prodynorphin-derived peptides, in
eicosanoids 477 neurohypophysis 466
GABA 479 Proenkephalin-derived peptides, in
galanin 476 neurohypophysis 469
gastrins 476 Proglumide, effect on food intake 30
interleukin-18 477 Prostaglandins, effect on oxytocin and vasopressin
melanocyte-stimulating hormone 477 release 477
opioids 470 Protein kinase A, quantal size 113
oxytocin 149, 475 Protein kinase C
relaxin 477 interaction with Ca2+ channels 509
vasoactive intestinal peptide 475 role in electrophysiological effects of
Oxytocin receptors 474 adenosine 336
Oxytocin secretory neurons 132 Proton gradient, cholinergic vesicles 104, 115
amino acids 142 Pseudoconditioning 215
biogenic amines 137 Purkinje cells 438
intrinsic properties 134 aging 217
peptides 146 density 440, 453, 456
synaptic inputs 135 electron microscopy 440
maturation 318 effect on magnocellular neurosecretory
pf-P synapses 449, 455 neurons 147
spines 448, 454, 458 Spinal cord
total area of layer 447 GABAergic transmission 77
zebrinI in 310, 314 substance P in during development 12
Pyramidal cell, structure 295 synaptic transmission 391-423
Spin glasses 290
Stereotypy, dopamine agonists 249
Quantal size 93-130 Steroids, effect on GABA channels 52
ACh packaging into vesicles 103 Striatum
data display and plotting 96 dopamine and asymmetries of posture and
frog 113 locomotion 229-256
GABAergic transmission 73
measurement 95
modelling miniatures 101 Subminiatures 112
Substance P, in magnocellular neurosecretory
monstrosities 104
neurons 150
rodents 119
shifting population 113 Substance P containing cells 1-21
sites of MEPC generation 101 embryonic development 2
serotonergic neuron co-localization 12
Statistical tests 98
Substantia nigra, GABAergic transmission 74
Quantal transmission 420
group | afferent - DSCT neurone connection Succinylcholine, interaction with tacrine 258
412 Sudden infant death syndrome 374
Quantal variance 414 Sulpiride, effect on apomorphine-induced
Quasiperiodicity, chaos 287, 288 rotation 239
Supraoptic nuclei, neurosecretory neurons 132
Quinuclidinylbenzilate, binding in brain, effect of
Synapse, diversity of non-linear characteristics 296
tacrine 263
Synaptic boutons, Clarke’s column 397
Synaptic transmission, spinal cord 391-423
Clarke’s column 391
Relaxin, effect on oxytocin and vasopressin physiology of DSCT neurones 405
release 477
quantal transmission at group 1 afferent —
REM sleep, pedunculopontine nucleus 369, 373
DSCT neurone connection 412
Respiration, sleep-related disorders 374
unresolved issues 417
Rhythmic functions, pedunculopontine Synaptic vesicles, quanta 95
nucleus 369 Synaptophysin, in cerebullum 314
Ro 5-4864 40
Ro 15-1788 176
Ro 15-4513, effect on behavioural action of
Tachykinins, in developing brain 2, 11
ethanol 176, 178 Tacrine
Rotatory behaviour, effect of dopamine agonists
Alzheimer’s disease 271
antidote against nerve agent poisoning 262
interaction with cholinesterases 259
interaction with drugs blocking myoneural
Satiety system 23, 25 junction 258
SCH 23390, effect on rotation 239, 240 interaction with glycolate psychotomimetic
Schizophrenia, pedunculopontine nucleus 376 drugs 258
Secretosomes 466 interaction with ion channels 265
opioid binding sites 470 interaction with morphine 257
oxytocin and vasopressin release 470 interaction with muscarinic receptors 263
Sensory modulation, pedunculopontine interaction with neurotransmitters 268
nucleus 370 Taste aversion, age-related changes 212
Sensory neglect/hyperattention syndrome 245 Tetramethrin, interaction with Ca2+ channels 501
Septal nuclei, GABAergic transmission 70 Tetraphenylboron, effect on neuromuscular
Serotonin syndrome 431 transmission 104
Sex differences, age-related changes in associative Thalamic neurons, pedunculopontine nucleus and
learning 207, 209 sleep 369
Skeletal muscle, neuroleptic malignant syndrome Thalamus, GABAergic transmission 71
426 Toxins, interaction with Ca2+ channels 500
SKF 38393, induced rotation 237 Turing machine 290
Sleep-wake mechanisms, pedunculopontine Turning behaviour
nucleus 369, 373 behavioural components 242
Small cell lung carcinoma, Ca2+ conductance 502 effect of dopamine agonists 235
Sodium, effect on quantal size 115 Tyrosine kinase, in brain, insulin receptor
Somatomotor responses, age-related changes in activity 353
associative learning 207
Somatomotor substrates, age-related changes 215
Somatostatin Vasoactive intestinal polypeptide, effect on
effect on food intake 27 oxytocin and vasopressin release 475