SUBJECT INDEX Abecarnil, anxiolytic properties 207 Alcohol withdrawal, GABA 921-934 Abstract thinking, Alzheimer’s disease 465 Alpidem, anxiolytic properties 207 Acetylcholine, synthesis and release in Alzheimer’s disease hippocampus, nerve growth factor 853, 856 arecoline 643-648 N-Acetylserotonin, pineal, clorgyline and age 897 cytokines 490 Acoustic startle reflex, opiate-dopamine early detection battery for dementia 433-479 interactions 415-426 clinical diagnosis 437 Addiction treatment, buprenorphine 531-538 cognitive assessment battery 445-466 Adenosine-3’ ,5’-monophosphate, magnetic resonance imaging 586 neurotensin-sensitive protein nerve growth factor 163, 858 phosphorylation 87 Amineptine, leukocyte B-adrenoceptors 357-367 Adenylate cyclase 1-Aminocyclopropanecarboxylic acid, anxiolytic 5-HT,, receptor interaction 741 action 751 lithium and antidepressants 709-716 Amitriptyline Adrafinil, motor activity 833 5-HT,, responsivity 731 Adrenal gland prophylactic efficacy 71-82 function in abstinent alcoholic men 771-780 supersensitivity to hypothermic effects of phenelzine methyltransferase 308 oxotremorine and nicotine 540, 544 a-Adrenergic receptors, motor activity 825-840 Amphetamine B-Adrenergic receptors acoustic startle reflex 419 leukocytes, amineptine 357-367 conditioning 841-850 pineal gland 898 induced behaviours, effect of 5-HT Adrenocorticotropic hormone depletion 105-117 abstinent alcoholic men 771-780 Amphetamine-haloperidol, motor activity 910 fast feedback regulation by cortisol 523-529 B-Amyloid precursor protein, interleukin-6 490 fenfluramine and dexamethasone 639, 641 Androgens, dopaminergic function 263 D-fenfluramine response in depression 785 Animal models ipsapirone response, anxiety and anxiety 205-212 depression 725-731 anxiolytics, infant separation 745-757 Affective disorders attention deficit hyperactivity disorder 129 cholinergic properties of drugs 545 behaviour, noradrenergic system 825-840 corticotropin releasing hormone 380 depression 199-204 genetic databases 173 role of S-HT 735-744 lithium administration by eye drops 315-321 tardive dyskinesia, diltiazem 717-722 magnetic resonance imaging 584, 585 Anorexia Age, monoamine metabolites in plasma 507 corticotropin releasing hormone 379-391 Aggression, phenylacetic acid in plasma 145 mood 15-23 Aging pituitary abnormalities 351-356 dietary choline and behaviour 677-688 Anterior hypothalamic—preoptic area, muscarinic glycosaminoglycan polysulfate in receptors and locomotion 279-284 dementias 323-342 Anticonvulsants, 2-propyl-l-aminopentane and melatonin synthesis 561-566 2-((2-propyl)pentylamino) MAO.-A inhibitor 896-900 acetamide 303-306 memory 435 Antidepressants nerve growth factor 161 blockade of 5-HTP induced depression 738 Agnosia, Alzheimer’s disease 459 forskolin binding in brain 709-716 AIDS 5-HT induced PI response 393-403 peptide T pharmacokinetics 791-801 leukocyte B-adrenoceptors 357-367 SPECT scanning, dementia 650 mechanisms of action 739 Akathisia, neuroleptics 223 metabolism in rat 285-289 Alcohol, antagonism by ganglioside and sialic olfactory bulbectomy model 202 acid 91-104 orthostatic hypotension 64, 66, 68 Alcoholism, adrenal function during pineal melatonin synthesis 895-902 abstinence 771-780 prophylactic efficacy 71-82 xii Subject Index psychotic depression 765-770 Bretazenil, anxiolytic properties 207 schizophrenia 2-6 Bromocriptine, effect on nucleus accumbens schizophrenic substance abuse 7-9 neurons 122 simulated home treatment of depression 63-70 BRON, abuse of 513-521 thyroid hormones 596 Bulimia, pituitary abnormalities 351-356 Anxiety Buprenorphine, treatment of heroin animal models 205-212, 745-757 dependence 531-538 ethanol and ganglioside 93, 95 Buspirone, animal models of anxiety 209, 749 ethanol withdrawal, GABA 922, 930 5-HT,, receptors 723-733 magnetic resonance imaging 587 Caerulein, hypnogenic action 817 Anxiolytic drugs Caffeine, in BRON 513-521 animal models 205-212 Calcium, neurotensin-sensitive protein infant rat separation test 745-757 phosphorylation 85 Apomorphine Calcium channel inhibitors acoustic startle reflex 419 haloperidol-induced dopaminergic growth hormone response, effect of supersensitivity 718, 719 methyltestosterone 263-268 schizophrenia 343 induced behaviours, effect of 5-HT Candidate loci, neuropsychiatric diseases 172, depletion 105-117 174, 176 low-dose, autoreceptor activation and Carbachol, muscarinic receptors and behavioural consequences 689-698 locomotion 279-284 Appetite suppression, corticotropin releasing Carbon dioxide, panicogenic effect 237-239 hormone 387 Carteolol, heart rate 702, 704 Arcaine 187 Cat Arecoline, Alzheimer’s disease 643-648 5-HT depletion and apomorphine or Arousal, depression 257 amphetamine induced behaviours 105-117 Astrocytes, interleukin-6 production 483, 485 naloxone effects on visual evoked Atropine potentials 567-579 antagonism of physostigmine effects 875 Catecholamines, MAOI 146 carbachol and locomotion 281 Caudate nucleus, neurotensin-sensitive protein Attention phosphorylation 83-89 Alzheimer’s disease 462 Cerebellum, in vivo modulation of HIV-positive drug abusers 653, 655 cGMP 229-235 Attention deficit hyperactivity disorder Cerebral blood flow, SPECT, HIV 649-662 animal model 129 Cerebrospinal fluid methylphenidate metabolism 213-220 cholecystokinin in 601-609 Auditory evoked potentials, lateralization 761 phenylacetic acid in, schizophrenia 41-47 Autoimmunity, candidate loci 175, 177 CGS 12066B, animal model of anxiety 749 Autonomic nerve dysfunction, stress 699-708 p-Chlorophenylalanine Autoradiography, cholecystokinin binding sites in effect on apomorphine and amphetamine brain 291-296 induced behaviours 105-117 Autoreceptors, apomorphine 689-698 5-HT induced phosphoinositide hydrolysis 393-403 Chlorpheniramine, in BRON 513-521 Behavioural modes, a-noradrenergic Cholecystokinin system 825-840 in CSF, psychosis and antipsychotic Behavioural Pattern Monitor 905, 906 response 601-609 Benzodiazepine agonists, GABA modulation of food intake in undernourished rats 405-413 receptor affinity 924 panicogenic effect 237-239 Benzodiazepine receptor ligands, anxiolytic Cholecystokinin receptors, localization in brain, properties 207 autoradiography 291-296 Benzodiazepines Choline, dietary, behavioural effects during animal models of anxiety 748 aging 677-688 sleep 817, 821 Choline acetyltransferase, nerve growth sodium divalproex interaction 269-273 factor 162, 163, 853, 856 thyroid hormones 596 Cholinergic function Beta-blockers, heart rate 699-708 Alzheimer’s disease 643 Bipolar affective disorder, lithium administration nerve growth factor 851-860 by eye drops 315-321 thermoregulation 873-884 Blood group markers 177 Cholinergic neurons, nerve growth factor and Blood pressure, nortriptyline 67 neostriatum 157-169 Body temperature, ethanol and ganglioside 93, 94 Cholinergic stimulation, locomotion 279-284 Subject Index Circadian rhythm, adrenal function in D-fenfluramine and HPA axis alcoholism 776 hormones 781-790 Clonidine genetic databases 173 information processing 497-502 5-HT 394, 401, 735-744 motor activity 828-838 HPA axis 637-642 Clorgyline, pineal melatonin synthesis, 5-HT;, receptors 726 aging 895-902 5-HT, receptors 49-61 Cocaine-haloperidol, motor activity 910-912 leukocyte B-adrenoceptors and amineptine Codeine, in BRON 513-521 treatment 357-367 Cognitive functioning lithium side effects 428 Alzheimer’s disease 435 magnetic resonance imaging 584, 585, 588 assessment battery 445-466 a-methyltryptophan as a therapeutic agent 936 diagnostics 436 phenylethylamine and phenylacetic acid 144 anorexia nervosa 20 post-psychotic, TRH test 369-378 arecoline 643-648 preparatory brain potentials 257-262 elderly, glycosaminoglycan polysulfate 323-342 prophylactic efficacy of tricyclic Conditioning with amphetamine 841-850 antidepressants 71-82 Confrontational naming, Alzheimer’s disease 450 pseudodementia 439, 463 Contingent negative variation, depression 257 psychotic, tricyclic antidepressants 765-770 Core temperature 541, 545 seasonal platelet 5-HT uptake 25-39 Cortical ablation, NMDA stimulated release of simulated home treatment with dopamine 666, 669 nortriptyline 63-70 Corticosterone, physostigmine and substance-abusing schizophrenic patients 1-13 thermoregulation 877, 881 temporal segmentation of response Corticotropin releasing hormone speed 249-255 anorexigenic effects in monkey 379-391 p-tyramine challenge test 241-247 induced B-endorphin release, interleukin-1 Desipramine potentiation of 554, 557 forskolin binding in brain 709-716 response in abstinent alcoholic men 771-780 prophylactic efficacy 71-82 Cortisol Development abstinent alcoholic men 771-780 cholecystokinin satiety in undernourished fast feedback regulation of ACTH 523-529 rats 405-413 fenfluramine and dexamethasone 640 nerve growth factor 161 D-fenfluramine response in depression 786 somatic and behavioural, dopamine D1 ipsapirone response, anxiety and receptors 129-138 depression 725-731 Dexamethasone suppression test Cough suppressant, BRON, abuse of 513-521 post D-fenfluramine hormone levels 786 Cytokines 482 role of S-HT in HPA axis escape 637-642 Alzheimer’s disease 490 Diabetes mellitus, autoimmunity 177, 178 potentiation of B-endorphin secretion 551-560 Diazepam production by stimulated astrocytes 485 heart rate 702, 705 thyroid hormone changes in panic disorder 598 Diet, phenylalanine, plasma metabolites 611-623 Debrisoquine, MAO inhibition 297-301 Dihydroergotamine, migraine 192 Dementia Diltiazem, oral stereotypies 717-722 arecoline 643-648 Dissociative anaesthetics, NMDA receptor 184 early detection battery 433-479 Dog, cholecystokinin receptors in brain 291-296 assessment, organic diagnosis 437 Domperidone, effect on nucleus accumbens cognitive assessment battery 445-466 neurons 124 screens 440 Dopamine HIV drug abusers, SPECT 649-662 apomorphine induced hypomotility 690-698 magnetic resonance imaging 586 inhibition of nucleus accumbens neurons 122 old age, glycosaminoglycan polysulfate MAOI 146 treatment 323-342 opiate interactions in acoustic startle Denial of illness, anorexia nervosa 15-21 reflex 415-426 Deprenyl, phenylethylamine in brain 146, 152 phenylethylamine effect on transmission 149, Depression 152 animal models 199-204 release from nucleus accumbens, NMDA role of S-HT 735-744 receptors 663-673 anorexia nervosa 19 turnover in brain, effects of SCH 23390 and cholinergic properties of drugs 545 ritanserin 861-872 corticotropin releasing hormone 380 Dopamine agonists, motor behaviour 903-919 Xiv Subject Index Dopamine antagonists GABA, ethanol withdrawal 921-934 dopamine and 5-HT turnover 861-872 Ganglioside, attenuation of intoxicating effects of methamphetamine interaction 803-815 ethanol 91-104 Dopamine D1 receptor Genetic databases, inborn errors of mediated inhibition of nucleus accumbens metabolism 171-181 neurons from ventral tegmental Glial cells, interleukin-6 production 483, 485 area 119-128 Glucocorticoids, thermoregulation 881 somatic and behavioural ontogeny 129-138 Glutamate Dopamine D2 receptor mRNA, distribution in NMDA receptor 184 primate brain 885-893 stimulated dopamine release 667 Dopaminergic function, androgens 263 Glycine Dopaminergic transmission, Ca2+ channel cerebellar cGMP 230 inhibitors 718, 720 NMDA receptor 184 Doxepin, prophylactic efficacy 71-82 Glycosaminoglycan polysulfate, treatment of old Drug abuse, HIV, SPECT 649-662 age dementias 323-342 Dynamical entropy, dopamine and motor G proteins behaviour 915 5-HT,, receptors 728 Dysnomia, Alzheimer’s disease 451 lithium and antidepressants 713 Dystonia, neuroleptics 222 lithium and light sensitivity in affective disorder 317 Growth hormone, response to apomorphine, effect Eating disorders, pituitary abnormalities 351-356 of methyltestosterone 263-268 Elderly, glycosaminoglycan polysulfate in Guanosine-3’ ,5’-monophosphate, cerebellum, in dementias 323-342 vivo modulation 229-235 B-Endorphin interleukin-1 potentiation of secretion 551-560 response to D-fenfluramine in depression 785 Hallucinations, BRON 518 Environmental temperature, antagonism of Haloperidol physostigmine effects 873-884 CSF cholecystokinin and antipsychotic Ergot compounds, migraine 192 response 605 Ethanol, antagonism by ganglioside or sialic diltiazem and oral stereotypies 717-722 acid 91-104 effect on nucleus accumbens neurons 122-126 Ethanol withdrawal, GABA 921-934 plasma levels in schizophrenics 225 Event related potentials Haloperidol-amphetamine, motor activity 910 clonidine and scopolamine 499 Haloperidol—cocaine, motor activity 910, 912 depression 251, 253 Haloperidol reductase, red blood cells 275-278 Excitatory amino acids Headache, 5-HT receptors 191-197 animal model of anxiety 750 Heart rate, beta-blockers and diazepam 699-708 in vivo modulation of CGMP 229-235 Height, monoamine metabolites in plasma 508 NMDA receptor 186 Heroin, prepulse inhibition 420, 422 Excitatory amino acid agonists, dopamine release Heroin addiction, buprenorphine 531-538 from nucleus accumbens 663-676 Hippocampus Exploration, ethanol and ganglioside 93, 95 antidepressants and 5-HT-induced PI Extinction learning, dietary choline 681, 683, 685 response 393-403 nerve growth factor and cholinergic function 851-860 Fast feedback, ACTH/cortisol 523-529 HIV Feeding behaviour peptide T 791-801 cholecystokinin 405-413 SPECT scanning, dementia 649-662 corticotropin releasing hormone 385, 386 Home treatment, depression 63-70 Fenfluramine Homovanillic acid effect on HPA axis 639 in brain, effect of SCH 23390 and HPA axis hormones and prolactin responses in ritanserin 864 depressed patients 781-790 in plasma, age, sex, weight and height Flunitrazepam correlates 503-512 binding to GABA receptors during ethanol Hospitalization/home treatment, depression 63 withdrawal 924 Human gene mapping library 173 hypnotic action reversed by Huntington’s chorea, nerve growth factor 163 proglumide 817-823 Hydralazine, methylation 309 Fluoxetine, 5-HT,, responsivity 731 Hydrocortisone hemisuccinate, ACTH Fluphenazine, schizophrenia 224 regulation 523-529 Forskolin, binding in brain, effect of lithium and 8-Hydroxy-(di-N-propylamino)tetralin, inhibition by antidepressants 709-716 adenylate cyclase 741 Subject Index 5-Hydroxyindoleacetic acid Hypothermia interhemispheric asymmetry in brain 761 ipsapirone induced, anxiety and pineal, clorgyline and age 897 depression 725-731 plasma, age, sex, weight and height physostigmine induced 875 correlates 503-512 p-Hydroxyphenelzine, MAO inhibition 297-301 m-Hydroxyphenylacetic acid, plasma, age, sex, Idazoxam, motor activity 828 weight and height correlates 503-512 Ifenprodil 186, 232, 233 5-Hydroxytryptamine Imipramine animal model of anxiety 209, 748, 750 effect on 5-HT induced PI response 379, 401 depletion and apomorphine or amphetamine interhemispheric asymmetry in binding in human induced behaviours 105-117 brain 760 depression post-psychotic depression, TRH test 373, 374 animal model 735-744 prophylactic efficacy 71-82 interhemispheric asymmetry in human schizophrenia 3, 4 brain 759-764 substance abuse 8 a-methyltryptophan as a therapeutic agent 935 seasonal platelet binding in depression 25-39 phosphoinositide hydrolysis in platelets, thyroid hormone changes in panic disorder 598 depression 49-61 Immunogenetic disease 177 phosphoinositide response in hippocampus, effect Inborn errors of metabolism, genetic of antidepressants 393-403 databases 171-181 pineal, clorgyline and age 897 Indoleacetic acid, plasma, age, sex, weight and role in HPA axis escape from dexamethasone height correlates 503-512 suppression 637-642 Infantile autism, magnetic resonance imaging 586 seasonal platelet uptake in depression 25-39 Infant separation, test for anxiolytics 745-757 turnover in brain, effect of SCH 23390 and Information processing ritanserin 861-872 clonidine and scopolamine 497-502 5-Hydroxytryptamine 1A receptors depression 249 antidepressants 740 Inositol monophosphate, 5-HT induced anxiety, animal model 748, 750 accumulation in platelets in anxiety disorders and depression 723-733 depression 49-61 candidate loci, schizophrenia 176 Integrated genetic databases 171-181 5-Hydroxytryptamine 1A receptor agonists, Interleukin-1 anxiolytic potential 209 Alzheimer’s disease 490 5-Hydroxytryptamine 1B receptors, animal model internalization in pituitary cells 553, 557 of anxiety 749, 750 potentiation of B-endorphin secretion 551-560 5-Hydroxytryptamine 1C receptor antagonists, Interleukin-6 482 migraine 194 Alzheimer’s disease 490 5-Hydroxytryptamine 1D receptors, migraine 191 neurite outgrowth and neuronal viability 486 5-Hydroxytryptamine 2 receptors production by stimulated astrocytes 483, 485 dopamine turnover 861-872 Iprindole, effect on 5-HT induced PI platelets, depresssion 49-61 response 397, 401 5-Hydroxytryptamine 2 receptor antagonists, Ipsapirone, response in anxiety disorders and migraine 193 depression 725, 726 5-Hydroxytryptamine 3 receptor antagonists, migraine 194 5-Hydroxytryptophan animal model of depression 738 Kainate receptors, modulation of cerebellar melatonin synthesis and aging 561-566 cGMP 230 Hyperthermia, amphetamine induced 841-850 Hypothalamic phospholipid liposomes, reduction of lithium side effects 428 Language skills, Alzheimer’s disease 446 Hypothalamus Lateralization eating disorders 351 anorexia nervosa 15-21 ontogeny of cholecystokinin induced modulation 5-HT in human brain 759-764 of food intake 406, 410 Learning, dietary choline in aging rats 677-688 Hypothalamus-pituitary—adrenal axis Leukocytes, depression, B-adrenoceptors and alcoholism 771, 776 amineptine treatment 357-367 response to D-fenfluramine in depressed Light patients 781-790 melatonin synthesis, effect of aging 561-566 role of 5-HT in escape from dexamethasone sensitivity in bipolar affective disorder, lithium suppression 637-642 administration by eye drops 315-321 Hypomotility, apomorphine induced 692, 694 Limbic dysfunction, model of depression 200, 202 xvi Subject Index Lithium NMDA receptor binding 184 administration by eye drops 315-321 Monkey forskolin binding in brain 709-716 behavioural effects of CRH 379-391 induced malignant syndrome 428-430 dopamine D2 receptor mRNA in brain 885-893 prophylactic efficacy 79 Monoamine oxidase Locomotion deamination of 2-propyl-1-aminopentane and amphetamine and apomorphine induced changes, 2-((2-propyl)pentylamino) effect of 5-HT depletion 105-117 acetamide 303-306 animal model of attention deficit hyperactivity methylated phenelzine 309 disorder 129 paranoid schizophrenics 45 ethanol-induced decrement, effect of ganglioside Monoamine oxidase inhibitors and sialic acid 91-104 effect on dopamine and phenylethylamine in low-dose apomorphine 691 brain 146 muscarinic receptors in basal forebrain 279-284 peripheral 297-301 pineal melatonin synthesis, aging 895-902 Monoamines, acidic metabolites in Magnetic resonance imaging 581-593 plasma 503-512 affective disorder 584, 585 Mood, anorexia nervosa 15-23 dementia 586 Motor activity infantile autism 586 dopaminergic agents, scaling approach 903-919 neurotic disorders 587 a-noradrenergic system 825-840 pituitary abnormalities in eating Motor skills, Alzheimer’s disease 461 disorders 351-356 Multi-infarct dementia, glycosaminoglycan schizophrenia 584, 585 polysulfate 323-342 Malignant hyperthermia, psychotropic drugs 427 Muscarinic-nicotinic mechanisms 539-549 Mandelic acid, in plasma, age, sex, weight and Muscarinic receptors, basal forebrain, height correlates 503-512 locomotion 279-284 Mania, magnetic resonance imaging 588 MDL 72222, migraine 194 Mecamylamine, augmentation of hypothermic Naloxone response to oxotremorine 542 inhibition of amphetamine-induced loss of Melatonin prepulse inhibition 420 clorgyline-induced synthesis, aging 895-902 visual evoked potentials 567-579 5-HTP, light and aging 561-566 Narcolepsy 177 Memory Neostriatum, nerve growth factor 157-169 aging 435 Nerve growth factor 851 Alzheimer’s disease 453 Alzheimer’s disease 858 arecoline 643-648 cholinergic function in hippocampus 853 clonidine and scopolamine 497 clinical implications 163 HIV positive drug abusers 655 distribution and binding sites in Methadone, HIV positive abusers, neostriatum 158 SPECT 649-662 injury 161 Methamphetamine, antagonism by SCH 23390 and neuronal transport 160 raclopride 803-815 ontogenetic changes 161 N-Methyl-D-aspartate receptor Nerve growth factor receptors 159 animal model of anxiety 750 Neuroleptic Malignant Syndrome 427 glutamate, glycine and polyamines 183-190 Neuroleptics modulation of cerebellar cGMP 230 schizophrenia 221-228 regulation of dopamine release from nucleus blood levels 225 accumbens 663-676 dosage strategies 223 Methylation, phenelzine 307-312 side effects 222 Methylatropine, antagonism of physostigmine verapamil interaction 343-349 effects 875 supersensitivity, diltiazem 717-722 Methylephedrine, in BRON 513-521 Neurons, interleukin-6 486 DL-threo-Methylphenidate, metabolism in Neuropsychological testing, HIV-positive drug humans 213-220 abusers 649-662 Methyltestosterone, growth hormone response to Neurotensin, sensitive protein apomorphine 263-268 phosphorylation 83-89 a-Methyltryptophan, therapeutic agent 935-938 Nicotine, hypothermic effect, amitriptyline-induced Metoclopromide, migraine 194 supersensitivity 540, 545 Migraine, 5-HT receptors 191-197 Nitric oxide, modulation of cGMP by excitatory MK-801 amino acids 231 dopamine release from nucleus accumbens 668 Noradrenaline, motor activity 826 Subject Index Nortriptyline in plasma prophylactic efficacy 71-82 age, sex, weight and height simulated home treatment of depression 63-70 correlates 503-512 Nucleus accumbens effect of dietary phenylalanine 611-623 dopamine D1 receptor mediated inhibition Phenylalanine of neurons from ventral tegmental cholecystokinin satiety ontogeny in rats 405-413 area 119-128 dietary, plasma phenylalanine, phenylethylamine dopamine release and NUDA and phenylacetic acid 611-623 receptors 663-673 Phenylethanolamine N-methyltransferase, phenelzine methylation 307-312 Phenylethylamine Obsessive-compulsive disorder, 5-HT, 4 analysis 140 receptors 730 dietary phenylalanine 611-623 Olfactory bulbectomy, model of depression 202 distribution and metabolism 142 Online Mendelian Inheritance in Man 173 electrophysiological effects 149 Ontogeny, cholecystokinin satiety in marker in neuropsychiatric disorders 143 undernourished rats 405-413 MAO effects 146 Open field, dietary choline and behaviour 679, modulation of catecholaminergic 83, 684 neurotransmission 139-156 Opiate, dopamine interactions in acoustic startle neuromodulator in dopaminergic reflex 415-426 neurotransmission 45 Opiate dependence, buprenorphine 531-538 urinary, paranoid schizophrenia 44 Opioid peptides, visual processing 567-579 Phosphoinositide Optic chiasm, naloxone and visual evoked 5-HT stimulated hydrolysis in hippocampus, potentials 570 effect of antidepressants 393-403 Oral stereotypies, quinpirole-induced, effect of 5-HT stimulated hydrolysis in platelets in diltiazem 717-722 depression 49-61 Orthostatic hypotension, nortriptyline 64, 66, 68 Photosensitivity, bipolar affective disorder 315 Over-the-counter cough suppressant, abuse Physostigmine, hypothermic and neuroendocrine of 513-521 responses, antagonism 873-884 Oxotremorine, hypothermic effect, mecamylamine Pindolol, heart rate 702, 704 sensitivity 541, 542 Pineal gland, melatonin response to clorgyline, aging 895-902 Pirenzepine, carbachol and locomotion 283 P300 761 Pituitary cells, interleukin-1 potentiation of Panic disorder endorphin secretion 551-560 cholecystokinin and carbon dioxide 237-239 Pituitary gland, eating disorders 351-356 5-HT;, receptors 728 Platelets sodium divalproex—benzodiazepine 5-HT, function in depression 49-61 interaction 269-273 seasonal 5-HT uptake and imipramine binding in thyroid hormones during treatment 595-600 depression 25-39 Paranoid schizophrenia Polyamines phenylacetic acid in CSF and serum 41-47 cerebellar CGMP 233 phenylacetic acid and phenylethylamine in modulation of NMDA receptor 184 brain 143 Postmortem brain, serotonergic interhemispherical Parkinson’s disease, phenylethylamine and asymmetry 759-764 catecholaminergic neurotransmission 152 Post-psychotic depression, thyroid releasing Pentobarbital, hypothermic effect, amphetamine hormone test 369-378 conditioning 846 Potassium, dopamine release from nucleus Peptide T, AIDS 791-801 accumbens 667, 672 Perceptual function, Alzheimer’s disease 459 Practice, psychometric testing 625-635 Pharmaco-EEG, serotonergic interhemispheric Praxis, Alzheimer’s disease 461 asymmetry 759-764 Prazosin, motor activity 835 Phencyclidine, NMDA receptor in Prepulse inhibition, acoustic startle 415, 419 schizophrenia 184 Primary degenerative dementia Pheneizine early detection battery 433-479 MAO inhibition 297-301 glycosaminoglycan polysulfate 323-342 methylation 307-312 Problem solving, Alzheimer’s disease 465 Phenolsulfotransferase, platelets, Procyclidine, antagonism of physostigmine depression 241-247 effects 875 Phenylacetic acid Prodrug, valproic acid 304 in CSF and serum in schizophrenia 41-47 Proglumide, reversal of hypnotic action of marker in neuropsychiatric disorders 143 flunitrazepam 817-823 xviii Subject Index Prolactin, response to D-fenfluramine in thyroid releasing hormone test in post-psychotic depression 786 depression 369-378 Prophylactic efficacy, tricyclic verapamil 343-349 antidepressants 71-82 Scopolamine Propranolol, heart rate 702, 705 antagonism of physostigmine effects 875 2-Propyl-1-aminopentane, deamination and information processing 497-502 anticonvulsant activity 303-306 Seasonal variation, platelet 5-HT uptake in 2-((Propyl)pentylamino)acetamide, deamination depression 25-39 and anticonvulsant activity 303-306 Semicarbazide-sensitive amine oxidase 303-306 Protein, neurotensin-sensitive Senile dementia, early detection battery 433-479 phosphorylation 83-89 Sensitization, amphetamine 842, 847 Protein kinase C, depletion and interleukin-1 Sensorimotor gating, opiate-dopamine potentiation of B-endorphin secretion 554, interaction 416, 422 597, Sensory modulation, naloxone 568, 573 Psychometric testing, practice effect 625-635 Separation Psychomotor retardation, depression 249, 257 animal model of depression 201 Psychotic depression, tricyclic test for anxiolytics 745-757 antidepressants 765-770 Serotonergic agents, migraine 191-197 Punishment, anxiolytic drugs 207 Sex differences CSF cholecystokinin in schizophrenics 604 monoamine metabolites in plasma 506 Quinpirole serotonergic lateralization 761 induced oral stereotypies, effect of Sialic acid, attenuation of intoxicating effects of diltiazem 717-722 ethanol 91-104 motor activity 909, 914 SKF 38393 Quisqualate receptors, modulation of cerebellar motor activity 909, 914 cGMP 230 nucleus accumbens neurons 122-126 Sleep ethanol and ganglioside 95 Raclopride, methamphetamine flunitrazepam and proglumide 817-823 antagonism 803-815 Slow release, methylphenidate 220 Rat strains, somatic and behavioural ontogeny and ~ Sodium divalproex, benzodiazepine dopamine D1 receptors 129-138 interaction 269-273 Reaction time Spatial scaling component, dopamine and motor clonidine and scopolamine 499 behaviour 914 depression 249, 257 Species differences Red blood cells, haloperidol reductase 275-278 antidepressant metabolism 285 Ritanserin, effect on dopamine and 5-HT turnover cholecystokinin receptors in brain 291 in brain 861-872 corticotropin releasing hormone 386 RO 15-1788, animal model of anxiety 748 SPECT scanning, HIV-positive drug Ro 15-4513, binding to GABA receptors during abusers 649-662 ethanol withdrawal 924 Spermidine, NMDA receptor 185 Stereotypy, apomorphine 693 Stress SCH 23390 animal models of depression 201 effect on dopamine and 5-HT turnover in beta-blockers, diazepam and heart rate 699-708 brain 861-872 induced hyperthermia 848 methamphetamine antagonism 803-815 Stroke, NMDA receptor 184 effect on nucleus accumbens neurons 122-126 Substance abuse ontogeny of dopamine D1 receptor 134 BRON 513-521 Schizophrenia HIV, SPECT 649-662 antidepressants and substance abuse 1-13 schizophrenics, antidepressants 6-9 candidate serotonergic gene 176 Sumatriptan, migraine 192 cholecystokinin in CSF 601-609 Suriclone, anxiolytic properties 207 genetic databases 173 haloperidol reductase in red blood cells 275-278 Tardive dyskinesia magnetic resonance imaging 584, 585 diltiazem 717-722 neuroleptics 221-228 neuroleptics 223 NMDA receptor 184 verapamil 343-349 phenylacetic acid in CSF and serum 41-47 Temporal discrimination, dietary choline 679, phenylacetic acid and phenylethylamine in 681, 684 brain 143, 152 Tetrabenazine, animal model of depression 736 Subject Index Thermoregulation Valproic acid muscarinic-nicotinic mechanisms 539-549 formation from physostigmine 873-884 2-((2-propyl)pentylamino)acetamide and Thyrotropin releasing hormone test, post-psychotic 2-propyl-l-aminopentane 304 depression 369-378 Vanillylmandelic acid, in plasma, age, sex, weight Thyroxine, changes during treatment of panic and height correlates 503-512 disorder 595-600 Vasopressin, induced B-endorphin release, Tourette syndrome, genetic databases 173 interleukin-1 potentiation of 554, 557 Transducin, lithium interaction with G Ventral tegmental area, dopamine D1 receptor proteins 317, 318 mediated inhibition of nucleus accumbens Tranylcypromine, forskolin binding in neurons 119-128 brain 709-716 Verapamil, schizophrenia 343-349 Trazodone, schizophrenia 3 Verbal memory Tricyclic antidepressants Alzheimer’s disease 453 induced malignant syndrome 427 arecoline 643-648 metabolism in rat 285-289 HIV-positive drug abusers 653, 655 orthostatic hypotension 64, 66, 68 Visual evoked potentials, naloxone 567-579 prophylactic efficacy 71-82 Visuospatial deficits, Alzheimer’s disease 457 psychotic depression 765-770 Visuospatial function, arecoline 643-648 schizophrenia 3 Vocabulary, dementia 446 simulated home treatment of depression 63-70 Trimipramine, metabolism in rat 285-289 Tryptophan hydroxylase, inhibition and evoked behaviours 105-117 Weight, monoamine metabolites in plasma 508 p-Tyramine challenge test, depression 241-247 Withdrawal, ethanol, GABA 921-934 Word fluency, Alzheimer’s disease 448 Ultrasonic vocalization, test for anxiolytics 745-757 Undernutrition, cholecystokinin and food intake 405-413 Yawning, apomorphine-induced 692