Progress in Nephrology: Proceedings of the Vth Symposium of the “Gesellschaft für Nephrologie”, held in Lausanne (Switzerland) 21–23 September 1967

420 Pages·1969·12.783 MB·English

by  Bodil Schmidt-Nielsen, William E. Lassiter, Françoise Roch-Ramel (auth.), Georges Peters M.D., Françoise Roch-Ramel Ph.D. (eds.)

Progress
in Nephrology
Proceedings of the Vth Symposium of the
"Gesellschaft fiir Nephrologie", held in Lausanne (Switzerland)
21-25 Sept. 1967
Edited by
Georges Peters. Fran«;;oise Roch-Ramel
With 21 5 Figures
Springer-Verlag Berlin Heidelberg GmbH
ISBN 978-3-540-04672-1 ISBN 978-3-642-87957-9 (eBook)
DOI 10.1007/978-3-642-87957-9
reserved. No part of this book may be translated or reproduced in any form without written permission
Springer-Verlag. ©by Springer-Verlag Berlin Heidelberg 1969. Library of Congress Catalog Card Number
Originally published by Springer-Verlag Berlin· Heidelberg in 1969
76-78289. The use of general descriptive names, trade names, trade marks, etc. in this
publication, even if the former are not especially identified, is not to be taken as a sign that such names, as
understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Title No.1563
Preface
The present volume contains the edited proceedings of the Vth Symposium
of the "Gesellschaft fiir Nephrologie" held in Lausanne, Switzerland, from
September 21 to September 23, 1967. The manuscripts were arranged according
to their contents rather than to their titles. An attempt was made to divide
the allotted space between different contributors according to the apparent
importance or originality of the contributions.
Most of the papers submitted were written in either German or a rather
inarticulate English, and subsequently, have been translated into English by
the editors and their collaborators. The editors are indebted to Mr. R. Darling,
student of medicine of the Faculte de Medicine de l'Universite de Lausanne, for
reviewing the English translation.
Editing was limited to requirements based on form rather than on content. In
a few instances, manuscripts which were inadequate in form were accepted because
their contents appeared interesting or important. A very few manuscripts were
either not submitted or could not be included in the present proceedings, because
they did not satisfy the editorial standards. Some papers are published in the
present proceedings in abstract form because they have been submitted elsewhere
for full publication.
The editors' responsibility does not extend to the factual content of the
manuscripts. The editors wish to apologize for the long delay in publishing these
proceedings, a delay which may be attributed to difficulties in communication
and cooperation with various authors.
The present volume has been printed with the help of a generous grant
donated by Sharp and Dohme G.m.b.H., Munich, a subsidiary of Merck and Co.
Inc., Rahway, N.J.jUSA. The editors wish to thank this company for their
liberal assistance.
It is hoped that the present volume which gives a just picture of the status
of nephrological research in the German speaking countries of Europe, will meet
its aim of making this work known to nephrologists throughout the world.
Lausanne, Aprill969
GEORGES PETERS FRANQOISE RocH-RAMEL
Table of Contents
1. The Renal Excretion of Nitrogen Containing Metabolites • • . • . 1
1.1. Urea . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1.1. B. SCHMIDT-NIELSEN: Comparative Physiology of Urea Excretion. 1
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . 11
1.1.2. W. E. LASSITER: The Renal Excretion of Urea . . . . . . . . . . 13
1.1.3. F. RAMEL, F. CHOMETY, G. PETERS: The Fate of Urea in the Rat's Kidney as
Studied by Micropuncture and Tissue Analysis . . . . . . . . . . . . 23
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
1.1.4. B. TRUNIGER, B. SCHMIDT-NIELSEN: Transtubular Movement of Urea and
Related Compounds . . . . . . . . . . . . . . . . . . . . . . 26
1.1.5. D. F. GROSSMANN, L. GEBAUER, A. NoLTE: Chronic Overloading with Urea in
Rats . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
1.1.6. D. F. GROSSMANN, K. F. KoPP: Kinetics of the Movements of Urea through a
Biological Membrane . . . . . . . . . . . 36
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
1.1.7. K. KRAMER: Urine Concentrating Mechanisms . . . . . . . . . . . 41
1.1.8. H. W. REINHARDT, K. ELLINGHAUS, H. J. KLOSE, P. DEETJEN: The Role of
Urea in the Renal Concentrating Operation in the Dog . . . . . . . 46
1.1.9. K. J. ULLRICH: The Transepithelial Urea Transport in Different Segments of the
Mammalian Nephron . . . . . . . . . . . . 49
1.2. Uric acid . . . . . . . . . . . . . . . . . 52
1.2.1. N. ZoLLNER: The Renal Excretion of Uric Acid 52
Discussion . . . . . . . . . . . . . . . . . 58
1.2.2. J. ScHIRMEISTER, N. K. MAN, W. HALLAUER: Study on Renal and Extrarenal
Factors Involved in the Hyperuricemia Induced by Furosemide . . . . . . . 59
1.2.3. J. MoELLER: Renal Biopsy in Patients with Hyperuricemia . . . . . . . . . 64
1.2.4. A. MASBERNARD, CH. HILTENBRAND, Y. M:EMIN: Benziodaron in the Long-Term
Management of Gout . . . . . . . . . . 65
1.3. Ammonia . . . . . . . . . . . . . . . 74
1.3.1. R. F. PITTS: Renal Excretion of Ammonia. 74
Discussion . . . . . . . . . . . . . . . 85
1.4. Experimental Uremia . . . . . . . . . 86
1.4.1. M. BRANDIS, G. BRAUN-SCHUBERT, K. H. GERTZ: Retrograde Flow of Fluid
within Superficial Tubules after Cessation of Glomerular Filtration 86
Discussion . . . . . . . . . . . . . . . . . . . . . 88
1.4.2. D. RENNER, R. HEINTZ: Cellular Metabolism in Uremia . . . . . 90
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . 93
1.4.3. W. ScHOEPPE, K. FEDERLIN, F. SoRGE: Intratubular Pressure, Glomerular
Capillary Pressure and Tubular Passage-Time in Rats with Masugi-Nephritis 94
1.4.4. V. PRAT, LuDMILA KoNfcKovA, W. RITZERFELD, H. LossE: The Pathogenesis of
Experimental Ascending E. coli Pyelonephritis . . . . . . . . . . . . 97
1.4.5. H. LossE, V. PRAT, LuDMILA KoNfcKovA, W. RITZERFELD: Trials of Anti
bacterial Drugs in Experimental Pyelonephritis . . . . . . . . . . . . . . 101
1.4.6. D. WALTHER, K. H. GoGGEL, K. HuBNER, W. ScHOEPPE: An Experimental
Investigation of the Hepatorenal Syndrome ................ 103
1.5. Clinical Uremia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108
1.5.1. A. BLUMBERG: Clinical and Therapeutic Considerations on Chronic Renal Failure 108
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
1.5.2. R. KLUTHE: Contribution to the Dietetic management of Chronic Renal Failure 120
VI Table of Contents
1.5.3. H. QuiRIN, V. HEINZE, A. TouRKANTONIS, R. KLuTHE: Clinical Experience with
the Combined Treatment of Chronic Renal Failure with Peritoneal Dialysis and
a Strict Low-Protein "Potatoe-Egg-Diet" . . 122
1.5.4. H. U. ZoLLINGER: The Pathology of Uremia ................ 126
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
1.5.5. A. HEIDLAND, K. KLfuscH, T. TAKUMA, E. ScHEITZA: Functional Patterns in
Chronic Renal Failure . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144
1.5.6. H. E. ScHAFER, ANNELORE SCHAFER: Immunologic Findings in Chronic Glome
rulonephritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
1.5.7. A. GoTTESLEBEN, A. PRILL, E. QuELLHORBT, E. VoLLES, F. ScHELER: The
Retention of Urea, Uric Acid and Creatinine in Renal Failure and their Relations
to Protein Changes in Blood and Cerebrospinal Fluid. Quantitative Immuno
chemical Findings. . . . . . . . . . . . . . . . . . . . . . . . . . . . 152
1.5.8. L. CAMPANACCI, G. F. GuARNIERI, N. SILIPRANDI, E. Fuscm: Studies on Blood
Acetoacetate, Pyruvate, Lactate, oc-Oxoglutarate and Citrate in Chronic Renal
Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
1.5.9. H. E. KELLER, H. J. KRAMER, G. A. JuTZLER, D. DoENECKE, G. TRAuT, D.
MuTING: Plasma Phenols in Renal Failure and their Elimination through the
Artificial Kidney . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162
1.5.10. K. KLuTSCH, A. HEIDLAND, L. GRIEBEL, F. GuNTHER: The Effect of Blood
Reinfusion and of THAM on Experimental Hypovolemic Acidosis . . 167
1.5.11. W. FRIEDRICH, A. LACKENSCHWEIGER, W. WEISSEL, E. ZIMMERMANN: Isolated
Renal Polyarteriitis . . . . . . . . . 171
2. Toxic Disturbances of Renal Functions . . . . . . . . . . . . . . 173
2.1. General Toxicology . . . . . . . . . . . . . . . . . . . . . . . 173
2.1.1. F. GLOOR: Morphological Aspects of the Acute Toxic Nephropathies 173
Discussion . . . . . . . . . . . . . . . . . . . . . . . 192
2.1.2. D. E. OKEN: Experimental Studies of Acute Renal Failure . 193
Discussion . . . . . . . . . . . . . . . . . . . . . . . 201
2.2. Special Toxicology . . . . . . . . . . . . . . . . . . . 203
2.2.1. M. WIEDERHOLT, K. HIERHOLZER: The Effect of Actinomycin D on Trans
epithelial Sodium Transport . . . . . . . . . . . . . . . . . . . . . . . 203
2.2.2. K. H. LANGER, W. THOENES, A. WARNING: Metabolic Tubular Failure Induced
by Local Application of Potassium Cyanide to the Surface of Rat Kidneys . . 210
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
2.2.3. H. C. BuRCK, F. PETRUCH: Renal Lesions after the Intramuscular Injection of
Glycerol in the Study of Acute Renal Failure . . . . . . . . . . . . . . . 217
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
2.2.4. F. P. BRUNNER, P. G. FRICK: Hypokalemia, Metabolic Alkalosis and Hyper
natremia Induced by Treatment with high Doses of Sodium-Penicillin G ... 225
2.2.5. K. G. TmELE, R. C. MuEHRCKE: Clinical Observations on Drug-Induced Nephro
toxicity: DL-Penicillamine and Aristolochic Acid . . . . . . . . . . . . . . 229
2.2.6. J. BRODEHL, K. GELLISSEN, W. HAGGE, H. ScHUMACHER: Reversible Fanconi
Syndrome due to a Toxic Degradation Product of a Tetracycline . . . . . . 234
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
2.2.7. U. C. DuBACH: Absorption, Fate and Elimination of Phenacetin and N-Acetyl
p-Aminophenol in Renal Failure . . . . . . . . . . . . . . . . . . . . . 240
2.2.8. J. BRODEHL, K. GELLISSEN, W. HAGGE: The Fanconi Syndrome in Hepatorenal
Glycogen Storage Disease . . . . . . . . . . . . . . . . . . . . . . . . 241
2.2.9. G. M. EISENBACH, H. CAIN, M. STEINHAUSEN: Functional and Morphologic
Investigation of the Effects of Subchronic Treatment with 2,4-Dinitrophenol on
the Rat's Kidney. . . . . . . . . . 244
3. Natriuretic and Anti-natriuretic Agents . . . . . . . . . . . . . . . . . . 249
Table of Contents VII
3.1. H. HoLZGREVE, K. LoESCHKE: Action of Diuretics in the Proximal Convoluted
Tubule of Rat Kidney . . . . . . . . . . . . . . . . . . . . . . . . . 249
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 254
3.2. P. DEETJEN, W.E.B"ii"NTIG, K.IlARDT, R.RoHDE: Diuretic EffectofEthacrynic
Acid in the Rat: a Micropuncture Study concerning the Relationship of Site
and Mode of Diuretic Action . . . . . . . . . . . . . . . . . . . . . . . 255
3.3. E. QuELLHORST, F. ScHELER, I. STEGEMANN: The Efficacy of Ethacrynic Acid
in the Treatment of Chronic Renal Failure . . . . . . . . . . . . . . . . . 262
3.4. W. LosERT, R. SrTT, G. SENFT t, K. v. BERGMANN, A. ZESCH: Biochem,ical Studies
on Mechanisms of Action of Compounds Influencing Tubular Na+Transport:
I. Aldosterone, Amiloride, Triamterene . . . . . . . . . . . . . . . . . . 267
3.5. A. ZESCH, G. SENFT t, W. LosERT: Biochemical Studies on Mechanisms of
Action of Compounds Influencing Tubular Na+ Transport: II. 6-Aminonicotin-
amide, Furosemide . . . . . . . . . . . . . . . . . . . 275
3.6. H.-J. MoHR: Submicroscopic Alterations of Tubular Epithelia Induced by
Furosemide . . . . . . . . . . . . . . . . . . . . 281
Discussion . . . . . . . . . . . . . . . . . . . . . 288
3. 7. W. HERMS, F. KERSTING: Studies on Oxygen Consumption and Changes of Tissue
Cation Concentrations in K+-Depleted Rabbit Kidney Slices, under the Influence
of Diuretic Agents, p-Chloromercuribenzoate and N-Ethylmalemide ..... 290
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294
3.8. J. EIGLER, J. KELTER, E. RENNER: The Effect of Amiprazide on Sodium and
Water Flux Across Frog Skin . 296
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
4. Renin, Angiotensin, Aldosterone . . . . . . . . . . . . . . . . . . . . . 302
4.1. A. BoHLE, A. HELBER, D. MEYER, J. ScH"ii"RHoLz, H. P. WoLFF: A Light and
Electron Microscopic Investigation of the Juxtaglomerular Apparatus of the
Kidneys of Patients with Conn's Syndrome . . . . . . . . . . . . . . . . 302
4.2. J. ScH"ii"RHOLZ, H. J. SCHMID, D. MEYER, A. BoHLE: Light and Electron Micro
scopic Investigations of the Juxtaglomerular Apparatus in a Patient with a
"Pseudo-Bartter"-Syndrome ...................... 312
4.3. D. MEYER, P. J. M!TTMEYER: Relationship between Serum-Sodium Concentra
tion, Hematocrit and Juxtaglomerular Granulation Index of the Mouse Kidney 322
4.4. H. P. WoLFF, CH. BARTH, S. RosCHER, P. VEcsm, J. B. BRowN, G. DusTERDIECK,
A. F. LEVER, J. I. S. RoBERTSON: Normokalemic Primary Aldosteronism ... 327
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330
4.5. P. FAARur, 0. MuNCK, J. LADEFOGED, F. R. MATHIESEN, F. PEDERSEN, P. A.
GAMMELGARD: Evaluation of Renal Hypertension with Special Reference to the
Morphology of the Juxtaglomerular Apparatus ............... 331
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334
4.6. D. REGOLI, G. ScHAECHTELIN, G. PETERS: The Renin Activity in Rat Plasma 335
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 336
4.7. H. DAHLHEIM, P. WEBER, I. HEROLD, H. PETSCHAUER, K. THURAU: Preparative
Methods to Purify Renin Substrate . . . . . . . . . . . . . . . . . . . . 337
4.8. M. NAGANO: Enzyme Activity in Isolated Glomeruli of Rats with Renal Hyper-
tension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
4.9. G. PETERS, J. PH. BoNJOUR, D. REGOLI: Renal Effects of Angiotensin and of
Postpituitary Peptides . . . . . . . . . . . . . . . . . . . . . . . . . 345
5. Urinary Concentration and Dilution . . . . . . . . . . . . . . . . . . . 348
5.1. J. ScHNERMANN, H. VA LTIN, H. FiscHBACH, W. NAGEL, M. HoRSTER, G. LIEBAU,
M. TABOR, A. GELTINGER, K. THURAu: Micropuncture Study of Tubular Sodium
and Water Reabsorption in Rats with Hereditary Hypothalamic Diabetes
insipidus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 348
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 354
5.2. G. F"ii"LGRAFF, G. HEINZ, A. HERZFELD, 0. HEIDENREICH: The Effect of Elevated
Plasma Calcium Concentrations on Renal Concentrating and Diluting Mechanisms 355
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 355
VIII Table of Contents
5.3. W. THoENES, K. H. LANGER: The Localization of Chloride Ions in the Proximal
Tubule, Studied by a Micropuncture Method . . . . . . . . . . . . . . . 357
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 364
5.4. P. SCHOLLMEYER, H. NIETH: Human Renal Oxygen Consumption and its Deter
minants in Intact and Impaired Function . . . . . . . . . . . . . . . . . 365
5.5. M. STEINHAUSEN, H. WEIDINGER, H. J. Ross, G. M. EISENBACH: Incident-Light
Microscopy of the Renal Surface During Stimulation of the Sympathetic Renal
Nerves ............................... . 370
6. Miscellaneous . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375
6.1. D. W. BEHRENBECK, A. DoRGE, H. W. REINHARDT: Balance of Electrolytes and
Sodium Rejection after Sodium Depletion by Means of Peritoneal Dialysis or of
Repeated Mannitol Infusions . . . . . . . . . . . . . . . . . . . . . . . 375
6.2. D. GEKLE, D. RosTOCK, G. KURTH: A Micropuncture Investigation of the Effect
of Parathormone on Proximal Tubular Fluid Reabsorption in the Rat Kidney 380
6.3. H. E. RENSCHLER, D. JAENKNER, E. KAMMERER, R. THOMA: The Influence of an
Intravenous Glucose Load on Renal Sodium Excretion .......... . 385
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
6.4. D. P. MERTZ, F. SCHINDERS: Influence of Acute Metabolic Changes in Acid-Base-
Balance on the Renal Sodium Excretion in Man . . . . . . . . . . . . . . 390
6.5. D. F. GROSSMANN, J. FREY: The Renal Clearance of Lissamine Green in the Rat 391
Subject Index. . . . . • • . . . . . . . • • • • • • • • . • • • • . . . . . . 395
List of Contributors
BALTZER, G., M.D., Medizinische Universitatsklinik, MankopffstraBe 1, D-355 MarburgfLahn,
Fed. Rep. of Germany
BARTH, C., M.D., II. Medizinische Universitatsklinik und Poliklinik, Landeskrankenhaus,
D-665 Homburg/Saar, Fed. Rep. of Germany
BEHRENBECK, D. W., M.D., Medizinische Universitatsklinik, D-53 Bonn-Venusberg, Fed.
Rep. of Germany
BLUMBERG, A., M.D., Medizinische Poliklinik der Universitat Bern, FreiburgstraBe 3,
CH-3000 Bern, Switzerland
BoHLE, A., M.D., Professor of Pathology. Chairman: Pathologisches Institut der Universitat,
LiebermeisterstraBe 8, D-74 Tiibingen, Fed. Rep. of Germany
BoNJOUR, J. PH., M.D., Department of Physiology, University of Michigan, East Medical
Building, Ann Arbor (48104), Michigan, U.S.A.
BRANDIS, M., M.D., Physiologisches Institut der Freien Universitat, Arnimallee 22,
D-1 Berlin-Dahlem 33, Germany
BRASS, H., M.D., Medizinische Abteilung II, Technische Hochschule, GoethestraBe 27-29,
D-51 Aachen, Fed. Rep. of Germany
BRAUN-SCHUBERT, G., Physiologisches lnstitut der Freien Universitat, Arnimallee 22,
D-1 Berlin-Dahlem 33, Germany
BRODEHL, J., M.D., Privatdozent, Universitats-Kinderklinik, Adenauer-Allee 119, D-53 Bonn,
Fed. Rep. of Germany
BROWN, J. J., M.B. Chairman: Medical Research Council Blood Pressure Research Unit,
Western, Infirmary, Glasgow, Scotland
BRUNNER, F. P., M.D., Medizinische Universitats-Poliklinik, Inselspital, CH-3008 Bern,
Switzerland
BucH, D., M.D., Pharmakologische Abteilung J. R. Geigy A.G., CH-4000 Basel, Switzerland
BUNTIG, W. E., M.D., Physiologisches Institut der Universitat, PettenkoferstraBe 12,
D-8 Miinchen 15, Fed. Rep. of Germany
BURCK, H. C., M.D., Medizinische Universitatsklinik, Ottfried-Miiller-StraBe, D-74 Tiibingen,
Fed. Rep. of Germany
CAIN, H., M.D., Professor of Pathology. Chairman: Pathologisches Institut am Stadtischen
Katharinenhospital, KriegsbergstraBe 60, D-7 Stuttgart, Fed. Rep. of Germany
C.AMPANACCI, L., M.D., Istituto di patologia medica dell'Universita di Padova, Policlinico
universitario, Via Giustiniani, I-35100 Padova, Italy
CHOMETY, FRANQOISE, Institut de Pharmacologia de l'Universite de Lausanne 21, rue du
Bugnon, CH-1005 Lausanne, Switzerland
COTTIER, P., M.D., Privatdozent. Chairman: Medizinische Abteilung Bezirksspital, CH-3800
Interlaken, Switzerland
DAHLMEIM, H., Ph.D., Physiologisches Institut der Universitat, PettenkoferstraBe 12,
D-8 Miinchen 15, Fed. Rep. of Germany
DEETJEN, P., M.D., Privatdozent, Physiologisches Institut der Universitat, Pettenkofer
straBe 12, D-8 Miinchen, Fed. Rep. of Germany
DoENECKE, D., M.D., I. Medizinische Universitiitsklinik, Landeskrankenhaus, D-665 Hom
burg/Saar, Fed. Rep. of Germany
DUBACH, U. C., M.D., Privatdozent, Medizinische Universitats-Poliklinik, HebelstraBe 1,
CH-4056 Basel, Switzerland
DusTERDIECK, G., Ph.D., Medical Research Council Blood Pressure Research Unit, Western
Infirmary, Glasgow, Scotland
EmLER, J., M.D., Privatdozent, Medizinische Universitats-Poliklinik und Medizinische Klinik,
OsmerheimerstraBe 200, D-5 Koln-Merheim, Fed. Rep. of Germany
X List of Contributors
EISENBACH, G. M., M.D., I. Physiologisches Institut der Universitat, .Akademiestra.Be 3,
D-69 Heidelberg, Fed. Rep. of Germany
ELLINGHAUS, K., Physiologisches Institut der Universitat, Pettenkoferstra.Be 1 a, D-8 Miin
chen 15, Fed. Rep. of Germany
ENDERLIN, F., M.D., Chirurgische Universitatsklinik, Biirgerspital, Spitalstra.Be 2, CH-4056
Basel, Switzerland
FAARUP, P., M.D., Institute for Experimental Medicine, University, Nerre-Allee 71,
DK-2300 Kebenhavn, Denmark
FEDERLIN, K., M.D., Privatdozent, Zentrum fiir Innere Medizin der Universitat Ulm,
D-79 Ulm/Donau, Fed. Rep. of Germany
FIAsCHI, E., M.D., Professor of Medicine. Chairman: Istituto di patologia medica dell' Uni
versita di Padova. Policlinico universitario. Via Giustiniani 12, I-35100 Padova, Italy
FISCHBACH, M., M.D., Pathologisches Institut der Universitat, Liebermeisterstra.Be 8,
D-14 Tiibingen, Fed. Rep. of Germany
FREY, J., M.D., Professor of Medicine. Chairman: II. Medizinische Universitatsklinik, Ludwig
Rehn-Stra.Be 14, D-6 Frankfurt/Main Siid 70, Fed. Rep. of Germany
FRICK, A., M.D., Abteilung Physiologie, Medizinische Fakultat der Technischen Hochschule
Aachen, z.Z. Hermann-Herder-Stra.Be 7, D-78 Freiburg/Breisgau, Fed. Rep. of Germany
FRICK, P. G., M.D., Professor of Medicine, Medizinische Universitatsklinik, Kantonsspital,
Ramistra.Be 100, CH-8000 Ziirich, Switzerland
FRIEDRICH, W., M.D., Prosektor, Wilhelminenspital der Stadt Wien, Montleartstra.Be 37,
A-1170 Wien XVI, Austria
FRITZ, K. W., M.D., Privatdozent, Medizinische Universitatsklinik, Richthofenstra.Be 63,
D-53 Bonn-Venusberg, Fed. Rep. of Germany
Ffu.GRAFF, G., M.D., Privatdozent, Lehrstuhl fiir Pharmakologie der Medizinischen Fakultat
der Technischen Hochschule Aachen, z.Z. Katharinenstra.Be 29, D-78 FreiburgjBreisgau,
Fed. Rep. of Germany
GAMMELGARD, P. A., M.D., Professor of Surgery, Department of Surgery H, Gentofte Hospital
Mellerup, DK 2900 Kebenhavn, Denmark
GEBAUER, L., Ph.D., now Mrs. REINEMER, II. Medizinische Universitatsklinik, Ludwig-Rehn
Stra.Be 14, D-6 Frankfurt/Main, Fed. Rep. of Germany
GEKLE, D., M.D., Universitats-Kinderklinik, Josef-Schneider-Stra.Be 2, D-87 Wiirzburg,
Fed. Rep. of Germany
GELLISSEN, K., M.D., St. Elisabeth-Krankenhaus, Kinderabteilung, D-5450 Neuwied, Fed.
Rep. of Germany
GELTINGER, A., Physiologisches Institut der Universitat, Pettenkoferstra.Be 12, D-8 Miin
chen 15, Fed. Rep. of Germany
GERTZ, K. H., Ph. D., Privatdozent, Physiologisches Institut der Freien Universitat, Arnim
allee 22, D-1 Berlin-Dahlem 33, Germany
GESSLER, U., M.D., Professor of Medicine. Chairman: 4. Medizinische Klinik der Stadtischen
Krankenanstalten, Kontumazgarten 14/18, D-85 Niirnberg, Fed. Rep. of Germany
GmoN, J. P., M.D., Chirurgische Universitatsklinik, Biirgerspital, Spitalstra.Be 21, CH-4000
Basel, Switzerland
GLOOR, F., M.D., Professor of Pathology, Pathologisches Institut der Universitat Basel,
Hebelstra.Be 24, CH-4056 Basel, Switzerland
GoGGEL, K. H., M.D., II. Medizinische Klinik der Universitat Frankfurt, Ludwig-Rehn
Stra.Be 14, D-6 Frankfurt/Main Siid 70, Fed. Rep. of Germany
GoTTESLEBEN, A., M.D., Neurologische Klinik der Universitat, v. Sieboldstra.Be 5, D-34 Got
tingen, Fed. Rep. of Germany
GRIEBEL, L., M.D., Medizinische Universitatsklinik, Luitpoldkrankenhaus 14, Josef-Schneider
Stra.Be 2, D-87 Wiirzburg, Fed. Rep. of Germany
GROSSMANN, D. F., Ph.D., II. Medizinische Universitatsklinik, Ludwig-Rehn-Stra.Be 14,
D-6 Frankfurt/Main Sud 10, Fed. Rep. of Germany
GuARNIERI, G. F., M.D., Istituto di chimica biologica dell' Universita di Padova, Via Marpolo,
I-35100 Padova, Italy
GUNTHER, F., M.D., Medizinische Universitatsklinik, Luitpoldkrankenhaus, Josef-Schneider
Stra.Be 2, D-87 Wiirzburg, Fed. Rep. of Germany