Progress in Medical Research

121 Pages·2018·4.135 MB·English

by  Mieczyslaw Pokorski

Advances in Experimental Medicine and Biology 1070
Neuroscience and Respiration
Mieczyslaw Pokorski E ditor
Progress
in Medical
Research
Advances in Experimental Medicine
and Biology
Neuroscience and Respiration
Volume 1070
SubseriesEditor
MieczyslawPokorski
Moreinformationaboutthisseriesathttp://www.springer.com/series/13457
Mieczyslaw Pokorski
Editor
Progress in Medical
Research
Editor
MieczyslawPokorski
OpoleMedicalSchool
Opole,Poland
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-89664-9 ISBN978-3-319-89665-6 (eBook)
https://doi.org/10.1007/978-3-319-89665-6
LibraryofCongressControlNumber:2018953571
#SpringerInternationalPublishingAG,partofSpringerNature2018
Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeor
part of the material is concerned, specifically the rights of translation, reprinting, reuse of
illustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,
andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,or
bysimilarordissimilarmethodologynowknownorhereafterdeveloped.
Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthis
publication does not imply, even in the absence of a specific statement, that such names are
exemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.
Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationin
thisbookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernor
the authors or the editors give a warranty, express or implied, with respect to the material
contained herein or for any errors or omissions that may have been made. The publisher
remainsneutralwithregardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations.
ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG.
Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland
Preface
The book series Neuroscience and Respiration presents contributions by
expert researchers and clinicians in the multidisciplinary areas of medical
research and clinical practice. Particular attention is focused on pulmonary
disorders as the respiratory tract is up front at the first line of defense for
organisms against pathogens and environmental or other sources of toxic or
disease-causingeffects.Thearticlesprovidetimelyoverviewsofcontentious
issuesorrecentadvancesinthediagnosis,classification,andtreatmentofthe
entire range of diseases and disorders, both acute and chronic. The texts are
thoughtasamergerofbasicandclinicalresearchdealingwithbiomedicineat
boththemolecularandfunctionallevelsandwiththeinteractiverelationship
betweenrespirationandotherneurobiologicalsystems,suchascardiovascular
function, immunogenicity, endocrinology and humoral regulation, and the
mind-to-bodyconnection.Theauthorsfocusonmoderndiagnostictechniques
and leading-edge therapeutic concepts, methodologies, and innovative
treatments. Theactionandpharmacologyofexisting drugs andthedevelop-
ment and evaluation of new agents are the heady area of research. Practical,
data-driven options to manage patients are considered. New research is
presented regarding older drugs, performed from a modern perspective or
from a different pharmacotherapeutic angle. The introduction of new drugs
andtreatmentapproachesinbothadultsandchildrenisalsodiscussed.
Body functions, including lung ventilation and its regulation, are ulti-
matelydrivenbythebrain.However,neuropsychologicalaspectsofdisorders
arestillmostlyamatterofconjecture.Afterdecadesofmisunderstandingand
neglect,emotionshavebeenrediscoveredasapowerfulmodifieroreventhe
probable cause of various somatic disorders. Today, the link between stress
andhealthisundeniable.Scientistsacceptapowerfulpsychologicalconnec-
tionthatcandirectlyaffectourqualityoflifeandhealthspan.Psychological
approaches, which can decrease stress, can play a major role in disease
therapy.
Neuromolecularandcarcinogeneticaspectsrelatingtogenepolymorphism
and epigenesis, involving both heritable changes in the nucleotide sequence
andfunctionallyrelevantchangestothegenomethatdonotinvolveachange
inthenucleotidesequence,leadingtodisorders,arealsotackled.
Clinicaladvancesstemmingfrommolecularandbiochemicalresearchare
but possible if research findings are translated into diagnostic tools,
v
vi Preface
therapeutic procedures, and education, effectively reaching physicians and
patients. All this cannot be achieved without a multidisciplinary, collabora-
tive, bench-to-bedside approach involving both researchers and clinicians.
The role of science in shaping medical knowledge and transforming it into
practicalcareisundeniable.
Concerning respiratory disorders, their societal and economic burden has
beenontheriseworldwide,leadingtodisabilitiesandshorteningoflife-span.
COPD alone causes more than three million deaths globally each year.
Concerted efforts are required to improve this situation, and part of those
efforts are gaining insights into the underlying mechanisms of disease and
staying abreast with the latest developments in diagnosis and treatment
regimens. It is hoped that the articles published in this series will assume a
leading position as a source of information on interdisciplinary medical
research advancements, addressing the needs of medical professionals and
allied health-careworkers, and becomea source ofreference andinspiration
forfutureresearchideas.
I would like to express my deep gratitude to Paul Roos, and Cynthia
Kroonen of Springer Nature NL for their genuine interest in making this
scientific endeavor come through and in the expert management of the
productionofthisnovelbookseries.
MieczyslawPokorski
Contents
Baker’sAsthma:IstheRatioofRyeFlour-SpecificIgE
toTotalIgEMoreSuitabletoPredicttheOutcomeof
ChallengeTestThanSpecificIgEAlone. . . . . . . . . . . . . . . . . . . . 1
V.vanKampen,I.Sander,R.Merget,T.Brüning,andM.Raulf
SERPINA1GeneVariantsinGranulomatosis
withPolyangiitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
MalgorzataHadzik-Blaszczyk,AnetaZdral,
TadeuszM.Zielonka,AdaRozy,RenataKrupa,AndrzejFalkowski,
KazimierzA.Wardyn,JoannaChorostowska-Wynimko,
andKatarzynaZycinska
HyperglycemiainChildrenHospitalizedwithAcuteAsthma. . . . 19
KhalidF.Mobaireek,AbdulrahmanAlshehri,AbdulazizAlsadoun,
AbdullahAlasmari,AbdullahAlashhab,MeshalAlrumaih,
MohammadAlothman,andAbdullahA.Alangari
SerumVitaminDConcentrationandMarkersofBone
MetabolisminPerimenopausalandPostmenopausal
WomenwithAsthmaandCOPD. . . . . . . . . . . . . . . . . . . . . . . . . . 27
K.Białek-Gosk,R.Rubinsztajn,S.Białek,M.Paplińska-Goryca,
R.Krenke,andR.Chazan
OscillationsofSubarachnoidSpaceWidthasaPotential
MarkerofCerebrospinalFluidPulsatility. . . . . . . . . . . . . . . . . . . 37
MarcinGruszecki,MagdalenaK.Nuckowska,ArkadiuszSzarmach,
MarekRadkowski,DominikaSzalewska,MonikaWaskow,
EdytaSzurowska,AndrzejF.Frydrychowski,UrszulaDemkow,
andPawelJ.Winklewski
VeryHighFrequencyOscillationsofHeartRateVariability
inHealthyHumansandinPatientswithCardiovascular
AutonomicNeuropathy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
MarioEstévez-Báez,CalixtoMachado,JulioMontes-Brown,
JavierJas-García,GerryLeisman,AdamSchiavi,
AndrésMachado-García,ClaudiaCarricarte-Naranjo,
andEliCarmeli
vii
viii Contents
ImprovementinHandTrajectoryofReachingMovements
byError-Augmentation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
SharonIsraely,GerryLeisman,andEliCarmeli
EstimationofPosturographicTrajectoryUsingk-Nearest
NeighborsClassifierinPatientswithRheumatoidArthritis
andOsteoarthritis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
BeataSokołowska,TeresaSadura-Sieklucka,
LeszekCzerwosz,MartaHallay-Suszek,BogdanLesyng,
andKrystynaKsiężopolska-Orłowska
EffectsofManualSomaticStimulationontheAutonomic
NervousSystemandPosture. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
GiovanniBarassi,RosaGraziaBellomo,CamilloDiGiulio,
GiuseppeGiannuzzo,GiuseppeIrace,ClaudiaBarbato,
andRaoulSaggini
Robot-AssistedBody-Weight-SupportedTreadmill
TraininginGaitImpairmentinMultipleSclerosisPatients:
APilotStudy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
MarekŁyp,IwonaStanisławska,BożenaWitek,
EwelinaOlszewska-Żaczek,MałgorzataCzarny-Działak,
andRyszardKaczor
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117
AdvsExp.Medicine,Biology-NeuroscienceandRespiration(2018)39:1–7
DOI10.1007/5584_2018_159
#SpringerInternationalPublishingAG2018
Publishedonline:15Feb2018
’
Baker s Asthma: Is the Ratio of Rye Flour-
Specific IgE to Total IgE More Suitable
to Predict the Outcome of Challenge Test
Than Specific IgE Alone
V. van Kampen, I. Sander, R. Merget, T. Brüning, and M. Raulf
Abstract conclusion, calculating the ratio of rye
Usually the diagnosis of baker’s asthma is flour-sIgE to tIgE failed to improve the chal-
based on specific inhalation challenge with lengetestpredictioninourstudygroup.
flours. To a certain extent the concentration
of specific IgE to flour predicts the outcome Keywords
of challenge test in bakers. The aim of this Allergy·Baker’sasthma·ImmunoglobulinE·
study was to evaluate whether the ratio of Inhalationchallenge·Occupationalallergy·
specificIgE(sIgE)tototalIgE(tIgE)improves Ryeflour
challengetestpredictionincomparisontosIgE
alone. Ninety-five bakers with work-related
respiratory symptoms were challenged with 1 Introduction
rye flour. Total IgE, sIgE, and the sIgE/tIgE
ratioweredetermined.Receiveroperatorchar- Baker’sasthmaisoneofthemostfrequentforms
acteristic(ROC)plotsincludingtheareaunder of occupational immunoglobulin E (IgE)-
the curve (AUC) were calculated using the mediatedallergy.In2014,64%of584confirmed
challengetestasgold-standard. TotalIgE and cases of occupational asthma in Germany were
sIgE concentrations, and their ratio were sig- caused by bakery-derived allergens, especially
nificantlyhigherinbakerswithapositivechal- wheat and rye flour (Deutsche Gesetzliche
lenge test than in those with a negative one Unfallversicherung (DGUV 2015)). In general,
(p < 0.0001, p < 0.0001, and p ¼ 0.023, but especially within the scope of compensation
respectively). In ROC analysis, AUC was claims, the specific inhalation challenge with
0.83 for sIgE alone, 0.79 for tIgE, and 0.64 suspected occupational allergens is considered
for the ratio. At optimal cut-offs, tIgE, sIgE, the gold standard for the diagnosis of occupa-
andtheratioreachedapositivepredictedvalue tional asthma (Vandenplas et al. 2017; Muñoz
(PPV)of95%,84%and77%,respectively.In et al. 2014). Since the specific challenge test is
cumbersome, has a potential for severe adverse
effects, and should only be performed at
V.vanKampen(*),I.Sander,R.Merget,T.Brüning,
andM.Raulf specialized centers, alternative methods to diag-
InstituteforPreventionandOccupationalMedicineofthe noseflourallergyareofgreatvalue.
GermanSocialAccidentInsurance,InstituteoftheRuhr The general association between the clinical
University(IPA),Bochum,Germany
responsiveness to allergens and the results of
e-mail:[email protected]
1