PROGRAM & ABSTRACT BOOK - Anaerobe Society of the Americas

144 Pages·2014·2.8 MB·English

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Contents
Course Directors iv
Welcome Letter v
About the Societies vi
Patrons vii
Exhibitors vii
Keynote Speaker viii
Lifetime Achievement Award ix
In Memoriam x
Accreditation xiii
Curricular Goals & Objectives xiii
Presenters & Faculty xiv
Disclosure Information xvii
Congress Program xx
Abstract Table of Contents 1
Abstracts 3
Poster Index 241
Author Index 252
Welcome Letter
Anaerobe Society of the Americas Welcome to Anaerobe 2014, a joint meeting of the Anaerobe Society of the
Americas (ASA) and the Society for Microbial Ecology and Diseases. This
PO Box 452058
forum brings together clinicians and scientists from around the world to
Los Angeles, CA 90045 USA
engage in presentations, dialogues, and interactions related to the clinical and
Phone: [phone] Fax: [phone]
microbiological aspects of anaerobic bacteriology. The Congress will explore
Web: www.anaerobe.org E-mail: [email protected]
the role of anaerobes in both health and disease, while addressing both
traditional and emerging technologies for identification and diagnosis.
Course Directors
Anaerobe 2014 again illustrates the international interest in the field of
Dale N. Gerding, M.D. Andrew B. Onderdonk, Ph.D. anaerobic bacteriology. The 189 papers included in this Abstract Book
ASA President SOMED President represent the work of nearly 600 scientists from more than 30 countries.
Hines VA Hospital Harvard Medical School
At this Congress, the Keynote Address will be given by Dr. Martin J. Blaser of
Maywood, IL, USA Boston, MA, USA
New York University. Dr. Blaser is investigating the human microbiome and
its effect on various disease conditions. He has recently authored the book,
Organizing Committee Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern
Plagues.
David M. Aronoff, M.D. Ronald J. Goldman, Ph.D.
ASA Secretary ASA Executive Director The Lifetime Achievement Award will be presented to Mike Cox of Anaerobe
Vanderbilt University Medical Center Los Angeles, CA, USA Systems. Mike has been on the forefront of promoting anaerobic bacteriology,
Nashville, TN, USA as the developer of laboratory technology, educator of laboratory
Ellie J.C. Goldstein, M.D.
methodology, and application of anaerobic bacteria in energy production.
Ellen Jo Baron, Ph.D. ASA Treasurer, Past President
Stanford University R.M. Alden Research Lab / UCLA We would like to thank the members of the Organizing Committee and the
Palo Alto, CA, USA Santa Monica, CA, USA Session Chairs for their assistance in formulating what promises to be another
exciting program. We also would like to thank those from industry—both
Eugenia Bezirtzoglou, M.D., Ph.D. Stuart Johnson, M.D.
patrons and exhibitors listed on page v—for the financial support that makes
Democritus University of Thrace ASA Past President
this Congress possible, as well as grants from the European Society of Clinical
Orestiada, Greece Loyola University
Microbiology and Infectious Diseases, Burroughs Welcome Fund, and the Gut
Stritch School of Medicine
Diane M. Citron Check Foundation.
Maywood, IL, USA
R.M. Alden Research Laboratory
Culver City, CA, USA Bennett Lorber, M.D. In addition, we are grateful for our continued relationship with Anaerobe
ASA Past President Systems for helping organize the Pre-Congress Workshop, Microbiology
Raina Nakova Fichorova, M.D., Ph.D. Temple University School of Medicine Educational Services for providing the continuing education accreditation
Harvard Medical School Philadelphia, PA, USA for laboratory scientists, and to our Anaerobe journal for sponsorship of the
Boston, MA, USA Young Investigator’s Competition.
Purima S. Kumar, D.D.S., Ph.D.
David Fredericks, M.D.
Ohio State University Very special thanks goes to Dr. Ronald and Pamela Goldman, who again have
University of Washington
Columbus, OH, USA done an exemplary job in bringing this meeting together.
Seattle, WA, USA
Wendy Garrett, M.D., Ph.D. Cynthia L. Sears, M.D. Our hope is that Anaerobe 2014 serves to foster stimulating discussions, as
ASA Immediate Past President well as cultivate personal relationships that continue to invigorate the entire
Harvard Medical School
Johns Hopkins University field beyond the timeframe of this Congress.
Boston, MA, USA
Baltimore, MD, USA
Dale N. Gerding, M.D. Andrew B. Onderdonk
ASA President SOMED President
©2014 Anaerobe Society of the Americas
iv v
About the Societies Patrons & Exhibitors
Anaerobe Society of the Americas gratefully acknowledges the following
about the anaerobe society
organizations for their generous support of this congress.
Founded in 1992, the Anaerobe Society of the Americas, a non-profit foundation,
serves as a forum for those interested in anaerobes, anaerobic infections, and Support for this activity was received in the form of educational grants from:
related matters. The Society aims: (1) to stimulate interest in anaerobes and to
encourage interchange among anaerobists from all disciplines, including medical, u Burroughs Wellcome Fund
dental, veterinary, environmental, and basic sciences; (2) to bring together u European Society of Clinical Microbiology and Infectious Diseases
investigators, clinicians, and laboratory scientists interested in anaerobic infections u Gut Check Foundation
for formal and informal meetings; (3) to review and assess new advances in the
field; (4) to discuss areas of controversy; and (5) to mark future directions. Support for this activity from commercial interests include:
There are four levels of membership: Doctoral, Non-Doctoral, Verified Student, Platinum Patrons
and Retired. Details and application form are available on our web site: www. u Cubist Pharmaceuticals
anaerobe.org. u Sanofi Pasteur
gold Patrons
u bioMerieux
u Merck & Co.
silver Patrons
u Anaerobe Systems
u Bio K+ International
bronze Patrons
about somed u Actelion Pharmaceuticals
Founded in 1988, the Society for Microbial Ecology and Disease is a non-profit u Alere
scientific society, with the mission to promote scientific knowledge and encourage u Anaerobe Journal / Elsevier
research and technology in the field of microbial ecology and its relation to dis-
u BDC Food
eases. The Society conducts annual Congresses and publishes the journal Microbial
u TechLab
Ecology in Health and Disease. The Society encourages the participation of an
interdisciplinary group of scientists in the study of the role of the microbiome in
exhibitors
health and disease.
u Advanced Instruments
Further information and membership forms are available at the SOMED website: u Bruker Daltonic
www.somed.nu/ u Cepheid
u Coy Laboratory Products
u Hardy Diagnostics
u Key Scientific Products
u List Biological Laboratories
u Microbiology International
u Shel Lab
vi vii
Lifetime
Keynote Speaker
Achievement Award
martin J. blaser, m.d. Marion (Mike) e. Cox, B.S., M.T.
Martin J. Blaser, M.D., is the George Mike Cox has been a major advocate for the field
and Muriel Singer Professor of Medicine, of anaerobic bacteriology. As C.E.O. of Anaerobe
Professor of Microbiology, and Director of Systems in Morgan Hill, CA, Mike has pioneered
the Human Microbiome Program at the NYU technology for the lab, while traveling across the
School of Medicine. He served as Chair of country and around the world educating laboratory
the Department of Medicine at NYU (2000- scientists on the proper methods of anaerobic identi-
2012). fication and susceptibility.
n Dr. Blaser did his undergraduate work at Mike became interested in microbiology while in
n
e
Gl the University of Pennsylvania in 1969, the Army stationed at Fort Ord in Monterey, CA,
arl graduated from the New York University and then completed his Bachelor degree in Biology
C
o: School of Medicine in 1973, and did his at the University of Houston in 1973. He went on
ot
Ph post-graduate training at the University of to become a microbiologist at Stanford University
Colorado School of Medicine (1973-1979). (1973-75) and then as Director of Research at International Shellfish Enterprises, he
He then was an Epidemic Intelligence Service Officer at the Centers for Disease investigated causes of massive mortalities of oysters in this hatchery (1975-77).
Control and Prevention (1979-1981).
While working in the clinical microbiology lab, he used VPI roll tube technique
A physician and microbiologist, Dr. Blaser is interested in understanding the and candle jars for his anaerobe workups and wanted to create a better method for
relationships that we have with our persistently colonizing bacteria. His work culturing anaerobic bacteria. In 1978, Mike founded Anaerobe Systems to develop
over the past 30 years focused on human pathogens, including Campylobacter new technology and products in the field of Microbiology. His patents include the
species and Helicobacter pylori, which also are model systems for understanding gloveless anaerobic chamber, preparation of anaerobic media, and anaerobic pro-
interactions of residential bacteria with their human hosts. Over the last decade, duction of hydrogen and other chemical products. His Pre-Reduced Anaerobically
he has been actively studying the relationship of the human microbiome to health Sterilized (PRAS) plated and tubed culture media are packaged and pre-reduced in
and such important diseases as asthma, obesity, diabetes, and allergies. oxygen-free foil packages, requiring no preconditioning, saving many hours of lab
work and anaerobic gas.
Over the course of his career, Dr. Blaser has served as the advisor for a large
number of students, post-doctoral fellows, and junior faculty, and he has been Over his 35 year career as a microbiologist, he has conducted hundreds of work-
actively involved in national scientific and professional organizations. He served shops on anaerobic methods, including the Pre-Congress Workshops offered with
as President of the Infectious Diseases Society of America, Chair of the Board every Anaerobe Society Congress. He has also encouraged anaerobic studies at
of Scientific Counselors of the National Cancer Institute, Chair of the Advisory such schools as Santa Clara University, offered internships, and assisted students to
Board for Clinical Research of the National Institutes of Health, and Founder of attend the Anaerobe Congresses.
the Foundation for Bacteriology and the Virtual Museum of Bacteria. He currently
Mike serves as a Counsellor of the Anaerobe Society of the Americas, as well as
serves on the Scientific Advisory Board of the Doris Duke Charitable Foundation.
a member of industry subcommittees on Antimicrobial Susceptibility Testing and
He was elected to the Institute of Medicine and the American Academy for Arts Abbreviated Bacterial Identification. And in recent years, he has been involved in pio-
and Sciences. He holds 24 U.S. patents relating to his research and has authored neering the use of microbes to create clean energy from food and agricultural waste.
over 500 original articles. Most recently, he wrote Missing Microbes: How the
In addition, Mike has been very active within his home community. He annually
Overuse of Antibiotics Is Fueling Our Modern Plagues, explaining the harmful
underwrites the Morgan Hill Youth Leadership, as well as being a generous con-
effects of overusing antibiotics to the general public.
tributor to such local organizations as the Morgan Hill Community Foundation,
Friends of the Morgan Hill Library, AAUW, Rotary Club of Morgan Hill, the
Morgan Hill Historical Society, and many science and education programs. In
appreciation for his contribution to his community, he was bestowed with the 2013
Leadership Excellence Award by Leadership Morgan Hill.
viii ix
In Memoriam In Memoriam
STePhen allen, M.D. (1943-2012) aBigail a. SalyerS, Ph.D. (1942-2013)
Dr. Allen was the James Warren Smith Professor Dr. Salyers, was known worldwide as a research
of Pathology and Laboratory Medicine and scientist, author, and professor at the University of
Director of Clinical Microbiology Laboratories Illinois at Urbana-Champaign and was the Keynote
at Indiana University (IU) Health and VA Speaker at Anaerobe 2004.
Medical Center in Indianapolis. He was also
President of The Anaerobe Society (2003-2004), Abigail had an undergraduate degree in mathemat-
overseeing Anaerobe 2004 in Annapolis, MD. ics and a Ph.D. in nuclear physics from George
Washington University, Washington, D.C. After four
He earned his Undergraduate and Masters years of teaching, research, and tenure at St. Mary’s
degree in Microbiology from IU Bloomington College in Maryland, she switched fields by taking
and MD degree from the IU School of Medicine courses in biochemistry and microbiology and secured
in 1970. He did his Pathology Residency at a second post-doctorate position in biochemistry and
Vanderbilt University and served as Medical microbiology from Virginia Polytechnical Institute.
Officer with the United States Public Health She studied, taught and did research at VPI (1973-1978).
Service at the Centers for Disease Control and
Prevention in Atlanta, GA (1974-1977). She came to University of Illinois in 1978 and became the first female tenured
professor in microbiology in 1983 and a full professor in 1988. While at Illinois,
Dr. Allen’s appointment in the IU Pathology Department began in 1977, where he Abigail was named a University Scholar, Faculty Member of the Year in the College
was responsible for the administration of Clinical Microbiology Laboratories at of Medicine, a member of the Center for Advanced Study, and an Affiliate in the
IU Health, Wishard, and the Veterans Administration Hospitals. He also served Institute for Genomic Biology.
as Director of the Disease Control Laboratories with the Indiana State Board of
Health (1994-2004). She received the Pasteur Award for Research and Teaching, the All-Campus Award
for Excellence in Teaching in the UI Medical School, and the Golden Apple Award
He belonged to many Medical and Pathology Societies and received numerous for Medical School Teaching three times. She was named the G. William Arends
awards and recognitions including membership in the Alliance of Distinguished and Professor in Molecular and Cellular Biology from 2004 until she retired in 2012.
Titled Professors.
She authored five books—including Bacterial Pathogenesis: A Molecular Approach
He served as a Trustee for the American Board of Pathology (1995-2006) and (1994), Bacterial Resistance to Antimicrobials (2002), and Revenge of the Microbes
President of that Board (2003). Through authorship and co-authorship of 30 text (2005)—and 200 peer-reviewed research articles, reviews, and chapters in books.
books and several hundred publications, Dr. Allen became respected internationally Her papers were cited widely (over 600 citations).
as a researcher and educator of his field of anaerobic microbiology.
Abigail was President of the American Society for Microbiology (2001-2002). Her
Steve was 69. research was supported by the Department of Energy and the National Institutes
of Health. In recognition of her standing in the scientific community, she served
several terms as a member of National Institutes of Health panels that reviewed
research grants. She was awarded an honorary doctorate from ETH University in
Zurich, Switzerland (2001).
Abigail was 70.
x xi
Accreditation/
In Memoriam
Goals & Objectives
FeliCja MeiSel-MikolajCzyk, M.D., Ph.D. Anaerobe 2014—the 12th biennial Congress of the Anaerobe Society of
(1927-2012) the Americas and the 37th Congress of the Society for Microbial Ecology and
Dr. Meisel-Mikolajczyk was Professor of Medical Disease—provides the forum for vigorous discussions of both the clinical and
Microbiology at the Medical University of Warsaw microbiological aspects of anaerobic infections, their diagnosis, and their therapy
among medical practitioners, researchers, and laboratory scientists.
in Poland. She was a long-time member of the
Anaerobe Society and a regular poster presenter at
Physician accreditation
the Anaerobe Congresses. No Physician Continuing Medical Education Units will be issued for the Congress.
Attendees may request Certificates of Attendance, free of charge (see below).
She came from a family of doctors. Her parents
worked at the National Institute of Hygiene, but clinical laboratory scientist accreditation
after the 1939 German invasion of Poland, they were Microbiology Educational Services is accredited by the California Department of
Health Services to provide continuing education for clinical laboratory scientists.
rescued from the Livov Jewish Ghetto by Professor
Rudolf Weigl to work at his Institute for the Study of Typhus and Viruses on devel- Microbiology Educational Services designates this educational activity for a
oping the anti-typhus vaccine. However, they were arrested in 1943 and deported maximum of 19.0 continuing education contact hours upon completion of the
to the Auschwitz concentration camp. Felicja, on the other hand, hid with people program and 7.0 continuing education contact hours upon completion of the
of “good will”—including Catholic nuns running an orphanage—through the war workshop. Clinical laboratory scientists should claim only those hours of credit
years, moving to and from 18 different places. At the conclusion of the war, she that they actually spent in the educational activity.
was reunited with her parents.
certificates of attendance
Certificates of Attendance may be obtained by completing the request form in
In 1952, she graduated from the Medical Academy of Medicine in Warsaw (now
your Delegate Packet and returning it to the Registration Table with completed
called the Medical University of Warsaw) and continued to work in its Department evaluation forms for sessions attended. Certificates will be emailed to attendees.
of Medical Microbiology. She became a Full Professor in 1985 and headed the
department (1992-1997). She guided generations of microbiologists. Even after her curricular goals & obJectives
Provide information on the latest developments in the field of anaerobic research,
retirement in 1997, she still came to work every day to supervise studies and write
including the role of anaerobes in human diseases, the epidemiology of anaerobic
articles for publication.
infections, and potential prevention strategies.
Prof. Meisel-Mikolajczyk’s scientific work mainly pertained to anaerobes. Her Provide recommendations in the diagnosis, screening, and treatment of anaerobic
initial research focused on Clostridium perfringens (the antigenic construction infections, including new laboratory techniques, utilization of antibiotics, and
of vegetative forms and spores of this bacteria) and, later, non-sporulating potential of probiotics.
anaerobes. In the 1980s, her focus was Bacteroides fragilis and was the first Provide an understanding for better utilization of the microbiology lab into the
researcher in Poland to investigate Clostridium difficile. She collaborated with delivery of patient care.
researchers around the world, producing more than 180 publications.
disclosures
She was a member of a number of scientific societies, both domestic and interna- Disclosures of relevant financial relationships by all session participants are
provided on pages xvi-xvii.
tional. Besides the numerous honors bestowed upon her by the Medical University,
she received the national awards of the Golden Cross of Merit and the Order of evaluation forms
Polonia Restituta Polish, both the highest awards for a Polish citizen. Please complete the Evaluation Form in your Delegate Packet and return it to the
Registration Table at the completion of the Congress.
Felicja was 85.
xii xiii
Presenters & Faculty Presenters & Faculty
Ernesto Abel-Santos, Ph.D. Diane M. Citron
Ellie J.C. Goldstein, M.D. Richard J. Lamont, Ph.D.
University of Nevada Las Vegas R.M. Alden Research Lab
R.M. Alden Research Lab University of Louisville
Las Vegas, NV, USA Culver City, CA, USA
University of California Louisville, KY, USA
Los Angeles
Mike J. Aldape, Ph.D. Georg Conrads, Ph.D.
Santa Monica, CA, USA Veronica Lazar, Ph.D.
VA Medical Center University Hospital
University of Bucharest
Boise, ID, USA Aachen, Germany
Romina S. Goldszmid, Ph.D. Bucharest, Romania
Center for Cancer Research,
David M. Aronoff, M.D. Laurie M. Cox, Ph.D.
NCI, NIH Caroline I. LeRoy
Vanderbilt University NYU Langone Medical Center
Frederick, MD, USA The University of Reading
Nashville, TN, USA New York, NY, USA
Reading, United Kingdom

Yiping Han, Ph.D.
Johan S. Bakken, M.D., Ph.D. Mike M. Cox
Columbia University Medical Center Bennett Lorber, M.D.
St. Luke’s Hospital Anaerobe Systems
New York, NY, USA Temple University
Duluth, MN, USA Morgan Hill, CA, USA
School of Medicine

David W. Hecht, M.D., M.B.A. Philadelphia, PA, USA
Ellen Jo Baron, Ph.D. Daniel B. DiGiulio, M.D.
Loyola University Medical Center
Stanford University Stanford University
Maywood, IL, USA Reet Mändar, M.D., Ph.D.
Palo Alto, CA, USA Stanford, CA, USA
University of Tartu
Sharon Hillier, M.D. Tartu, Estonia
Christine M. Bassis, Ph.D. Adam Driks, Ph.D.
Magee Women’s Research Institute
University of Michigan Loyola University Medical Center
Pittsburgh, PA, USA Jeanne M. Marrazzo, M.D.
Ann Arbor, MI, USA Maywood, IL, USA
University of Washington

Gary B. Huffnagle, Ph.D. Seattle, WA, USA
Eugenia Bezirtzoglou, M.D., Ph.D. Adrianne N. Edwards, Ph.D.
University of Michigan
Democritus University of Thrace Emory University
Ann Arbor, MI, USA Pierre-Jean Maziade, M.D.
Orestiada, Greece Atlanta, GA, USA
Pierre-Le Gardeur Hospital
Curtis Huttenhower, Ph.D. Lachenaie, QC Canada
Martin J. Blaser, M.D. Raina N. Fichorova, M.D, Ph.D.
Harvard University
Human Microbiome Program Brigham and Women’s Hospital
Cambridge, MA, USA L. Clifford McDonald, M.D.
New York University Boston, MA, USA
Centers for Disease Control and
Langone Medical Center
Stuart Johnson, M.D. Prevention
New York, NY, USA David N. Fredricks, M.D.
Stritch School of Medicine Atlanta, GA, USA
Fred Hutchinson Cancer Center
Loyola University Chicago
Richard S. Blumberg, M.D. University of Washington
Maywood, IL, USA Tore Midtvedt, M.D., Ph.D.
Brigham and Women’s Hospital Seattle, WA, USA
Karolinska Institute
Boston, MA, USA
Lloyd H. Kasper, M.D. Stockholm, Sweden
Kevin Garey, Pharm.D.
Geisel School of Medicine,
Alojz Bomba, D.Sc. University of Houston
Dartmouth College Marika Mikelsaar, Ph.D.
Pavol Jozef Šafárik University Houston, TX, USA
Hanover, NH, USA University of Tartu
Košice, Slovak Republic
Tartu, Estonia
Wendy Garrett, M.D., Ph.D.
Maria T. Kowal, Ph.D.
Laurent Bouillaut, Ph.D. Harvard Medical School
University of Edinburgh Nigel P. Minton, Ph.D.
Tufts University School of Medicine Cambridge, MA, USA
Edinburgh, United Kingdom The University of Nottingham
Boston, MA, USA
Nottingham, United Kingdom
Dale N. Gerding, M.D.
Sarah A. Kuehne, Ph.D.
Nadiya V. Boyko, D.Sc. Hines VA Hospital
University of Nottingham Grigoria Mitropoulou, PH.D.
Uzhhorod National University Stritch School of Medicine
Nottingham, United Kingdom Democritus University of Thrace
Uzhhorod, Ukraine Loyola University Chicago
Orestiada, Greece
Maywood, IL, USA
Purnima S. Kumar, D.D.S, Ph.D.
Paul Carlson Jr., Ph.D.
Ohio State University
University of Michigan
Columbus, OH, USA
Ann Arbor, MI, USA
xiv xv
Presenters & Faculty Disclosure Information
Hercules Moura, Ph.D. József Sóki, Ph.D. This Congress has been planned and implemented in accordance with the Essential
Centers for Disease Control and University of Szeged Areas and Policies of the Accreditation Council for Continuing Medical Education
Prevention Szeged, Hungary (ACCME). The Anaerobe Society of the Americas (ASA) has attempted to
Atlanta, GA, USA
ensure balance, independence, objectivity, and scientific rigor in this continuing
Joseph A. Sorg, Ph.D.
medical education activity. All individuals in a position to control the educational
Elisabeth Nagy, M.D., Ph.D., D.Sc. Texas A&M University
content of this activity, as well as all oral presenters, have disclosed to ASA any
University of Szeged College Station, TX, USA
Szeged, Hungary financial interests or other relationships they have had in the past 12 months with
Dennis L. Stevens, M.D., Ph.D. commercial interests whose product(s) will be referred to in presentations, may be
Carl Erik Nord, M.D. VA Medical Center providing educational grants, or ‘in-kind’ support of this activity.
Karolinska Institute Boise, ID, USA
Stockholm, Sweden Although the existence of a commercial interest relationship in itself does not
Glenn S. Tillotson, Ph.D. imply bias or decrease the value of presentations, this information is provided
Andrew B. Onderdonk, Ph.D. TranScrip Partners to the audience to allow them to make their own judgments. It remains for the
Harvard Medical School Exton, PA, USA
audience to determine whether the speaker’s interest or relationships may influence
Boston, MA, USA
the presentation with regard to exposition or conclusion.
Kerin L. Tyrell
Panagiotis Papatheodorou, Ph.D. R.M. Alden Research Lab
The ACCME Standards for Commercial Support require that presentations be free
Albert-Ludwigs-Universität Freiburg Culver City, CA, USA
of commercial bias and any information regarding commercial products/services
Freiburg, Germany
Meera Unnikrishnan, Ph.D. be based on scientific methods generally accepted by the medical community. If
Patricia J. Freda Pietrobon, Ph.D. The University of Warwick a presentation has discussion of unlabeled/investigational use of a commercial
Sanofi Pasteur Coventry, United Kingdom product, that information must be disclosed to the participants of the activity.
Swiftwater, PA, USA
Gayatri Vedantam, Ph.D. The disclosure information received from each individual is presented on the
Dave H. Pincus University of Arizona following pages. All disclosure information has been reviewed for conflict of
bioMérieux Tucson, AZ, USA
interest by the ASA Program Committee. Conflicts identified and resolved are
Hazelwood, MO, USA
noted below. If no notation is made, a conflict of interest was not in existence.
Mark H. Wilcox, M.D.
Adam J. Ratner, M.D., M.P.H. University of Leeds
Columbia University Leeds, United Kingdom
New York, NY, USA
Alan J. Wolfe, Ph.D.
Thomas V. Riley, Ph.D. Stritch School of Medicine
The University of Western Australia Loyola University Chicago
Nedlands, Western Australia Maywood, IL, USA
Marie-Bénédicte Romond, Ph.D. Vincent B. Young, M.D.
University of Lille Nord de France The University of Michigan
Lille, France Ann Arbor, MI, USA
Cynthia L. Sears, M.D.
Johns Hopkins University
School of Medicine
Baltimore, MD, USA
xvi xvii
Disclosure Information
Participant Disclosure Kevin Garey, Pharm.D. Cubist (G), Merck (G), Summit (G)
The following presenters do not have financial relationships with commercial Will address future treatment strategies of
C. difficle
interests; no relationships between commercial interests and first degree relatives
exist, and do not intend to discuss an unapproved/investigative use of commercial Dale Gerding, M.D. Actelion (C), Gojo (G), Merck (C), Rebiotix
product / device. (C), Sanofi-Pasteur (C), Summit (C),
Viropharma/Shire License (C)
Mike J. Aldape, Ph.D. Bennett Lorber, M.D.
Will discuss non-toxigenic C. difficle for
David M. Aronoff, M.D. Reet Mändar, M.D., Ph.D. CDI prevention
Christine M. Bassis, Ph.D. Jeanne M. Marrazzo, M.D.
Ellie J.C. Goldstein, M.D Bio-K+ (C, G, S), Cerexa (G), Cubist (C,
Martin J. Blaser, M.D. L. Clifford McDonald, M.D.
G, S), Forest (C, G, S), Merck (C, G, S),
Alojz Bomba, D.Sc. Tore Midtvedt, M.D., Ph.D. Novartis (C, G), Rempex (C, G)
Laurent Bouillaut, Ph.D. Marika Mikelsaar, Ph.D. Will discuss antimicrobials in the pipeline
Georg Conrads, Ph.D. Nigel P. Minton, Ph.D.
Yiping Han, Ph.D. None
Daniel B. DiGiulio, M.D. Hercules Moura, Ph.D. Will discuss FadA as a diagnostic marker
Adam Driks, Ph.D. Elisabeth Nagy, M.D., Ph.D., D.Sc. and a synthetic peptide to prevent F.
Adrianne N. Edwards, Ph.D. Carl Erik Nord, M.D. nucleatum colonization
Raina N. Fichorova, M.D, Ph.D. Andrew B. Onderdonk, Ph.D. David W. Hecht, M.D., M.B.A. bioMérieux (S)
David N. Fredricks, M.D. Panagiotis Papatheodorou, Ph.D.
Sharon Hillier, M.D. Cepheid (G), Merck (C)
Wendy Garrett, M.D., Ph.D. Adam J. Ratner, M.D., M.P.H.
Ronald J. Goldman, Ph.D. Thomas V. Riley, Ph.D. Curtis Huttenhower, Ph.D. Danone Research (G), Seres Health (C, O)
Romina S. Goldszmid, Ph.D. Marie-Bénédicte Romond, Ph.D. Stuart Johnson, M.D. Bio-K+ (C, S), Summit (C)
Gary B. Huffnagle, Ph.D. Cynthia L. Sears, M.D.
Purnima S. Kumar, D.D.S, Ph.D. Phillips Oral Healthcare (G)
Lloyd H. Kasper, M.D. József Sóki, Ph.D.
Maria T. Kowal, Ph.D. Joseph A. Sorg, Ph.D. Pierre-Jean Maziade, M.D. Bio-K+ (C, S)
Sarah A. Kuehne, Ph.D. Dennis L. Stevens, M.D., Ph.D. Grigoria Mitropoulou, PH.D. Wyeth (R)
Richard J. Lamont, Ph.D. Kerin L. Tyrell
Patricia J. Freda Pietrobon, Ph.D. Sanofi Pasteur (E, O, S)
Veronica Lazar, Ph.D. Meera Unnikrishnan, Ph.D.
Will discuss C. difficle vaccine
Caroline I. LeRoy Vincent B. Young, M.D.
Dave H. Pincus bioMérieux (E)
The following presenters have information to disclose as follows: Glenn S. Tillotson, Ph.D. Roche (C), Shionogi (C), Summit (C)
Gayatri Vedantam, Ph.D Stellar Biopharmaceuticals (C, G)
Ernesto Abel-Santos, Ph.D. SporDiff (O)
Mark H. Wilcox, M.D. Actelion (C, G), Astellas (C, G), Astra-
Johan S. Bakken, M.D., Ph.D None
Zeneca (C), Bayer (C), BioMérieux (G),
Will discuss fecal microbiota transplantation
Cubist (C, G), Durata (C), Johnson &
Ellen Jo Baron, Ph.D. Cepheid (E, O) Johnson (C), Merck (C), Nabriva (C),
Novacta (C), Novartis (C), Optimer (C),
Eugenia Bezirtzoglou, M.D., Ph.D. Wyeth (R)
Pfizer (C, G, S), Sanofi-Pasteur (C), Summitt
Nadiya V. Boyko, D.Sc. None (G), The Medicines Co. (C, G), VH Squared
Will discuss future products (C), Viropharma (C)
Paul Carlson Jr., Ph.D. Coy Lab Products (G) Alan J. Wolfe, Ph.D. Astellas (G)
Diane M. Citron Toltec (G)
Laurie M. Cox, Ph.D. Anaerobe Systems (O) C=Consultant, E-Employment, G=Grants, O=Ownership/Stock, R-Research,
S=Speaker
Mike M. Cox Anaerobe Systems (O)
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