Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology PDF
Preview Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology
Professor Hein .J.J :snelleW 33 sraeY of Cardiology and Arrhythmology Professor Hein J.J. Wellens: 33 Years of Cardiology and Arrhythmology Edited hy J.L.R.M. Smeets, P.A. Doevendans, M.E. Josephson, Ch. Kirchhof and M.A. Vos SPRINGER-SCIENCE+BUSINESS MEDIA, B.Y. Library of Congress Cataloging-in-Publication Data ISBN 978-94-010-5799-8 ISBN 978-94-011-4110-9 (eBook) DOI 10.1007/978-94-011-4110-9 Printed an acid-free paper All Rights Reserved © 2000 Springer Science+Business Media Dordrecht Originally published by Kl uwer Academic Publishers in 2000 Softcover reprint ofthe hardcover Ist edition 2000 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permis sion from the copyright owner. v Contents Introduction XI Durrer D., Schoo ,.L Schuilenburg R.M., snelleW :.J.J.H The role of premature beats ni eht initiation and eht termination of supraventricular tachycardia ni eht Wolff-Parkinson-White syndrome. Comment by Prof .P .lemuoC .DM Circulation ;7691 :63 644-662 snelleW H.J.J., Durrer :.D Supraventricular tachycardia htiw tfel aberrant conduction due ot retro grade invasion into eht left bundle branch. Comment by Prof .R .amalS .DM Circulation ;8691 :83 474-479 12 snelleW ,.J.J.H Reinier ,.M Schuilenburg R.M., Durrer :.D Electrical stimulation of eht heart ni patients htiw Wolff-Parkinson-White syndrome; epyT .A Comment by Prof .A Castellanos, .DM Circulation ;1791 :34 99-114 72 snelleW H.J.J., Reinier ,.M Schuilenburg ,.M.R Durrer :.D Electrical stimulation of eht heart ni patients with ventricular tachycardia. Comment by Prof .E.M Josephson. .DM Circulation ;2791 :64 216-226 34 snelleW ,.J.J.H neluemreV ,.A Durrer :.D Ventricular noitallirbif occurring no arousal morf sleep by auditory stimuli. Comment yb Prof .rD A.A.M. .edliW Circulation ;2791 :64 661-665 55 snelleW H.J.J., Durrer :.D Effect of digitalis no atrioventricular conduction and circusmovement at chycardias ni patients with eht Wolff-Parkinson-White syndrome. Comment by Prof .D.E Robles ed ,anideM .DM Circulation ;3791 :74 1229-1233 36 snelleW H.J.J., Lie ,.I.K Durrer :.D Further observations no ventricular tachycardia sa studied yb electrical stimulation of eht .traeh Chronic recurrent ventricular tachycardia dna ventricular tachy cardia during acute myocardial infarction. Comment yb Prof .L.A ,tiW .DhP Circulation ;4791 :94 647-653 96 eiL ,.I.K snelleW H.J.J., Schuilenburg R.M., Becker A.E., Durrer :.D Factors influencing prognosis of bundle branch block complicating acute anteroseptal infarction. The value of siH bundle -er cordings. Circulation ;4791 :05 935-941 97 snelleW H.J.J., Janse M.J., naV Dam R.Th., naV Capelle F.lL., Meijne ,.G.N Mellink ,.M.H Durrer :.D Epicardial mapping and surgical treatment ni Wolff-Parkinson-White syndrome; epyT .A Comment by Prof .J.M .esnaJ .DhP mA Heart J ;4791 :88 69-78 78 Lie ,.I.K snelleW H.J.J., naV Capelle F.lL., Durrer :.D Lidocaine ni eht prevention of primary ven- tricular .noitallirbif Comment by Prof .I.K .eiL .DM weN Eng J deM ;4791 :192 1324-1326 99 IV snelleW ,.1.1.H Durrer :.D WPW syndrome dna lairta .noitallirbif Relation between refractory period of accessory pathway dna ventricular etar during atrial .noitallirbif Comment by Prof .J Gallagher, .DM mA J Cardiol ;4791 :43 777-782 501 snelleW ,.J.J.H Durrer :.D The elor of accessory atrioventricular pathway ni reciprocal tachycardia. Comment by Prof .R Lazzara, .DM Circulation ;5791 :25 58-72 311 snelleW ,.J.J.H Lie ,.I.K Bar FW, Wesdorp lC., Dohmen ,.1.H Duren ,.R.D Durrer :.D Effect of amiodarone ni eht Wolff-Parkinson-White syndrome. Comment by Prof .G Fontaine, .DM mA J Cardiol ;6791 :83 189-194 331 snelleW ,.1.1.H Duren D.R., Lie KI.: Observations no mechanisms of ventricular tachycardia ni .nam Comment by Prof WG. Stevenson, .DM Circulation ;6791 :45 237-244 341 srekcaW ,.hT.1.F Busemann Sokole ,.E Samson ,.G naV der Schoot lB., Lie KI., Liem KL., snelleW :.1.1.H eulaV dna limitations of Thallium-201-scintigraphy ni eht acute phase of myocardial -ni .noitcraf Comment by Prof .hT.J.F ,srekcaW ,DM .DhP New lgnE J deM ;6791 :592 1-5 551 snelleW H.J.J., Bar FWH.M., eiL ,.I.K Duren D.R., Dohmen :.1.H Effect of Procainamide, Propra lolon dna limapareV no mechanism of recurrent ventricular tachycardia. Comment by Prof D.? Zipes, .DM mA J Cardiol ;7791 :04 579-585 361 snelleW H.J.J., Bar FWH.M., Lie KI.: The value of eht electrocardiogram ni eht differential diag sison of a tachycardia htiw a widened QRS-complex. Comment by Prof .J.A Camm, .DM mA J Med ;8791 :46 27-33 371 Becker A.E., Anderson ,.H.R Path M.R.C., Durrer ,.D snelleW :.1.1.H The anatomical substrates of Wolff-Parkinson-White syndrome. A clinicopathologic correlation ni seven patients. Comment by Prof A.E. ,rekceB .DM Circulation ;8791 :75 870-879 381 Farre ,.J ssoR ,.D Wiener I., Bar FW, tganaV ,.1.E snelleW :.1.1.H Reciprocal tachycardias gnisu accessory pathways htiw gnol conduction .semit Comment by .rD .J Fami. mA J Cardiol ;9791 :44 9011-9901 791 snelleW ,.1.1.H Bar FW, Gorgels ,.P.A tganaV :.1.E esU of Ajmaline ni identifying patients with eht Wolff-Parkinson-White syndrome dna a short refractory period of their accessory .yawhtap mA J Cardiol ;0891 :54 130-133 512 snelleW ,.1.1.H Bar FW, Farre ,.J Ross D.L., Wiener ,.I tganaV :.1.E Initiation dna termination of ventricular tachycardia yb supraventricular stimuli. Comment by Prof .I ,reneiW .DM mA J -raC loid ;0891 :64 576-582 122 ssoR ,.L.D Farre l, Bar FWH.M., tganaV ,.1.E Brugada ,.P Wiener ,.1 snelleW :.J.J.H Spontaneous termination of circus movement tachycardia utilizing na atrioventricular accessory :yawhtap inci dence, etis of block dna mechanisms. Comment by Prof DL ,ssoR .DM Circulation ;1891 :36 1129-1139 132 IIV De Zwaan ,.c Bar EWH.M., Wellens H.J.J.: Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction. Comment by :ID .C de Zwaan, ,DM .DhP Am Heart J ;2891 :301 730-736 542 Den Dulk ,.K Lindemans EW., Bar FW., Wellens H.J.J.: Pacemaker related tachycardia. Comment by .rD .K den ,ktuD ,DM .DhP PACE ;2891 :5 476-485 352 Friedman P.L., Brugada ,.P Kuck K.-H., Roy D., Farre J., Bar FWH.M., Wellens :.J.J.H Inter- and intra-atrial dissociation during spontaneous atrial flutter: Evidence for a focal origin of the arrhyth- mia. Comment by .L.P Friedman, ,DM .DhP Am J Cardiol ;2891 :05 756-761 562 Oorgels A.P.M., Beekman H.D.M., Brugada ,.P Dassen WR.M., Richards D.A.B., Wellens H.J.J.: Extrastimulus related shortening of the first postpacing interval in digitalis induced ventricular tachycardia. Observations during programmed electrical stimulation in the conscious dog. Com- ment by Prof MR. ,nesoR .DM J Am Coil of Cardiol ;3891 :I 840-857 572 Roy D., Brugada ,.P Wellens H.J.J.: Atrial tachycardia facilitating initiation of ventricular tachycardia. Comment by Prof .D ,yoR .DM PACE ;3891 :6 47-52 792 Weiss J., Brugada ,.P Roy D., Bar EWH.M., Wellens H.J.J.: Localization of the accessory pathway in the WPW syndrome from the ventriculo-atrial conduction time of right ventricular apical extrasystoles. Comment by Prof .1 ,ssieW .DM PACE ;3891 :6 260-267 503 Oreen M., Heddle B., Dassen W, Wehr M., Abdollah H., Brugada ,.P Wellens H.J.J.: The value of QRS alternation in diagnosing the site of origin of narrow QRS supraventricular tachycardia. Comment by MS. ,neerG .DM Circulation ;3891 :86 368-373 313 Kuck K.-H., Brugada ,.P Wellens H.J.J.: Observations on the antidromic type of circus movement tachycardia in the Wolff-Parkinson-White syndrome. J Am Coil of Cardiol ;3891 :5 0101-3001 123 Heddle WE, Brugada ,.P Wellens H.J.J.: Multiple circus movement tachycardias with multiple ac- cesory pathways. J Am Coil Cardiol ;4891 :4 168-175 133 Braat S.H., Brugada ,.P Den Dulk ,.K naV Ommen ,.v Wellens H.J.J.: Value of lead V R4 for recog nition of the infarct coronary artery in acute inferior wall myocardial infarction. Comment by s.H.J.G. Braat, .DM Am J Cardiol ;4891 :35 1451-8351 143 Waldecker B., Brugada ,.P Zehender M., Stevenson WO., Den Dulk K., Wellens H.J.J.: Importance of modes of electrical termination of ventricular tachycardia for the selection of implantable an- titachycardia devices. Comment by Prof .B ;lekcedtaW .DM Am J Cardiol ;6891 :75 150-155 743 Stevenson WO., Brugada ,.P Waldecker B., Zehender M., Wellens H.J.J.: Clinical, angiographic and electrophysiologic findings in patients with aborted sudden death as compared to patients with sustained ventricular tachycardia after myocardial infarction. Comment by Prof M Zehendel: .DM Circulation ;5891 :6 1146-1152 553 VIII Kersschot I.E., Brugada ,.P Ramentol ,.M Zehender ,.M Waldecker ,.B Stevenson WG., Geibel ,.A De Zwaan ,.c Wellens H.J.J. and The Interuniversity Cardiology Institute, The Netherlands: fE fects of early reperfusion ni acute myocardial infarction on arrhythmias induced yb programmed stimulation. A prospective, randomized .yduts Comment by .I Kersschot, .DM J Am Coli Cardiol 1986; :7 1234-1242 365 Lemery ,.R Brugada ,.P Cheriex ,.E Wellens :.J.J.H Reversibility of tachycardia-induced left ven tricular dysfunction after closed-chest catheter ablation of the atrioventricular junction for intrac- table atrial fibrillation. Comment by .C.E Cheriex, .DM Am J Cardiol ;7891 :06 1406-1408 377 Bar EW., Vermeer E, eD Zwaan ,.c Ramentol M., Braat ,.S Simoons M.L., Hermens ,.T.W naV der Laarse ,.A Verheugt EWA., Krauss X.H., Wellens :.J.J.H eulaV of admision electrocardiogram ni predicting outcome of thrombolytic therapy ni acute myocardial infarction. Comment by Prof .L.M Simoons, .DM Am J Cardiol 1987; :95 6-13 183 Wellens H.J.J., Brugada ,.P Bar EW: Indications rof use of intracardiac electrophysiological studies rof diagnosis of site or origin and mechanism of tachycardias. Comment by Prof .S Saksena, .DM Circulation 1987; 75: III no-U8 393 Gorgels ,.M.P.A soV M.A., Letsch I.S., Verschuuren E.A., Bar EWH.M., Janssen J.H.A., Wellens H.J.J.: Usefulness of the accelerated idioventricular rhythm sa a marker rof myocardial necrosis and reperfusion during thrombolytic therapy ni acute myocardial infarction. Comment by A.P.M. ,s/egroG .DM Am J Cardiol ;8891 :16 231-235 104 Trappe H.-J., Brugada ,.P Talajic M., Della Bella ,.P Lezaun ,.R Mulleneers ,.R Wellens :.J.J.H Prog nosis of patients with ventricular tachycardias and ventricular fibrillation. Role of the underlying etiology. Comment by Prof .I.H ,epparT .DM J mA Coli Cardiol ;8891 :21 166-174 114 Lemery R., Brugada ,.P Della Bella ,.P Dugemier ,.T Wellens :.J.J.H Ventricular fibrillation ni xis adults without overt heart disease. Comment by .M ,cijalaT .DM J Am Coli Cardiol 1989; :31 911-916 423 Lemery ,.R Brugada ,.P Della Bella ,.P Dugernier ,.T naV den Dool ,.A Wellens H.J.J.: Non-ischemic ventricular tachycardia: clinical course and long-term follow-up ni patients without clinicallyovert heart disease. Comment by .R ,yremeL .DM Circulation ;9891 :97 990-999 134 Cruz EE.S. Cheriex E.C., Smeets J.L.R.M., Atie ,.J Peres ,.K.A Penn O.C.K.M., Brugada ,.P Wellens H.J.J.: Reversibility of tachycardia-induced cardiomyopathy after cure of incessant supraventricu- lar tachycardia. Comment by .S.E.F Cruz ,ohliF .DM J mA Coli Cardiol ;0991 :61 739-744 443 Atie ,.J Brugada ,.P Brugada ,.J Smeets J.L.R.M., Cruz EE.S., Peres ,.A Roukens ,.P.M Wellens :.J.J.H Clinical and electrophysiologic characteristics of patients with antidromic circus movement tachy cardia ni the Wolff-Parkinson-White syndrome. Comment by .I Atie, .DM Am J Cardiol1990; :66 1082-1091 453 Wellens H.J.J., Atie, ,.J Smeets J.L.R.M., Cruz ,.S.E.F Gorgels ,.P.A Brugada :.P The electrocardio- gram ni patients with multiple accessory pathways. J Am Coli Cardiol ;0991 :61 157-547 469 XI Della Bella ,.P Brugada P, Talajic ,.M Lemery ,.R Tomer ,.P Lezaun ,.R Dugemier ,.T Wellens RJ.J.: Atrial fibrillation ni patients with na accessory pathway: Importance of the conduction properties of the accessory pathway. Comment by P Della ,alleB .DM J Am Coli Cardiol 1991; :71 1352-1356 774 Atie ,.J Brugada P, Brugada ,.J Smeets J.L.R.M., Cruz EE., Roukens ,.P.M Gorgels A., Bar EW.RM., Wellens H.J.J.: Clinical presentation and prognosis of left main coronary disease ni the .s0891 Comment by Prof .rD F.WH.M. .raB .ruE Heart J ;1991 :21 495-502 584 Rodriguez L.M., Smeets ,.J O'Hara G.E., Geelen P, Brugada ,.P Wellens H.J.J.: Incidence and timing of recurrences of sudden death and ventricular tachycardia during antiarrhythmic drug treatment after myocardial infarction. mA J Cardiol ;2991 :96 1403-1406 497 Mont ,.L Seixas ,.T Brugada ,.p Brugada ,.J Simonis E, keirK ,.E Smeets J.L.R.M., Wellens :.J.J.H The electrocardiographic, clinical, and electro physiologic spectrum of idiopathic monomorphic ventricular tachycardia. Comment by .L ,tnoM .DM mA Heart J ;2991 :421 746-753 305 Lucas C.M.RB., naV der neeV EH., Cherieux E.C., Lorusso ,.R Havenith ,.M Penn O.C.K.M., Wellens :.J.J.H Long-term follow-up 21( ot 53 weeks) after dynamic cardiomyoplasty. Comment by .C Lucas, .DM J mA Coil Cardiol ;3991 :22 758-767 315 eD Chillou c., Rodriguez L.-M., Doevendans ,.P Loutsidis ,.K naV den Dool ,.A Metzger ,.J Bar EW.RM., Smeets J.L.R.M., Wellens RJ.J.: Effects on the signal-averaged electrocardiogram of opening the coronary artery yb thrombolytic therapy or percutaneous transluminal coronary na gioplasty during acute myocardial infarction. Comment by .HC ed Chillou, .DM Am J Cardiol ;3991 :17 805-809 725 Metzger ,.T.J eD Chillou C., Cheriex ,.E Rodriguez L.M., Smeets J.L.R.M., Wellens :.J.J.H eulaV of the 12-lead electrocardiogram ni arrhythmogenic right ventricular dysplasia and absence of cor relation with echocardiographic .gnidnif Comment by .J ,regzteM .DM Am J Cardiol ;3991 :27 964-967 535 Rodriguez ,.M.L Smeets J.L., Baiyan Xie, De Chillou C., Cheriex E.C., Pieters E, Metzger ,.J Den Dulk ,.K Wellens :.J.J.H Improvement ni left heart function yb ablation of VA nodal conduction ni selected patients with lone atrial fibrillation. Am J Cardiol ;3991 :27 1137-1141 345 Konings ,.S.T.K Kirchhof C.J.H.J., Smeets J.R.L.M., Wellens H.J.J., Penn O.c., Allessie :.A.M High density mapping of electrically induced atrial fibrillation ni humans. Circulation ;4991 :98 1665-1680 549 soV M.A., Verduyn S.C., Gorgels ,.M.P.A Lipcsei G.C., Wellens H.J.J.: Reproducible induction of early afterdepolarizations and torsade ed pointes arrhythmias yb d-sotalol and pacing ni dogs with chronic atrioventricular block. Comment by .A.M ,soV .DhP Circulation ;5991 :19 864-872 569 Crijns H.J.G.M., Smeets J.L.R.M., Rodriguez ,.M.L Meijer ,.A Wellens :.J.J.H Cure of interfascicular reentrant ventricular tachycardia yb ablation of the anterior fascicle of the left bundle branch. Comment by Prof H.J.G.M. ,snjirC .DM J Cardiovasc Electrophysiol ;5991 :6 486-492 583 x eD Vreede-Swagemakers ,.M.J.J slegroG A.PM., Dubois-Arbouw WI., naV eeR J.W, nemeaD MJ.A.P, Houben L.G.E., snelleW HJJ.: Out-of-hospital cardiac arrest ni eht :s0991 A population based yduts ni eht Maastricht aera no incidence, characteristics dna .lavivrus Comment by Prof .G Breithardt, MD and Prof .M Borggrefe, .DM J Am iloC Cardiol ;7991 :03 1500-1505 195 Smeets J.L.R.M., Ben-Haim ,.A.S Rodriguez ,.M-.L Timmermans c., snelleW HJJ.: weN dohtem rof cipocsoroulfnon endocardial mapping ni .snamuh Accuracy assessment dna tsrif clinical -er .stlus Comment by J.L.R.M. Smeets, ,DM PhD. Circulation ;8991 :79 :42 2426-2432 106 snelleW HJJ., uaL c.-P, ztiredi.iL ,.B Akhtar ,.M odlaW ,.L.A Camm AJ., Timmermans ,.C esT ,.F-.H gnuJ W, Jordaens ,.L sreyA ,.G rof eht METRlX investigators. :retrevoirtA na implantable ecived rof eht treatment of lairta .noitallirbif Comment by Prof .B Liideritz, .DM Circulation ;8991 :89 1651-1656 116 Zipes ,.P.D snelleW HJJ.: Sudden cardiac .htaed Comment by Prof .E.H Kulbertus, .DM Circulation ;8991 :89 2334-2351 126 Geelen J.L.M.C., Doevendans PA., Jongbloed RJ.E., snelleW H.JJ., Geraedts :.M.P.J Molecular eg sciten of inherited gnol TQ syndromes. Comment by .M.F.A.P Doevendans, ,DM PhD. Eur Heart J ;8991 :91 1427-1433 746 Nabar ,.A Rodriquez L.-M., Timmermans ,.c naV ned looD ,.A Smeets J.L.R.M., snelleW HJJ.: fE tcef of right lairta isthmus ablation on eht occurrence of lairta .noitallirbif Observations ni ruof patient groups having epyt I lairta rettulf htiw or without associated lairta .noitallirbif Comment by .rD .Y Lokhandwala. Circulation ;9991 :99 1441-1445 756 Timmermans ,.C Rodriguez ,.M-.L sreyA G.M., Lambert ,.H Smeets J.L.R.M., neyealV J.WS., lA bert ,.A snelleW HJJ.: tceffE of butorphanol tartrate no shock-related discomfort during internal atrial defibrillation. Circulation ;9991 :99 :41 1837-1842. 766 J.L.R.M. Smeets, ,.DM ,.DhP Associate Professor of ,ygoloidraC University Hospital Maastricht, Maastricht, The Netherlands. PA. Doevendans, ,.DM ,.DhP Assistant Professor of ,ygoloidraC University Hospital Maastricht, Maastricht, The Netherlands. .E.M Josephson, ,.DM ,.DhP Professor of Medicine, Harvard Medical ,loohcS Director of eht raH -drav Thorndike Electrophysiology Institute, Beth learsI Deaconess Medical ,retneC Boston, .ASU .hC ,fohhcriK ,.DM PhD., Assistant Professor of ,ygoloidraC University Hospital Maastricht, saaM ,thcirt The Netherlands. .A.M soV ,.DhP Associate Professor of ,ygoloidraC ytisrevinU latipsoH ,thcirtsaaM Maastricht, The Netherlands. IX noitcudortnI tiele ,14[ taken from a hook published ni 1986 (7) on 53 years of Cardiology ni Amsterdam ni commemo ration of professor Dirk Durrer. The investigations reported ni this article were FRITS .L MElJLER This book si published at the occasion of a congress, based on: called 'Future of arrhythmology: lessons from the .I Previous hypothesis of the presence of two con past, promises for tomorrow', organized ni April 2000 nections between atrium and ventricle ni the WPW-syndrome with different electrophysiologic sa a tribute ot Professor Hein Wellens. He will be 56 properties allowing a circus movement with anter later this year. It si a privilege and distinct pleasure ot be allowed and hopefully be able to write na Intro ograde conduction over one AV-pathway and ret duction rof this collage of highlights of the scientific rograde conduction over the other. work of Dr Hein Wellens and his group produced .2 The definite demonstration of the presence of a over a period of approximately 30 years. eW lla know second atrio-ventricular pathway by epicardial that Dr Wellens, like myself, si a pupil of the famous mapping ni a patient with WPW operated upon Dr Dirk Durrer, professor of Cardiology and Clinical because of na atrial septal defect .131 Physiology at the University of Amsterdam. When .3 The availability of a safe versatile clinical stimu lator allowing by timed premature stimulation the Wellens started ot work ni the Wilhelmina Gasthuis ni Amsterdam ni the mid-sixties, the Amsterdam exposure of differences in electrophysiologie prop group had established its name ni animal experimen erties of the two AV-connections resulting ni ni lat electroeardiology, but the step from dogs, goats duction of the circus movement tachycardia. and rats to humans had ton yet heen taken. The tran sition came with the excitation study of the isolated This si lla common knowledge now, but ni those days perfused human heart ni 5691 ]1[ and Durrer's study ti was new and revealing. nI the last sentence of this of epicardial excitation of human patients with ostium commentary, typical Wellens' vintage, he gave most primum defects ]21 and WPW ]3[ during cardiac sur of the credit for this study ot his teacher Dr Dirk gery together with Dr Jan Roos ni Leiden. nI ym per Durrer. As described elsewhere both the observations ception ti has been Hein Wellens who had the cour leading ot the article and the writing o{ eht article ti age and the foresight ot take the knowledge and the self will always be remembered as na exciting jour techniques, acquired ni the previous 51 years yb Dur nev intu a newly discovered land at the hands oj a ,rer Professor Henk van 'led Tweel and others, to the brillian!, inspiring and RnitavitolI/ .ediuR Nohody will patient in the cath lab. Dr Wellens' name appears for accuse em of degrading Durrer when I dare ot say that the first time inl967 14[ ni the list of papers of the without the vision and ambitions of Hein Wellens, Amsterdam group. Leo Schoo would probably not have built the 'versa This article si also the first puhlieation of this tile clinical stimulator' mentioned ahove. From now hook. The first paper with Wellens sa tsrif (and single) on Wellens' name appears ni publications ni connec author, no VA conduction ahnormalities, appeared ni tion with members of the Amsterdam group for an 196~ ni Diseases of the Chest (5). mor:-t that time no other 01 years, but after his transfer ot Maastricht, the name of Wellens sa the principal author of numer Wellens was on his own and continued ot be very ous publications on cardiac electrophysiology, first ni productive. Against lla odds, and helieve me there Amsterdam and later ni Maastricht, became a land were many, he managed ot establish his own, now mark rof quality and innovation. Hein Wellens' thesis world famous, school of electrocardiology. at the University of Amsterdam published ni 1791 on: 'Electrical Stimulation of the Heart ni the Study and It will be clear that the whole development of clinical Treatment of Tachycardias' 161 has set the stage for electrocardiology ni the Netherlands si not a one-man the future development of clinical electrophysiology show. Durrer together with Henk van dcr Twccl laid of the heart. the hase for experimental cardiovascular electrophys iology ni The Netherlands. The stimulator that tI si not without (historical) interest ot take note of Wellens mentioned ni his commentary was the lanif the first part of Wellens' commentary on his first -ra rcsult of 51 years of trial and error ni the animal 1.teemS et al ,).I.de( Professor IIeill./..I. Wellells: 33 lean o/Cwdio{ogr alld Arrhlllllll%gr. .'lP xi-Xl. © 2000 Kh/\f'er Academic Pubhshers.
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