PROCEEDINGS OF THE SECOND INTERNATIONAL SYMPOSIUM ON 1\ BASIC ENVIRONMENT AL PROBLEMS OF MAN IN SPACE PARIS, 14 - 18 JUNE 1965 ORGANIZED BY THE INTERNATIONAL ASTRONAUTICAL FEDERATION AND THE INTERNATIONAL ACADEMY OF ASTRONAUTICS WITH THE SUPPORT AND COOPERATION OF UNESCO, THE INTERNATIONAL ATOMIC ENERGY AGENCY, THE WORLD HEALTH ORGANIZATION, THE WORLD METEOROLOGICAL ORGANIZATION, AND THE INTERNATIONAL TELECOMMUNIC.\TIO~ UNION EDITED BY HILDING BJURSTEDT, M. D. PROFESSOR, KAROLINSKA INSTITUTET STOCKHOLlI.l WITH 180 FIGURES 1967 SPRINGER-VERLAG WIEN GMBH ISBN 978-3-7091-3034-6 ISBN 978-3-7091-3032-2 (eBook) DOI 10.1007/978-3-7091-3032-2 All rights reserved This book, or parts thereof, may not be reproduced in any form (including photostatic or microfilm form) without written permission of the publishers © 1967 by Springer-Verlag Wien Originally published by Springer-Verlag Wien New York in 1967 Softcover reprint of the hardcover I st edition 1967 Library of Congress Catalog Card Number 65·21971 Preface The Sl'colld International Symposium on Basic Environmental Problems of Man in Space was held 14-18 June 1965 at Unesco House, Paris. It was or- ganized by thf' International Astronautical Federation and the International Academy of Astronautics with the support and cooperation of Unesco, the International Atomic EUl'rgy Agency, the World Health Organization, the World MeteOl'ological Ol'ganization. and the International Telecommunication Union. Thc Sympmliulll was devotcd to four main problem areas, viz. (1) ecophysi- ology, (2) psychophysiology and engineering psychology, (3) special man- machine probh~ms. and (4-) biot,echnology. A total of 30 papers-all by special invitation--wpl'(' PI'PRf'lltl'd during \) half-day working sessions. Eight ofthe papers were from the P,S,A" S fl'Olll the U,S,S,R., and 14from other countries. The pres- entations includcd foUl' ~,!pneral review papers. The working languages were English, Russian. ami Fl't'Ilch, This volul1H' contaiwl aH the papers of the Symposium and also reports the discussionK foHowing individual papers. Papers in the Russian language appeal' in full also in English, Abstracts appear in all three languages, trans- lations being ~;upplipd by eOUl'tesy of Unesco. For the reporting of discussions the following sysü'lll wal' used, Each person asking a question or making a comment from the flool' was given a "question and answer" form immediately after he had finished sppaking. Thc questioner and the session speaker were asked to writp down thpir qtlPstions. answers or comments at their earliest conwnience and to "PÜII'1l thp completed form the same day if possible. In addition alJ thp rlis('ussionK wel'e tapee! to check on any forms which were not ,'eturned OT' \\'("'P 10sl, Th!' tapPR also provided a safeguard against undecipher- able informatioll, Fol' "('RKOIlS of space it has been necessary to condense the discussioml cOllsiderably, allel to rcport them in the English language only. On behalf of thp orgallizenl of this Symposium, the International Astro- nautical Fpdel'ation ami tl1l' International Academy of Astronautics, I gratefully acknowledgp thp carl'ful wo!'k and wholehearted co-operation of the Springer- Verlag in thc ]ll'oduetioll (lf this second Man-in-Space volume. As Editor, I wish to express IllY sincpl'(' gratitucle to Miss HELENE VAN GELDER who greatly facilitated thc editorial \\"Ol'k by most efficient assistance in the organization of the Symposium, I alll greatly indebted to Miss IRENE UNANDER-SCHARIN for her skilful assistanee in the I'eporting of the discussions and in other editorial maUers. Stockholm. Oct.ollf'I' IH66 H. Bjurstedt Organizing Committee of thc Symposium Ohairman: Prof. HILDING A. BJURSTEDT, Director, Laboratory of Avia- tion Medicine, Karolinska Institutet, Stockholm (Sweden). Vice-Ohairmen: Dr. W. RANDOLPH LOVELACE II, Director, Lovelace Founda- tion for Medical Education and Research, Albuquerque, N.M. (U.S.A.). Prof. N. M. SISSAKIAN, Presidium, U.S.S.R. Academy of Sciences, Moscow (U.S.S.R.). Members: Prof. R. K. ANDJUS, Institute of Physiology, University of Belgrade (Yugosla via). Prof. M. FLORKIN, Biochemistry Laboratory, University of Liege (Belgium). Prof. O. H. GAUER, Physiological Institute of the Free University of Berlin (German Federal RepubIic). Med. Gen. R. GRANDPIERRE, former Director, "Centre d'En- seignement et de Recherches de Medecine Aeronau- tique," Paris (France). Air Comm. W. K. STEWART, R.A.F. Institute of Aviation Medicine, Farnborough (U. K.). Prof. J. WALAWSKI, Academy ofMedicine, Warsaw (Poland). Contents Opening Romarks. By H. Bjurstedt, A. ~Iatveyev, E. A. Brun, W. H. Pickering, C. S. Draper, S. Forssman, and E. Vassy ............................. 1 Funetional Disturbanees of Vestibular Ol'igin of Significance in Spa<3e Flight. By A. Graybiel. C\Vith 19 Figures) ...... . ............................ S Diseussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32. . . . . . . . . . . . . . C .UIPBELL -- GRAYBlEL -- PICHLER - BJl;RtiTEDT. HCHOTOPhIe rrp06JIeMbI 3HO!Jlu3110JIOrHH, H. 1\1. ülcaKlIll . . . . . . . . . . . . . . .. . . 3. 3. . English Translation: Some Problems of Eeophysiology. Hy N. ~I. Sissakian 49 Diseussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . .6 .0 . . . . . . . . . . . . . GRAYBIEL - CHERNIGOVSKY - 'VIUTE - TOBIAS - MAYO - PACE - GAUER - CAMPBELl,. Bioecological and Biomedical Monitoring for Advanced Man in Spaee Projeets. By f'..J. Clemedson .. . ............ . ....... . .... . ... . ............... , 61 Diseussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . .7 .9 . . . . . . . . . . . . . NOVAK - CLElIfEDSON . Somo Problems of Behaviour R elating to Space Flight. Hy 'V. K. Stewart .. . . 80 Diseussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .S 9. . . . . . GAUER - STEWART - GRANDPIERHE. hOM6uIII1pOBallHhle B03AeticTBUfl qlaHTOPOB HOCMlI'leCHOro IIOJlera Ha HCHoTophle !fJYHlH\111I opralIU3Ma, 1'. IU. (J>paHK, H. H. JIIIBIIIII~, ~[. A. ApcellLeBa, 3. H. AnaHaCeHItO, JI. A. BeJIUeBa, A. B. 1'00IOBKIIHa, B. H. KJIIIßIOBn~};llit, 1\1. A. II:Y'lHe~oBa, .lI. )),. JIYKLlIlloBa 11 E. e. l\'leiiaepoB. (22 PRe.) . . . . ... 90 English Translation: Combined Effeet.s of Spaco Flight Fact.on; on Some Funct.ions of the Organism. By G. 1\1. Frank, N. N. Livshitz, M. A. Arsenieva, Z. I. Apanasenko, IJ. A. ßelliaeva, A. V. Golovkina, V. Y. Klimovitsky, M. A. Kuznetsova, IJ. D. Loukianova, and E. S. Meizerov. ("'ith 22 Fignres) 123 Disenssion .......... . . . ............... . ... . ... . ...... . ... . .. . ... . .. 140 KLEIN - FRANK -- HARTELS -- TEH-POGOSSIAN - PICHLEH - TOB lAS. Interaotion of Radiation and Other Environmental Stresses in Biologieal Systems. By C. A. '1'obias, N. M. Amer, J. Je Ashikawa, J. T. JJymall, JJ. W. ~leDonald, J. V. Slater, C. A. Sondhans, and P. W. Todd. (With 10 Figuros) ...................... . ..................... . ........... 141 Diseussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1. 57. . . . . . . . . . . . . . GHAYBIEL - TOBIAS - NOVAK - TEH-POGOSSIAN - Mmo - GRAUL. Toleranee to the Combined Effoots of Hypothormia, Anoxia, and Ionizing Radiation. By R. I{. Andjns, Olivera Matie, and Nndezda Savkovie. (With 8 Figures) ......................................................... 159 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . .1 69. . . . . . . . . . . . . . NOVAK - ANDJUS. VI Contents Hpl1Tepl111 paAl1al\110HHOH 6eaonaCHOCTl1 AJII1TeJIbHblX IWCMl1lJeCKI1X nOJIeTOB, 10. l'. l'pHropLeB, E. E. KOBlUleB, A. ß. JIeoeAHHCKnii, 10. r. HelJleAOB, ß. r. ßb[- cO~Knii, H. ß. PLImOB, B. A. lUapKenoB, JI. H. CMHpeHHLIii, ß. E. f],mKIfH 11 H. H. f],epoeHeBa. (3 Pl1c.) ........... .. . ... . ... ... .......... .. .. .. 170 English 1'rallslation: Criteria of Radiation Safety in Prolonged Space Flights. By Yu. G. Grigoryev, E. E. Kovalyev, A. V. Lebedinsky, Yu. G. Nefedov, V. G. Vysotsky, N. I. Ryzhov, ß. A. Markelov, L. N. Smirenny, V. E. Dudkin, and N. N. Derbeneva. (With 3 Figures) ... 185 Discussion . .. .... . .. ..... . .... . . .. .... . .. . . .. ......... .......... . .. 196 TOBIAs - FRANK - WHITE - ANDJUS - GRAYBIEL. Cardiopulmonary Effects of Acceleration in Relation to Space Flight. By E. H. Wood, W. J. Rutishauser, N. ßanehero, A. C. Nolan, A. G. Tsakiris, and D. E. Donald. (With 9 Figures) .................................. 198 Discussion .. . ...... ...... ........ . . ........... .... .. ......... . ... . . 210 BARTELS - WOOD - PACE - GRANDPIERRE. Fluid Metabolisrn and Circulation During and After Sirnulated Weightlessness. By O. H. Gauer, P. Eekert, D. Kaiser, and H. J. Linkenbach. (With 7 Figures) 212 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 2. 20. . . . . . . . . . . . . . GRANDPIERRE - GAUER - GRAYBIEL - WHITE - ROTH - WEBB - PACE - ANDJUS. Vascular Reactivity to Neurohormones in Subgravity Simulated by Immersion Method. By J. Walawski and Z. Kaleta. (With 6 Figures) .......... .. . . 222 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 2. 2. 8 . . . . . . . . . . . . . GAUER - WALAWSKI - LAWTON. Un probleme original en biologie aerospatiale: l'action des vibrations mecaniques au niveau cellulaire. Par P. Grognot, R. Loubiere et A. Pfister. (Avec 1 Figure) ... .. ..... .. ... . . .. . ......... .. . .. .. . ....... .......... ... , 229 The Toxic Effects of Breathing Oxygen. By J. Ernsting• .................... 234 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . 2. 5. 6 . . . . . . . . . . . . . GRANDPIERRE - ERNSTING - BARTELS - TOBIAS - LOUBIERE. BJBHIHl1e Ha OpraHI13M AJII1TeJIbHOrO npe6b1BaHI1II (100 CYTOK) ß aTMocljJcpe 'IHCTOrO HI1CJIOpOAa npl1 06mCM AaBJIeHl111 198 111M pT. CT., H. A. AraAmaHJIH, 10. 11. BHiJHH, l'. ß. f],OPOHIIH, A. r. KY3He~oB 11 A. P. MaHcYPoB . . . ... 258 English Translation: Effects on the Organisrn of Prolonged Exposme to Pure Oxygen (Up to 100 Days) at a Total Ambient Pressure of 198 rnrn Hg. By N. A. Agadzhanyan, Yu. P. ßizin, G. P. Doronin, A. G. Kuznetsov, and A. R. Mansurov. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 2. 6. 7 . . . . . . . . . . . . Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 27. 3. . . . . . . . . . . . . . ANDJUS - PROKOVSKY - NOVAK - CULVER - PACE. The Formation of Carbon Monoxide in the Living Organisrn - a Factor To Be Considered in Space Flight. By T. Sjöstrand .... . ...... .. . ........... . 274 Discussion ......................................................... 278 BIGET - SJÖSTRAND - TOBlAS - ROTH. Examples of Defense Against Low Oxygen and High Carbon-Dioxide Tensions in the Animal Kingdom. By H. ßartels. (With 6 Figures) ..... ...... .. .. 279 Action des champs electromagnetiques hyperfrequences sur l'incorporation de la Methionine 35 Spar la rate et la foie chez la souris. Par L. Miro, R. Loubiere et A. Pfister ............................................ 288 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.9 7. . . . . . . . . . . . . . PICHLER - MIRO - CAMPBELL - PACE. Contents VII HeHOTophle peSYJIbTaThI MejlMl\MHCHMX MCCJIeAOBaHMn, rrpOBeAeHHbIX BO BpeMH IIOJIeTa Kopa6JIH "BocXOA", 10. lU. BOllblHKHH M n. B. BaCMln,eB. (5 PMC.) 298 English Translation: Some Results of Medical Investigations During the Voskhod Spaceship Flight. By Yu. M. Volynkin and P. V. Vasilyev. (With 5 Figures) ...... . .................................................. 312 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32.1 . . . . . . . . . . . . . . . WEBB - VASILYEV - GRAYBIEL - WHITE - PACE - LINDSEY - ROTH- STEWART - GAUER - CAMPBELL. L'activite electrocorticographique lors des differentes phases du vol en avion ou en fusee. Par P. Buser, G. Chatelier, J. Ginet et R. Grandpierre. (Avec 7 Figlu'es) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . 3. 2.3 . . . . . . . . . . . . . Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .3 3.4 . . . . . . . . . . . . . PROCTOR - BUSER - FLICKINGER - MAYO - VASILYEV. HeHOTophle BOIlPOChI AefITeJIbHOCTM ceHcopHbIX CMCT8M rrpHMellMTeJIbHO K 3aAaqaM IWCMMqeCKotl IPM3MOJIOrMM, B. ,[l. rlleaep, B. A. KHClIJIKOB, B. A. KomeBHlIROB, B. H. lIepHllroBCKHH M JI. A. lIHCTOBH'l. (8 PMC.) ................•..•• 335 English Translation: So me Prob10ms of the Activity of SensOl'y Systems As Applied to Space Physiology. By V. D. Glezer, V. A. Kislyakov, V. A. Kozhevnikov, V. N. Chernigovsky, and L. A. Chistovich. (With 8 Figures) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. .. . 3. 5. 0. . . . . . . . . . . . Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . .3 60 . . . . . . . . . . . . . TOBlAS - CHERNIGOVSKY. II pOUJIeMbI llaAelliHOCTM qeJIOBe[,a B CMCTeMax YllpaBJIeHHH HOCMH'leCHMM HOpaUJIeM, n. K. HcaKoB, B. A. nOnOB M lU. lU. CHlIbBeCTpOB. (1 PI1C.) ........... 361 English Translat'ion: Some Problems of Man's Reliability in Spacecraft Control and Guidance Systems. By P. K. Isakov, V. A. Popov, and ~I. M. Silvestrov. (With 1 Figure) ........ . ............................ 368 DisCllssion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 3. 7. 2 . . . . . . . . . . . . . GRAYBIEL - POPO V - CAMPBELL - LAMPERT - VVHITE - FLICKINGER. Physiological, Behavioral, and Subjective Reactions to Stress. By Marianne Frankenhaeuser. (vVith 12 Fignres) . . ....... . .... . .... . ... . ......... . . 374 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 3. 8. 7. . . . . . . . . . . . NOVAK - FRANKENHAEUSER - PACE - MILLER - STEWART - Popov. On tho Dangors of Over-Arousal. By D. E. Broadbent ....... . . . . . . . . . .. .. 3. 8. 9 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . .. .. 39. 8 PROCTOR - BROADBENT - PACE. Habitability : General Principles and Applications to Space Vehicles. By J. F. Kuhis .... . .... . ..... . .. . ... . .......................... . ...... 399 <DH3HOJIOfO-fMfl1eHUqeCHaH Ol\8HHa CHCTOill llil13HeHIIOfO ooeCrreqeHHH HOCMM'leCHUX HOpaOJIetl "BocToH" H "BocXOA", r. H. BOPOHlfH, A. ~1. reHlIH 11 A. r. c])OMIIH. (3 Puc.) ... . ........ . ....................•....................•..• 428 Englüh Translation: Physiological ami Hygienical Evaluation of Life Support Systems of tho "Vostok" and "Voskhod" Spacecraft. By G. I. Voronin, A. ~1. Guenin, and A. G. Fomin. (With 3 Figures) ........ 439 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .4 .4 .5 . . . . . . . . . . . . JOHNSTON - GUENIN - CULVER - PACE - WHITE - TER-POGOSSIAN. Numerical Indices of Cardiovascular Status. By P. Howard, G. H. Bylord, J. Stoddart, and M. J. Alhvood .... . ............. . .. . ................ 447 VllI Conl(' lIfs DiBcuSIIion ........ ....... ........................................ . 452 P "CE - How,uw - H OTH. Computer Utilization of T imo-Lino Morlit'ül nato. (rom M an in Spaoo Fl ighl .. ß y J. f '. J.[ndsey. (Wit lt 10 }~igurM) 41)3 Discllssion ..... . .... . 4711 Thc Dcvolopmcnt of Spaco Suit Systems. By n. S. John8ton. (With 14 Figures) 478 Discussion P O I>Q\' - J O I :<l"'OS _ . l:H EII SiCO\'SKY - ütr~S I N - V"SILYE" '" PIIOKO"SKY . ']110 U Lilit}' of All tomatf!<1 SystillTIS in t ho Soareh for E)(t nlotl'rroatrio.] Lire. B~' O. E. Ue)'llUlds mul H .... Kll'lu. (With 8 Fi~ lres) ........... 494 D iscussioll . . . . . . . . . . .. .... .......... . ....... .... .. . 505 !-' RA S K -- KI.~IN - B " I(T h:/ .-; - L .UIPJ-:ItT -- 'l'OlllMj. Tho R olo or Infl'fl.!'()(1 S!)OOt,I'OQCOpy in t .ho Biologicul "~xplo rl\t.ion of Mars. By n. (t J{(~M. (WiM. 2 1 'Figm~'")'''' ' 006 J)iSCllssion .................. . 531 P.~Cf: - '1h:.I. - TOIl l AS - 1<'ll.-\N K. Opening Remarks HILDING BJURSTEDT, Chairman of the Symposium: An International Symposium on Basic Environmental Problems of Man in Space convened in this room on October 29, 1962. I deem it an honor to again address an international symposium around the same title. It appears to me that, with this second symposium, its organizers, the Inter- national Astronautical Federation and the International Academy of Astro- nautics, have already started a tradition. Thie may sound like a paradox when applied to a field where ecience and technology rush forward at an ever increasing speed. However, no one thinks of defending tradition in days that are making tradition, and so I leave it to futurity to look back and judge the strength of our motives to reunite here at Unesco House, to find out what has been accom- plished since we adjourned last time, and to exchange ideas on the problems that are before uso Speaking for the Organizing Committee of this symposium -thOS6 ofyou who were with us in 1962 will have noticed in the present program- me that this group is in the main unchanged-I can only verify that our first symposium had barely come to a elose before this veteran committee started preparations for another symposium along lines that had just proven themselves exceptionally rewarding. The common objectives of these symposia are to stimulate educational and scientific activity and progress, to encourage international cooperation in this particular problem area, and to further advancement of research in the basic aspects of the many problems at hand. Ultimately, these objectives are all concerned with the safety of man in space. That this symposium, like its predeces- sor, has enjoyed such prompt and strong response from leaders in this field, individuals as weIl as nations and groups of nations, demonstrates a concern for human well-being and adesire to expand research information on the prob- lems of man in space on a truly international basis. This, I believe, is a heartening sign that ethics and the humanities have not been left behind in the race to conquer outer space. I might remind you that the initiative to these symposia was taken jointly by responsible men of science on two Continents. This fact was reflected in the composition of the Study Group for our first Symposium that was appointed in 1961 by the International Astronautical Federation and the International Academy of Astronautics. Another feature of the composition of this Group was what might be referred to as the principle of "good geographical represen- tation" . This principle haH been maintained, not only in the first steps of organiz- ing our Study Groups, but also in the setting up of Organizing Committees, and in the choice of speakers and papers for our symposia. Plans for the present symposium were first drawn up by a Study Group, which was organized by the Federation and the Academy, and which met here in Paris in September 196:{. The members of the Organizing Committee for the first Symposium were invited to make recommendations as regarded plans and program for a second Symposium. The Group agreed that a second Symposium Man in Space II 1 2 Opening Remarks seemed highly desirable, and it was considered feasible to hold another five-day symposium at Unesco House during the second half of June, 1965. An Organizing Committee was formed with-as I have just mentioned- essentially the same members as those constituting the committee for the first symposium. The Committee met in Paris in May 1964, when the plans and program for the present symposium were finalized. Our first symposium was devoted to three main research areas, namely (1) ecophysiology, (2) psychophysiology, and (3) the acquisition, analysis and control of physiological and psychological data. During the last few years there has been a rapid growth of engineering psychology, special man-machine prob- lems, and biotechnology in bioastronautics, and the Group consequently agreed to add these problem areas to those of ecophysiology and psychophysiology. The printed program outlines the subjects to be discussed. This afternoon 4 general review papers will be presented, which together will cover most of the problem areas we have before uso Monday and Tuesday will be devoted to environ- mental physiology. This section comprises 13 papers and is by far the largest. Many of the remaining 17 papers deal with problems of an interdisciplinary nature. .Problems of psychophysiology and engineering psychology will be presented and discussed on Thursday. Friday, finally, will be devoted to special man-machine problems and biotechnology. It has been a great pleasure for me to work with the Organizing Committee, ever since it first got together as a Study Group in 1961. My friends in the Com- mittee, who have relieved me of so much responsibility, have certainly been looking forward to seeing their plans realized. The two vice-chairmen of the Committee, Professor SISSAKIAN and Dr. LOVELACE have cooperated in the preparations and in the organization of this Symposium with great enthusiasm. Without the support of their leading organizations, the U.S.S.R. Academy of Sciences and the National Aeronautics and Space Administration, both spiritually and from the material point of view, our two symposia would not have been possible. A major part of the total effort to arrange this symposium has been expended by the authors of the 30 paper to be presented at this symposium. It is already evident from the advance information in the preprints, that there will again be an abundancy of primary, first-class, experimental material available for discussion during this Symposium. As was the case last time, the Organizing Committee takes great pride in this fact, which shows the rapid progress in this field, and also that the space age continues to benefit from the best efforts of scientists in many countries and disciplines. On behalf of the Organizing Committee, I would like to thank all of you who have expended so much time and effort in the preparation their papers. We are very grateful to those of you who have travelled long distance for coming here and sharing with us their ideas and experience. Speaking for the Organizing Committee I would also like to express our heartfelt gratitude to Miss HELF;NE VAN GELDER, Secretary of the International Academy of Astronautics, for her skillful and unfailing interest and work to get this symposium into orbit. A. MATVEYEV, Assistant, Director-General for Science, representing the Director- General of Unesco: It gives me great pleasure to welcome you to Unesco House on behalf of the Director General. Mr. MAHEU has asked me to express to you his great regret at being unable to welcome you in person. As you know, he was present at the opening ofthe first symposium on Man in Space here at Unesco in October, 1962,