Proceedings of Light-Activated Tissue Regeneration and Therapy Conference PDF
Preview Proceedings of Light-Activated Tissue Regeneration and Therapy Conference
Proceedings of Light-Activated Tissue Regeneration and Therapy Conference Ronald Waynant Darrell B. Tata l Editors Proceedings of Light-Activated Tissue Regeneration and Therapy Conference RonaldW.Waynant DarrellB.Tata TheFoodandDrugAdministration TheFoodandDrugAdministration 10903NewHampshireAvenue CDRH/OSEL/DivisionofPhysics SilverSpring,MD20993 SilverSpring,MD20993 USA USA ISBN978-0-387-71808-8 e-ISBN978-0-387-71809-5 LibraryofCongressControlNumber:2008922319 #2008SpringerScience+BusinessMedia,LLC Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewritten permissionofthepublisher(SpringerScience+BusinessMedia,Inc.,233SpringStreet,NewYork,NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software,orbysimilarordissimilarmethodologynowknoworhereafterdevelopedisforbidden. Theuseinthispublicationoftradenames,trademarks,servicemarksandsimilarterms,eveniftheyare notidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubject toproprietaryrights. Printedonacid-freepaper. 987654321 springer.com Contents Forword .......................................................................... xi Contributors ................................................................... xvii Keynote MitochondrialMechanismsofLaserPhototherapy ................... xxvii TiinaI.Karu PartIMechanisms 1 Mechanisms .................................................................. 3 DarrellB.TataandRonaldW.Waynant 2 Near-IRPicosecondPulsedLaserInducedSuppression ofMetabolicActivityinMalignantHumanBrainCancer: AnIn-VitroStudy ........................................................... 11 DarrellB.TataandRonaldW.Waynant PartIIWoundHealing 3 Combined660and880nmLightImprovesHealing ofRecalcitrantDiabeticUlcers ............................................ 23 DeboraG.Minatel,MarcoAndreyC.Frade,SuzeleiC.Franca, GilL.Almeida,andChukukaS.Enwemeka 4 BlueLightPhoto-DestroysMethicillinResistant Staphylococcusaureus(MRSA)In-Vitro ................................. 33 ChukukaS.Enwemeka,DeborahWilliams,SteveHollosi,andDavidYens v vi Contents 5 PhotobiomodulationfortheTreatmentofRetinalInjury andRetinalDegenerativeDiseases ....................................... 39 JanisT.Eells,KristinaD.DeSmet,DianaK.Kirk,MargaretWong-Riley, HarryT.Whelan,JamesVerHoeve,T.MichaelNork,JonathanStone, andKrisztinaValter 6 Irradiationwitha780nmDiodeLaserAttenuatesInflammatory CytokinesWhileUpregulatingNitricOxideinLPS-Stimulated Macrophages:ImplicationsforthePrevention ofAneurysmProgression ................................................. 53 LilachGavish,LouiseS.Perez,PetachiaReissman,andS.DavidGertz 7 NewAspectsofWoundHealing .......................................... 59 A.Lipovsky,AnkriR.Nitzan,Z.A.Landoy,J.Jacobi,andR.Lubart PartIIIPhotodynamicTherapy 8 AnIntroductiontoLow-LevelLightTherapy .......................... 67 StuartK.Bisland 9 EnhancingPhotodynamicEffectUsingLow-Level LightTherapy .............................................................. 81 StuartK.Bisland 10 LightFractionatedALA-PDT:FromPre-ClinicalModels toClinicalPractice ........................................................ 89 D.J.Robinson,H.S.deBruijn,E.R.M.deHaas,H.A.M.Neumann, andH.J.C.M.Sterenborg 11 CombinationImmunotherapyandPhotodynamic TherapyforCancer ....................................................... 99 MichaelR.Hamblin,AnaP.Castano,andPawelMroz 12 Patient-SpecificDosimetryforPhotodynamicTherapy .............. 115 JarodC.Finlay,JunLi,XiaodongZhou,andTimothyC.Zhu 13 NovelTargetingandActivationStrategies forPhotodynamicTherapy ............................................. 127 JuanChen,IanR.Corbin,andGangZheng PartIVCardiovascular 14 LightTherapyfortheCardiovascularSystem ........................ 151 HanaTuby,LydiaMaltz,andUriOron Contents vii PartVDentistry 15 Introduction:Overview ................................................. 159 DonaldE.Patthoff 16 OpticalCoherenceTomographyImagingforEvaluating thePhotobiomodulationEffectsonTissueRegeneration inPeriodontalTissue .................................................... 173 CraigB.Gimbel 17 PhotobiomodulationLaserStrategiesinPeriodontalTherapy ...... 181 AkiraAoki,AristeoAtsushiTakasaki,AmirPourzarandian, KojiMitzutani,SenarathM.P.M.Ruwanpura,KengoIwasaki, KazuyukiNoguchi,ShigeruOda,HisashiWatanabe,IsaoIshikawa, andYuichiIzumi 18 CombinedNewTechnologiestoImproveDental ImplantSuccessandQuantitativeUltrasoundEvaluation ofNIR-LEDPhotobiomodulation ...................................... 191 JerryE.Bouquot,PeterR.Brawn,andJohnC.Cline 19 PhotobiomodulationbyLowPowerLaserIrradiation InvolvesActivationofLatentTGF-b1 ................................. 207 PraveenR.Arany PartVIDiabetes 20 TheRoleofLaserinDiabeticManagement ........................... 215 LeonardoLongo 21 He-NeLaserIrradiationStimulatesProliferation andMigrationofDiabeticWoundedFibroblastCells ................ 221 NicoletteHoureldandHeidiAbrahamse 22 TheRoleofColostrumProline-RichPolypeptides inHumanImmunologicalandNeurologicalHealth .................. 233 AndrewKeech,JohnI.Buhmeyer,andDickKolt PartVIINeuroscience 23 PhototherapyandNerveTissueRepair ................................ 247 ShimonRochkind viii Contents 24 LaserRegenerationofSpineDiscsCartilage:Mechanism, In-VivoStudyandClinicalApplications .............................. 259 EmilSobol,AndreiBaskov,AnatolyShekhter,IgorBorshchenko, andOlgaZakharkina PartVIIIFDARegulations 25 RequirementsforFDAApproval ...................................... 269 SankarBasu PartIXPain 26 PainReliefwithPhototherapy:SessionOverview .................... 273 MaryDyson 27 IsReliefofPainwithLow-LevelLaserTherapy(LLLT) aClinicalManifestationofLaser-InducedNeuralInhibition? ...... 277 RobertaChow 28 ComplexRegionalPainSyndrome:ANew ApproachtoTherapy ................................................... 283 AllanGardiner,RobertE.Florin,andConstanceHaber PartXElectricFieldInteractions 29 Introduction .............................................................. 295 MartinJ.C.vanGernert 30 ThePainfulDerivationoftheRefractiveIndex fromMicroscopicConsiderations ...................................... 297 BernhardJ.Hoenders 31 IndependentApplicationsofNear-IRBroadbandLightSource andPulsedElectricPotentialintheSuppression ofHumanBrainCancerMetabolicActivity: AnIn-VitroStudy ....................................................... 307 DarrellB.TataandRonaldW.Waynant 32 ElectroencephalogramChangesCausedbyMobile PhonesaProtectiveDevice ............................................. 315 MbonuNgozy,WeilerElmar,andSchroeterCareen Contents ix Appendix1A3DDoseModelforLowLevelLaser/LED Therapy,BiostimulationandBioinhibition ................... 327 JamesD.Carroll Appendix2DoesBodyContouringNeedtoBePainful? .................. 331 MichailM.Pankratov Appendix3EffectofFarInfraredTherapyonInflammatory ProcessControlAfterSciaticCrushinginRats .............. 347 CarolinaL.R.B.Nuevo,RenataAmadeiNicolau, RenatoAmaroZaˆngaro,AldoBrugnera,Jr., andMarcosTadeuTavaresPacheco Appendix4EffectsofDiodeLaserTherapy ontheAcellularDermalMatrix ............................... 357 L´ıviaSoares,Mar´ıliadeOliveira,S´ılviaReis, andAntoˆnioPinheiro Appendix5LaserTherapyinInflammation: PossibleMechanismsofAction ................................ 361 RodrigoAlvaroB.LopesMartins Appendix6ASystematicReviewofPost-operativePain ReliefbyLow-LevelLaserTherapy(LLLT)After ThirdMolarandEndodonticSurgery(SlidesOnly) ......... 393 JanM.Bjordal Index ........................................................................... 441 Foreword The contents of this book represent most of the material presented at the second conferenceon“Light-ActivatedTissueRegenerationandTherapy”anEngineering ConferenceInternational(ECI).ThisConferencewasheldinTomar,Portugalfrom June 24 to 29, 2007 and focused on the use of lasers, light and electromagnetic radiation for medical treatments. The methodology was first presented by Finsen, who used light (mostly sunlight), to cure tuberculosis in the late 19th century. He wasawardedtheNobelPrizein1903.Hisworkledtosanatoriumsthroughoutthe world,butFinsen’sworkwasmostlyforgottenbythe1940sinfavorofnewwork on antibiotic drugs. After the invention of the laser in 1960 medical research became interested in its possible use. Andre Mester in Hungary tried lasers in medicineandhisworkledtolaseruseinmedicine.Thisworkspreadtonumerous usesoflowpoweredgaslaserapplicationsfortreatingabroadspectrumofmedical illnesses, afflictions, injuries and cosmetic treatments. The major body of early applicationsusedlasershencethefieldwascalledlasertherapy,buttheexposures were very low hence many other names were sometimes used to make the low exposure obvious. Early workers thought that the coherence of a laser might be necessary, but later work with non-coherent sources such as LEDs, broadband sources, etc. has worked and shows that lasers are not needed. Experiments with sources oflongerwavelengthsalsoworkand shorter wavelengthsmay also work, buthaveyettobetested. SinceMester’sworkinthe1960sthelasertherapyfieldhasspreadalloverthe world. The mechanism of how the therapy works has not yet been accepted worldwide although this conference presents some views. Nor has the therapy been accepted by all ofthe medical professions. Yet the therapy has been applied tonearly100applicationsandsuccessfuldouble-blindedstudiesshowingpositive resultshavebeensubmittedforsomeoftheapplications.Inaddition,lighttherapy treatments have migrated to cosmetics treatments as well as to physical therapy treatmentsandtotreatmentsforaccidentinjuriesinthechiropracticarea.Storiesof nearly miraculously recoveries utilizing these therapies are often told. Many new applications come from small companies that find it difficult to fund the develop- mentandmarketpreparationoftheirtherapies. ThisbookbeginswithapaperfromTiinaKaru,theladywhohasgenerateda mountainofworkinthisfieldincludingoveronehundredpublicationsandatleast xi
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