Probiotics and Prebiotics in Pediatrics

260 Pages·2019·9.343 MB·English

by  Francesco Savino

nutrients
Probiotics and
Prebiotics in
Pediatrics
Edited by
Francesco Savino and Yvan Vandenplas
Printed Edition of the Special Issue Published in Nutrients
www.mdpi.com/journal/nutrients
Probiotics and Prebiotics in Pediatrics

Probiotics and Prebiotics in Pediatrics
SpecialIssueEditors
FrancescoSavino
YvanVandenplas
MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade
SpecialIssueEditors
FrancescoSavino Yvan Vandenplas
UniversitariaCitta`dellaSaluteedellaScienzadiTorino Vrije Universiteit Brussel
Italy Belgium
EditorialOffice
MDPI
St.Alban-Anlage66
4052Basel,Switzerland
ThisisareprintofarticlesfromtheSpecialIssuepublishedonlineintheopenaccessjournalNutrients
(ISSN 2072-6643) from 2018 to 2019 (available at: https://www.mdpi.com/journal/nutrients/
specialissues/probioticsandprebioticsinpediatrics)
Forcitationpurposes,citeeacharticleindependentlyasindicatedonthearticlepageonlineandas
indicatedbelow:
LastName,A.A.; LastName,B.B.; LastName,C.C.ArticleTitle. JournalNameYear,ArticleNumber,
PageRange.
ISBN978-3-03897-950-0(Pbk)
ISBN978-3-03897-951-7(PDF)
(cid:2)c 2019bytheauthors. ArticlesinthisbookareOpenAccessanddistributedundertheCreative
Commons Attribution (CC BY) license, which allows users to download, copy and build upon
publishedarticles,aslongastheauthorandpublisherareproperlycredited,whichensuresmaximum
disseminationandawiderimpactofourpublications.
ThebookasawholeisdistributedbyMDPIunderthetermsandconditionsoftheCreativeCommons
licenseCCBY-NC-ND.
Contents
AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
YvanVandenplasandFrancescoSavino
ProbioticsandPrebioticsinPediatrics:WhatIsNew?
Reprintedfrom:Nutrients2019,11,431,doi:10.3390/nu11020431 . . . . . . . . . . . . . . . . . . . 1
Gianluca Ianiro, Gianenrico Rizzatti, Manuel Plomer, Loris Lopetuso, Franco Scaldaferri,
FrancescoFranceschi,GiovanniCammarotaandAntonioGasbarrini
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and
Meta-AnalysisofRandomizedControlledTrials
Reprintedfrom:Nutrients2018,10,1074,doi:10.3390/nu10081074 . . . . . . . . . . . . . . . . . . 6
YvanVandenplas,BernardBerger,VirgilioPaoloCarnielli,JanuszKsiazyk,HannaLagstro¨m,
ManuelSanchezLuna, NathaliaMigacheva, Jean-MarcMosselmans, Jean-CharlesPicaud,
MikePossner,AtulSinghalandMartinWabitsch
Human Milk Oligosaccharides: 2(cid:2)-Fucosyllactose (2(cid:2)-FL) and Lacto-N-Neotetraose (LNnT)
inInfantFormula
Reprintedfrom:Nutrients2018,10,1161,doi:10.3390/nu10091161 . . . . . . . . . . . . . . . . . . 21
Maria Maragkoudaki, George Chouliaras, Antonia Moutafi, Athanasios Thomas,
ArchodoulaOrfanakouandAlexandraPapadopoulou
Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938
and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind,
Placebo-ControlledTrial
Reprintedfrom:Nutrients2018,10,1189,doi:10.3390/nu10091189 . . . . . . . . . . . . . . . . . . 33
HaniaSzajewskaandAndreaHorvath
Lactobacillus rhamnosus GG in the Primary Prevention of Eczema in Children: A Systematic
ReviewandMeta-Analysis
Reprintedfrom:Nutrients2018,10,1319,doi:10.3390/nu10091319 . . . . . . . . . . . . . . . . . . 44
StineBrandtBering
Human Milk Oligosaccharides to Prevent Gut Dysfunction and Necrotizing Enterocolitis in
PretermNeonates
Reprintedfrom:Nutrients2018,10,1461,doi:10.3390/nu10101461 . . . . . . . . . . . . . . . . . . 55
AriannaAceti,IsadoraBeghetti,LucaMaggio,SilviaMartini,GiacomoFaldellaandLuigi
Corvaglia
FillingtheGaps:CurrentResearchDirectionsforaRationalUseofProbioticsinPretermInfants
Reprintedfrom:Nutrients2018,10,1472,doi:10.3390/nu10101472 . . . . . . . . . . . . . . . . . . 70
Mar´ıa D´ıaz, Luc´ıa Guadamuro, Irene Espinosa-Martos, Leonardo Mancabelli, Santiago
Jime´nez, Cristina Molinos-Norniella, David Pe´rez-Solis, Christian Milani, Juan Miguel
Rodr´ıguez,MarcoVentura,CarlosBouson˜o,MiguelGueimonde,AbelardoMargolles,Juan
Jose´D´ıazandSusanaDelgado
Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk
ProteinAllergyunderaRestrictedDiet
Reprintedfrom:Nutrients2018,10,1481,doi:10.3390/nu10101481 . . . . . . . . . . . . . . . . . . 80
v
Boz˙enaCukrowska
Microbial and Nutritional Programming—The Importance of the Microbiome and Early
ExposuretoPotentialFoodAllergensintheDevelopmentofAllergies
Reprintedfrom:Nutrients2018,10,1541,doi:10.3390/nu10101541 . . . . . . . . . . . . . . . . . . 91
Erik Wejryd, Magal´ı Mart´ı, Giovanna Marchini, Anna Werme, Baldvin Jonsson, Eva
LandbergandThomasR.Abrahamsson
LowDiversityofHumanMilkOligosaccharidesisAssociatedwithNecrotisingEnterocolitisin
ExtremelyLowBirthWeightInfants
Reprintedfrom:Nutrients2018,10,1556,doi:10.3390/nu10101556 . . . . . . . . . . . . . . . . . . 103
Daniela da Silva Souza, Soraia Tahan, Thabata Koester Weber, Humberto Bezerra de
Araujo-FilhoandMauroBatistadeMorais
Randomized, Double-Blind, Placebo-ControlledParallelClinicalTrialAssessingtheEffectof
FructooligosaccharidesinInfantswithConstipation
Reprintedfrom:Nutrients2018,10,1602,doi:10.3390/nu10111602 . . . . . . . . . . . . . . . . . . 118
Chian-FengHuang,Wei-ChuChieandI-JenWang
EfficacyofLactobacillusAdministrationinSchool-AgeChildrenwithAsthma: ARandomized,
Placebo-ControlledTrial
Reprintedfrom:Nutrients2018,10,1678,doi:10.3390/nu10111678 . . . . . . . . . . . . . . . . . . 129
MariaElisabettaBaldassarre,ValentinaPalladino,AnnaAmoruso,SerenaPindinelli,Paola
Mastromarino,MargheritaFanelli,AntonioDiMauroandNicolaLaforgia
RationaleofProbioticSupplementationduringPregnancyandNeonatalPeriod
Reprintedfrom:Nutrients2018,10,1693,doi:10.3390/nu10111693 . . . . . . . . . . . . . . . . . . 140
NicoleBozziCionci,LoredanaBaffoni,FrancescaGaggı`aandDianaDiGioia
Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the
Prevention/TreatmentofPaediatricDiseases
Reprintedfrom:Nutrients2018,10,1723,doi:10.3390/nu10111723 . . . . . . . . . . . . . . . . . . 162
KlaudiaFerus´,NataliaDrabin´ska,UrszulaKrupa-KozakandElz˙bietaJarocka-Cyrta
A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of
SupplementationwithPrebioticSynergy1onIronHomeostasisinChildrenandAdolescents
withCeliacDiseaseTreatedwithaGluten-FreeDiet
Reprintedfrom:Nutrients2018,10,1818,doi:10.3390/nu10111818 . . . . . . . . . . . . . . . . . . 189
FernandaCristofori,FlaviaIndrio,VitoLeonardoMiniello,MariaDeAngelisandRuggiero
Francavilla
ProbioticsinCeliacDisease
Reprintedfrom:Nutrients2018,10,1824,doi:10.3390/nu10121824 . . . . . . . . . . . . . . . . . . 199
AnnaPa¨rtty,SamuliRautavaandMarkoKallioma¨ki
ProbioticsonPediatricFunctionalGastrointestinalDisorders
Reprintedfrom:Nutrients2018,10,1836,doi:10.3390/nu10121836 . . . . . . . . . . . . . . . . . . 212
SergeiGerasimov,JesperGantzel,NataliiaDementieva,OlhaSchevchenko,OrisiaTsitsura,
NadiiaGuta,ViktorBobykandViraKaprus
RoleofLactobacillusrhamnosus(FloraActiveTM)19070-2andLactobacillusreuteri(FloraActiveTM)
12246inInfantColic:ARandomizedDietaryStudy
Reprintedfrom:Nutrients2018,10,1975,doi:10.3390/nu10121975 . . . . . . . . . . . . . . . . . . 226
vi
Benjam´ınMart´ınMart´ınezandMariaJose´Lo´pezLin˜a´n
LettertotheEditorRe:DiazM.,etal.Nutrients2018,10,1481
Reprintedfrom:Nutrients2019,11,468,doi:10.3390/nu11020468 . . . . . . . . . . . . . . . . . . . 241
Mar´ıa D´ıaz, Luc´ıa Guadamuro, Irene Espinosa-Martos, Leonardo Mancabelli, Santiago
Jime´nez, Cristina Molinos-Norniella, David Pe´rez-Solis, Christian Milani, Juan Miguel
Rodr´ıguez,MarcoVentura,CarlosBouson˜o,MiguelGueimonde,AbelardoMargolles,Juan
Jose´D´ıazandSusanaDelgado
Reply:“LettertotheeditorRe:DiazM.,etal.Nutrients2018,10,1481”
Reprintedfrom:Nutrients2019,11,476,doi:10.3390/nu11020476 . . . . . . . . . . . . . . . . . . . 244
vii

About the Special Issue Editors
Francesco Savino is the Chief Pediatrician of Unit S.S.D. Sub-intensive care of early infancy at
the Children’s Hospital “Regina Margherita” of Citta` della salute e della Scienza of Torino. He is
also a professor of the School for Pediatricians of the University of Torino. His research interests
include minor digestive problems in infancy: colic, gastroesophageal reflux, and metabolism of early
childhood—in particular hormones such as leptin, IGF-1, ghrelin, and adiponectin of breast-fed and
formula-fed infants. He also directs a project on gut microbiota in colicky infants which focuses on
treating breastfed colicky infants with probiotics. Dr. Savino also leads or participates in several other
studies for investigating hormones in breast milk. He has participated in clinical trials involving
gut microflora, probiotics, and new formulas for treating infantile colic, and is an active teacher of
medical students and mentor to research trainees. Dr. Savino organized a scientific International
Meeting on Advances on Infantile Colic.Dr. Savino recently published two Cochrane reviews as
corresponding Author: “Pain relieving agents for infantile colic” 2016-CD009999, and “Dietary
treatment for infantile colic” 2108. CD011029He is an author of more than 133 scientific reports.
Yvan Vandenplas studied medicine and trained in pediatrics (1981–1986) at the Vrije Universiteit
Brussels. He became Head of the Unit for Pediatric Gastroenterology and Nutrition in 1987, and
is Head of the KidZ Health Castle at the University Hospital Brussels (UZ Brussel) and the Chair
of Pediatrics since 1994. Yvan’s main interests are gastro-esophageal reflux (diagnostic procedures,
treatment), eosinophilic esophagitis, infant nutrition, probiotics and prebiotics, cow’s milk protein
allergy, functional gastrointestinal disorders, and Helicobacter pylori. He has published many
original research and review papers on topics such as infant nutrition, gastro-esophageal reflux, and
functional gastrointestinal disorders. He is now one of the Associate Editors of the Journal of
Paediatric Gastroenterology and Nutrition. He is also the Chair of the ESPGHAN Special Interest
Group on “Gut Microbiota & Modifications”. Yvan has more than 450 publications listed in Medline,
and over 1000 oral presentations at different international meetings.
ix