Principles of Toxicology Testing PDF
338 Pages·2007·6.601 MB·English
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Principles of Toxicology Testing juxtaposes the principles of animal toxicology testing with in vitro alternative methods to highlight the importance of both fields for interpretation of the significance and relevance of the other. Beginning with the fundamentals of toxicology, the book details in vivo testing in animals and describes acute, subchronic, and chronic studies as well as toxicology testing for mutagenicity and carcinogenicity. Presenting the advantages and disadvantages of each method, it introduces in vitro alternative testing such as cellular methods for acute systemic toxicity, target organ, and local toxicity. The author considers contemporary issues such as chemical exposure, high throughput screening, and the standardization and validation of in vitro techniques.
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