Potential clinical applications of TMS in pediatrics Aaron Boes, MD, PhD

79 Pages·2015·2.69 MB·English

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Potential clinical applications of TMS inO pediatrics
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Aaron Boes, MD, PhD
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Sidney R. Baer Clinical Neuroscience Fellow, BIDMC
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Pediatric Neurologist, MGH
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Disclosure: Off-label uses of TMS will be discussed

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Topics
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Highlight of a few areas in which TMS may find clinical
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applications in the pediatric population in the near future.
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- Depression

- Rehabilitation O
- Epilepsy D
- Autism
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- ADHD
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- Tourrettes
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Please interrupt, ask questions.
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Challenges and opportunities in pediatrics
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Neurodevelopmental disorders are common. 1 in 6 (Boyle,
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2011)

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Neuropsychiatric disease = #1 worldwide cause of disability

age 10-24 and overall (Lancet, 2011 & 2013)
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Current therapies are inadequate
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Current knowledge gap in clinical neurology and psychiatry…
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Brain disorders currently conceptualizedT of in terms of

dysfunctional networks (Bianchi, 2012)
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Diagnoses are based on behavior \ subjective symptoms,

not network dysfunction. O

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Therapy does not target dysfunctional networks.

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Bridging the gap – Diagnosis and therapOy targeting
dysfunctional networks C

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Why Pediatrics – Why now?
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All neurodevelopmental disorders and almOost 2/3 of neuropsychiatric

disorders manifest in the pediatric population
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(Kessler, 2005)

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Prevention or early diagnosis \ intervention leads to better outcomes.
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Research on adults may not apply to pediatric patients
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Interventions in younger people = better return oOn investment
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Heckman, Science, 2006
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Depression
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