Polymeric Drugs and Drug Delivery Systems

234 Pages·2019·8.129 MB·English

by  Kim, Sung Wan, Ottenbrite, Raphael M

©2001 CRC Press LLC

TOC_Tech_Poly_183160 10/24/2000 10:13 AM Page v
Table of Contents
Preface
1. SEMITELECHELIC POLY[N-(2-HYDROXYPROPYL)-
METHACRYLAMIDE] FOR BIOMEDICAL APPLICATIONS
ZHENG-RONG LU, PAVLA KOPE CˇKOVÁ,and JINDRICH KOPE CˇEK
Introduction
Synthesis of Semitelechelic HPMA Polymers
Characterization of Semitelechelic HPMA Polymers
Modification of Proteins with Semitelechelic HPMA Polymers
Modification of Biomedical Surfaces with Semitelechelic
HPMA Polymers
Conjugation with Hydrophobic Anticancer Drugs
Conclusions
References
2. THERMORESPONSIVE POLYMERIC MICELLES
FOR DOUBLE TARGETED DRUG DELIVERY
J. E. CHUNGand TERUO OKANO
Introduction
Preparation of Thermoresponsive Polymeric Micelles
(Scheme 3)
On–Off Switchable Drug Release from Thermoresponsive
Polymeric Micelles
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Cytotoxicity of Polymeric Micelles Modulated by
Temperature Changes
References
3. pH/TEMPERATURE-SENSITIVE POLYMERS
FOR CONTROLLED DRUG DELIVERY
SOON HONG YUK, SUN HANG CHO, SANG HOON LEE,
JUNG KI SEO,and JIN HO LEE
Introduction
Experimental Section
Results and Discussion
Conclusions
References
4. DESIGN OF POLYMERIC SYSTEMS FOR TARGETED
ADMINISTRATION OF PEPTIDE AND PROTEIN DRUGS
EMO CHIELLINI, ELISABETTA E. CHIELLINI, FEDERICA CHIELLINI,
and ROBERTO SOLARO
Introduction
Experimental
Results and Discussion
Conclusions
References
5. DRUG RELEASE FROM IONIC DRUGS
FROM WATER-INSOLUBLE DRUG-POLYION
COMPLEX TABLETS
NANDINI KONARand CHERNG-JU KIM
Introduction
Experimental
Results and Discussion
Conclusions
References
6. POLYCHELATING AMPHIPHILIC POLYMERS (PAP)
AS KEY COMPONENTS OF MICROPARTICULATE
DIAGNOSTIC AGENTS
VLADIMIR P. TORCHILIN
Imaging Principles and Modalities
Loading of Liposomes and Micelles with Contrast Agents
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Diagnostic Liposomes and Micelles with PAPs
Experimental Visualization with PAP-Containing
Microparticular Contrast Agents
References
7. BIOCONJUGATION OF BIODEGRADABLE POLY
(LACTIC/GLYCOLIC ACID) TO PROTEIN, PEPTIDE,
AND ANTI-CANCER DRUG: AN ALTERNATIVE
PATHWAY FOR ACHIEVING CONTROLLED RELEASE
FROM MICRO- AND NANOPARTICLES
TAE GWAN PARK
Introduction
Controlled Release from PLGA Microspheres
Conjugation of PLGA to Drugs
Conjugation of PLGA to Lysozyme
Conjugation of PLGA to an Amino Acid Derivative
Conjugation of PLGA to Doxorubicin
Conclusion
References
8. ELASTIN–MIMETIC PROTEIN NETWORKS
DERIVED FROM CHEMICALLY CROSSLINKED
SYNTHETIC POLYPEPTIDES
R. ANDREW MCMILLANand VINCENT P. CONTICELLO
Introduction
Results and Discussion
Conclusions
References
9. GENETICALLY ENGINEERED PROTEIN DOMAINS
AS HYDROGEL CROSSLINKS
CHUN WANG, RUSSELL J. STEWART,and JINDRICH KOPEC ˇEK
Introduction
Hydrogels as Biomaterials
Genetically Engineered Biomaterials
Coiled Coils
Designs of Hybrid Hydrogels
Conclusions and Future Perspectives
References
©2001 CRC Press LLC
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10. SUPERPOROUS HYDROGEL COMPOSITES: A NEW
GENERATION OF HYDROGELS WITH FAST
SWELLING KINETICS, HIGH SWELLING RATIO
AND HIGH MECHANICAL STRENGTH
KINAM PARK, JUN CHEN,and HAESUN PARK
Introduction
Swelling Kinetics of Hydrogels
Hydrogels, Microporous Hydrogels,
and Macroporous Hydrogels
Superporous Hydrogels (SPHs)
Methods of Preparing Porous Hydrogels
Superporous Hydrogel Composites (SPHs)
Applications
Future of SPHs and SPH Composites
References
11. STRUCTURE AND SOLUTE SIZE EXCLUSION OF
POLY(METHACRYLIC ACID)/POLY(N-ISOPROPYL
ACRYLAMIDE) INTERPENETRATING POLYMERIC
NETWORKS
JING ZHANGand NICHOLAS A. PEPPAS
Introduction
Experimental
Results and Discussion
Conclusion
References
12. THERMODYNAMICS OF WATER SORPTION
IN HYALURONIC ACID AND ITS DERIVATIVES
P. A. NETTI, L. AMBROSIO,and L. NICOLAIS
Introduction
Materials
Results
Discussion
Conclusions
References
13. PHOTOCROSSLINKED POLYANHYDRIDES WITH
CONTROLLED HYDROLYTIC DEGRADATION
AMY K. BURKOTHand KRISTI S. ANSETH
Introduction
Experimental
Results
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Conclusions
References
14. NOVEL CYTOKINE-INDUCING MACROMOLECULAR
GLYCOLIPIDS FROM GRAM-POSITIVE BACTERIA
MASAHITO HASHIMOTO, YASUO SUDA, YOSHIMASA IMAMURA,
JUN-ICHI YASUOKA, KAZUE AOYAMA, TOSHIHIDE TAMURA,
SHOZO KOTANI, andSHOICHI KUSUMOTO
Introduction
Material and Methods
Results and Discussion
References
15. HYDROPHOBE MODIFIED CATIONIC
POLYSACCHARIDES FOR TOPICAL
MICROBICIDE DELIVERY
GEORGE L. BRODE, GUSTAVO F. DONCEL, andJOHN E. KEMNITZER
Introduction
Rationale for Design
Chemistry of Vehicles
DCE Vehicle Characterization
Anti-Viral Design Parameters
Contraceptive Design Parameters
Vehicle Bioadhesion
Summary
Future Considerations
References
16. NOVEL ANTIMICROBIAL N-HALAMINE
POLYMER COATINGS
S.D. WORLEY, M. EKNOIAN, J. BICKERT,andJ.F. WILLIAMS
Introduction
Experimental
Results and Discussion
Conclusion
References
17. DESIGN OF MACROMOLECULAR PRODRUG
OF CISPLATIN ATTACHED TO DEXTRAN
THROUGH COORDINATE BOND
TATSURO OUCHI, MITSUO MATSUMOTO,TATSUNORI MASUNAGA,
YICHI OHYA,KATSUROU ICHINOSE, MIKIROU NAKASHIMA,
MASATAKA ICHIKAWA, andTAKASHI KANEMATSU
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Introduction
Experimental
Results and Discussion
References
18. SYNTHESIS OF LINEAR AND HYPERBRANCHED
STEREOREGULAR AMINOPOLYSACCHARIDES
BY OXAZOLINE GLYCOSYLATION
JUN-ICHI KADOKAWA, HIDEYUKI TAGAYA, andKOJI CHIBA
Introduction
Experimental
Results and Discussion
Conclusions
References
19. DIAMETER AND DIAMETER DISTRIBUTIONS
OF POLY(L-LACTIDE) MICROSPHERES BY
RING-OPENING POLYMERIZATION OF L-LACTIDE
AND FROM EARLIER SYNTHESIZED POLYMERS
STANLEY SLOMKOWSKIandSTANLEYSOSNOWSKI
Introduction
Experimental Part
Results and Discussion
Conclusions
References
20. EXAMINATION OF FLUORESCENT MOLECULES AS
IN SITU PROBES OF POLYMERIZATION REACTIONS
FRANCIS W. WANGandDEBORAH G. SAUDER
Introduction
Experimental
Results
Conclusions
References
21. SELF-ETCHING, POLYMERIZATION-INITIATING
PRIMERS FOR DENTAL ADHESION
CHETAN A. KHATRI, JOSEPH M. ANTONUCCI,
andGARY E. SCHUMACHER
Introduction
Experimental
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Results and Discussion
References
22. BIOACTIVE POLYMERIC COMPOSITES BASED ON
HYBRID AMORPHOUS CALCIUM PHOSPHATES
JOSEPH M. ANTONUCCI, DRAGO SKRTIC,
ARTHUR W. HAILER, andEDWARD D. EANES
Introduction
Experimental
Results and Discussion
Conclusion
References
©2001 CRC Press LLC
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Preface
OVERthe last quarter century we have seen the field of biorelated poly-
mers for medical applications undergo a dramatic transition from the
pragmatic and/or serendipic approach to applying basic research principles.
Specifically, we have seen the development of many new polymeric materi-
als for intended applications and solutions to problems related to those ap-
plications. The development during this time has been dynamic with the
consistent emergence of new findings. Consequently, one can anticipate a
literal explosion of new clinical products and applications that will be de-
rived from this multidisciplinary field in the next millenium.
The basis of this book is to expose the reader to the important areas of syn-
thetic biorelated polymers systems and the potential impact they will have in
the 21st Century. Consequently, we deliberated over the appropriate areas to
be covered in this book, what value these would provide, and who could
benefit. The chapters are written to emphasize the chemical and physical
properties of several unique polymer systems and the many stages involved
in their physiological adaptations to achieve an intended utilization. The im-
portance of multidisciplinary knowledge and skills are unprecedented since
the field encompasses chemistry, materials science, engineering, biochem-
istry, biophysics, pharmacology, physiology, and clinical studies.
There are 22 chapters in the book and they cover the most important
aspects of polymers as drugs, prodrugs, drug delivery systems, and in situ
prostheses. The major features promulgated are synthesis, derivatization,
degradation, characterization, application, and evaluation techniques as
well as new biodegradable materials, assemblies, hydrogels, telechelic
polymers, derivatized polysaccharides, micro- and nanoparticles, mimetic
©2001 CRC Press LLC