Polycystic Ovary Syndrome

178 Pages·2012·2.907 MB·English

by  S. Mukherjee

POLYCYSTIC OVARY
SYNDROME

Edited by Srabani Mukherjee
Polycystic Ovary Syndrome
Edited by Srabani Mukherjee

Published by InTech
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Copyright © 2012 InTech
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First published February, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Polycystic Ovary Syndrome, Edited by Srabani Mukherjee
p. cm.
ISBN 978-953-51-0094-2

Contents

Preface IX
Chapter 1 Management of Women with Clomifene Citrate Resistant
Polycystic Ovary Syndrome – An Evidence Based Approach 1
Hatem Abu Hashim
Chapter 2 Psycho-Social and Sexual Well-Being in Women with
Polycystic Ovary Syndrome 21
J.E. de Niet, H. Pastoor, R. Timman and J.S.E. Laven
Chapter 3 Android Subcutaneous Adipose Tissue Topography in
Females with Polycystic Ovary Syndrome:
A Visible Phenotype Even in Juveniles 47
Moeller Reinhard, Giuliani Albrecht, Mangge Harald, Tafeit Erwin,
Glaeser Margit, Schrabmair Walter and Horejsi Renate
Chapter 4 Embryoprotective Therapy of Infertile Women with
Polycystic Ovary Syndrome 61
Robert Hudeček and Renata Krajčovičová
Chapter 5 Obesity in Polycystic Ovary Syndrome 77
Carlos Moran, Monica Arriaga,
Gustavo Rodriguez and Segundo Moran
Chapter 6 Association of Gestational Diabetes Mellitus in Women with
Polycystic Ovary Syndrome and Evaluation of Role of
Metformin in Reducing the Risk 93
Fauzia Haq Nawaz and Tahira Naru
Chapter 7 Polycystic Ovary Syndrome and Cardiovascular Disease 105
Barış Önder Pamuk, Derun Taner Ertugrul,
Hamiyet Yılmaz and M. Muzaffer İlhan
Chapter 8 Polycystic Ovary Syndrome in the Non-Gynaecological
Practice – Can We Use a Common Medical Approach? 137
Gyula Petrányi
VI Contents

Chapter 9 Implications of Insulin Resistance / Hyperinsulinemia on
Reproductive Function in Infertile Women with
Polycystic Ovary Syndrome 155
Tetsurou Sakumoto, Yoshimitsu Tokunaga, Yoko Terada,
Hideaki Tanaka, Makoto Nohara,
Aritoshi Nakaza and Masahiro Higashi

Preface

“The beginning of knowledge is the discovery of something we do not understand.”
Frank Herbert (1920-1986)
Polycystic Ovary Syndrome (PCOS) is a common heterogenous disorder in women of
reproductive age. It is a leading cause of anovulatory infertility all over the world.
Having an early onset during pre-pubertal years, it has been associated with many
reproductive complications. Over the years there has been a paradigm shift in thought;
it is no longer just a gynecological concern but has a strong metabolic component too.
Women with PCOS have a markedly increased risk of developing central obesity,
Type 2 Diabetes and cardiovascular diseases. Research in this field has been
progressing at an incredible rate, however even with staggering data available,
researchers have not been able to fully understand this endocrine enigma. Questions
regarding its pathophysiology and its possible long-term reproductive and metabolic
outcomes are being tackled by rigorous research, but no definite conclusions have
been reached yet. The focus in this book is drawn towards understanding the clinical
and metabolic manifestations, as well as the impact that they have on the psychosocial
well-being in women with PCOS. Some therapeutic options such as the use of insulin
sensitizing agents and ovulation inducers to improve fertility, as well as impact of
lifestyle and dietary modifications to reduce obesity and its associated consequences,
have been highlighted in this text. Analysis of this ongoing research has incited the
search for alternative and improved treatments to alleviate these health concerns with
great zeal. This book aims to offer fellow researchers a comprehensive overview of the
current knowledge of the developments in this expanding field.

Srabani Mukherjee
Department of Molecular Endocrinology,
National Institute for Research in Reproductive Health (ICMR), Mumbai,
India