Platelet rich fibrin in regenerative dentistry : biological background and clinical indications

274 Pages·2017·15.01 MB·English

by  Choukroun, Joseph, Miron, Richard J

PlateletRichFibrinin
RegenerativeDentistry
Platelet Rich Fibrin in Regenerative Dentistry
BiologicalBackgroundandClinicalIndications
Editedby
RichardJ.Miron,Dr.med.dent.,DDS,BMSC,MSc,PhD
DepartmentofPeriodontology
CollegeofDentalMedicine
NovaSoutheasternUniversity
FortLauderdale,Florida,USA
JosephChoukroun,MD
Privatepractice,PainTherapyCenter
Nice,France
Thiseditionfirstpublished2017
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LibraryofCongressCataloging-in-PublicationData
Names:Miron,RichardJ.(RichardJohn),1983–editor.|Choukroun,Joseph,1952–editor.
Title:Plateletrichfibrininregenerativedentistry:biologicalbackgroundandclinicalindications/editedbyRichard
J.Miron,JosephChoukroun.
Description:Hoboken,NJ:Wiley,2017.|Includesbibliographicalreferencesandindex.|
Identifiers:LCCN2017017750(print)|LCCN2017018765(ebook)|ISBN9781119406891(pdf)|
ISBN9781119406808(epub)|ISBN9781119406815(cloth)
Subjects:|MESH:OralSurgicalProcedures|Fibrin–therapeuticuse|Platelet-RichPlasma|TissueEngineering|
BoneRegeneration
Classification:LCCRK307(ebook)|LCCRK307(print)|NLMWU600|DDC617.522–dc23
LCrecordavailableathttps://lccn.loc.gov/2017017750
CoverDesign:Wiley
CoverImages:(Foreground,PRFclot&instruments)CourtesyofJonathanDuToit;(Background,centrifugeimage)
CourtesyofJosephChoukroun
Setin10/12ptWarnockProbyAptaraInc.,NewDelhi,India
PrintedintheUnitedStatesofAmerica
10 9 8 7 6 5 4 3 2 1
Tomyparents,family,andfriendswhohaveallsacrificedfartooofteninmypursuitofacareer
inacademicdentistry
Tomyclassmates,colleagues,andmentorswhoconstantlyraisedthebarandstrivedforbetter
TotheteamatAdvancedPRFEducationwhomadeexcellenceinteachingatoppriority
IngratitudetomyMentorsandProfessorsattheUniversityofMontpellierandStrasbourg,
France.Youreducationandmentorshiphasgivenmethemeanstoinnovateinthetreatmentof
painandwoundhealing.
vii
Contents
AbouttheAuthors xiii
Foreword xv
Preface xvii
 PlateletRichFibrin:ASecond-GenerationPlateletConcentrate 1
JosephChoukrounandRichardJ.Miron
1.1 Introduction 1
1.2 Briefhistoryofplateletconcentrates 4
1.3 ThedevelopmentofPRFfromPRP 5
1.4 EffectofPRFonperiosteumbehavior 8
1.5 ThefirstcasetreatedwithPRF 8
1.6 Conclusion 11
References 11
 BiologicalComponentsofPlateletRichFibrin:GrowthFactorRelease
andCellularActivity 15
MasakoFujioka-KobayashiandRichardJ.Miron
2.1 Introduction 16
2.2 CellcomponentsofPRF 16
2.3 Advantagesofathree-dimensionalfibrinnetwork 18
2.4 Growthfactorsinblood 19
2.5 PRPversusPRFforgrowthfactorrelease 20
2.6 L-PRFversusA-PRFvsA-PRF+—newfindingswiththelow-speed
centrifugationconceptandlow-timeinducesevenhighergrowthfactorrelease 22
2.7 i-PRFversusPRP—growthfactorrelease 24
2.8 CellbehaviorinresponsetoL-PRF,A-PRF,andA-PRF+ 25
2.9 CellbehaviorinresponsetoPRP,i-PRF 26
2.10 Futureprospective 26
References 29
 IntroducingtheLow-SpeedCentrifugationConcept 33
JosephChoukrounandShahramGhanaati
3.1 Introduction 33
3.2 DevelopmentofadvancedsolidPRFmatricesfollowingthelowspeed
centrifugationconcept(LSCC) 34
3.3 DevelopmentofaninjectablePRF(i-PRF)followingthelowspeed
centrifugationconcept(LSCC) 38
viii Contents
3.4 Plateletsandleukocytesarekeyelementsintheregenerationprocess 39
3.5 Clinicalinsights 41
3.6 Conclusion 42
References 42
 UsesofPlateletRichFibrininRegenerativeDentistry:AnOverview 47
RichardJ.Miron,GiovanniZucchelli,andJosephChoukroun
4.1 Introduction 47
4.2 ExtractionsocketmanagementwithPRF 48
4.3 SinuselevationsprocedureswithPRF 48
4.4 UseofPRFforsoft-tissuerootcoverage 49
4.5 UseofPRFforperiodontalregeneration 50
4.6 UseofPRFfortheregenerationofsofttissuesaroundimplants 50
4.7 UseofPRFinguidedboneregeneration 51
4.8 UseofPRFinvariousotheraspectsofdentistryandmedicine 54
4.9 Conclusion 54
References 54
 UseofPlateletRichFibrinfortheManagementofExtractionSockets:Biological
BasisandClinicalRelevance 59
RichardJ.MironandJonathanDuToit
5.1 Introduction 59
5.2 Naturaldimensionalchangesoccurringpost-extraction 60
5.3 Conventionalsocketgraftingandridgepreservationtechniques 63
5.4 Immediateimplantplacementintofreshextractionsockets 66
5.5 OverviewofutilizingPRFinextractionsockets 68
5.5.1 SocketgraftingandridgepreservationwithPRF 68
5.5.2 Preventingpostoperativepainandinfection 71
5.6 Discussionandfutureresearch 74
References 77
 MaxillarySinusFloorElevationintheAtrophicPosteriorMaxillae:Anatomy,
Principles,Techniques,Outcomes,andComplications 81
AlbertoMonje,Hom-LayWang,andRichardJ.Miron
6.1 Introduction 81
6.2 Anatomicalconsiderations 82
6.2.1 Embryologicdevelopment 82
6.2.2 Maxillarysinusdimension 83
6.2.3 Vascularization 83
6.2.4 Liningmembrane 84
6.2.5 Sinussepta 86
6.3 Biologicalprinciples 86
6.4 Surgicaltechniques 87
6.5 Clinicaloutcomes 88
6.6 Surgicalandpost-surgicalcomplications 89
6.6.1 Schneiderianmembraneperforation 89
6.6.2 Acuteorchronicinfections 91
6.6.3 Hemorrhage 92
6.6.4 Implantmigration 92
Contents ix
6.7 Conclusion 93
References 93
 MaxillarySinusFloorElevationProcedureswithPlateletRichFibrin:Indications
andClinicalRecommendations 99
RichardJ.Miron,MichaelA.Pikos,andHom-LayWang
7.1 Introduction 99
7.2 PRFasasolegraftingmaterialduringsinusliftingprocedures 100
7.3 PRFfortherepairofSchneiderianmembranes 103
7.4 PRFfortheclosureofthelateralmaxillaryaccesswindow 104
7.5 Discussionandfutureoutlook 105
References 111
 UseofPlateletRichFibrinfortheTreatmentofMuco-GingivalRecessions:Novel
ImprovementsinPlasticAestheticSurgeryUtilizingTheFibrinAssistedSoft
TissuePromotion(FASTP)Technique 115
Alexandre-AmirAalamandAlinaKrivitskyAalam
8.1 Introduction 115
8.2 PlasticperiodontalprocedureswithPRF 117
8.3 Fibropromotion:thebasicmechanismofFibrin-AssistedSoftTissue
Promotion(FASTP)technique 117
8.3.1 Biotensegrity 118
8.3.2 Volume 120
8.4 FASTP:thesurgicaltechnique 120
8.4.1 Incision 120
8.4.2 Rootpreparationanddecontamination 120
8.4.3 Volumepacking 121
8.4.4 Suturing 121
8.5 Conclusion 123
References 123
 UseofPlateletRichFibrinforPeriodontalRegeneration/RepairofIntrabony
andFurcationDefects 127
RichardJ.Miron,BrianL.Mealey,andHom-LayWang
9.1 Introduction 127
9.2 Roleofbarriermembranesinperiodontalregeneration 129
9.3 Roleofbone-graftingmaterialsinperiodontalregeneration 129
9.4 Biologicagents/growthfactorsforperiodontalregeneration 130
9.5 Plateletrichfibrin(PRF)asapotentialautologousbiologicalagentfor
periodontalregeneration 131
9.6 IntrabonydefectregenerationwithPRF:resultsfromcontrolledclinicaltrials 131
9.7 FurcationdefectregenerationwithPRF 134
9.8 Discussionandfutureresearch 135
References 137
 PlateletRichFibrinasanAdjuncttoImplantDentistry 145
HowardGluckman
10.1 Introduction 146
10.2 PRFtreatmentofperi-implantdefects 146
x Contents
10.3 PRFandsoft-tissuehealingatimplants 147
10.4 Osseointegration 149
10.5 Techniquestoimproveprimarystabilityinpoorbonequality 151
10.6 TheuseofPRFatosteotomypreparation 152
10.7 ThefutureofPRFandimplants 154
References 154
 GuidedBoneRegenerationwithPlateletRichFibrin 159
RichardJ.Miron,MichaelA.Pikos,YufengZhang,andTobiasFretwurst
11.1 Introduction 159
11.2 OverviewofGBR 160
11.3 AvailableoptionsofGBR 161
11.4 Non-resorbablePTFEmembranes 161
11.5 Titaniummesh 166
11.6 Collagen-basedresorbablemembranes 166
11.7 Syntheticresorbablemembranes 167
11.8 Plasma-richproteinsasgrowthfactorsformembranes 167
11.9 Choiceofbone-graftingmaterialsduringGBRprocedures 169
11.10 AlternativestrategiestoinducenewboneformationduringGBRprocedures 170
11.11 RecentsurgicalapproachesusingPRFincombinationwithGBR 170
11.12 PRFasabarriermembraneinGBRprocedures 171
11.13 PRFincombinationwithbone-graftingmaterials 172
11.14 StudiesinvestigatingPRFforGBR 173
11.15 Discussionandfutureresearch 177
References 179
 ModernApproachtoFullArchImmediateLoading:TheSimonpieriTechnique
withPRFandi-PRF 185
AlainSimonpieri
12.1 Introduction 186
12.2 Immediateloadinginimplantdentistry—whatissuccess? 187
12.3 Biologicalrequirements 188
12.4 Anatomicalandsurgicalrequirements 189
12.4.1 Implantplacement 189
12.4.2 Systematicappositiongraft 194
12.4.3 Flapmanagementandsuturetechnique 195
12.5 Prostheticrequirements 195
12.6 Finalresults 200
12.7 Documentedlong-termstability 201
12.8 Long-termstatisticalresults:fullarchimmediateimplantplacement
andloading 202
12.8.1 The“FastGuide”Systemforimmediateimplantplacement 204
12.8.2 Aninjectable-PRF(i-PRF)foradequategraftstabilityandcompaction 205
12.8.3 ThecollagenTwinMatrix 205
12.8.4 Canwegetmoresofttissue? 205
12.8.5 Potentialwoundhealing:exampleofaestheticfailurewithoutmanagementof
tensionandregenerationwithaTwinMatrixandPRF 205
12.9 Conclusion 207
References 209
Contents xi
 UseofPlateletRichFibrininFacialAestheticsandRejuvenation 215
CleopatraNacopoulos
13.1 Introduction 215
13.2 Featuresoftheskin 217
13.3 Agingandtheepidermalbarrierfunctionmechanismsinskinaesthetics 219
13.4 Pre-evaluationandpatientselection 219
13.5 Conventionaltherapiesinfacialaesthetics 220
13.6 Lasersandepidermalbarrierfunction 222
13.7 Overviewofutilizingplateletderivativesinfacialaesthetics 222
13.8 ClinicalproceduresutilizingPRFinfacialaesthetics 222
13.9 i-PRFinjectionswithadermarollers 227
13.10 i-PRFinjectionswithadermapen 228
13.11 i-PRFandPRFformesotherapybysyringeinjections 228
13.12 Plateletconcentrateduringthevampiretechnique 229
13.13 AugmentationtechniqueswithPRFmatrixandi-PRF—combinationTherapies 229
13.14 NasolabialfoldrejuvenationwithPRFandi-PRF 229
13.15 UseofPRFandi-PRFforlipaugmentation 230
13.16 PDOthreadsusingPRFandi-PRF 230
13.17 Conclusion 231
References 234
 UseofPlateletRichFibrininOtherAreasofMedicine 237
RichardJ.MironandJosephChoukroun
14.1 Introduction 237
14.2 EffectsofPRFoncellactivityinvitro 238
14.3 EvidencethatPRFimprovessoft-tissuewoundhealing/regenerationinvivo 238
14.4 ClinicalstudiesevaluatingtheuseofPRFinmedicine 239
14.5 PRFforregenerationofchroniclegulcers 240
14.6 PRFforcartilage(knee)regeneration 241
14.7 PRFfortheregenerationofligamentsandtendons 242
14.8 PRFinorthopedicmedicine 242
14.9 PRFforskinregeneration 243
14.10 Discussionandfutureperspectives 243
References 245
 FutureResearchwithPlateletRichFibrin 251
RichardJ.MironandJosephChoukroun
15.1 PRFandcentrifugationspeeds 251
15.2 EffectofhematocritcountonPRFscaffolds 252
15.3 TheinfluenceofPRFforthetreatmentofosteonecrosisofthejaw 252
15.4 Injectableplateletrichfibrinasapotentialtherapyfortemporomandibular
jointdisorders 253
15.5 Potentialuseofplateletrichfibrinforpulpregeneration 253
15.6 Plateletrichfibrinandperiodontalregeneration 256
15.7 Potentialuseofstemcellsderivedfromblood 256
15.8 PRF:regenerationbygrowthfactors,leukocytes,orfibrin? 256
15.9 PRFanditsdegradationproperties 257
15.10 PRFandosteoinduction 258
References 258
Index 263
xiii
AbouttheAuthors
Editor,RichardJ.Miron,Dr.med.dent.,DDS, AlinaKrivitskyAalam,DDS,MSc
BMSC,MSc,PhD Diplomate,AmericanAcademyBoardof
AdjunctProfessor Periodontology
DepartmentofPeriodontology Diplomate,AmericanBoardofOral
CollegeofDentalMedicine Implantology
NovaSoutheasternUniversity PrivateOffice,CenterforAdvanced
FortLauderdale,Florida,USA PeriodontalandImplantTherapy
LosAngeles,California,USA
Co-Editor,JosephChoukroun,MD
Privatepractice,PainTherapyCenter, AntonSculean,Dr.med.dent.,Dr.h.c.,M.S.
Nice,France Professor,ExecutiveDirectorandChairman
DepartmentofPeriodontology
AlainSimonpieri,DDS UniversityofBern
Professor Bern,Switzerland
DepartmentofOralsurgery
UniversityFedericoIINaples BrianL.Mealey,DDS,MS
Naples,Italy ProfessorandGraduateProgramDirector
DepartmentofPeriodontics
AlbertoMonje,DDS,MS,PhD UTHealthScienceCenteratSanAntonio
ResearchAssociate SanAntonio,Texas,USA
DepartmentofPeriodonticsandOral
Medicine CleopatraNacopoulos,DDS,PhD
TheUniversityofMichigan,Schoolof ResearchAssociate
Dentistry LaboratoryforResearchofthe
AnnArbor,Michigan,USA MusculoskeletalSystem
KATHospital,SchoolofMedicine,National
Alexandre-AmirAalam,DDS,MSc andKapodistrian
Diplomate,AmericanAcademyBoardof UniversityofAthens
Periodontology Athens,Greece
Diplomate,AmericanBoardofOral
Implantology GiovanniZuchelli,DDS,PhD
ClinicalAssistantProfessor,HermanOstrow Professor
SchoolofDentistryofUSC DepartmentofBiomedicalandNeuromotor
Sciences
UniversityofBologna
Bologna,Italy