PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH Edited by Venketeshwer Rao Phytochemicals – A Global Perspective of Their Role in Nutrition and Health Edited by Venketeshwer Rao Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. 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Publishing Process Manager Masa Vidovic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Phytochemicals – A Global Perspective of Their Role in Nutrition and Health, Edited by Venketeshwer Rao p. cm. ISBN 978-953-51-0296-0 Contents Preface IX Chapter 1 Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents 1 James Hamuel Doughari Chapter 2 Structural Analysis of Flavonoids and Related Compounds – A Review of Spectroscopic Applications 33 Pedro F. Pinheiro and Gonçalo C. Justino Chapter 3 Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material 57 Katarzyna Szewczyk and Anna Bogucka - Kocka Chapter 4 Analytical Methods and Phytochemistry of the Typical Italian Liquor “Limoncello”: A Review 93 Marcello Locatelli, Giuseppe Carlucci, Salvatore Genovese and Francesco Epifano Chapter 5 The Effects of Non-Thermal Technologies on Phytochemicals 107 Gemma Oms-Oliu, Isabel Odriozola-Serrano and Olga Martín-Belloso Chapter 6 Phytochemical Constituents and Activities of Morinda citrifolia L. 127 Duduku Krishnaiah, Rajesh Nithyanandam and Rosalam Sarbatly Chapter 7 Flavonoids in some Iranian Angiosperms 151 Mitra Noori Chapter 8 Phytochemicals from Beilschmiedia anacardioides and Their Biological Significance 167 Nkeng-Efouet-Alango Pépin VI Contents Chapter 9 Phenolic Constituents and Antioxidant Properties of some Thai Plants 187 Pitchaon Maisuthisakul Chapter 10 Lignans: Chemical and Biological Properties 213 Wilson R. Cunha, Márcio Luis Andrade e Silva, Rodrigo Cassio Sola Veneziani, Sérgio Ricardo Ambrósio and Jairo Kenupp Bastos Chapter 11 The Genus Galanthus: A Source of Bioactive Compounds 235 Strahil Berkov, Carles Codina and Jaume Bastida Chapter 12 Silymarin, Natural Flavonolignans from Milk Thistle 255 Sameh AbouZid Chapter 13 Phytocannabinoids 273 Afeef S. Husni and Stephen J. Cutler Chapter 14 Alkaloids and Anthraquinones from Malaysian Flora 287 Nor Hadiani Ismail, Asmah Alias and Che Puteh Osman Chapter 15 Phytochemistry of some Brazilian Plants with Aphrodisiac Activity 307 Cinara V. da Silva, Fernanda M. Borges and Eudes S. Velozo Chapter 16 A Phytochemical and Ethnopharmacological Review of the Genus Erythrina 327 João X. de Araújo-Júnior, Mariana S.G. de Oliveira, Pedro G.V. Aquino, Magna S. Alexandre-Moreira and Antônio E.G. Sant’Ana Chapter 17 Phytochemistry, Pharmacology and Agronomy of Medicinal Plants: Amburana cearensis, an Interdisciplinary Study 353 Kirley M. Canuto, Edilberto R. Silveira, Antonio Marcos E. Bezerra, Luzia Kalyne A. M. Leal and Glauce Socorro B. Viana Chapter 18 General Introduction on Family Asteracea 375 Maha Aboul Ela, Abdalla El-Lakany and Mohamad Ali Hijazi Chapter 19 Bioavailability of Phytochemicals 401 Indah Epriliati and Irine R. Ginjom Chapter 20 Ximenia americana: Chemistry, Pharmacology and Biological Properties, a Review 429 Francisco José Queiroz Monte, Telma Leda Gomes de Lemos, Mônica Regina Silva de Araújo and Edilane de Sousa Gomes Contents VII Chapter 21 Phytochemicals and Their Pharmacological Aspects of Acanthopanax koreanum 451 Young Ho Kim, Jeong Ah Kim and Nguyen Xuan Nhiem Chapter 22 Polyphenol Antioxidants and Bone Health: A Review 467 L.G. Rao, N. Kang and A.V. Rao Chapter 23 The Pentacyclic Triterpenes , -amyrins: A Review of Sources and Biological Activities 487 Liliana Hernández Vázquez, Javier Palazon and Arturo Navarro-Ocaña Chapter 24 Phytochemical Studies of Fractions and Compounds Present in Vernonanthura Patens with Antifungal Bioactivity and Potential as Antineoplastic 503 Patricia Isabel Manzano Santana, Mario Silva Osorio, Olov Sterner and Esther Lilia Peralta Garcìa Chapter 25 The Inhibitory Effect of Natural Stilbenes and Their Analogues on Catalytic Activity of Cytochromes P450 Family 1 in Comparison with Other Phenols – Structure and Activity Relationship 519 Renata Mikstacka, Zbigniew Dutkiewicz, Stanisław Sobiak and Wanda Baer-Dubowska Preface Since global recognition of the dietary guidelines that include increased consumption of plant-based foods for the prevention of chronic diseases and maintaining good health, there has been a considerable interest in the biologically active compounds that are present in plant foods. These compounds have been referred to, among other terms, as ‘Phytochemicals’, ‘Phytonutrients’, ‘Nutraceuticals’ and ‘Functional ingredients”. They include a multitude of compounds having different chemical identities, biological activities and mechanisms of action. The scope of ‘Phytochemicals’ has expanded beyond their initial applications to food to include therapeutics, pharmaceuticals and cosmeceuticals. Although advancements have been made in the field of phytochemicals in the past few decades, more information on the analytical methods of isolation and characterization, their occurrence, biological activity, mechanisms of action and applications to the food and other health industries need to be obtained through systematic scientific investigations. Recognizing this need for more information, a plan to publish a book that brings together up to date information on various aspects of phytochemicals was initiated. This book is a collection of several articles that range in scope from the diversity of their occurrence and chemical characteristics, analytical challenges in their isolation and characterization, and the undertaking of basic and clinical researches to evaluate their biological activities both in animal and human health. The book provides a global perspective related to the phytochemicals present not only in foods but also in medicinal plants. Internationally recognized authors that have expertise in their own respective areas within the phytochemical discipline have contributed to this book. Contents of this important and timely book are useful not only to the researchers but also to health professionals, government regulatory agencies and industrial personnel. It is with this vision that we present this book to our readers and are confident that it will serve as a standard reference book in this important field of human nutrition and health. Dr. A. V. Rao Professor Emeritus, Department of Nutritional Sciences, Faculty of Medicine University of Toronto, Canada
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