Phyllanthus species: scientific evaluation and medicinal applications

375 Pages·2012·13.775 MB·English

by  Kuttan, Ramadasan(Editor);Harikumar, K B(Editor)

Botany & Plant Science
P
The genus Phyllanthus has over 1,000 species
distributed worldwide, many of which have been h Traditional Herbal Medicines for Modern Times
used indigenously for the treatment of a variety
of ailments for generations. Researchers have y
developed ways to analyze the potential of these
l
plants and demonstrated the pharmacological l Phyllanthus Species
action and various chemical entities present in a
each of them. They have validated the folklore
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claims and used this knowledge to design cost-
effective and reliable sources of medicine.
t Scientific Evaluation and
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The first book to exclusively examine the genus
Phyllanthus, Phyllanthus Species: Scientific
u Medicinal Applications
Evaluation and Medicinal Applications begins
with a systematic classification and identification s
manual for various plants in the genus, followed

by the scientific evaluation of the species for
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modern medicinal use. This reference compiles
cutting edge research from countries around
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the world, including the UK, Malaysia, India,
Indonesia, Spain, Cuba, and China. Topics
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covered include phylogenetic analysis of
Phyllanthus, chemistry of the genus, anti-cancer, c
anti-diabetic and chemo- protective effects,
i
genotoxicity, clinical trials involving Phyllanthus,
e
and various formulations containing different
plants from the genus Phyllanthus. s
Phyllanthus Species: Scientific Evaluation and
Medicinal Applications describes in detail the
taxonomy, cultivation, and marketing, identification
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of geographic and genetic hot spots, chemistry,
u
scientific evaluation, and clinical trials of various t
t
species of Phyllanthus. Written for researchers a
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and educators in academia, industry, agriculture,

and the interested general public, this book’s up- •

to-date references make it a powerful resource H
Edited by
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providing first-hand information on Phyllanthus.
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Ramadasan Kuttan
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K11136 r K. B. Harikumar
K11136_Cover.indd 1 7/26/11 11:40 AM

Phyllanthus Species
Scientific Evaluation and
Medicinal Applications
Traditional Herbal Medicines For Modern Times
Each volume in this series provides academia, health sciences, and the herbal medi-
cines industry with in-depth coverage of the herbal remedies for infectious diseases,
certain medical conditions, or the plant medicines of a particular country.
Series Editor: Dr. Roland Hardman
Volume 1
Shengmai San, edited by Kam-Ming Ko
Volume 2
Rasayana: Ayurvedic Herbs for Rejuvenation and Longevity, by H.S. Puri
Volume 3
Sho-Saiko-To: (Xiao-Chai-Hu-Tang) Scientific Evaluation and Clinical
Applications, by Yukio Ogihara and Masaki Aburada
Volume 4
Traditional Medicinal Plants and Malaria, edited by Merlin Wilcox,
Gerard Bodeker, and Philippe Rasoanaivo
Volume 5
Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical
Applications, edited by Haruki Yamada and Ikuo Saiki
Volume 6
Traditional Medicines for Modern Times: Antidiabetic Plants, edited by
Amala Soumyanath
Volume 7
Bupleurum Species: Scientific Evaluation and Clinical Applications, edited by
Sheng-Li Pan
Volume 8
Herbal Principles in Cosmetics: Properties and Mechanisms of Action, by
Bruno Burlando, Luisella Verotta, Laura Cornara, and Elisa Bottini-Massa
Volume 9
Figs: The Genus Ficus, by Ephraim Philip Lansky and Helena Maaria Paavilainen
Traditional Herbal Medicines for Modern Times
Phyllanthus Species
Scientific Evaluation and
Medicinal Applications
Edited by
Ramadasan Kuttan
K. B. Harikumar
CRC Press
Taylor & Francis Group
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Boca Raton, FL 33487-2742
© 2012 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20111205
International Standard Book Number-13: 978-1-4398-2146-6 (eBook - PDF)
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Contents
Series Preface ............................................................................................................ix
Preface....................................................................................................................xiii
About the Editors .....................................................................................................xv
Contributors ...........................................................................................................xvii
Chapter 1 Taxonomy of the Genus Phyllanthus ...................................................1
Sheeja T. Tharakan
Identification Manual for Some Species of the Genus
Phyllanthus L. of Phyllanthaceae with Special Reference to the
Indian Subcontinent ...........................................................................23
A. Lalithamba
Chapter 2 Current Pharmacopoeial Status of Phyllanthus Species:
P. emblica, P. amarus, and P. fraternus ............................................37
Raman Mohan Singh and Vivekanandan Kalaiselvan
Chapter 3 Cultivation, Economics, and Marketing of Phyllanthus Species .......47
B. R. Rajeswara Rao
Chapter 4 Phylogenetic Analysis of Phyllanthus Species ...................................71
Srinivasu Tadikamalla
Chapter 5 Genetic Resources of Phyllanthus in Southern India:
Identification of Geographic and Genetic Hot Spots and Its
Implication for Conservation ..............................................................97
G. Ravikanth, R. Srirama, U. Senthilkumar, K. N. Ganeshaiah,
and R. Uma Shaanker
Chapter 6 Phytochemistry of the Genus Phyllanthus .......................................119
Lutfun Nahar, Satyajit D. Sarker, and Abbas Delazar
Chapter 7 Hyphenated Techniques in the Study of the Genus Phyllanthus .....139
Satyajit D. Sarker, Lutfun Nahar, and Abbas Delazar
v
vi Contents
Chapter 8 Anti-inflammatory Activity of Various Species of Phyllanthus ......149
K. B. Harikumar and Ramadasan Kuttan
Chapter 9 Hepatoprotective Effects of Plants in the Family Phyllanthaceae ...157
V. V. Asha
Chapter 10 Anticancer Studies of Phyllanthus amarus ......................................171
K. B. Harikumar and Ramadasan Kuttan
Chapter 11 Anticancer Activity of Phyllanthus emblica ....................................183
Jeena Joseph and Ramadasan Kuttan
Chapter 12 The In Vivo and In Vitro Proapoptotic and Antiangiogenic
Effects of Phyllanthus urinaria .......................................................193
Jong-Hwei S. Pang, Sheng-Teng Huang, Rong-Chi Yang, and
Hsiao-Ting Wu
Chapter 13 Phyllanthus and Hepatitis B, Hepatitis C, and HIV Infections .......205
S. P. Thyagarajan
Chapter 14 Antiviral Activities of Phyllanthus orbicularis, an Endemic
Cuban Species ..................................................................................219
Gloria del Barrio and Francisco Parra
Chapter 15 Diabetes and Diabetic Complications and Phyllanthus species ......235
Geereddy Bhanuprakash Reddy and Palla Suryanarayana
Chapter 16 Chemoprotective, Genotoxic, and Antigenotoxic Effects of
Phyllanthus Sp. .................................................................................255
Rakesh K. Johri
Chapter 17 Antiaging Effects of Phyllanthus Species ........................................267
Vasudevan Mani and Shanmugapriya Thulasimani
Chapter 18 Toxicity Studies of Phyllanthus Species ..........................................279
K. N. S. Sirajudeen
Contents vii
Chapter 19 Clinical Trials Involving Phyllanthus Species .................................289
Mulyarjo Dirjomuljono and Raymond R. Tjandrawinata
Chapter 20 Immunomodulatory Activity of Brahma Rasayana, an Herbal
Preparation Containing Phyllanthus emblica as the Main
Ingredient .........................................................................................315
Praveen K. Vayalil, Ramadasan Kuttan, and Girija Kuttan
Chapter 21 Triphala: An Ayurvedic Drug Formulation .....................................325
Sandhya T. Das and K. P. Mishra
Chapter 22 Kalpaamruthaa: A Successful Drug against Various Ailments .......331
P. Sachdanandam and P. Shanthi