Table Of Content

Pharmacol. Ther. Vol. 71, No. 3, pp. V-VIII, 1996 ISSN 0163-7258/96 $32.00 Copyright © 1996 Elsevier Science Inc. ELSEVIER VOLUME 71 CONTENTS Numbers 1/2 Cancer Mechanism And Risk Assessment Contents Preface International Expert Panel I. THE USE OF MECHANISTIC DATA IN THE on Carcinogen Risk RISK ASSESSMENTS OF TEN CHEMICALS: Assessment, American An Introduction to the Chemical-Specific Reviews Health Foundation I]. MECHANISTIC DATA AND THE RISK ASSESSMENT OF DNA-REACTIVE RODENT TUMORIGENS John Whysner, Vinyl Chloride Mechanistic Data and Risk Assessment: C. Clifford Conaway, DNA Reactivity and Cross-Species Quantitative Risk Lynne Verna, Extrapolation and Gary M. Williams C. Clifford Conaway, Formaldehyde Mechanistic Data and Risk Assessment: John Whysner, Endogenous Protection from DNA-Adduct Formation Lynne K. Verna, and Gary M. Williams Lynne Verna, N-Nitrosodiethylamine Mechanistic Data and Risk John Whysner, Assessment: Bioactivation, DNA-Adduct Formation, and Gary M. Williams Mutagenicity, and Tumor Initiation Lynne Verna, 2-Acetylaminofluorene Mechanistic Data and Risk John Whysner, Assessment: DNA Reactivity, Enhanced Cell and Gary M. Williams Proliferation and Tumor Initiation John Whysner, Benzidine Mechanistic Data and Risk Assessment: Lynne Verna, Species-and Organ-Specific Metabolic Activation and Gary M. Williams Il. MECHANISTIC DATA AND THE RISK ASSESSMENT OF EPIGENETIC RODENT TUMORIGENS John Whysner d-Limonene Mechanistic Data and Risk Assessment: and Gary M. Williams Absolute Species-Specific Cytotoxicity, Enhanced Cell Proliferation, and Tumor Promotion John Whysner and Butylated Hydroxyanisole Mechanistic Data and Risk Gary M. Williams Assessment: Conditional Species-Specific Cytotoxicity, Enhanced Cell Proliferation, and Tumor Promotion (contents continued on next page) Volume Contents (contents continued from previous page) John Whysner, 153 Phenobarbital Mechanistic Data and Risk Assessment: Peter M. Ross, Enzyme Induction, Enhanced Cell Proliferation, and and Gary M. Williams Tumor Promotion John Whysner 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Mechanistic Data and Gary M. Williams and Risk Assessment: Gene Regulation, Cytotoxicity, Enhanced Cell Proliferation, and Tumor Promotion John Whysner Saccharin Mechanistic Data and Risk Assessment: Urine and Gary M. Williams Composition, Enhanced Cell Proliferation, and Tumor Promotion Number 3 Wallace C. Duncan, Jr. Circadian Rhythms and the Pharmacology of Affective Illness Barbara J. Pleuvry and Biochemical Aspects of Chronic Pain and its Relationship Gabriela Rocha Lauretti to Treatment Jean-Luc Daval, Adenosine Physiology and Pharmacology: How About Frédéric Nicolas, and A, Receptors? Jean-Francois Doriat Volume 71 List of Contents, Author Index, and Key Word Index