Table Of Content

AUTHOR INDEX Aldini, R. 167 Johnson, J.P. 1 Bazzoli, F. 167 Kitteringham, N. R. Bjare, U. 355 Bulkley, G. B. 375 Marley, R. J. 217 Curtis, J. F. 261 Mazzella, G. 167 McCormick, B. A. 239 Meredith, P. A. 67 Donnelly, R. 67 Donowitz, M. 375 Dufton, M. J. 199 Park, B. K. 105 Pirmohamed, M. 105 Eling, T. E. 261 Elliot, H. L. 67 Elmer, G.I. 217 Reilly, P.M. 375 Roda, A. 167 Roda, E. 167 Festi, D. 167 Rojkind, M. 81 Frenkel, K. 127 Schiller, H. J. 375 Gebhardt, R. 275 Goldberg, S. R. 217 Snow, E. T. 31 Struthers, A.D. 187 Grisham, M. B. 375 Harris, M. L. 375 Zetter, B. R. 239 AUTHOR INDEX Aldini, R. 167 Johnson, J.P. 1 Bazzoli, F. 167 Kitteringham, N. R. Bjare, U. 355 Bulkley, G. B. 375 Marley, R. J. 217 Curtis, J. F. 261 Mazzella, G. 167 McCormick, B. A. 239 Meredith, P. A. 67 Donnelly, R. 67 Donowitz, M. 375 Dufton, M. J. 199 Park, B. K. 105 Pirmohamed, M. 105 Eling, T. E. 261 Elliot, H. L. 67 Elmer, G.I. 217 Reilly, P.M. 375 Roda, A. 167 Roda, E. 167 Festi, D. 167 Rojkind, M. 81 Frenkel, K. 127 Schiller, H. J. 375 Gebhardt, R. 275 Goldberg, S. R. 217 Snow, E. T. 31 Struthers, A.D. 187 Grisham, M. B. 375 Harris, M. L. 375 Zetter, B. R. 239 SUBJECT INDEX Acetaminophen, zonal hepatic injury 312 mechanism of action 189 2-Acetylaminofluorene, zonal hepatic injury 313 pharmacological properties 187 Acetylcholinesterase inhibitors, kinetic-dynamic post myocardial infarction studies 191 responses reperfusion injury and free radicals 192 Acetyl-CoA carboxylase, zonation in liver 291 Antidepressants, idiosyncratic reactions 105-125 N-Acetylcysteine 386 amineptine 116 Acidification, mineralocorticoids 20 amitriptyline 116 Addressins 247, 248 carbamazepine 117 Adenosine-3’ ,5'-monophosphate, role in host factors and drug metabolism 115 cirrhosis 85 5-HT re-uptake blockers 117 Na*,K*+-Adenosine triphosphatase, effects of hypersensitivity reactions 112, 117 aldosterone 10, 18 lofepramine 118 Adenosine triphosphate, effect of aldosterone 17 metabolism 111 Adhesive interactions in angiogenesis and mianserin 118 metastasis 239-260 monoamine oxidase inhibitors 119 Adrenal cells, serum-free culture 367 nomifensine 119 a-Adrenoceptor blockers, kinetic-dynamic organ directed toxicity 106 responses 70 pharmacogenetics and drug metabolism 114 B-Adrenoceptor blockers, kinetic-dynamic structure 109 responses 72 zimeldine 120 Age Antifibrogenic therapy, cirrhosis 82, 91 antidepressant toxicity 115 Antihypertensive drugs 67-79 antihypertensive drug response 74 dose-concentration-response relationships 68 Agranulocytosis, induced by antidepressant kinetic-dynamic responses 70 drugs 108, 115 constancy and predictability 74 Albumin, zonation in liver 298 individualized dosage and regimes 75 Aldosterone variability acidification 20 Antiinflammatory drugs, treatment of liver gene expression 6 cirrhosis 87 K+ transport 18 Antioxidant defense mechanisms lipid metabolism 16 endogenous 382 Na* transport 12 exogenous 383 Aldosterone induced proteins 7 Anti-oxidant therapy, inflammatory bowel Aldosterone receptors 2 disease 396 O*-Alkylguanine DNA alkyltransferase, inhibition Anti-oxidant vitamins, inflammatory bowel by arsenic 38 disease 393 Allyl alcohol, zonal hepatic injury 310 Anti-tumor promoters, effect on DNA Amiloride 13 damage 146 Amineptine Apical membrane, aldosterone effects on Nat hepatotoxicity 107 transport 12 idiosyncratic toxicity 116 Aplastic anemia, induced by antidepressants 108 Amino acid metabolism, zonation in liver 293 Arachidonic acid 2-Aminofluorene metabolism and generation of free radicals 378 peroxidase-catalysed DNA adducts 268 metabolism by prostaglandin H synthase 262 prostaglandin H synthase-dependent carcinogeneis 268 oxidation 267 Arachidonic acid cascade inhibitors, treatment of 2-Amino-3-methylimidazo(4,5-f)quinoline, inflammatory bowel disease 399 metabolism by prostaglandin H Arsenic, carcinogenesis synthase 267 DNA repair and gene expression 37 5-Aminosalicylic acid, treatment of inflammatory threshold effects and multiple targets 34 bowel disease 396 Asbestos, oxidative DNA damage 144 Amitriptyline Ascorbic acid hepatotoxicity 107 chromium reductant 44 idiosyncratic toxicity 116 inflammatory bowel disease 393 neurotoxicity 109 L-Azetidine-2-carboxylic acid, treatment of liver Ammonia metabolism, zonation in liver 295 cirrhosis 92 Angiogenesis, metastasis, adhesive interactions 239-260 Angiotensin converting enzyme inhibitors Bacteria, inflammatory bowel disease 391 adverse effects 193 Basolateral membrane, effect of aldosterone 17 hemodynamic and symptomatic effects in chronic Benzidine, metabolism by prostaglandin H heart failure 190, 193 synthase 267 vi SUBJECT INDEX Benzo(a)pyrene Cholesterol DNA interaction 144, 147 gallstone formation 173 prostaglandin H synthase-dependent gallstone treatment 174 oxidation 266 nucleation 173 ROS formation 136 serum-free cell culture media 367 Beryllium, carcinogenesis 36 supersaturation in bile 172 cellular immunity and nucleic acid synthesis in liver, zonation 293, 316 metabolism 50 Chromium, carcinogenesis Bile redox processing and DNA interactions 39 cholesterol nucleation 173 ROS induction 138 cholesterol supersaturation 172 speciation and complex chemistry 35 zonation of formation 306 Chromosomes Bile acids 167 effect of arsenic 38 detergency 168 effect of chromate 40 inflammatory bowel disease 390 effect of nickel 48 ionizing properties 171 Chronic heart failure, angiotensin converting lipophilicity 168 enzyme inhibitors 187-197 treatment of gallstones 174 Cigarette smoke, free radicals 380 water solubility and pH dependence 170 Cilazapril 188, 189 zonation of synthesis in liver 306, 316 effect on chronic heart failure 190 Blood pressure, antihypertensive drugs 67-79 Cirrhosis, fibrogenesis 81-104 BM 15766 314 antithrombogenic therapy 91 Breast cancer cells, serum-free culture 368 antiinflammatory and immunosuppressor Brefeldin A 14 therapy 87 hepatoprotection 85 loss of GS-positive cells 297 treatment to eradicate etiologic agent 84 Cadmium Citrate synthase, in kidney, stimulation by carcinogenesis 36 aldosterone 10, 17 protein interactions and gene expression 51 Clofibrate, zonal hepatic injury 314 zonation of hepatotoxicity 315 Cocaine-related behaviours, pharmacogenetic Caffeic phenethyl ester 146 techniques 224 Calcium, tumor metastasis 34 Colchicine, treatment of liver cirrhosis 88 Calcium antagonists, kinetic-dynamic Collagen responses antifibrogenic therapy 91 Capillary tube formation, effect of extracellular steroid effects on synthesis 87 matrix elements 244 Collagenase inducers, treatment of liver Captopril 187, 188 cirrhosis 94 effect on chronic heart failure 190, 191, 193, Collagen propeptides, treatment of fibrosis 95 194 Collagen receptor integrins 250 Carbamazepine Colon, anti-oxidant potential 394 bioactivation 117 Concentration-effect analysis 69 cocaine interactions, genetic differences 229 antihypertensive drugs 71 hematologic toxicity 108 Conjugation reactions, zonation in liver 304 hepatotoxicity 107 Copper idiosyncratic toxicity 117 inflammatory bowel disease 392, 393 Carbohydrate metabolism, zonation in liver 288 zonation of hepatotoxicity 315 Carcinogenesis 128 Copper(II)3,5-diisopropylsalicylic acid 385 metals 31-65 Corticosteroids, treatment of inflammatory bowel ROS and oxidative DNA damage 149 disease 398 Carcinogens Corticosterone binding protein 4 activation by prostaglandin H synthase 263, Crohn’s disease 266 immunoregulation 393 mediated ROS formation and utilization 135 intestinal epithelial permeability 394 Carnitine palmitoyltransferase, zonation in mucin depletion 392 liver 292 smoking 380 Catalase therapy 395 endogenous 382 trace elements and vitamin deficiency 392 exogenous 385 Curcumin 146 CD44, tumor metastasis 247 Cyclic nitroxides 385 Cell culture 355 Cytochrome oxidase 382 serum-free 357-368 Cytochrome P450 isoenzymes in liver Cell transformation, role of ROS 149 acinar localization 301 Chelating agents, effect on free radical-mediated development 303 injury Cytochrome P450 monooxygenase, zonation in Chenodeoxycholic acid, treatment of liver 300 gallstones 174 Cholelithiasis 171 cholelitholysis 178 Desferal-Mn 385 pharmacotherapy 174 treatment of inflammatory bowel disease 398 Cholephilic compounds, zonal transport 306 Desferoxamine 386 SUBJECT INDEX Desipramine, hepatotoxicity 107 Fibrosis, liver, ethanol induced 310 Development, liver 279 Fluorescence-activated cell sorter, amino acid and nitrogen metabolism 296 hepatocytes 279 carbohydrate metabolism 291 Fluoxetine cytochrome P450 303 hepatotoxicity 107 enzyme gradients 284 idiosyncratic toxicity 118 hepatocyte proliferation 282 Fluvoxamine lipid metabolism 293 hepatotoxicity 107 Diethylnitrosamine, zonal hepatic injury 313 idiosyncratic toxicity 118 3,4-Dihydroxybenzoate 93 Fosinopril 188, 189 7,12-Dimethylbenz(a)anthracene Free radicals formation of oxidized DNA bases 147 anti-oxidant defense mechanisms 382 ROS formation 136 inflammatory bowel disease 388 Dimethvlsulfoxide 385 ischemia/reperfusion injury 192, 386 Dimethylthiourea 385 sources 377 DNA tissue injury 380 effect of arsenic on repair processes 37 cadmium binding 51 carcinogen-induced damage 144 Gallstones 171 carcinogen-mediated formation of oxidized cholesterol nucleation 173 bases 147 cholesterol supersaturation 172 chromium-induced damage 40 formation of 173 effect of ionizing radiation 139 pharmacotharapy 174 metal compound induced damage 32 Garlic and onion oils 146 nickel-induced damage 48 Gemfibrozil 314 tumor promoter induced damage 142, 145 Gene amplification, arsenic 39 DNA ligase II, inhibition by arsenic 38 Gene expression, zonation in liver 317, 321 Dothiepin, hepatotoxicity 107 Genetic correlation, drug responses 219 Doxazosin, kinetic-dynamic responses 70 Genetic selection, behaviour and drug Drug abuse, pharmacogenetic studies 224 responses 221 Giant cells, carcinogenesis 150 Glucocorticoids Eagle’s MEM 357 antifibrogenic activity 87 Ebselen 386 treatment of inflammatory bowel disease 398 E-cadherin 250 Gluconeogenesis, zonation in liver 289, 315 EGCG 146 Glucuronidation, zonation in liver 304 Enalapril 188 Glutamate, uptake in liver, zonation 294, 316 effect on chronic heart failure 190, 191 Glutamine, uptake in liver, zonation 294 kinetic-dynamic responses 72, 76 Glutamine synthetase, in liver, zonation 295, 316 Endothelial cells, inflammatory bowel disease 390 y-Glutamyltransferase, zonation in liver 306 Endothelial cell trigger mechanism, free radical- Glutathione mediated reperfusion injury 388 chromium complexes 43 Endothelial-leukocyte adhesion molecule-1 240 peroxidase-catalysed conjugate formation 269 tumor metastasis 246 zonation in liver 305 Energy metabolism, zonation in liver 286 Glutathione S-transferases, zonation in liver 305 Enterhepatic drugs 175 Glycogen metabolism, zonation in liver 288 Epidermal growth factor, zonation in liver 319 Glycolysis, zonation in liver 290, 315 Epithelial cells, serum-free culture 365 Growth factors, serum-free cell culture media 360 Epithelial tissues, effect of mineralocorticoids 11 Guillain-Barre syndrome, antidepressant Epoxide hydrolase, zonation in liver 303 effects 109 Ethanol oxidation and pathology, zonation in liver 309 N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, Na* transport 13 H*, secretion, mineralocorticoids 20 Extracellular matrix Halothane, zonal hepatic injury 312 angiogenesis 242 H-CAM/CD44 247 tumor interactions 249 Heat shock proteins, induction by arsenic 39 Hematologic system, antidepressant toxicity 108 Hematopoietic cells, serum-free culture 363 Fatty acid binding protein, zonation in liver 292 Hemochromatosis 83 Fatty acid oxidation, zonation in liver 292 Hemolytic anemia, induced by antidepressant a-Fetoprotein, zonation in liver 298 drugs Fetuin 368 Hepatitis, antidepressant drugs 107 Fibrinogenesis in cirrhosis 81-104 Hepatitis virus, treatment 84 antifibrogenic therapy 91 Hepatocyte heterogeneity 276 antiinfiammatory and immunosuppressor determination and regulation 316 therapy 87 functional significance 315 hepatoprotection 85 gene expression 317, 321 interferons 84 methods for studying 277 Fibroblasts, serum-free culture 366 proliferation 282 Fibronectin 249 zonation of intermediary metabolism 284 viii SUBJECT INDEX zonation of metabolism of endo- and Laminin 250 xenobiotics 299 Lazaroids 386, 398 zonation of pathology 308 Leukocyte-endothelial cell interaction, Hepatoprotection, liver cirrhosis 85 inflammatory bowel disease 389, 400 Hermes-1 247 Leukocyte-function-associated antigen-1, role on Heterochromatin, nickel interactions 49 metastasis 251 Hormones Levorphanol, pharmacogenetic studies 231 serum-free cell culture media 360 Lidocaine, induced seizures, genetic factors 227 zonation in liver 319 Lipids Hybridomas, serum-free culture 365 effect of aldosterone on metabolism 16 Hydrogen peroxide peroxidation 380 oxidative DNA damage 142 serum-free cell culture media 361 tumor promoter induced formation 133 zonation of metabolism in liver 291 Hydroperoxide-dependent oxidation of Lipoprotein, zonation of metabolism in liver 293 xenobiotics 263 Lisinopril 188 8-Hydroxyl(oxo)guanine effect on chronic heart failure 190, 193 effect of ionizing radiation 141 Lithogenic bile 172 effect of tumor promoters 143 Liver 5-Hydroxymethyl uracil 139 antidepressant toxicity 107 11-B-Hydroxysteroid dehydrogenase, cirrhosis 81-104 mineralocorticoid receptors 4 antifibrogenic therapy 82, 92 5-Hydroxytryptamine re-uptake blockers, antiinflammatory and immunosupressor idiosyncratic toxicities 117 therapy 87 Hypertransaminasemia, bile acid induced 177 hepatoprotection 85 Hypoxia, zone-specific damage in liver 287 treatment to eradicate etiologic agent 84 development and structure 279 hepatocyte heterogeneity 276 determination and regulation 316 Imipramine functional significance 315 hepatotoxicity 107 innervation 320 idiosyncratic toxicity 117 zonation of gene expression 317 neurotoxicity 109 zonation of intermediary metabolism 284 Immunoregulation, inflammatory bowel amino acid and nitrogen 293 disease 393 Immunosuppressor therapy, treatment of liver carbohydrate 288 lipids 291 cirrhosis 87 oxidative energy 286 Inflammation plasma proteins 297 co-carcinogenic effects 132 zonation of metabolism of endo- and liver cirrhosis 87, 89 xenobiotics 299 Inflammatory bowel disease bile formation 306 experimental models 392, 394 conjugation reactions 304 free radicals and oxygen metabolites 375-400 mixed-function oxidase 300 pathophysiology 388, 392 zonation of pathology therapy 395 ethanol oxidation 309 Insectivores, venomous 202, 210 heavy metal accumulation 314 Insulin, serum-free cell culture media 360 peroxisomes and peroxisome Insulin-like growth factor, serum-free cell culture proliferators 314 media 360 xenobiotic toxicity 310 Integrins, tumorigenesis 249, 251, 253 zonation of signal input 317 Interferons, antifibrogenic activity 84 Intestinal epithelial permeability, inflammatory Local anesthetics, induced seizures, genetic bowel disease 394 differences 226 Lofepramine Intracellular adhesion molecule-1 241 hepatotoxicity 107 Ionizing radiation idiosyncratic toxicity 118 oxidative DNA damage 135 neurotoxicity 109 ROS production 135 Lymphocyte homing receptors, lymphoid tumor Iron, zonation of hepatotoxicity 314 metastasis 247 Ischemia, inflammatory bowel disease 391 Lymphoid cells, serum-free culture 363 Ischemia/reperfusion injury, toxic oxygen Lysyloxidase inhibitors, antifibrogenic activity 94 metabolites 386 Macrophages Ketogenesis, zonation in liver 292 activating agents 132 Kidney formation of ROS 132 acidification 20 Magnesium, nickel interactions 49 effect of angiotensin converting enzyme Mannitol 385 inhibitors 194 Maprotiline, hepatotoxicity 107 mineralocorticoid hormone receptors 3, 5 Mast cells, inflammatory bowel disease 390 Na* and K* transport 18, 19 Mast cell stabilizers, treatment of inflammatory Kindling, cocaine, genetic differences 225 bowel disease 399 Kupffer cells 280 MEL-14 248 SUBJECT INDEX ix Melanotransferrin, zonation in liver 314 Nitroimidazoles, treatment of inflammatory bowel Menadione, zonal hepatic injury 312 disease 399 Metabolic zonation, liver 276, 315 Nomifensine Metals hepatotoxicity 107 carcinogenesis 32 idiosyncratic toxicity 119 arsenic 34, 37 Nonsteroidal antiinflammatory drugs, treatment of beryllium 36, 50 inflammatory bowel disease 399 cadmium 36, 51 chromium 35, 39 nickel 35, 45 Okadaic acid, PMN activation 133 PMN activation 133 Oltipraz 386 ROS induction 138 Opiate-related behaviours, pharmacogenetics 231 zonation of hepatotoxicity 314 Oxaproline containing peptides, treatment of liver Metastasis cirrhosis 93 angiogenesis, adhesive interactions 239-260 B-Oxidation, zonation in liver 292 metals 34 Oxidative damage, nickel carcinogenesis 48 Methotrexate, liver cirrhosis 91 Oxidative energy metabolism, zonation in 3-Methylcholanthrene, ROS formation 136 liver 286 Metronidazole, treatment of inflammatory bowel 2-Oxoglutarate inhibitors, treatment of liver disease 399 cirrhosis 93 Mezerein, oxidative DNA damage 145 Mianserin bioactivation 119 Palytoxin, PMN activation 133 hematologic toxicity 108 Perindopril 188 hepatotoxicity 107 effect on chronic heart failure 190 idiosyncratic toxicity 118 Peroxidase-mediated bioactivation 266, 268 a2-Microglobulin, zonation in liver 298 Peroxisomes, zonation in liver 314 Mineralocorticoid hormones 1-29 Phagocytes, carcinogenesis 150 acidification 20 Pharmacodynamic modelling 69 gene expression 6 Pharmacogenetics 217-237 K+ transport 18 drug-abuse research 224-233 Na* transport 12 Phenamil 14 receptors 2 Phorbol esters, induction of oxidative burst 132 Mitogenic fibrinogen receptor 368 Phosphoenolpyruvate carboxy kinase, in liver Monoamine oxidase inhibitors gene expression 321 hepatotoxicity 107 zonation 289 idiosyncratic toxicities 119 Plasma protein metabolism, zonation in liver 297 Morphine, pharmacogenetic studies 231 Plasma renin activity, antihypertensive drug Mucin depletion, inflammatory bowel disease 391 response 74 Mucosal addressins 247, 248 Platelet-derived growth factor, serum-free cell Mutagenesis culture media 361, 366 arsenic 37 Platelet-endothelial cell adhesion molecule-1 252 cadmium 52 Polycyclic aromatic hydrocarbons chromium 41 formation of oxidized DNA bases 147 nickel 46 prostaglandin H synthase-dependent prostaglandin H synthase-dependent oxidation 266 oxidation 266 ROS formation 136 Myeloperoxidase, ROS utilization 137 Polyethylene glycol polymer—superoxide Myocardial infarction, effect of angiotensin dismutase 384 converting enzyme inhibitors 191 Polymorphonuclear leukocytes Myocardial ischemia 193 activating agents 132 formation of ROS 131 oxidative DNA damage 145 NADPH-cytochrome c reductase, zonation in Polyunsaturated lecithins, effect on liver liver 300 cirrhosis 94 NADPH-dependent oxidase, generation of free Potassium, mineralocorticoids and transport of 18 radicals 379 Praziquantel 84 Neovascularization, extracellular matrix Prazosin, kinetic-dynamic responses 70 endothelium 242 Primary biliary cirrhosis, protection and Neural cells, serum-free culture 367 treatment 85 Neuropathy, induced by antidepressants 109 Primary sclerosing colangitis, protection and Neutrophils, inflammatory bowel disease 389 treatment 85 Nickel, carcinogenesis Progesterone, inhibition of liver cirrhosis 91 interaction with heterochromatin and Proline analogs, treatment of liver cirrhosis 92 magnesium 49 Prolyl-4-hydroxylase inhibitors, antifibrogenic PMN activation 133 potential 87, 93 protein interactions 45 Prostaglandin H synthase, xenobiotic metabolism uptake and cellular metabolism 35 by 261-273 Nifedipine, kinetic-dynamic responses 70 Prostaglandins, prevention of liver cirrhosis 85 Nitrogen metabolism, zonation in liver 293 Proteins, serum-free cell culture media 358 Nitrogen, oxidized metabolites 379 Pyridine 2,4-dicarboxylate 93 x SUBJECT INDEX Quinapril 188 Tamoxifen 146 effect on chronic heart failure 190 12-O-Tetradecanoyl-phorbol-13-acetate induced oxidative burst 132 oxidative DNA damage 145 Ramipril 188 Thiazide diuretics, kinetic-dynamic responses 73 effect on chronic heart failure 190 Thrombocytopenia, induced by antidepressant Reactive oxygen species drugs 107 anti-oxidant defense mechanisms 382 Thymine glycol carcinogenesis 149 effect of ionizing radiation 139 carcinogen-mediated formation 136 effect of tumor promoters 143 formation by tumor promoter mediated Trace elements, inflammatory bowel disease 392 processes 131, 145 Transferrin, serum-free cell culture medium 359 inflammatory bowel disease 388 Transferrin receptors, zonation in liver 314 ischemia/reperfusion injury 386 Transforming growth factor, serum-free cell nickel induced production 48 culture media 361 oxidative DNA damage 142, 145, 149 Trazodone, hepatotoxicity 107 production by ionizing and U.V. radiation 135 Trimazosin, kinetic-dynamic responses 72 role in cell transformation 149 2,4,6-Trinitrobenzine sulfonic acid, inflammatory sources 129, 138, 377 bowel disease 395 tissue injury 380 Tumor-endothelial/tissue adhesive interaction 243, tumor promoters 142 Renin-angiotensin system 189 Tumor metastasis, endothelial adhesion Reperfusion injury molecules 245 angiotensin converting enzyme inhibitors 192 Tumor promoters 129 toxic oxygen metabolites 386 formation of reactive oxygen species 131 Retinoids, treatment of fibrosis 95 oxidative DNA damage 142, 145 12-O-Retinoyl-phorbol-13-acetate, oxidative DNA Tumors damage 145 interactions with extracellular matrix 249 metals 32 Saliva, mammals Ubiquitin, effect of arsenic 39 chemical properties 206 UDP-glucuronyl transferase, zonation in liver 304 evolutionary significance of venom 211 Ulcerative colitis 388 need fora venom 210 immunoregulation 393 pharmacology 207 intestinal epithelial permeability 394 purification of toxic components 205 mucin depletion 392 toxic properties 200, 203 smoking 380 Sarcophytol A 146 therapy 395 Schistosomiasis, liver cirrhosis 83, 84 trace elements and vitamin deficiency 392 Seizures Urea synthesis, zonation in liver 295 cocaine-induced, genetic factors 224 Urinary bladder lidocaine-induced, genetic factors 227 mineralocorticoids and acidification 20 Selenium, inflammatory bowel disease 392, 393 mineralocorticoid receptors 2 Serum-free cell culture Na* transport 12 basal media composition 357 Ursodeoxycholic acid commercially available media 368 protection against liver cirrhosis 85 conditioned media 362 treatment of gallstones 174 epithelial cells 365 U.V. radiation, ROS production 135 fibroblasts 366 hematopoietic cells 363 hybridomas 365 Vascular-cellular adhesion molecule-1 241 media supplements 358 tumor metastasis 246 neural cells 367 Venomous mammals 199-215 Sex differences envenomation and symptomology 203 alcohol dehydrogenase in liver 309 evolutionary significance 211 lipid metabolism in liver 291 folklore 200 Shrews, venomous 200 pharmacology of saliva 207 Skin, antidepressant toxicity 108 purification of toxic components of saliva 205 Sodium, aldosterone and transport of 12 species and distribution 202 Sodium cromoglycate, treatment of inflammatory Vitamins bowel disease 399 inflammatory bowel disease 393 SPARC 245 serum-free cell culture media 359 Steroids, treatment of liver cirrhosis 87 VLA-2, tumorgenicity 251, 253 Sulfotransferase, zonation in liver 304 Sulphasalazine, treatment of inflammatory bowel disease 396 Wilson’s disease, liver cirrhosis 83 Superoxide dismutase 382, 383 WR2721 398 treatment of inflammatory bowel disease 397 Superoxide dismutase mimics 385 treatment of inflammatory bowel disease 398 Xanthine oxidase inhibitors 383 SUBJECT INDEX Zimeldine gene expression 317 hepatotoxicity 107 intermediary metabolism 284 idiosyncratic toxicity 117, 120 metabolism of endo- and xenobiotics 299 Zinc, inflammatory bowel disease 392 pathology 308 Zonation in liver 27£ -354 signal input 317