Table Of Content

PHARMACOLOGY & THERAPEUTICS Chemotherapy, Toxicology and Metabolic Inhibitors Executive Editor: A. C. Sartorelli Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, New Haven, Connecticut 06510, USA General and Systemic Pharmacology Executive Editor: W. C. Bowman University of Strathclyde, Department of Physiology & Pharmacology, Royal College, 204 George Street, Glasgow GI 1XW, Scotland Clinical Pharmacology and Therapeutics Executive Editor: A. M. Breckenridge University of Liverpool, Department of Pharmacology & Therapeutics, P.O. Box 147, Liverpool L69 3BX, England Subscription Rates—Annual Institutional Subscription Rate (1993): £1100.00 (US$1760.00). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscription rates for Japan are available on request. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A., and for the remainder of the world to Pergamon Press Ltd, Headington Hil! Hall, Oxford OX3 OBW, England. At the end of the year, the Subscriber will receive, free, the annual subject index. © 1993 Pergamon Press Ltd Published monthly —twelve issues per annum Second class postage paid at RAHWAY NJ. Postmaster send address corrections to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A. Back Issues Back issues of all previously published volumes are available direct from Pergamon Press offices. Publishing and Advertising Offices Pergamon Press Ltd Pergamon Press Inc. Headington Hill Hall 660 White Plains Road Oxford OX3 0BW Tarrytown England New York 10591-5153, U.S.A. PHARMACOLOGY & THERAPEUTICS Chemotherapy, Toxicology and Metabolic Inhibitors Executive Editor: A. C. Sartorelli Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, New Haven, Connecticut 06510, USA General and Systemic Pharmacology Executive Editor: W. C. Bowman University of Strathclyde, Department of Physiology & Pharmacology, Royal College, 204 George Street, Glasgow GI 1XW, Scotland Clinical Pharmacology and Therapeutics Executive Editor: A. M. Breckenridge University of Liverpool, Department of Pharmacology & Therapeutics, P.O. Box 147, Liverpool L69 3BX, England Subscription Rates—Annual Institutional Subscription Rate (1993): £1100.00 (US$1760.00). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscription rates for Japan are available on request. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A., and for the remainder of the world to Pergamon Press Ltd, Headington Hil! Hall, Oxford OX3 OBW, England. At the end of the year, the Subscriber will receive, free, the annual subject index. © 1993 Pergamon Press Ltd Published monthly —twelve issues per annum Second class postage paid at RAHWAY NJ. Postmaster send address corrections to Pergamon Press Inc., 660 White Plains Road, Tarrytown, NY 10591-5153, U.S.A. Back Issues Back issues of all previously published volumes are available direct from Pergamon Press offices. Publishing and Advertising Offices Pergamon Press Ltd Pergamon Press Inc. Headington Hill Hall 660 White Plains Road Oxford OX3 0BW Tarrytown England New York 10591-5153, U.S.A. Volume 50, 1991, Numbers 1-3 CONTENTS Number 1 Role of site-selective cAMP analogs in the control and reversal of malignancy: Y. S. Cho-Chung, T. Clair, G. Tortora and H. Yokozaki Neuroendocrine rhythms: M. H. Hastings Vascular activities of the endothelins: M. D. Randall The dynamics of drug resistance in Plasmodium falciparum: W. H. Wernsdorfer and D. Payne Cyclic nucleotide-dependent protein kinases: J. D. Scott Number 2 Biological and NMR markers for cancer: M. Czuba and I. C. P. Smith Ca?+ extrusion across plasma membrane and Ca?+ uptake by intracellular stores: L. Missiaen, F. Wuytack, L. Raeymaekers, H. De Smedt, G. Droogmans, I. Declerck and R. Casteels The drug interaction potential of ranitidine: An update: U. Klotz and H. K. Kroemer The potential use of catalytic RNAs in therapy of HIV infection and other diseases: J. J. Rossi, E. M. Cantin, N. Sarver and P. A. Chang Regulatory functions of calmodulin: A. R. Means, M. F. A. VanBerkum, I. Bagchi, K. P. Lu and C. D. Rasmussen Number 3 The regulation of adenylyl cyclase by receptor-operated G proteins: A. Levitzki and A. Bar-Sinai The potential importance of swainsonine in therapy for cancers and immunology: K. Olden, P. Breton, K. Grzegorzewski, Y. Yasuda, B. L. Gause, O. A. Oredipe, S. A. Newton and S. L. White Intracellular messengers and the control of protein synthesis: S. J. Morley and G. Thomas Morphologic and morphometric techniques for the detection of drug- and toxin-induced changes in lung: P. Davies Guanylyl cyclase-linked receptors: D. L. Garbers The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics: H. J. Little Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators: G. Weckbecker Structure and function of G protein coupled receptors: T. Jackson Contribution of the glutathione S-transferases to the mechanisms of resistance to Aflatoxin B,: J. D. Hayes, D. J. Judah, L. I. McLellan and G. E. Neal