Pharmacology for Anaesthesia and Intensive Care

388 Pages·2021·6.986 MB·English

by  Tom Peck, Benjamin Harris

Pharmacology
for Anaesthesia and Intensive
Care

Pharmacology
for Anaesthesia
and Intensive Care
Tom Peck
ConsultantAnaesthetist,RoyalHampshireCountyHospital,Winchester;HonoraryConsultant,
UniversityHospitalSouthampton
Benjamin Harris
ConsultantAnaesthetistandIntensivist,BasingstokeandNorthHampshireHospital,
HampshireHospitalsNHSFoundationTrust
UniversityPrintingHouse,CambridgeCB28BS,UnitedKingdom
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CambridgeUniversityPressispartoftheUniversityofCambridge.
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www.cambridge.org
Informationonthistitle:www.cambridge.org/9781108710961
DOI:10.1017/9781108591317
TomPeckandBenjaminHarris©2021
Thispublicationisincopyright.Subjecttostatutoryexception
andtotheprovisionsofrelevantcollectivelicensingagreements,
noreproductionofanypartmaytakeplacewithoutthewritten
permissionofCambridgeUniversityPress.
Firstpublished2000
Secondedition2003
Thirdedition2008
Fourthedition2014
8thprinting2019
Fifthedition2021
PrintedintheUnitedKingdombyTJBooksLimited,PadstowCornwall
AcataloguerecordforthispublicationisavailablefromtheBritishLibrary.
LibraryofCongressCataloging-in-PublicationData
Names:Peck,T.E.,author.|Harris,Benjamin(ConsultantAnaesthetist),author.
Title:Pharmacologyforanaesthesiaandintensivecare/TomPeck,ConsultantAnaesthetist,RoyalHampshireCounty
Hospital,Winchester;HonoraryConsultant,UniversityHospitalSouthampton,BenjaminHarris,Consultant
Anaesthetist,HampshireHospitalsNHSTrust.
Description:Fifthedition.|Cambridge,UnitedKingdom;NewYork,NY:CambridgeUniversityPress,2021.|Includesindex.
Identifiers:LCCN2020039003(print)LCCN2020039004(ebook)|ISBN9781108710961(paperback)|
ISBN9781108591317(ebook)
Subjects:LCSH:Pharmacology.|Anesthetics.
Classification:LCCRM300.P3962021(print)|LCCRM300(ebook)|DDC615.1–dc23
LCrecordavailableathttps://lccn.loc.gov/2020039003
LCebookrecordavailableathttps://lccn.loc.gov/2020039004
ISBN978-1-108-71096-1Paperback
CambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyof
URLsforexternalorthird-partyinternetwebsitesreferredtointhispublication
anddoesnotguaranteethatanycontentonsuchwebsitesis,orwillremain,
accurateorappropriate.
...........................................................................................................................................................................
Everyefforthasbeenmadeinpreparingthisbooktoprovideaccurateandup-to-dateinformationthatisinaccordwith
acceptedstandardsandpracticeatthetimeofpublication.Althoughcasehistoriesaredrawnfromactualcases,everyeffort
hasbeenmadetodisguisetheidentitiesoftheindividualsinvolved.Nevertheless,theauthors,editors,andpublisherscan
makenowarrantiesthattheinformationcontainedhereinistotallyfreefromerror,notleastbecauseclinicalstandardsare
constantlychangingthroughresearchandregulation.Theauthors,editors,andpublishersthereforedisclaimallliabilityfor
directorconsequentialdamagesresultingfromtheuseofmaterialcontainedinthisbook.Readersarestronglyadvisedtopay
carefulattentiontoinformationprovidedbythemanufacturerofanydrugsorequipmentthattheyplantouse.
Contents
Preface vii
ForewordbyAnthonyAbsalom ix
Section I Basic Principles 14. AdrenoceptorAntagonists 207
15. Anti-Arrhythmics 217
1. DrugPassageacrosstheCell
Membrane 1 16. Vasodilators 233
2. Absorption,Distribution, 17. Antihypertensives 245
MetabolismandExcretion 8
3. DrugAction 23 Section IV Other Important
4. DrugInteraction 37 Drugs
5. Isomerism 42
18. CentralNervousSystem 253
6. PharmacokineticModelling 47
19. AntiemeticsandRelated
7. AppliedPharmacokinetic Drugs 266
Models 68
20. DrugsActingontheGut 275
8. MedicinalChemistry 80
21. IntravenousFluids,Mineralsand
Nutrition 280
Section II Core Drugs in
22. Diuretics 295
Anaesthetic Practice
23. Antimicrobials 301
9. GeneralAnaestheticAgents 93 24. DrugsAffectingCoagulation 331
10. Analgesics 127 25. DrugsUsedinDiabetes
11. LocalAnaesthetics 156 Mellitus 346
26. CorticosteroidsandOtherHormone
12. MuscleRelaxantsandReversal
Agents 168 Preparations 355
Section III Cardiovascular Drugs
13. Sympathomimetics 189 Index 363
v

Preface
Thisfiftheditioncontinuestopushdownwhatseemstobeasuccessfulavenue.Theoverall
size and feel remains the same with changes limited to depth and scope of information
ratherthansimplyexpandingthenumberofdrugsdiscussed,especiallyinSectionsIIIand
IV.Appliedkineticsandtotalintravenousanaesthesiacontenthasbeenexpandedandnew
information on the environmental impact of anaesthetic agents has been added where
relevant.
Thiseditionalsowelcomesanewco-author,DrBenHarris,whobringsawelcomedepth
of knowledge to the intensive care content which has been expanded and re-written in
places.
ItshouldbenotedthatthisistheonlyeditionwithoutthedirectinvolvementofDrSue
Hill.Althoughnotlistedasanauthorinthefirsteditionshewasthewiseheadwhoguided,
shapedandencouragedtwoambitioustraineesinwhatseemedanimpossibleventure.Her
inputintothisbookoverthepast20yearsishardtooverestimate.Sheiscurrentlyenjoying
awell-earnedretirement.
ThankyouSue.
vii