Pharmacology for Anaesthesia and Intensive Care

390 Pages·2010·3.59 MB·English

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PharmacologyforAnaesthesiaandIntensiveCare
THIRD EDITION
Thethirdeditionofthismarket-leadingbookhasbeenthoroughlyupdatedand
expanded,withadditionalcontributionsfromexpertsinthefield,toincludeallnew
drugsavailabletotheanaesthetistandintensivecarespecialist.Basic
pharmacologicalprinciples,vitaltounderstandinghowindividualdrugsactually
havetheireffects,aredealtwithmethodicallyandwithmanyhighlyannotated
diagramsandtables.Withhospitalinfectionsbecomingincreasinglyprevalent,the
importantsectiononantibioticshasbeenfurtherexpanded.Withthethirdedition,
thiswellestablishedtitlecontinuestoprovideitsreaderswiththemostconciseyet
comprehensivecoverageofallaspectsofpharmacology.Anidealaidtostudyand
practiceforjuniorandtraineeanaesthetists,criticalcarenursesandallphysicians
andhealthcareprofessionalsworkingintheatre,accidentandemergency
departmentsorintensivecareunits.
TomPeckisaConsultantAnaesthetistatRoyalHampshireCountyHospital,
Winchester.
SueHillisaConsultantNeuroanaesthetistatSouthamptonGeneralHospital.
MarkWilliamsisaConsultantAnaesthetistatRoyalPerthHospital,Australia.
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Pharmacology for Anaesthesia
and Intensive Care
THIRD EDITION
TomPeck,SueHillandMarkWilliams
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CAMBRIDGEUNIVERSITYPRESS
Cambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,Sa˜oPaulo,Delhi
CambridgeUniversityPress
TheEdinburghBuilding,CambridgeCB28RU,UK
PublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYork
www.cambridge.org
Informationonthistitle:www.cambridge.org/9780521704632
(cid:1)C TomPeckSueHillandMarkWilliams2008
Thispublicationisincopyright.Subjecttostatutoryexception
andtotheprovisionsofrelevantcollectivelicensingagreements,
noreproductionofanypartmaytakeplacewithout
thewrittenpermissionofCambridgeUniversityPress.
Firstpublished2000
PrintedintheUnitedKingdomattheUniversityPress,Cambridge
AcataloguerecordforthispublicationisavailablefromtheBritishLibrary.
LibraryofCongressCataloging-in-PublicationData
Peck,T.E.
Pharmacologyforanaesthesiaandintensivecare/TomPeck,S.Hill,MarkWilliams.–3rded.
p.;cm.
Includesbibliographicalreferencesandindex.
ISBN978-0-521-70463-2(pbk.)
1.Pharmacology. 2.Anesthetics. 3.Anesthesia. 4.Criticalcaremedicine.
I.Hill,S.A.(SueA.) II.Williams,Mark(MarkAndrew)1965- III.Title.
[DNLM: 1.Anesthetics–pharmacology. 2.CardiovascularAgents–pharmacology.
3.IntensiveCare.QV81P367p2007]
RM300.P396 2007
615(cid:2).1–dc22 2007029048
ISBN978-0-521-70463-2paperback
CambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofURLsfor
externalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnotguarantee
thatanycontentonsuchwebsitesis,orwillremain,accurateorappropriate.
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CONTENTS
Preface page ix
Foreword xi
SECTION I Basicprinciples 1
1 Drugpassageacrossthecellmembrane 1
2 Absorption,distribution,metabolismandexcretion 8
3 Drugaction 24
4 Druginteraction 40
5 Isomerism 45
6 Mathematicsandpharmacokinetics 50
7 Medicinalchemistry 85
SECTION II Coredrugsinanaestheticpractice 99
8 Generalanaestheticagents 99
9 Analgesics 135
10 Localanaesthetics 163
11 Musclerelaxantsandanticholinesterases 175
SECTION III Cardiovasculardrugs 197
12 Sympathomimetics 197
13 Adrenoceptorantagonists 217
14 Anti-arrhythmics 228
15 Vasodilators 246
16 Antihypertensives 258
SECTION IV Otherimportantdrugs 270
17 Centralnervoussystem 270
18 Antiemeticsandrelateddrugs 282
19 Drugsactingonthegut 292
20 Intravenousfluids 298
21 Diuretics 305
22 Antimicrobials 311
23 Drugsaffectingcoagulation 335
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vi Contents
24 DrugsusedinDiabetes 347
25 Corticosteroidsandother
hormonepreparations 353
Index 360
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CONTRIBUTOR
Dr.A.S.Grice,BSc,DCH,FRCA,ConsultantAnaesthetist,Exeter
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PREFACE
Thethirdeditionhasseenfurtherchanges.Themathematicssectionhasbeenover-
hauledandexpandedtogiveabetterbaseforthekinetics.Anadditionalchapter
hasbeenaddedonintravenousfluids,andthechaptersonintravenousandvolatile
anaestheticshavebeencombinedwithanexpandedsectiononthemolecularmech-
anismofanaesthesia.
Wehavetriedtomaintainthestyleoftheprevioustwoeditionswithanemphasis
onclaritybothintermsofpresentationandcontent.Inadditionwehavetriedvery
hardtoeliminatethosesmallerrorsthataredisproportionatelyirritating.Wehope
thatthisbookwillcontinuetobeahelpfulaidtothewiderangeofreadersitappears
tohaveattracted.
TomPeck
SueHill
MarkWilliams
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