Pharmaceutical Research 2005: Vol 22 Table of Contents

2005·4.9 MB·English

PHARMACEUTICAL RESEARCH
An Official Journal of the American Association of Pharmaceutical Scientists
VOLUME TABLE OF CONTENTS
Volume 22 Number 1 January 2005
REVIEW
Polyethylene Glycol-Conjugated Copolymers for Plasmid DNA Delivery
Minhyung Lee and Sung Wan Kim
COMMENTARY
Predicting Drug Disposition via Application of BCS: Transport/Absorption/Elimination Interplay
and Development of a Biopharmaceutics Drug Disposition Classification System
Chi-Yuan Wu and Leslie Z. Benet
RESEARCH PAPERS
Drug Delivery and Targeting
Polymeric Micelles Based on Amphiphilic Scorpion-like Macromolecules: Novel Carriers for
Water-Insoluble Drugs
Jelena Djordjevic, Maryan Barch, and Kathryn E. Uhrich
Concentration Determination of a Recombinant Vaccine Antigen Adsorbed onto an Alum Adjuvant
by Chemiluminescent Nitrogen Detection
John V. Amari, Philip Levesque, Zhirui Lian, Trish Lowden, and Uditha deAlwis
In Vitro and ex Vivo Intestinal Tissue Models to Measure Mucoadhesion of Poly (Methacrylate)
and N-Trimethylated Chitosan Polymers
Simon Keely, Atvinder Rullay, Carolyn Wilson, Adrian Carmichael, Steve Carrington,
Anthony Corfield, David M. Haddleton, and David J. Brayden
Vitamin D;—Based Conjugates for Topical Treatment of Psoriasis: Synthesis, Antiproliferative Activity,
and Cutaneous Penetration Studies
Shimon Ben-Shabat, Rachel Benisty, Uri Wormser, and Amnon C. Sintoy
Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
Pharmacokinetics and Pharmacodynamics of PEGylated IFN-} la Following Subcutaneous
Administration in Monkeys
Donald E. Mager, Berend Neuteboom, and William J. Juskol
Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model
of Inflammatory Pain
Denis Projean, Sophie Dautrey, Huy Khan Vu, Thierry Groblewski, Jean-Louis Brazier,
and Julie Ducharme
CONTENTS (Continued)
Comparative Effects of Fibrates on Drug Metabolizing Enzymes in Human Hepatocytes
Thomayant Prueksaritanont, Karen M. Richards, Yue Qiu, Kristine Strong-Basalyga, Alisha Miller,
Chunze Li, Roy Eisenhandler, and Edward J. Carlini
Stereoselective Taurine Conjugation of (R)-Benoxaprofen Enantiomer in Rats: /n Vivo and in Vitro
Studies Using Rat Hepatic Mitochondria and Microsomes
Kiminori Mohri, Kenji Okada, and Leslie Z. Benet
Functional Evidence for P-glycoprotein at the Nose-Brain Barrier
Candace L. Graff and Gary M. Pollack
Computational Biopharmaceutics
Estimation of Transdermal Permeation Parameters in Non-stationary Diffusion Experiments.
Application to Pre-treatment Studies with Terpenes
A. Boix, C. Peraire, R. Obach, and J. Domenech
Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based
and Empirical Approaches
Kiyomi Ito and J. Brian Houston
Molecular Biopharmaceutics and Drug Disposition
A Fluorometric Screening Assay for Drug Efflux Transporter Activity in the Blood-Brain Barrier
Corbin J. Bachmeier and Donald W. Miller
Antibodies as Drug Carriers III: Design of Oligonucleotides with Enhanced Binding Affinity
for Immunoglobulin G
Enzo Palma, David G. Klapper, and M. J. Cho
Formulation Design, Engineering, and Processing
The Effect of Inert Atmospheric Packaging on Oxidative Degradation in Formulated Granules
Rajiv Mahajan, Allen Templeton, Amy Harman, Robert A. Reed, and Rey T. Chern
Effects of Excipients on the Hydrogen Peroxide—Induced Oxidation of Methionine Residues
in Granulocyte Colony-Stimulating Factor
Jin Yin, Jhih-Wei Chu, Margaret Speed Ricci, David N. Brems, Daniel 1. C. Wang,
and Bernhardt L. Trout
How Much Particle Surface Corrugation Is Sufficient to Improve Aerosol Performance of Powders?
Nora Y. K. Chew, Patricia Tang, Hak-Kim Chan, and Judy A. Raper
Crystallization of Cephalothin Sodium During Lyophilization from tert-Buty! Alcohol—Water
Cosolvent System
Chitra Telang and Raj Suryanarayanan
Mensuration and Cleaning of the Jets in Andersen Cascade Impactors
Marten Svensson, Gunilla Pettersson, and Lars Asking
CONTENTS (Continued)
Preformulation
Suitability of the Upper Airway Models Obtained from MRI Studies in Simulating
Drug Lung Deposition from Inhalers
T. Ehtezazi, K. W. Southern, D. Allanson, 1. Jenkinson, and C. O'Callaghan
AAPS Electronic Scientist
Sandra E. Hawken
Volume 22 Number 2 February 2005
EDITORIAL
Pharmaceutical Sciences, Scientists, and Journals—A Tribute to Pharmaceutical Research for Us
Coming of Age
Bernard Testa
EXPERT REVIEW
Bioadhesive Dosage Forms for Esophageal Drug Delivery
Hannah Batchelor
COMMENTARY
Oral Dosage Form Performance Tests: New Dissolution Approaches
Walter W. Hauck, Thomas Foster, Eric Sheinin, Todd Cecil, William Brown, Margareth Marques,
and Roger L. Williams
RESEARCH PAPERS
Drug Delivery and Targeting
pH-Dependent Dissolution in Vitro and Absorption in Vivo of Weakly Basic Drugs: Development
of a Canine Model
Rong Zhou, Paul Moench, Christopher Heran, Xujin Lu, Neil Mathias, Teresa N. Faria,
Doris A. Wall, Munir A. Hussain, Ronald L. Smith, and Duxin Sun
FKS506 Microparticles Mitigate Experimental Colitis with Minor Renal Calcineurin Suppression
Alf Lamprecht, Hiromitsu Yamamoto, Nathalie Ubrich, Hirofumi Takeuchi, Philippe Maincent,
and Yoshiaki Kawashima
A Polymeric Nanoparticle Consisting of mPEG-PLA-Toco and PLMA-COONa as a Drug Carrier:
Improvements in Cellular Uptake and Biodistribution
Yilwoong Yi, Jae Hong Kim, Hye-Won Kang, Hun Seung Oh, Sung Wan Kim, and Min Hyo Seo
Engineering Polysaccharide-Based Polymeric Micelles to Enhance Permeability of Cyclosporin A
Across Caco-2 Cells
Mira F. Francis, Mariana Cristea, Yali Yang, and Francoise M. Winnik
CONTENTS (Continued)
Reversible Lipidization Prolongs the Pharmacological Effect, Plasma Duration, and Liver Retention
of Octreotide
Liyun Yuan, Jeff Wang, and Wei-Chiang Shen
Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
Altered Pharmacokinetics of Paclitaxel in Experimental Hepatic or Renal Failure
Mari Jiko, Ikuko Yano, Masahiro Okuda, and Ken-ichi Inui
Pharmacokinetics of Substrate Uptake and Distributicn in Murine Brain After Nasal Instillation
Candace L. Graff, Rong Zhao, and Gary M. Pollack
Molecular Biopharmaceutics and Drug Disposition
A Randomly Coiled, High-Molecular-Weight Polypeptide Exhibits Increased Paracellular
Diffusion in Vitro and in Situ Relative to the Highly Ordered
a-Helix Conformer
Nazila Salamat-Miller, Montakarn Chittchang, Ashim K. Mitra, and Thomas P. Johnston
Metformin Transport by Renal Basolateral Organic Cation Transporter hOCT2
Naoko Kimura, Masahiro Okuda, and Ken-ichi Inui
Estimation of the Three-Dimensional Pharmacophore of Ligands for Rat Multidrug-Resistance -
Associated Protein 2 Using Ligand-Based Drug Design Techniques
Shuichi Hirono, Izumi Nakagome, Rie Imai, Kazuya Maeda, Hiroyuki Kusuhara,
and Yuichi Sugiyama
Formulation Design, Engineering, and Processing
The Relation Between Granule Size, Granule Stickiness, and Torque in the High-Shear
Granulation Process
A. M. Bouwman, M. J. Henstra, J. J. M. E. Hegge, Z. Zhang, A. Ingram, J. P. K. Seville,
and H. W. Frijlink
Preparation of Microparticles by Micromixers: Characterization of Oil/Water Process and Prediction
of Particle Size
Kathrin Schalper, Stephan Harnisch, Rainer H. Miiller, and Gesine E. Hildebrand
Influence of Lipid Nanocapsules Composition on Their Aptness to Freeze-Drying
Claire Dulieu and Didier Bazile
Study of Pharmaceutical Solid Dispersions by Microthermal Analysis
Marc Galop
Preformulation
Raffinose Crystallization During Freeze-Drying and Its Impact on Recovery of Protein Activity
Koustuv Chatterjee, Evgenyi Y. Shalaev, and Raj Suryanarayanan
Use of 2,2'-Azobis(2-Amidinopropane) Dihydrochloride as a Reagent Tool for Evaluation
of Oxidative Stability of Drugs
Seema Betigeri, Ajit Thakur, and Krishnaswamy Raghavan
CONTENTS (Continued)
Deliquescence in Binary Mixtures
Adnan K. Salameh and Lynne S. Taylor
Book Reviews
Kinam Park
AAPS Electronic Scientist
Sandra E. Hawken
Volume 22 Number 3 March 2005
RESEARCH PAPERS
Computational Biopharmaceutics
Compartmental Modeling of Transdermal lontophoretic Transport II: Jn Vivo Model Derivation
and Application
Akhmad Kharis Nugroho, Oscar Della-Pasqua, Meindert Danhof, and Joke A. Bouwstra
Drug Delivery and Targeting
Intravenous Hydrophobic Drug Delivery: A Porous Particle Formulation of Paclitaxel (AI-850)
Julie A. Straub, Donald E. Chickering, Jonathan C. Lovely, Huimin Zhang, Bhavdeep Shah,
William R. Waud, and Howard Bernstein
A Novel, Lipid-Free Nanodispersion Formulation of Propofol and Its Characterization
Hongming Chen, Zhong Zhang, Orn Almarsson, Jean-Francois Marier, Dina Berkovitz,
and Colin R. Gardner
A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA
Lloyd B. Jeffs, Lorne R. Palmer, Ellen G. Ambegia, Cory Giesbrecht, Shannon Ewanick,
and lan MacLachlan
Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian
Cells in Vitro and in Vivo
Mini Thomas, Qing Ge, James J. Lu, Jianzhu Chen, and Alexander M. Klibano,
A New Class of 5-Fluoro-2’-deoxyuridine Prodrugs Conjugated with a Tumor-Homing Cyclic Peptide
CNGRC by Ester Linkers: Synthesis, Reactivity, and Tumor-Cell—Selective Cytotoxicity
Zhouen Zhang, Hiroshi Hatta, Kazuhito Tanabe, and Sei-ichi Nishimoto
Bis(carbamoyloxymethyl) Esters of 2’.3’-Dideoxyuridine 5’-monophosphate (ddUMP) as Potential
ddUMP Prodrugs
Saeed R. Khan, Srinivas K. Kumar, and David Farquhar
Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
Significant Intestinal Excretion, One Source of Variability in Pharmacokinetics of COL-3.,
a Chemically Modified Tetracycline
Jing Li, Shufeng Zhou, Hung Huynh, and Eli Chan
CONTENTS (Continued)
Acute Changes in Muscle Blood Flow and Concomitant Muscle Damage after an Intramuscular
Administration
Pierre Jean Ferré, Eckart Thein, Isabelle Raymond-Letron, Pierre-Louis Toutain,
and Hervé Pierre Lefebvre
Relationship Between Loperamide-Induced Sedative Effect and Digoxin Pharmacokinetics
in Healthy Japanese Subjects
Michiya Kobayashi, Hiroshi Saitoh, Michiko Yamaguchi, Takeshi Saito, Hiroyoshi Fujita,
Manabu Suno, Kazuo Matsubara, and Bruce J. Aungst
Pharmacokinetic and Tissue Distribution Mechanism of Mouse Recombinant Heat Shock Protein 70
in Mice
Seiji Takemoto, Makiya Nishikawa, and Yoshinobu Takakura
Formulation and Evaluation of Aerosolized Celecoxib for the Treatment of Lung Cancer
Alfred Haynes, Madhu Sudhan Shaik, Abhijit Chatterjee, and M. Singh
Preformulation
Phase Behavior of Amorphous Molecular Dispersions II: Role of Hydrogen Bonding in Solid
Solubility and Phase Separation Kinetics
Madhav Vasanthavada, Wei-Qin (Tony) Tong, Yatindra Joshi, and M. Serpil Kislalioglu
Molecular Biopharmaceutics and Drug Disposition
Isolated Rafts from Adriamycin-Resistant P388 Cells Contain Functional ATPases and Provide
an Easy Test System for P-glycoprotein—Related Activities
Karsten Bucher, Camille A. Besse, Sarah W. Kamau, Heidi Wunderli-Allenspach,
and Stefanie D. Kriimer
Characterization of Polarized Expression of Point- or Deletion-Mutated Human BCRP/ABCG2
in LLC-PK1 Cells
Tappei Takada, Hiroshi Suzuki, and Yuichi Sugiyama
Interaction of the Macrolide Antibiotic Azithromycin with Lipid Bilayers: Effect on Membrane
Organization, Fluidity, and Permeability
A. Berquand, N. Fa, Y. F. Dufréne, and M.-P. Mingeot-Leclercq
Formulation Design, Engineering, and Processing
Novel Film Modifiers to Alter the Physical Properties of Composite Ethylcellulose Films
Lai Wah Chan, Kang Teng Ong, and Paul Wan Sia Heng
Comparative Investigation by Two Analytical Approaches of Enthalpy Relaxation for Glassy Glucose,
Sucrose, Maltose, and Trehalose
Kiyoshi Kawai, Tomoaki Hagiwara, Rikuo Takai, and Toru Suzuki
AAPS Electronic Scientist
Sandra E. Hawken
CONTENTS (Continued)
Volume 22 Number 4 April 2005
CONFERENCE REPORT
Method Validation and Measurement of Biomarkers in Nonclinical and Clinical Samples
in Drug Development: A Conference Report
Jean W. Lee, Russ S. Weiner, Jeff M. Sailstad, Ronald R. Bowsher, Dean W. Knuth,
Peter J. O’Brien, Jean L. Fourcroy, Rakesh Dixit, Lini Pandite, Robert G. Pietrusko,
Holly D. Soares, Valerie Quarmby, Ole L. Vesterqvist, David M. Potter, James L. Witliff,
Herbert A. Fritche, Timothy O’Leary, Lorah Perlee, Sunil Kadam, and John A. Wagner
RAPID COMMUNICATIONS
In Vitre and Pharmacophore-Based Discovery of Novel hPEPT1 Inhibitors
Sean Ekins, Jeffrey S. Johnston, Praveen Bahadduri, Vanessa M. D'Souza, Abhijit Ray,
Cheng Chang, and Peter W. Swaan
Micrometer-Scale Particle Sizing by Laser Diffraction: Critical Impact of the Imaginary Component
of Refractive Index
Alice Beekman, Daxian Shan, Alana Ali, Weiguo Dai, Stephen Ward-Smith,
and Merrill Goldenberg
RESEARCH PAPERS
Computational Biopharmaceutics
Data Supplementation: A Pharmacokinetic/Pharmacodynamic Knowledge Creation Approach
for Characterizing an Unexplored Region of the Response Surface
Ene 1. Ette, Hui-May Chu, and Christopher J. Godfrey
A Population Pharmacokinetic Model! for Montelukast Disposition in Adults and Children
Rohini Ramakrishnan, Elizabeth Migoya, and Barbara Knorr
Covariate Detection in Population Pharmacokinetics Using Partially Linear Mixed Effects Models
Peter L. Bonate
Drug Delivery and Targeting
Transdermal Delivery of Human Growth Hormone Through RF-Microchannels
Galit Levin, Amikam Gershonowitz, Hagit Sacks, Meir Stern, Amir Sherman, Sergey Rudaev,
Inna Zivin, and Moshe Phillip
Nipecotic Acid: Systemic Availability and Brain Delivery After Nasal Administration of Nipecotic
Acid and n-Butyl Nipecotate to Rats
Hongna Wang, Anwar A. Hussain, and Peter J. Wedlund
Local Delivery of Vancomycin for the Prophylaxis of Prosthetic Device—Related Infections
Dakshina M. Chilukuri and Jaymin C. Shah
Lyophilized Paclitaxel Magnetoliposomes as a Potential Drug Delivery System for Breast Carcinoma
via Parenteral Administration: /n Vitro and in Vivo Studies
J. Q. Zhang, Z. R. Zhang, H. Yang, Q. Y. Tan, S. R. Qin, and X. L. Qiu
CONTENTS (Continued)
Development and Characterization of Bioadhesive Vaginal Films of Sodium Polystyrene Sulfonate
(PSS), a Novel Contraceptive Antimicrobial Agent
Sanjay Garg, Kavita Vermani, Alka Garg, Robert A. Anderson, William B. Rencher,
and Lourens J. D. Zaneveld
Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
Pharmacokinetics and Tissue Retention of (Gd-DTPA)-Cystamine Copolymers, a Biodegradable
Macromolecular Magnetic Resonance Imaging Contrast Agent
Xinghe Wang, Yi Feng, Tianyi Ke, Mathias Schabel, and Zheng-Rong Lu
Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005
Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and
Pharmacokinetic/Pharmacodynamic Modeling
Sangeeta Raje, Jennifer Cornish, Amy H. Newman, Jianjing Cao, Jonathan L. Katz,
and Natalie D. Eddington
Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the
Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2)
Chihiro Kondo, Reiko Onuki, Hiroyuki Kusuhara, Hiroshi Suzuki, Michiko Suzuki,
Noriko Okudaira, Maho Kojima, Kazuya Ishiwata, Johan W. Jonker, and Yuichi Sugiyama
Differential Contributions of rOat! (Slc22a6) and rOat3 (Sic22a8) to the in Vivo Renal Uptake
of Uremic Toxins in Rats
Tsuneo Deguchi, Yousuke Kouno, Tetsuya Terasaki, Akira Takadate, and Masaki Otagiri
Preformulation
Investigation of Solubility and Dissolution of a Free Base and Two Different Salt Forms
as a Function of pH
Shoufeng Li, SuiMing Wong, Sundeep Sethia, Hassan Almoazen, Yatindra M. Joshi,
and Abu T. M. Serajuddin
A Natural Compound (Ginsenoside Re) Isolated from Panax ginseng as a Novel Angiogenic Agent
for Tissue Regeneration
Ya-Chun Huang, Chiung-Tong Chen, Sung-Ching Chen, Po-Hong Lai, Huang-Chien Liang,
Yen Chang, Lin-Chien Yu, and Hsing-Wen Sung
Molecular Biopharmaceutics and Drug Disposition
Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney
Harunobu Tahara, Masayuki Shono, Hiroyuki Kusuhara, Hajime Kinoshita, Eiichi Fuse,
Akira Takadate, Masaki Otagiri, and Yuichi Sugiyama
Treatment of Hyperbilirubinemia in Eisai Hyperbilirubinemic Rat by Transfecting Human
MRP2/ABCC2 Gene
Masakazu Hirouchi, Hiroshi Suzuki, and Yuichi Sugiyama
High-Performance Frontal Analysis of the Binding of Thyroxine Enantiomers to Human
Serum Albumin
Tomoko Kimura, Keiko Nakanishi, Terumichi Nakagawa, Akimasa Shibukawa,
and Katsumi Matsuzaki
CONTENTS (Continued)
Formulation Design, Engineering, and Processing
Development of Novel Nonaqueous Ethylcellulose Gel Matrices: Rheological
and Mechanical Characterization
P. W. S. Heng, L. W. Chan, and K. T. Chow
Freeze-Drying Process Design by Manometric Temperature Measurement:
Design of a Smart Freeze-Dryer
Xiaolin (Charlie) Tang, Steven L. Nail, and Michael J. Pikal
AAPS Electronic Scientist
Sandra E. Hawken
Volume 22 Number 5 May 2005
RAPID COMMUNICATION
A Strategy to Identify Stable Membrane-Permeant Peptide Inhibitors of Myosin Light Chain Kinase
Sidn-Eleri Owens, W. Vallen Graham, Dario Siccardi, Jerrold R. Turner, and Randall J. Mrsny
RESEARCH PAPERS
Computational Biopharmaceutics
P-Glycoprotein Induction and Tumor Cell-Kill Dynamics in Response to Differential Doxorubicin
Dosing Strategies: A Theoretical Pharmacodynamic Model
Kenneth T. Luu and James A. Uchizono
Molecular Biopharmaceutics and Drug Disposition
Intracellular Delivery of Bak BH3 Peptide by Microbubble-Enhanced Ultrasound
Manabu Kinoshita and Kullervo Hynynen
Experimental and Computational Studies of Epithelial Transport of Mefenamic Acid Ester Prodrugs
Kamonthip Wiwattanawongsa, Vimon Tantishaiyakul, Luelak Lomlim, Yon Rojanasakul,
Sirirat Pinsuwan, and Sanae Keawnopparat
Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
The Talinolol Double-Peak Phenomenon Is Likely Caused by Presystemic Processing After
Uptake from Gut Lumen
Werner Weitschies, Annika Bernsdorf, Thomas Giessmann, Michael Zschiesche,
Christiane Modess, Vera Hartmann, Claudia Mrazek, Danilo Wegner, Stefan Nagel,
and Werner Siegmund
PEGylation of Octreotide: |. Separation of Positional Isomers and Stability Against Acylation
by Poly(p,.-lactide-co-glycolide )
Dong Hee Na and Patrick P. DeLuca
CONTENTS (Continued)
PEGylation of Octreotide: II. Effect of N-terminal Mono-PEGylation on Biological Activity
and Pharmacokinetics
Dong Hee Na, Kang Choon Lee, and Patrick P. DeLuca
Drug Delivery and Targeting
Comparative Study of the Skin Penetration of Protein Transduction Domains
and a Conjugated Peptide
Luciana B. Lopes, Colleen M. Brophy, Elizabeth Furnish, Charles R. Flynn, Olivia Sparks,
Padmini Komalavilas, Lokesh Joshi, Alyssa Panitch, and M. Vitoria L. B. Bentley
Human Skin Permeation of Branched-Chain 3-O-Alkyl Ester and Carbonate Prodrugs of Naltrexone
Haranath K. Vaddi, Mohamed O. Hamad, Jianhong Chen, Stan L. Banks, Peter A. Crooks,
and Audra L. Stinchcomb
Effect of Particle Size of Nanospheres and Microspheres on the Cellular-Association and Cytotoxicity
of Paclitaxel in 4T1 Cells
Sinjan De, Donald W. Miller, and Dennis H. Robinson
Regional Radiochemotherapy Using /n Situ Hydrogel
Ali Azhdarinia, David J. Yang, Dong-Fang Yu, Richard Mendez, Changsok Oh,
Saady Kohanim, Jerry Bryant, and E. Edmund Kim
Preformulation
The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids
Laura M. Land, Ping Li, and Paul Michael Bummer
Non-native Intermediate Conformational States of Human Growth Hormone in the Presence
of Organic Solvents
Muppalla Sukumar, Sacha M. Storms, and Michael R. De Felippis
Comparison of Molecular Mobility in the Glassy State Between Amorphous Indomethacin
and Salicin Based on Spin-Lattice Relaxation Times
Katsuhiko Masuda, Sachio Tabata, Yasuyuki Sakata, Tetsuo Hayase, Etsuo Yonemochi,
and Katsuhide Terada
Interactions of Poly(vinylpyrrolidone) with Ibuprofen and Naproxen: Experimental
and Modeling Studies
Svetla Bogdanova, Ilza Pajeva, Petya Nikolova, lvanka Tsakovska, and Bernd Miiller
Formulation Design, Engineering, and Processing
Surface Energy and Interparticle Forces Correlations in Model pMDI Formulations
Daniela Traini, Philippe Rogueda, Paul Young, and Robert Price
Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte
Layer-by-Layer Nanoassembly
Nikhil Pargaonkar, Yuri M. Lvov, Ning Li, Jan H. Steenekamp, and Melgardt M. de Villiers
AAPS Electronic Scientist
Sandra E. Hawken