Table Of Content

PHARMACEUTICAL RESEARCH Official Journal of the American Association of Pharmaceutical Scientists Volume 11 Number 1 January 1994 CONTENTS EDITORIAL REVIEW Immunopotentiation and Delivery Systems for Antigens for Single-Step Immunization: Recent Trends and Progress M. Zahirul 1. Khan, Joan P. Opdebeeck, and lan G. Tucker RESEARCH ARTICLES Feasibility Study on Spray-Drying Protein Pharmaceuticals: Recombinant Human Growth Hormone and Tissue-Type Plasminogen Activator (Biotec/PT) Marco Mumenthaler, Chung C. Hsu, and Rodney Pearlman Moisture-Induced Aggregation of Lyophilized Insulin (Biotec/APQ) Henry R. Costantino, Robert Langer, and Alexander M. Klibanov Transcellular Transport of Benzoic Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism (PDD) Akira Tsuji, Hitomi Takanaga, Ikumi Tamai, and Tetsuya Terasaki Intracellular Visualization of Ampicillin-Loaded Nanoparticles in Peritoneal Macrophages Infected in Vitro with Salmonella typhimurium (PDD) Huguette Pinto-Alphandary, Olivier Balland, Michel Laurent, Antoine Andremont, Francis Puisieux, and Patrick Couvreur REPORTS Conformational Analysis, Molecular Modeling, and Quantitative Structure—Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride Transport (MNPC) Chris L. Waller, Steven D. Wyrick, W. Evans Kemp, Hee Moon Park, and Forrest T. Smith Measurement of Glass Transition Temperatures of Freeze-Concentrated Solutes by Differential Scanning Calorimetry (PT/PDD) Lih-Min Her and Steven L. Nail Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in Rats (Biotec/PPDM) Yukiya Hashimoto, Kazuwa Nakao, Norio Hama, Hiroo Imura, Sachiyo Mori, Masayuki Yamaguchi, Masato Yasuhara, and Ryohei Hori Acidic Fibroblast Growth Factor: Evaluation of Topical Formulations in a Diabetic Mouse Wound Healing Model (Biotec) Bozena Matuszewska, Martina Keogan, Dennis M. Fisher, Keith A. Soper, Chao Min Hoe, A. Christine Huber, and Joseph V. Bondi Acid-Catalyzed Peptide Bond Hydrolysis of Recombinant Human Interleukin 11 (Biotec/APQ) Richard A. Kenley and Nicholas W. Warne CONTENTS (Continued) Primary Culture of Rat Gastric Epithelial Cells as an in Vitro Model to Evaluate Antiulcer Agents (Pharmacol) Hongjian Zheng, Praful K. Shah, and Kenneth L. Audus Diffusion Rates and Transport Pathways of Fluorescein Isothiocyanate (FITC)-Labeled Model Compounds Through Buccal Epithelium (PDD) A. Janet Hoogstraate, Christopher Cullander, J. Fred Nagelkerke, Sevda Senel, J. Coos Verhoef, Hans E. Junginer, and Harry E. Boddé Effect of Cyclodextrins on Protein Binding of Drugs: The Diflunisal/Hydroxypropyl-B-Cyclodextrin Model Case (PDD/PPDM) Evangelos E. Sideris, Michael A. Koupparis, and Panayotis E. Macheras Analysis of the Combined Effect of 1-Menthol and Ethanol as Skin Permeation Enhancers Based on a Two-Layer Skin Model (PDD) Daisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto, and Masayuki Kimura Interaction Between Drugs and Pressure-Sensitive Adhesives in Transdermal Therapeutic Systems Takemasa Kokubo, Kenji Sugibayashi, and Yasunori Morimoto Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. III. Drug Release from Fatty Suppository Bases Containing Amylodextrin (PDD) Gerrit H. P. Te Wierik, Anko C. Eissens, and Coenraad F. Lerk An Organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release Preparations (PDD) Shinji Narisawa, Minako Nagata, Chieko Danyoshi, Hiroyuki Yoshino, Kazuo Murata, Yoshiyuki Hirakawa, and Kazuo Noda Bioavailability of Flumequine After Semisimultaneous Administration to Veal Calves (PPDM) Bert A. Meijer, Kristel G. F. Ceyssens, Wytze Th. de Jong, and Ben I. J. A. C. de Gréve Biodistribution of Mixed Fluorocarbon—Hydrocarbon Dowel Molecules Used as Stabilizers of Fluorocarbon Emulsions: A Quantitative Study by Fluorine Nuclear Magnetic Resonance (NMR) (PPDM) Leila Zarif, Michéle Postel, Bernard Septe, Leo Trevino, Jean G. Riess, Anne-Marie Mahé, and René Follana Validation of a Variable Direction Hysteresis Minimization Pharmacodynamic Approach: Cardiovascular Effects of Alfentanil (PPDM) Nishit B. Modi and Peter Veng-Pedersen pH-Related Changes in the Absorption of Dipyridamole in the Elderly (PPDM/CS) Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Tami L. O'Sullivan, John G. Wagner, and Jennifer B. Dressman Disposition of Glycosidase Inhibitors in the Isolated Perfused Rat Liver: Hepatobiliary and Subcellular Concentration Gradients of 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin (PPDM) Esther D. Faber, Johannes H. Proost, Roelof Oosting, and Dirk K. F. Meijer Influence of a Fat-Rich Meal on the Pharmacokinetics of a New Oral Formulation of Cyclosporine in a Crossover Comparison with the Market Formulation (PPDM) Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Joachim Grevel, Peter W. Liicker, and Klaus Kutz CONTENTS (Continued) Comparison of the Pharmacokinetics of an Ondansetron Solution (8 mg) When Administered Intravenously, Orally, to the Colon, and to the Rectum (PPDM) Poe-Hirr Hsyu, J. Frederick Pritchard, Haig P. Bozigian, Thomas L. Lloyd, Rita H. Griffin, Robert Shamburek, Gopal Krishna, and William H. Barr Pharmacokinetic Analysis of in Vivo Metabolism of Amino Acid or Dipeptide Conjugates of Salicylic Acid in Rabbit Intestinal Microorganisms (PPDM) Koyo Nishida, Mitsuhiko Kido, Hitoshi Sasaki, and Junzo Nakamura Epimerization and Hydrolysis of Dalvastatin, a New Hydromethylglutary! Coenzyme A (HMG-CoA) Reductase Inhibitor (APQ) Chong Min Won Psychometric Evaluation of Measures of Organizational Commitment and Intention to Quit Among Pharmaceutical Scientists (EMMS) Sheldon Xiaodong Kong, Albert I. Wertheimer, Joaquima Serradell, William F. McGhan TECHNICAL NOTE Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis (PPDM) Sayed M. H. Al-Habet, Connie Nosbisch, Tracy Williamson, Che-Chung Tsai, and Jashvant D. Unadkat ASSOCIATION NEWS AND ANNOUNCEMENTS PHARMACEUTICAL RESEARCH Official Journal of the American Association of Pharmaceutical Scientists Volume 11 Number 2 February 1994 CONTENTS RESEARCH ARTICLE In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum Corneum (PDD) Fumiyoshi Yamashita, Hiroto Bando, Yasuo Koyama, Shuji Kitagawa, Yoshinobu Takakura, and Mitsuru Hashida REPORTS Evaluation of Retinoids as Therapeutic Agents in Dermatology (MNPC) Anita H. Lewin, Mary E. Bos, F. Christopher Zusi, Xina Nair, Gary Whiting, Pamela Bouquin, Geraldine Tetrault, and F. Ivy Carroll Solubility Predictions for Solid Nitriles and Tertiary Amides Based on the Mobile Order Theory (MNPC/PDD) Paul Ruelle and Ulrich W. Kesselring Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol Hayat Alkan-Onyuksel, Suganthi Ramakrishnan, Hee-Byung Chai, and John M. Pezzuto Pharmacokinetics and Tissue Distribution of Recombinant Human Transforming Growth Factor Beta, (rhTGF-8, After Topical and Intravenous Administration in Male Rats (Biotec/PPDM) Thomas F. Zioncheck, Sharon A. Chen, Louise Richardson, Marina Mora-Worms, Catherine Lucas, Derf Lewis, James D. Green, and Joyce Mordenti Solute Absorption from the Airways of the Isolated Rat Lung. IV. Mechanisms of Absorption of Fluorophore-Labeled Poly-a,B-| N(2-Hydroxyethyl)-DL-Aspartamide] (Biotec/PDD) Peter R. Byron, Zhuang Sun, Hirokazu Katayama, and Frantisek Rypacek Colonic Absorption of Insulin-like Growth Factor I in Vitro (Biotec/PDD) Elizabeth Quadros, Nancy M. Landzert, Sheryl LeRoy, Fancis Gasparini, and Gregory Worosila Formulation and in Vitro—in Vivo Evaluation of Buccoadhesive Morphine Suifate Tablets (PDD) Sule Anlar, Yilmaz Capan, Olgun Giiven, Ahmet Gégiis, Turgay Dalkara, A. Atilla Hincal The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2’-Ester Prodrugs (PDD) Zezhi Shao, Gee-Bae Park, Ramesh Krishnomoorthy, and Ashim K. Mitra Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters. II]. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs (PDD) Zezhi Shao and Ashim K. Mitra Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in Pigs (PDD) Nancy A. Monteiro-Riviere, Alfred O. Inman, and Jim E. Riviere CONTENTS (Continued) Comparative Molecular Field Analysis Combined with Physicochemical Parameters for Prediction of Polydimethylsiloxane Membrane Flux in Isopropanol (PDD) Rong Liu and Lloyd E. Matheson Intestinal Absorption of (—) Carbovir in the Rat (PDD/PPDM) Inmaculada Soria and Cheryl L. Zimmerman The Controlled Release of Prednisolone Using Alginate Gel (PDD) Shinya Sugawara, Teruko Imai, and Masaki Otagiri Effect of Formulation Additives upon the Intranasal Bioavailability of a Peptide Drug: Tetracosactide (ACTHI1-24) (PDD) Patrick Wiithrich, Myriam Martenet, and Pierre Buri Determination of Transport Rates for Arginine and Acetaminophen Rabbit Intestinal Tissues in Vitro (PDD) Peter W. Swaan, Gary J. Marks, Frederick M. Ryan, and Phillip L. Smith Effect of Some Penetration Enhancers on Epithelial Membrane Lipid Domains: Evidence from Fluorescence Spectroscopy Studies (PDD) T. Marjukka Turunen, Arto Urtti, Petteri Paronen, Kenneth L. Audus, and J. Howard Rytting Effect of the H,-Receptor Antagonist, Cimetidine, on the Pharmacokinetics and Pharmacodynamics of the H,-Receptor Antagonists Hydroxyzine and Cetirizine in Rabbits (PPDM) Xueyu Chen, F. Estelle R. Simons, and Keith J. Simons Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation (PPDM) Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Wolfgang Tetzloff, Joachim Grevel, and Klaus Kutz In Vivo and in Vitro Blood—Brain Barrier Transport of 3-Hydroxy-3-Methyylglutary!l Coenzyme A (HMG-CoA) Reductase Inhibitors (PPDM) Akira Saheki, Tetsuya Terasaki, Ikumi Tamai, and Akira Tsuji Efflux of Zidovudine and 2’ ,3'-Dideoxyinosine Out of the Cerebrospinal Fluid When Administered Alone and in Combination to Macaca nemestrina (PPDM) Tove Tuntland, Rashid J. Ravasco, Sayed Al-Habet, and Jashvant D. Unadkat Phenobarbital Removal Characteristics of Three Brands of Activated Charcoals: A System Analysis Approach (PPDM/Toxicol) Nishit B. Modi, Peter Veng-Pedersen, Dale Eric Wurster, Mary J. Berg, and Dorothy D. Schottelius In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood—Brain Barrier and the Effect of Transport Inhibitors (PPDM) Rosalinde Masereeuw, Ulrich Jaehde, Mariska W. E. Langemeijer, Albertus G. de Boer, and Douwe D. Breimer Fluorometric Study of the Molecular States of 2,5-diphenyloxazole in Ground Mixtures with y-Cyclodextrin (APQ/PDD) Keiji Yamamoto, Toshio Oguchi, Etsuo Yonemochi, Yoshisuke Matsumura, and Yoshinobu Nakai CONTENTS (Continued) TECHNICAL NOTES Entrapment of Proteins in Poly(L-Lactide) Microspheres Using Reversed Micelle Solvent Evaporation (Biotec/PT) Yoshiki Hiyashi, Sumie Yoshioka, Yukio Aso, Alain Li Wan Po, and Tadao Terao Lack of Pharmacokinetic Interaction Between Cimetidine and Tirilazad Mesylate (PPDM) Joseph C. Fleishaker, Laura K. Hulst, and Gary R. Peters Degradation of the Antiarthritic Prodrug, 3-Carbox y-5-methyl-N-[4-(trifluoromethoxy)phenyl]-4-isoxazolecarboxamide, in Aqueous Solution Michael Brandl and James A. Kennedy COMMENTARY Further Commentary: Physiological Parameters in Laboratory Animals and Humans Robert B. Sothern and Scott A. Gruber PHARMACEUTICAL RESEARCH Official Journal of the American Association of Pharmaceutical Scientists Volume 11 Number 3 March 1994 CONTENTS REPORTS Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit Disintegration-Type Wax Matrix Tablets (PT/PDD) Makoto Otsuka and Yoshihisa Matsuda Physicomechanical Characterization of the Extrusion-Spheronization Process. I. Instrumentation of the Extruder (PT) Rajen D. Shah, Mohan Kabadi, David G. Pope, and Larry L. Augsburger Transport of Low and High Molecular Peptides Across Rabbit Peyer's Patches (Biotec/PDD) Shingo Haseto, Hiroyuki Ouchi, Tomonori Isoda, Takashi Mizuma, Masahiro Hayashi, and Shoji Awazu An Enzyme-Linked Immunosorbent Assay (ELISA) for Quantitation of Adducts of Granulocyte— Macrophage Colony Stimulating Factor (GM-CSF) and Human Serum Albumin (HSA) in Stressed Solution Mixtures (Biotec/APQ) Ramasamy Kumarasamy, James Bausch, Diane Kopcha, Suman Patel, and Eugene McGonigle Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes (Pharmacol) Kouichi Funato, Chikamasa Yamashita, Junko Kamada, Sachiko Tominaga, and Hiroshi Kiwada Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion Model (PDD) Yasuo Koyama, Hiroto Bando, Fumiyoshi Yamashita, Yoshinobu Takakura, Hitoshi Sezaki, and Mitsuru Hashida Controlled Release of Paracetamol from Amylodextrin Tablets: Jn Vitro and in Vivo Results (PDD) Jacoba van der Veen, Anko C. Eissens, and Coenraad F. Lerk Pharmacokinetic Analysis of the Absorption Enhancing Action of Decanoic Acid and Its Derivatives in Rats (PDD/PPDM) Koji Takahashi, Teruo Murakami, Atsuko Kamata, Ryoko Yumoto, Yutaka Higashi, and Noboru Yata Diffusion and Metabolism of Prednisolone Farnesylate in Viable Skin of the Hairless Mouse (PDD) Kakuji Tojo, Kayoko Yamada, and Tomohiro Hikima Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex Formation (PDD) Andrew X. Chen, §. William Zito, and Robert A. Nash Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes (PPDM/PDD) Hideyoshi Harashima, Kazuya Sakata, Kouichi Funato, and Hiroshi Kiwada Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake Sites (PPDM) Takao Aoyama, Hajime Kotaki, Yasufumi Sawada, and Tatsuji lga CONTENTS (Continued) Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood-Brain Barrier Permeability of Peptides (PPDM) Elsbeth G. Chikhale, Ka-Yun Ne, Philip S. Burton, and Ronald T. Borchardt Accumulation Kinetics of Propranolol in the Rat: Comparison of Michaelis—Menten-Mediated Clearance and Clearance Changes Consistent with the ** Altered Enzyme Hypothesis” (PPDM) Cornelia Weber, Klaus Stoeckel, and David Lalka Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog (PPDM) Jeffrey S. Barrett, Robert J. Gould, Joan D. Ellis, Marie M. Holahan, Maria T. Stranieri, Joseph J. Lynch, Jr., George D. Hartman, Nathan Ihle, Mark Duggan, Ofir A. Moreno, and Anthony D. Theoharides Site-Differential Gastrointestinal Absorption of Benazepril Hydrochloride in Healthy Volunteers (PPDM) Keith K. H. Chan, Akshay Buch, Robert D. Glazer, Vivian A. John, and William H. Barr Dose-Dependent Pharmacokinetics of L-693,612, a Carbonic Anhydrase Inhibitor, Following Oral Administration in Rats (PPDM) Bradley K. Wong, Patrick J. Bruhin, and Jiunn H. Lin Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells (PPDM) Ulrich Jaehde, Rosalinde Masereeuw, Albertus G. De Boer, Gert Fricker, J. Fred Nagelkerke, J. Vonderscher, and Douwe D. Breimer Analytical Chiral Separation of the Stereoisomers of a Novel Carbonic Anhydrase Inhibitor and Its Deethylated Metabolite, and the Assignment of Absolute Configuration of the Human Metabolite and Chiral Degradation Products (APQ) Bogdan K. Matuszewski, Marvin L. Constanzer, and Mary Kiganda TECHNICAL NOTES Novel Stabilizing Method for Antisense Oligodeoxynucleotides (Biotec) Toshihiko Sueishi, Toshinobu Seki, Kazuhiko Juni, Tetsuya Hasegawa, Mineo Saneyoshi, and Takeo Kawaguchi 'H-NMR and '°C-NMR Spectral Assignments of Spiramycins I and III (MNPC) Kumar Ramu, Sachin Shringarpure, Steven Cooperwood, John M. Beale, and John §. Williamson Rapid Synthesis of 3-['*F]Fluoro-1-(2'-Nitro-1'-Imidazolyl)-2-Propanol ({'*F]Fluoromisonidazole) (MNPC) Abdallah Cherif, David J. Yang, Wayne Tansey, E. Edmund Kim, and Sidney Wallace PHARMACEUTICAL RESEARCH REVIEWERS FOR THE EDITORIAL OFFICE, JAPAN (October 1992—September 1993) PHARMACEUTICAL RESEARCH Official Journal of the American Association of Pharmaceutical Scientists Volume 11 Number 4 April 1994 CONTENTS RESEARCH ARTICLES The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids (PDD) Bruno C. Hancock and George Zografi Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous System (PT) Toshiyuki Niwa, Hirofumi Takeuchi, Tomoaki Hino, Akira Itoh, Yoshiaki Kawashima, and Katsumi Kiuchi REPORTS Chromatographic Methods for Quantitative Analysis of Native, Denatured, and Aggregated Basic Fibroblast Growth Factor in Solution Formulations (Biotec/APQ) Victoria Sluzky, Zahra Shahrokh, Pamela Stratton, Gert Eberlein, and Y. John Wang Characterization of Aerosols of Human Recombinant Deoxyribonuclease I (rhDNase) Generated by Jet Nebulizers (Biotec/PDD) David Cipolla, lgor Gonda, and Steven J. Shire Controlled Release of Theophylline Monohydrate from Amylodextrin Tablets: Jn Vitro Observations (PDD) Jacoba Van der Veen, Gerrit H. P. Te Wierik, Liesbeth Van der Wal, Anko C. Eissens, and Coenraad F. Lerk Entrapping Efficiency and Drug Release Profile of an Oil-in-Water (o/w) Emulsion Formulation Using a Polydimethylsiloxane-Coated Glass Bead Assay (PDD) Toshiya Minagawa, Yoshiro Kohno, Toshio Suwa, and Akira Tsuji A Quantitative Concept of the Mechanism of Intestinal Lymphatic Transfer of Lipophilic Molecules (PDD/PPDM) Teruhisa Ichihashi, Toru Nagasaki, Yasushi Takagishi, and Hideo Yamada Alveolar Permeability Enhancement by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent Mechanism (PDD) Li Ying Wang, Joseph K. H. Ma, Wei Fang Pan, David Toledo-Velasquez, Carl J. Malanga, and Yongyut Rojanasakul Activation of Fc Receptor-Mediated Phagocytosis by Mouse Peritoneal Macrophages Following the Intraperitoneal Administration of Liposomes (PDD/PPDM) Yukihiko Aramaki, Makoto Murai, and Seishi Tsuchiya The Effect of Temperature and pH on the Solubility of Quinolone Compounds: Estimation of Heat Fusion (PDD) Xuangiang Yu, Gail L. Zipp, and G. W. Ray Davidson Ill Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid (PDD) Peter Langguth, Hans P. Merkle, and Gordon L. Amidon Pharmacodynamics of Phenobarbital Anesthesia and Pentylenetetrazol-Induced Maximal Seizures in a Rat Model of Neoplastic Spinal Cord Compression (PPDM) Amnon Hoffman, Jose Alfon, Tzony Siegal, and Tali Siegal CONTENTS (Continued) Effects of Acute and Chronic Inflammation on the Pharmacokinetics of Prednisolone in Rats (PPDM) Varun Garg, Yuen Yi Hon, and William J. Jusko Simulation for the Analysis of Distorted Pharmacodynamic Data (PPDM) Yukiya Hashimoto, Junko Ozaki, Toshiko Koue, Atsuko Odani, Masato Yasuhara, and Ryohei Hori Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of Administration (PPDM) Eva Bredberg, Hans Lennernds, and Lennart Paalzow An Assessment of the 4-6-20 Rule for Acceptance of Analytical Runs in Bioavailability, Bioequivalence, and Pharmacokinetic Studies (APQ/PPDM) Robert O. Kringle The Use of Fourier Transform Infrared (FT-IR) Spectroscopy to Determine the Diffusion Coefficients of Alcohols in Polydimethylsiloxane (APQ) Varaporn Buraphacheep, Dale Eric Wurster, and Dale E. Wurster A Simple and Rapid Fluorometric Determination Method of a,-Acid Glycoprotein in Serum Using Quinaldine Red (APQ/PPDM) Hitoshi Imamura, Toru Maruyama, Hiroaki Okabe, Hidekata Shimada, and Masaki Otagiri Synthesis and Evaluation of Amino Analogues of Valproic Acid (MNPC) K. R. Scott, Sandra Adesioye, Patricia B. Ayuk, Ivan O. Edafiogho, Dolly John, Patrick Kodwin, Thomasena Maxwell-Irving, Jacqueline A. Moore, and Jesse M. Nicholson Development and Evaluation of Sustained-Release Ibuprofen—Wax Microspheres. Il. Jn Vitro Dissolution Studies (PT) Christianah M. Adeyeye and James C. Price TECHNICAL NOTES Dosing Reproducibility from Experimental Albuterol Suspension Metered-Dose Inhalers (Biotec/PDD) Peter R. Byron Adsorption of Beta-Blockers onto Polyisobutylcyanoacrylate Nanoparticles Measured by Depletion and Dielectric Methods (PDD) Emmanuelle Benoit, Odile Prot, Philippe Maincent, and Jacques Bessiére A Novel Assay to Determine the Hemolytic Activity of Drugs Incorporated in Colloidal Carrier Systems (PDD/Toxicol) Thomas K. Bock and Bernd W. Miller Variability in Gastric pH and Delayed Gastric Emptying in Yucatan Miniature Pigs Rebecca L. Oberle and Helena Das Mathematical Analysis and Optimization of a Flow-Through Diffusion Cell System Hoo-Kyun Choi and James T. Angello Videomicroscopy Techniques for Agglomeration Studies Lorraine E. Pena, Barbara L. Lee, and James F. Stearns Effects of Sampling Chamber Volume and Geometry on Aerodynamic Size Distributions of Metered-Dose Inhalation Aerosols Measured with the Andersen Cascade Impactor Michiel Van Oort, Rebecca O. Gollmar, and Robert J. Bohinski ASSOCIATION NEWS AND ANNOUNCEMENTS