Pharmaceutical Calculations 15

469 Pages·2016·18.27 MB·English

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Pharmaceutical Calculations
15 h Edit ion
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P h a rm a c e u t ic a l
Ca lc u la t ion s
15 h Edit ion
H war C. A sel, Phd
Professor and Dean Emeritus
College of Pharmacy
University of Georgia
Athens, Georgia
Shelly J. S ck , Phd, RPh
Professor
College of Pharmacy
Southwestern Oklahoma State University
Weatherford, Oklahoma
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15th Edition
Copyright © 2017 Wolters Kluwer
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. Copyright © 2010, 2006, 2001,
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Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Ansel, Howard C., 1933- , author. | Stockton, Shelly J., author.
Title: Pharmaceutical calculations / Howard C. Ansel, Shelly J. Stockton.
Description: 15th edition. | Philadelphia : Wolters Kluwer, [2016] | Includes
bibliographical references and index.
Identifiers: LCCN 2015039620 | ISBN 9781496300713 (alk. paper)
Subjects: | MESH: Drug Dosage Calculations. | Pharmaceutical
Preparations—administration & dosage.
Classification: LCC RS57 | NLM QV 748 | DDC 615.1/401513—dc23 LC record available at http://lccn.loc.
gov/2015039620
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any
warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of
each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions,
medication history, laboratory data and other factors unique to the patient. The publisher does not provide medi-
cal advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher,
are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and
treatments.
Given continuous, rapid advances in medical science and health information, independent professional verifica-
tion of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options
should be made and healthcare professionals should consult a variety of sources. When prescribing medication,
healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert)
accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify
any changes in dosage schedule or contraindications, particularly if the medication to be administered is new,
infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no
responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of
products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
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Preface
T he 15th edition of Pharmaceutical Calculations marks the introduction of Professor Shelly
Stockton as co-author. Professor Stockton’s experience in pharmacy practice and her exper-
tise in teaching pharmaceutics and pharmacy calculations are reflected in her substantial
contributions to this textbook. Combined with the many progressive changes recom-
mended by a select review team of pharmacy students, practitioners, and educators, this new
edition maintains the standard for today’s academic and basic practice requirements in the
subject area of pharmaceutical calculations.
Each chapter has been thoroughly revised with the focus directed toward providing
basic pharmaceutical calculations along with supporting explanations of the pharmaceutical
or clinical purpose underpinning each type of calculation. Hundreds of new problems have
been added to include many current products encountered in pharmacy practice. Relevance
is further demonstrated by the inclusion of select product labels directly linked to example
problems. New in this edition are Authors’ Extra Points that provide brief explanations of
select underlying subjects, as: pharmacopeias, electronic prescriptions, drug names, and the regu-
lation of pharmacy compounding. A section on equianalgesic dosing for narcotic analgesics has
been added to Chapter 10 along with dosing tables related to the subject.
All of the valued features of the previous edition have been retained and enhanced,
including the following: in-chapter example problems with step-by-step solutions; end-of-
chapter practice problems with answers; Case-in-Point features that provide clinical or phar-
maceutical case studies; Calculations Capsules that provide boxed summaries of chapter
calculations; CalcQuiz sections that provide a limited number of unsolved problems, useful as
homework, quiz, or assessment exercises; and, the Comprehensive Review Problems at the end
of the book that provide multipart solved problems for student use as a final self-assessment.
T hroughout its history, this textbook has served as a valuable resource in meeting the
instructional needs of pharmacy students in the area of pharmaceutical calculations. T his
new edition is expected to continue to meet that need.
Compan on Web s te
Pharmaceutical Calculations, 15th edition, includes additional resources for both instructors and
students, available on the book’s companion Web site at http://thePoint.lww.com/Ansel15e.
Resources for Students
•  Interactive math calculations Quiz Bank, with more than 400 review problems and
detailed solutions
Resources for instructors
•  CalcQuiz Solutions
•  Searchable Full Text Online
See the inside front cover for more details, including the passcode you will need to gain
access to the Web site.
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Acknowledgments
T he author gratefully acknowledges the contributions to this revision by the following per-
sons: Tom Schoenbachler, for insights into contemporary community pharmacy practice;
Deborah Elder, for contributions in the area of pharmacy compounding; Ken Duke, for
problems in the area of nuclear pharmacy; Warren Beach, for some Case-in-Point calcula-
tions; Flynn Warren, for a host of problems including many relating to institutional phar-
macy practice; Michael Ansel and Catherine Chuter, for information on the verification and
data processing of electronic prescriptions; Les Ramos and Margaret Ramos, for their input
in various areas of clinical calculations; Hardeep Saluja and Sarai Flynn for contributions to
the chapter on bioavailability and pharmacokinetics; Patra Kositchaiwat and Ryan Varghese
for their input in the area of electrolyte solution calculations; and Loyd V. Allen, Jr. for
his continued courtesy in allowing use of formulas published in the International Journal of
Pharmaceutical Compounding.
Gratitude is expressed to the following reviewers, whose experience was drawn upon
during the planning process and whose thoughtful analysis and constructive comments led
to many of the changes in this revision: Stacy Cairns, Kimberly Daugherty, David Dubins,
Heather Gegenhuber, Nancy Kleiman, William Kolling, Kimberly Nguyen, and Tien Phan.
Particular thanks are offered to Tari Broderick, Senior Acquisitions Editor, and
Stephanie Roulias, Product Development Editor, for their support and guidance during the
revision process and to the other exceptional people at Wolters Kluwer Health | Lippincott
Williams & Wilkins for their work in the design, preparation, and production of this revi-
sion. Finally, special appreciation is extended to Tom Conville for his expertise in copyedit-
ing and assistance in resource development.
Howard C. Ansel
Athens, Georgia
Shelly J. Stockton
Weatherford, Oklahoma
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