Phagocytosis–Past and Future PDF
Preview Phagocytosis–Past and Future
Academic Press Rapid Manuscript Reproduction Based on the Conference "A Century Since Metchnikoff: Phagocytosis—Past and Future" Held in the Province of Messina, Sicily, Italy, September 22-27, 1980 Phagocytosis—Past and Future Edited by Manfred L. Karnovsky Department of Biological Chemistry Harvard Medical School Boston. Massachusetts Liana Bolis Department of Comparative Physiology University of Messina Sicily, Italy 1982 ACADEMIC PRESS A Subsidiary of Harcourt Brace Jovanovich, Publishers New York London Paris San Diego San Francisco Säo Paulo Sydney Tokyo Toronto COPYRIGHT © 1982, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW1 7DX Library of Congress Cataloging in Publication Data Main entry under title: Phagocytosis—past and future. Outgrowth of a symposium held at the University of Messina, Sept. 22-27, 1980. Bibliography: p. Includes index. 1. Phagocytosis—Congresses. I. Karnovsky, Manfred, Date. II. Bolis, Liana. [DNLM: 1. Phagocytosis. QW 690 P534] QR187.P4P49 1982 616.07'9 82-11461 ISBN 0-12-400050-9 PRINTED IN THE UNITED STATES OF AMERICA 82 83 84 85 9 8 7 6 5 4 3 2 1 Contributors Numbers in parentheses indicate the pages on which the authors' contributions begin. Jon S. Abramson1 (463), Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455 S. K. Adeniyi-Jones2 (193), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 M. Aellig (149), Laboratoire Central de Chemie Clinique, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011 Lausanne, Switzerland Β. A. Askonas (505), Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, England Bernard M. Babior (157), Hematology Service, Department of Medicine, Tufts University School of Medicine, and New England Medical Center Hospital, Boston, Massachusetts 02111 John A. Badwey (193, 419), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 M. Baggiolini (339), Wander Research Institute, Wander Ltd., CH-3001 Berne, Switzerland Frederik Β. Bang3 (567), Department of Pathobiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, and Marine Biological Laboratory, Woods Hole, Massachusetts 02543 Zvi Bar-Shavit (259), Department of Membrane Research, Weizmann Institute of Science, Rehovot, Israel Elmer L. Becker (87), Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 P. Bellavite (167), Istituto di Patologia Generale, Facolta di Medicina e Chirurgia, Universita di Padova-Sede di Verona, Verona, Italy 'Present address: Department of Pediatrics, Bowman-Gray School of Medicine, Winston-Salem, North Carolina 27103. 2Present address: National Institutes of Health, Bethesda, Maryland 20205. 3Deceased. ix χ Contributors G. Berton (167), Istituto di Patologia Generale, Facoltâ di Mediana e Chirurgia, Universitâ di Padova-Sede di Verona, Verona, Italy J. Thomas Blake (239), Department of Immunology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065 Robert W. Bonser (131), Molecular Biology Department, The Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709 James A. Braatz (323), Laboratory of Immunodiagnosis, National Cancer In- stitute, National Institutes of Health, Bethesda, Maryland 20205 Richard T. Briggs (215), Department of Biological Sciences, Smith College, Northampton, Massachusetts 01063, George Cianciolo (67), Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, North Carolina 27710 Charles G. Cochrane (543), Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California 92037 B. Dewald (339), Wander Research Institute, Wander Ltd., CH-3001 Berne, Switzerland David Drath4 (419), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 Robert M. Fauve (295), Unité d'Immunophysiologie Cellulaire, Institut Pasteur, 75724 Paris Cedex 15, France Douglas T. Fearon (375), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 Elisabeth Fontan (295), Unité d'Immunophysiologie Cellulaire, Institut Pasteur, 75724 Paris Cedex 15, France Richard J. Freer5 (87), Department of Pharmacology, University of Connecticut Health Center, Farmington, Connecticut 06032 J. Frei (149), Laboratoire Central de Chemie Clinique, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011 Lausanne, Switzerland Elaine Κ. Gallin (29), Physiology Department, Armed Forces Radiology Research Institute, Bethesda, Maryland 20014 John I. Gallin (519), Bacterial Diseases Section, Laboratory of Clinical Investiga- tion, National Institute of Allergy and Infectious Diseases, National In- stitutes of Health, Bethesda, Maryland 20205 Rachel Goldman (259), Department of Membrane Research, Weizmann Institute of Science, Rehovot, Israel Siamon Gordon (287), Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England Otto Götze (357), Abteilung für Immunologie, Zentrum für Hygiene und Humangenetik der Universität, 3400 Göttingen, Federal Republic of Germany 4Present address: University of Texas Medical School, Houston, Texas 77030. 'Present address: Department of Pharmacology, Medical College of Virginia, Richmond, Virginia 23298. Contributors xi C. M. Grosskinsky (505), Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, England P. D'Arcy Hart (437), Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, England W. R. Henderson (449), Department of Medicine, School of Medicine, Universi- ty of Washington, Seattle, Washington 98195 Ronald B. Herberman (323), Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205 Brigitte Hevin (295), Unité d'Immunophysiologie Cellulaire, Institut Pasteur, 75724 Paris Cedex 15, France G. A. Higgs (105), Department of Prostaglandin Research, The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, England Beate I. Hirsch (1), Department of Graduate Studies, The Rockefeller Univer- sity, New York, New York 10021 James G. Hirsch6 (1), Department of Graduate Studies, The Rockefeller University, New York, New York 10021 S. T. Hoffstein (47), Department of Medicine, New York University Medical Center, New York, New York 10016 A. Jörg (449), Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195 C. Michael Jones7 (323), Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205 E. C. Jong (449), Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195 Manfred L. Karnovsky (193, 215, 419), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 Morris J. Karnovsky (193, 215), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 S. J. Klebanoff (449), Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195 Η. M. Korchak (47), Department of Medicine, New York University Medical Center, New York, New York 10016 Janis Lazdins8 (419), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 P. C. J. Leijh (429), Department of Infectious Diseases, University Hospital, 2333 AA Leiden, The Netherlands Edward J. Leonard (475), Department of Immunology, Walter Reed Army In- stitute of Research, Washington, D.C. 20012 S. H. Liu (553), Department of Ophthalmology, The Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 6Present address: Josiah Macy Jr. Foundation, New York, New York 10020. 7Present address: University of Texas at Houston, Houston, Texas 77030. 8Present address: Pfizer, Inc., Groton, Connecticut 06340. xii Contributors R. M. Locksley (449), Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195 G. A. Lutty (553), Department of Ophthalmology, The Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 M. Maillard (149), Laboratoire Central de Chemie Clinique, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011 Lausanne, Switzerland M. Markert (149), Laboratoire Central de Chemie Clinique, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011 Lausanne, Switzerland Monte S. Meitzer (475), Laboratory of Immunology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205 Elaine L. Mills9 (463), Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455 Paul H. Naccache (87), Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 Carol A. Nacy (475), Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20012 Carl F. Nathan (391), The Rockefeller University, New York, New York 10021 A. Pätz (553), Department of Ophthalmology, The Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Marilyn C. Pike (67), Division of Rheumatic and Genetic Diseases, Duke Univer- sity Medical Center, Durham, North Carolina 27710 R. A. Prendergast (553), Department of Ophthalmology, The Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Paul Q. Quie (463), Department of Pediatrics and Laboratory of Medical Pathology and Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 P. G. Ramsey (449), Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195 John M. Robinson (193, 215), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Alan S. Rosenthal (239), Department of Immunology, Merck Sharp & Dohme Research Laboratories, Rah way, New Jersey 07065 F. Rossi (167), Istituto di Patologia Generale, Facolta di Mediana e Chirurgia, Universita di Padova-Sede di Verona, Verona, Italy D. L. Sacks (505), Division of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, England J. Schnyder (339), Wander Research Institute, Wander Ltd., CH-3001 Berne, Switzerland Ramadan I. Sha'afi (87), Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06032 'Present address: Department of Pediatrics, McGill University, and Montreal Children's Hospital, Montreal PQ H3H1P3, Canada. Contributors xiii Henry J. Showell10 (87), Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 Marvin I. Siegel (131), Molecular Biology Department, The Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, North Carolina 27709 J. E. Smolen (47), Department of Medicine, New York University Medical Center, New York, New York 10016 Ralph Snyderman (67), Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, North Carolina 27710 Roy J. Soberman11 (419), Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115 Thomas P. Stossel (13), Hematology-Oncology Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114 John S. Sundsmo (357), Department of Molecular Immunology, Research In- stitute of Scripps Clinic, La Jolla, California 92037 James W. Thomas12 (239), Department of Immunology, Merck Sharp & Dohme Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065 D. C. Thompson (553), Department of Ophthalmology, The Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Ronald W. Walenga13 (87), Department of Pharmacology, University of Connec- ticut Health Center, Farmington, Connecticut 06032 G. Weissmann (47), Department of Medicine, New York University Medical Center, New York, New York 10016 Masonori Yanai14 (463), University of Minnesota Medical School, Minneapolis, Minnesota 55455 Helen L. Yin (13), Hematology-Oncology Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114 R. van Furth (429), Department of Internal Medicine and Infectious Diseases, Academisch Ziekenhuis Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands 10Present address: Pfizer Central Research, Pfizer, Inc., Groton, Connecticut 06340. "Present address: Department of Medicine, Harvard Medical School. 12Present address: Department of Pathology, The Jewish Hospital of St. Louis, St. Louis, Missouri 63110. ,3Present address: Department of Pharmacology, School of Medicine, Univer- sity of Syracuse, Syracuse, New York 13210. 14Present address: Nagasaki University Hospital, Nagasaki City, Nagasaki 852, Japan. Preface The functions of phagocytic leukocytes in the host-parasite relationship are well understood in 1982, as we hope this volume attests. A hundred years ago those functions had not begun to be appreciated. It was between 1879 and 1882 that Metchnikoff, working in Messina, "discovered" phagocytosis, or, better, formulated for the first time, in a dramatic and forceful way, the concept of a role for "wandering" cells in the control of infection and injury. In October 1980, fifty investigators met in the Province of Messina, Sicily, to examine the current status of the field whose explosive development Metchnikoff had triggered a century before. The topics discussed were largely in the areas of cell biology, cellular immunology, and biochemistry. They ranged from aspects of cellular movement and the ingestion process per se, to definition of substances that affect the function of phagocytic leukocytes, and to the nature of cidal mechanisms at the molecular level. Though at first blush this suggests a very broad coverage of the field, the editors and contributors all recognize that a wealth of matters, mainly more clinically linked, remain to be surveyed. The organizers of, and participants in, the meeting in Messina—who are the editors of, and contributors to this book — ensured that the observance of the centennial was not merely ceremonial. Taking stock of a field is often a valuable exercise. It can be productive, too, in preparing the springboard for the next ven- tures. We are deeply grateful for help received from many quarters. The World Health Organization was the sponsor and the University of Messina was the academic core of the enterprise. The list of those organizations that helped launch the meeting and discussions that led to this book is long: Fidia Research Laboratories (Abano Terme); Lirca Laboratories; Merck Sharp & Dohme Re- search Laboratories; E. R. Squibb and Sons, Inc.; the Upjohn Company; the Well- come Research Laboratories; Lederle Laboratories; and the Sterling - Winthrop Research Institute. Even longer is the list of agencies and institutions in Sicily, and of individuals, whose efforts made it possible for the scientists to enjoy both their science and the ambience. To thank them all would require a separate chapter. XV xvi Preface The organization of the topics will seem idiosyncratic to some. It bears little resemblance to that of the meeting. However, every book with multiple authors needs editors, and the latter have tried in this instance to fashion a coherent structure. The individual chapters reflecting the talks that were given were modified by the discussion and exchange of views in Messina. Each certainly con- tributes to the field information that is seminal, significant, and salient. Manfred L. Karnovsky Liana Bolis
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