Table Of Content

pHCONTROLLEDDRUGRELEASEFORDENTALAPPLICATIONS OAFDTIHSESOEUFRNTITAVHTEEIRROSNEIDQTPOYURCIEOTRSFOEEFRMNLETOONEFRTDIPSDTHAFOIOLITRNOHSPTEOAHPGREHTRDYIAEADGLURFAEUTELEFOSIFCLLHMOEONLT UNIVERSITYOFFLORIDA Copyright1997 by JohnF.Wironen TomyparentsJeanneandFrancisWironen,andtomyuncle,thelateRev. AureliusGariepy.Betterrole-modelscouldnotexist. ACKNOWLEDGMENTS IwouldliketoexpressmydeepestgratitudetoDr.ChristopherBatich,my committeechairmanandmentor,forhispatientunderstandingandencouragement,and forthefreedomhegrantedmeduringmystudies.Veryfewadvisorswouldhaveallowed methetremendousopportunitiesIhaveenjoyedunderhisguidance.Specialthanksto myothercommitteemembersincludingDr.AnthonyBrennan.Dr.ElliotDouglas.Dr. JalascoklMiekechtooltshkayn,kaDnrd.DSrh.enJ,ohwnhoRewyhniolledsnoftoarnthoefifriceixaclelmleemntbecrritoifqmueysacnodmmaidtvticeee.,hIawsould helpedmeagreatdealtowardfulfillingmygoals,andhastaughtmetobeabetter scientistintheprocess, 1cannotfullyexpressmygratitudetomyfellowstudentsandcolleagues,now dearfriends,whohelped,cajoled,andencouragedmeduringmytenure.Theseinclude DrewAmery,JackieArnold,JesseArnold,TravisArola,ShannonEggcrs,BobHadba, PenelopeKao,JamesKirk,AdamLecky,GilbertoLunardi,JamesMarotta.PaulMartin, TomMiller,Dr.LynnPeck.ChrisSakcalcs,Dr.BillToreki,WeiLei,ChrisWidenhouse. Dr.JunYan,StacyZambo,andMikeZamora. mewheInwtohuelbdilllsikaentdopeaxtpeenrdwoarskpenceicaelsstahraynktsotkoeJepammeesoMnartortatcakfwoerruendfuaiel.inIglwyourlemdianldsiong liketothankTravisArolaforhishelpwiththeswellingexperiments,andWeiLeiforhis constantaidandadvice.SpecialthankstoPaulManinforhishelpwithSEM'sand prreomciensdsi.ngIwmoeulthdatlitkheerteotishamnokremyto2l0ifenitehcaenswaonrdknaenpdhescwhsooaln.dmy"littlebrother"Mattfor TABLEOFCONTENTS ACKNOWLEDGMENTS LISTOFTABLES LISTOFFIGURES ABSTRACT CHAPTIENRTR1ODUCTION CHAPTBEARC2KGROUND. SMyAntThEesRiDIsFAoALfS/MiMAcIMrhNoeADsapoqMhrucEerDoeTFusHAsO/phEDaMSsAeMicrosphcres MSyinctmhsepsihseroefsStsytruebneIn4t.nnVsiincyaljiPyyrliodaidneedMifclruoosnpdheeres MLSoiynactdrhioensPgCiashonlfioocfMlrifehciearDuxonroisdundpgdMmheieeacrnIlrednoosaadsdmrdpeuhtedgedhrMseMAoitnlcS-tcrjiurolbopeiisoaonprDtthepiietrccreeslepreasmsriantaitoinon loadingFDFDlfrTiTueuyeocgcmrhiigSndooieSflqtuLDueboerpiasuhdgleySdoMliutciroonpaCnoinccleenstrationo: MeasiuePHemirgechne-tnPtorfeLcotihasediioSnnwgeMleAlnaiasnlugyrsoeifmsMeinctrocsfpthheerSeuse.ingofMicrospheres Comparisonoftwotcchmqu lingofDmgloadedMtcrospherc :regressiondataanalyst EfficacyofMicrospheresinBrothS,m CHAPTCSEyOnRNtShCeLsiUsSIONS CHAPTFSEyUnRtTh6UesRiEsaWnOdRLoKading USTOFREFERENCES 129 BIOGRAPHICALSKETCH 136 APPENDIX:PUBLICATIONS 137 LISTOFTABLES labk page 3.1PolymerCompositions 36 3.2Solubilityoffluoridesaltsinselectedsolvents(%w/w) 39 3.3Citricacidbufferrccepies 52 4.1Sizeandsizedistributionofmicrosphercsandmicroparticlesinmicrons 70 4.2Percentloadinganalysis 71 4.3EiqmuaigliinbgrituemchsnwieqluleinagnvdaPlueepspefro'rsmiteccrhonsipqhueeresatvariouspH'sasmeasuredbydigit7a5l 4.4ThevaluesofbcalculatedfordifferentcoordinationnumbersinvariouspHbuffe7r6s 44..56TLihneeavralrueegsreosbstiaoinnaendafloyrsitsheofexecoenstsrovloedlurmeleeeasqeuactuirovness3v.e5rsaunsdt31”.6aresimilar..9717 4.7Linearregressionanalysisofselectedcontrolledreleasecurvesversuslinear