Table Of Content

Vi H: Cytoplasmic Ca?* determines the Zhang L, Weiner JL, Valiante TA, Velumian Electrophysiological evidence for the rate of Ca?* entry into Mardin-Darby AA, Watson PL, Jahromi SS, Schertzer presence of an apical H* -ATPase in canine kidney-focus (MDCK-F) cells S, Pennefather P, Carlen PL: Whole-cell Malpighian tubules of Formica 95 recording of the Ca?* -dependent slow polyctena: intracellular and luminal pH Wong PYD — Leung AYH afterhyperpolarization in hippocampal measurements 288 neurones: effects of internally applied Zhou Z, Lipsius SL: Delayed rectifier Young JA — Komwatana P anions 247 potassium current (/,) in latent atrial Zhang S-L, Leyssens A, Van Kerkhove E, pacemaker cells isolated from cat right Zegarra-Moran O — Galietta LUV Weltens R, Van Driessche W, Steels P: atrium 341 Subject index A Ca?* oscillator 89 Ca?* permeability 95 A7 cells 387 Ba?* 52 Ca?* release 174 Acetylcholine 75 BaClz 552 Ca?* Sensitivity 363, 506 Acidification 267 Barium 258 Ca?* spikes 396 Action potential 44 Baroreflexes 177 Ca?* store(s) 89, 174, 534 Action-potential-induced Ca 2* influx Basic fibroblast growth factor (bFGF) 161 Ca?* video imaging 95 214 Basilar artery 459 Ca?* -activated K* channels 465 Adenosine triphosphatase inhibitor 396 Basolateral K*-permeability 171 Ca?*-activated K* current 189 Adenosine triphosphate 524, 534 Basolateral membrane(s) 83, 101, 328 Ca?*-ATPase 89 Adenosine triphosphate (ATP) 433 Basolateral potassium concentration 288 Ca?*-dependent K* and Cl-currents 534 Adenosine 5’-triphosphate (ATP) 534 BayK8644 214 Ca?* -permeable glutamate receptors 310 Adenosine 5’-[a,f-methylene]tri- BCECF 258 [Ca?*], 320 phosphate (pp-[CH2]pA) 2',7'-bicarboxyethyl-5(6) - [Ca?*], influx 427 524 carboxyfluorescein (BCECF) 258 [Ca*]; oscillations 221 Adenylate cyclase 446 Biomedical technology 348 [Ca?*], 320 Adrenal chromaffin cells 524 2',7'-Bis(carboxyeth-5y(l6)) - Ca, extracellular 231 Adrenal endothelial cells 524 carboxyfluorescein 267 Ca intracellular 534 Adrenalectomy 183 Bladder wall tension 304 Caecum 83 a- and f-adrenergic agents 396 Blood flow (skin, forearm) 177 Caffeine 12,129, 174, 189 a,-Adrenergic stimulation 506 Body temperature 351, 371 Caffeine-induced Ca?* release 174 Afterdepolarization 548 Boltzmann function 459 Caffeine-sensitive Ca2* stores 174 Afterhyperpolarization 247 Bombesin 412 Calcium 396, 465, 499 Agarose-cushion electrodes 453 Bradykinin 524 Calcium activity 412 Alanine 121 Brain 360 Calcium channel(s) 206, 276, 459 Aldosterone 110 Brain slices 247 Calcium channel currents 239 Amiloride 75, 101, 110, 258, 267 Brain tissue PO, 348 Calcium current 12, 402, 419 Amino acids 121, 481 Brain-derived neurotrophic factor Calcium, intracellular 524 1-Amino-cyclopentane- trans-1,3- (BDNF) 161 Calcium oscillation 189 dicarboxylic acid (t-ACPD) 161 Branched-chain amino 481 Calcium removal 199 a-Amino-3-hydroxy-5-methyl-4- Brattleboro rat cochlea 446 Calcium-activated channel 440 isoxazole propionate (AMPA) 310 Brown adipose tissue 351 Calcium-activated potassium current 247 a-Aminoisobutyric acid 491 Brown adipose tissue thermogenesis 40 Calcium-dependent potassium current 12 Anion exchange 101 Brushborder fluorescence 110 Calcium-induced calcium release 129 Anterior pituitary 221 Brush-border membrane (BBM) 5 Calium oscillations 129 Anterior pituitary GH3 cells 12 Butyrate 472 Calmodulin 363 Antidiuresis 354 cAMP 101, 146, 396 Antidiuretic hormone 446 Cc cAMP-dependent protein kinase 146 Apical membrane 83, 387 cAMP-regulated epithelium 412 Apical protein 5 Ca, cytoplasmic 199 cAMP-stimulated Cl” transport 284 Arginase 481 Ga** 387 Carbachol 412, 419, 462 Arginine 121, 481 Ca** channel blockers 189 Carbachol (CCh) 231 Arterial microvessels 506 Ca?* channel inactivation 239 Cardiac filling pressure 177 Arterioles 459 Ca?* channels 12, 95, 161 Cardiac Ic, 419 ATP 44, 412, 427, 433, 524, 534 Ca?* chelator, 1,2-bis(2-aminophenoxy) Cardiac myocyte 402 ATP-sensitive K* channel 284 ethane-N,N,N’,N’,-tetraacetic acid Cardiac pacemaker cells 341 ATP-sensitive potassium channel 31 acetoxymethyl ester (BAPTA/AM) Cardiac sodium current 146 Atrial distension 276 396 Cardiomyocytes 516, 548 Atrial natriuretic peptide 276 Ca?* current(s) 161, 214, 221 Cardiomyopathic hamster (CHF 147) 516 Atrial pacemaker cells 341 Ca?* entry 95, 254 Catalase 548 Atrium 276 Ca?* homeostasis 199 Cation channel(s) 254, 387 Atrophy 155 Ca?* influx 214, 427, 524 Cation channels poorly selective 387 Avian salt gland cells 231 Ca?* oscillations 95 cDNA 5 Vi H: Cytoplasmic Ca?* determines the Zhang L, Weiner JL, Valiante TA, Velumian Electrophysiological evidence for the rate of Ca?* entry into Mardin-Darby AA, Watson PL, Jahromi SS, Schertzer presence of an apical H* -ATPase in canine kidney-focus (MDCK-F) cells S, Pennefather P, Carlen PL: Whole-cell Malpighian tubules of Formica 95 recording of the Ca?* -dependent slow polyctena: intracellular and luminal pH Wong PYD — Leung AYH afterhyperpolarization in hippocampal measurements 288 neurones: effects of internally applied Zhou Z, Lipsius SL: Delayed rectifier Young JA — Komwatana P anions 247 potassium current (/,) in latent atrial Zhang S-L, Leyssens A, Van Kerkhove E, pacemaker cells isolated from cat right Zegarra-Moran O — Galietta LUV Weltens R, Van Driessche W, Steels P: atrium 341 Subject index A Ca?* oscillator 89 Ca?* permeability 95 A7 cells 387 Ba?* 52 Ca?* release 174 Acetylcholine 75 BaClz 552 Ca?* Sensitivity 363, 506 Acidification 267 Barium 258 Ca?* spikes 396 Action potential 44 Baroreflexes 177 Ca?* store(s) 89, 174, 534 Action-potential-induced Ca 2* influx Basic fibroblast growth factor (bFGF) 161 Ca?* video imaging 95 214 Basilar artery 459 Ca?* -activated K* channels 465 Adenosine triphosphatase inhibitor 396 Basolateral K*-permeability 171 Ca?*-activated K* current 189 Adenosine triphosphate 524, 534 Basolateral membrane(s) 83, 101, 328 Ca?*-ATPase 89 Adenosine triphosphate (ATP) 433 Basolateral potassium concentration 288 Ca?*-dependent K* and Cl-currents 534 Adenosine 5’-triphosphate (ATP) 534 BayK8644 214 Ca?* -permeable glutamate receptors 310 Adenosine 5’-[a,f-methylene]tri- BCECF 258 [Ca?*], 320 phosphate (pp-[CH2]pA) 2',7'-bicarboxyethyl-5(6) - [Ca?*], influx 427 524 carboxyfluorescein (BCECF) 258 [Ca*]; oscillations 221 Adenylate cyclase 446 Biomedical technology 348 [Ca?*], 320 Adrenal chromaffin cells 524 2',7'-Bis(carboxyeth-5y(l6)) - Ca, extracellular 231 Adrenal endothelial cells 524 carboxyfluorescein 267 Ca intracellular 534 Adrenalectomy 183 Bladder wall tension 304 Caecum 83 a- and f-adrenergic agents 396 Blood flow (skin, forearm) 177 Caffeine 12,129, 174, 189 a,-Adrenergic stimulation 506 Body temperature 351, 371 Caffeine-induced Ca?* release 174 Afterdepolarization 548 Boltzmann function 459 Caffeine-sensitive Ca2* stores 174 Afterhyperpolarization 247 Bombesin 412 Calcium 396, 465, 499 Agarose-cushion electrodes 453 Bradykinin 524 Calcium activity 412 Alanine 121 Brain 360 Calcium channel(s) 206, 276, 459 Aldosterone 110 Brain slices 247 Calcium channel currents 239 Amiloride 75, 101, 110, 258, 267 Brain tissue PO, 348 Calcium current 12, 402, 419 Amino acids 121, 481 Brain-derived neurotrophic factor Calcium, intracellular 524 1-Amino-cyclopentane- trans-1,3- (BDNF) 161 Calcium oscillation 189 dicarboxylic acid (t-ACPD) 161 Branched-chain amino 481 Calcium removal 199 a-Amino-3-hydroxy-5-methyl-4- Brattleboro rat cochlea 446 Calcium-activated channel 440 isoxazole propionate (AMPA) 310 Brown adipose tissue 351 Calcium-activated potassium current 247 a-Aminoisobutyric acid 491 Brown adipose tissue thermogenesis 40 Calcium-dependent potassium current 12 Anion exchange 101 Brushborder fluorescence 110 Calcium-induced calcium release 129 Anterior pituitary 221 Brush-border membrane (BBM) 5 Calium oscillations 129 Anterior pituitary GH3 cells 12 Butyrate 472 Calmodulin 363 Antidiuresis 354 cAMP 101, 146, 396 Antidiuretic hormone 446 Cc cAMP-dependent protein kinase 146 Apical membrane 83, 387 cAMP-regulated epithelium 412 Apical protein 5 Ca, cytoplasmic 199 cAMP-stimulated Cl” transport 284 Arginase 481 Ga** 387 Carbachol 412, 419, 462 Arginine 121, 481 Ca** channel blockers 189 Carbachol (CCh) 231 Arterial microvessels 506 Ca?* channel inactivation 239 Cardiac filling pressure 177 Arterioles 459 Ca?* channels 12, 95, 161 Cardiac Ic, 419 ATP 44, 412, 427, 433, 524, 534 Ca?* chelator, 1,2-bis(2-aminophenoxy) Cardiac myocyte 402 ATP-sensitive K* channel 284 ethane-N,N,N’,N’,-tetraacetic acid Cardiac pacemaker cells 341 ATP-sensitive potassium channel 31 acetoxymethyl ester (BAPTA/AM) Cardiac sodium current 146 Atrial distension 276 396 Cardiomyocytes 516, 548 Atrial natriuretic peptide 276 Ca?* current(s) 161, 214, 221 Cardiomyopathic hamster (CHF 147) 516 Atrial pacemaker cells 341 Ca?* entry 95, 254 Catalase 548 Atrium 276 Ca?* homeostasis 199 Cation channel(s) 254, 387 Atrophy 155 Ca?* influx 214, 427, 524 Cation channels poorly selective 387 Avian salt gland cells 231 Ca?* oscillations 95 cDNA 5 Cell culture 396 6,7-dinitroquinoxaline-2,3-dione Glutamate 161 Cell excitability 221 (DNQX) 161 Glutamate receptor agonists 161 Cell transformation 89 2,5-di-(tetr-butyl) -1,4- Glutamate receptors 310 Cell volume 462 benzohydroquinone 89 Glutamine 121, 481 Central mammalian neurones 174 Diurnal rhythm 183 Glycerol 387 Cerebral arterioles 459 Divalent cations 387 G-protein(s) 206, 472 Cerebral blood flow 183 Dorsal-root ganglion neurons 214 @-Grammotoxin 214 CFPAC-1 cells 534 DRG neuron 402 GTP-binding protein 363 CFTR 284 Duchenne (DMD) patients 499 Guanine-nucleotide-binding protein 206 cGMP 419 Duchenne muscular dystrophy 499 Guanosine triphoshate 206 Channel blockers 440 Duodenum 83 Guanosine-5'-o(2-thio- Charging compensator 453 diphosphate)(GDP[fS]) 472 Charybdotoxin 465 E Guanosine-5’-O-(3-thiotriphosphate) Chloride conductance 44 GTP[y-S] 161 Chloride current 231 Ear 258 Guanylate-cyclase 419 Chloride/bicarbonate exchange 267 Ear inner 258 GVIA 161 8-(4-chlorophenylthio)-cAMP 221 Electrodes multiwire surface 348 Cholera toxin 221 Electrolytic lesions 371 Cl” channel 472 Electrophysiologie 341 H Cl” channel blockers 231 Electrostimulation 155 H-89 {N[2-(p-bromocinnamylamino) - Cl” currents 534 Endogenous natriuretic factors 357 Cl” secretion 396, 462 Endolymph secretion 446 ethyl] -5-isoquinolinesulphonamide} 146 Cl” transport 101, 284 Endolymphatic longitudinal K* gradient H*-ATPase 288 Cl -conductance, (colon) 472 446 Heart 419 Cl-/HCO3 exchange 267 Enterocytes 83 HeLa cells 129 Cochlea 446 Epididymal epithelium 396 Hepatocytes 21 Cold acclimation 40, 351 Epithelia 387 Hexose transport 83 Collecting ducts 354, 481 Epithelial cell line HT25 427 “Hidden Markov models” 328 Colon 101, 462 Epithelial cells 284 High-voltage-activated calcium current Colonic crypt cells 267 Epithelium 171 402 Colonic crypts 472 EPO mRNA 21 Hippocampal neurones 247 Colonic epithelial cell function 110 Equilibrium potential 189 Hippocampal slices 310 Colonic-crypt-drived epithelia 110 Erythropoietin mRNA 21 Colonocyte monolayer culture 110 Euglycaemic subjects 378 Hippocampus 183 Histamine 433 «@-Conotoxin 161 Evoked currents 121 Histamine-evoked Ca?* oscillations 129 «-Conotoxin GVIA 214 Exercise 177 [SH]-N-methyl scopolamine 516 Continence reflex 304 Exercise prolonged 378 H20,2 552 Contractile force 155 Exocrine pancreas 75 Contractile proteins 363 Exocytosis 276 H,0>2 induced hyperpolarization 552 Holding potentials 146, 433 Contraction 363 Extraocular muscle 542 Hot environment 177 Coprodeum 83 HT29 427 Coronary artery smooth muscle 254 F Human adenomatous parathyroid cells Cortical collecting duct 328 320 Corticosterone 183 Fibre types 155 Human epithelial cells 284 Crypt axis 462 Field-potential 214 Human erythrocytes 357 Cg 320 Fluorescent indicator dyes 75 Human isolated colonocytes 267 Cs* 68 Force-velocity relation 542 Cg ions 52 Forearm blood flow 177 Human parathyroid 320 Cultured muscle 499 Formica polyctena 288 Human T lymphocytes 465 Hyperglycaemic subjects 378 Cultured renal cell lines 333 Forskolin 189, 221, 284 Hyperinsulinaemia 378 Cultured retinal ganglion neurons 161 Frog skin epithelium 171 Cystic fibrosis 284 Fura-2 171, 412, 427, 499 Hyperpolarization-activated inward current 68 Cystic fibrosis gene product 284 Fura-2 fluorescence 161 Cytoplasmic Ca?* 95 Fura-2 microfluorometry 524 Hypothalamic lesions 371 Cytoplasmic Ca?* oscillator 89 Fura-2/Mn?* quenching technique 95 Hypothermia 371 Hypotonicity 387 Cytoplasmic calcium 174, 199 Furosemide 101 Hypoxia 21, 371 Cytosolic calcium 524 Furosemide-induced diuresis 354 Cytosolic pH 258 G D Gastric fundic factor (GFF) 491 i, channel 68 Gastric fundic inhibition 491 IL-2 receptor 61 Daidzein 254 Gene expression 21 Ileal smooth muscle 363 Delayed rectifier 139 Genistein 254 llium 83 Developing neurons 402 GH; cells 221 Immunofluorescence 5 Diadenosine 524 Glia 52 Inactivation 239 Di-4-ANEPPS 548 Glial cells 310 Inexcitability 548 Diazoxide 284 Glibenclamide 284 Inferior oblique muscle 542 DIDS 101 Glucocorticoid hormones 110 Inner ear 258 Dietary phosphate (P;) restriction 5 Glucose kinetics 378 Inositol (1,4,5) triphosphate 231 Dimethyl amiloride 101 Glucose oxidation 378 Inositol 1,4,5-triphosphate 89, 95 Vill Inositol-triphosphate (InsP3) 129 Length/force relation 506 N InsP; 129 Leukotriene Dg 472 Na* absorption 110 Instruments and techniques 348, 453 Li* 68 Insulin 378 Liquid ion-exchange microelectrodes 354 Na channel subunits 360 Na* conductance 258 Insulin-secreting cells 31 Low-P; diet 5 Intercellular communication 89 L-type Ca?* current 12 Na*/amino acid coupling stoichiometry 121 Interleukin-2 61 L-type calcium current 419 Na*/Ca?* exchange stoichiometry 199 Internally applied anions 247 Luteinizing hormone-releasing hormone Intestinal mucosa 491 (LHRH) 296 Nadolol 396 Na*/H* Exchange 101, 267, 333 Intestinal transport 83 Lymphocyte 465 Intracellular acidification 267 Lysine 481 Na*/H* exchanger 258 Intracellular application of cAMP 146 Nak ATPase 446 Intracellular Ca2* 75, 320, 412, 499, 534 Na-K-Cl cotransport fluxes 357 Intracellular Ca?* concentration 161 Na*-K*-Cl~ -cotransporter 462 Intracellular Ca** measurements 427 M Na-P; cotransport 5 Intracellular Ca?* release 524 Natriuresis 357 Intracellular calcium 12, 171 Madin and Darby canine kidney cells Natriuretic factors 357 Intracellular microelectrode technique 44 357 Neonatal mice 446 Intracellular perfusion 146 Madin-Darby canine kidney cells 89 Nerve cell culture 206 Intracellular pH 75, 258 Madin-Darby canine kidneys-focus Neuronal caicium channel 206 Intracellular pH regulation 267 (MDCK-F) cells 95 Neurones 174, 247 Inwardly rectifying K* conductance 320 Malpighian tubulus 288 Neurons, developing 402 lon channel modulation 453 Mammalian CNS neurones 247 Neurotensin 412 lon channels 52, 328 Matrix substrata 110 NH,CI pulses 75 lon transport 357 Maxi-K channels 440 Nicotine 524 lon transport differentiation 110 M-current suppression 296 Nifedipine 161, 402 lonophoresis 433 MDCK cells 333 Nitric oxide 419 lon-sensitive microelectrodes 288 MDCK-F cells 95 5-Nitro-2-(3-phenylpropylamino) MDX mouse muscle fibres 499 (NPPB) 231 Ischaemia 44 l5x protein 139 Mechanical properties 155 N-methyl glucamine (NMG*) 68 Mechanoreceptor discharge 304 N-methyl-D-glucamine (NMDG*) 101 Isobutylmethylxanthine 221 3-isobutyl-1-methylxanthine (IBMX) Membran carriers 121 Non-selective cation channel 254 146 Membrane currents 433 Noradrenaline 396, 433 Isolated cardiomyocytes 548 Membrane potential(s) 320, 459, 552 Noradrenaline responsiveness 351 Membrane voltage 412 Noradrenaline turnover 40 Isolated hepatocytes 21 Isolated sinoatrial node cells 68 1-(3-mercapto-propanoic acid) 8-D-ar- N-phenylanthranilic acid (DPC) 231 Isolated tubule 328 ginine vasopressin (dD-AVP) 446 Nucleotide receptor 534 Isoquinolinesulphonamide 146 Metabotropic glutamate receptors 161 Nystatin 427 1 -(5-isoquinolinylsulfonyl-)2 - a-Methyl glucoside 83 methylpiperazine (H7) 296 Methylene blue 419 O Methylsulfate 247 2-Methylthioadenosine triphosphate Oestradiol 40 J (2MeSATP) 524 Oestradiol-treated rats 351 Jejunum 83 Methylxanthines 129 Onset of inactivation 239 mGluR agonists 161 Oocytes 440, 453 Microelectrode(s) 171, 354 Ornithine 481 K Micropunches 516 Oscillations 189, 231 Kainate 310 Microspectrofluorimetry 267 Osmolality of endolymph 446 Karp channels 552 Microvessels 506 Oxalate absorption, colon 101 K channel 139 Micturition reflex 304 Oxalate secretion, colon 101 K* channel(s) 52, 171, 328, 465, 472 Mineralocorticoid hormones 110 Oxidative capacity 351 K* channel blockade 310 minK channel 139 Oxygen consumption 351 K* conductance 258 M.-muscarinic receptors 516 K* conductance, (colon) 472 Mn?* quenching 95 P K* current(s) 129, 189, 310, 320, 534, Monolayer cultures 110 552 Motor units, slow 155 31P NMR spectroscopy 75 K* pipette 68 Miller (glial) cells 52 31P nuclear magnetic resonance (NMR) K* secretion 110, 446 Multiwire surface electrodes 348 spectroscopy 75 K* Sensitivity 506 Muscarine 296, 524 Pacemaker cells 341 K*-permeability 171 Muscarinic receptors 419 Pancreas 75 K current 12 Muscarinic-receptor activation 231 Pancreatic B-cell 552 Kidney 354 Muscle 61, 542 Pancreatic ducts 412 Kidney cells 89 Muscle, atrophy 155 Paracellular permeation by inulin 491 Kidney collecting ducts 481 Muscle fibre(s) 44, 499 Parathyroid cells 320 Kidney cortex (system NaPi-1) 5 Muscular Na* channels 61 Patch clamp 61, 161, 310, 328, 402, 419, Kidney-focus (MDCK-F) cells 95 Myoballs 61 465 Myocytes 276 Patch-clamp 31, 206, 231, 284, 427, 459, Myopathy 516 472, 552 L Myosin light-chain kinase 363 PCO, 333 La** block 139 Myosin-light chain phosphatase 363 “Perforated-patch technique” 206 Large intestine 83 Myotubes 499 Perilymph 446 Periodic oscillations 189 “Respiratory” acidaemia 333 Tetrameric channel formation 440 Permeability, selective 68 Respiratory responses 371 Thapsigargin 89, 171, 396, 427, 534 pH measurements, luminal + intracellular Retina 52 Theophylline 129 288 Retinal ganglion neurons 161 Thermogenesis 40 pH regulation 267 Reversal potential 189, 341 Thermoregulation 177 Phenylephrine 506 Right atrial pressure 177 Thyrotropin releasing hormone (TRH) 12 Phloridzin 83 Right atrium 341 Thyrotropin-releasing hormone 221 4-B-Phorbol 12,13-dibutyrate (PDBu) RINm5F cells 31 Tight-epithelium 171 296 Ruthenium red 129 Tissue PO 348 Phorbol ester 31, 296 Ryanodine 12, 129, 189, 276 Tolbutamide 552 Phosphoinositidase C inhibitor U73122 Transitional cells 258 89 Transmitter modulation 310 Photodynamic damage 548 Ss Transmonolayer electrical potential pH-sensitive conductance 258 difference 110 Phytohaemagglutinin stimulation 465 Salidiuretic action 357 TRH-induced inhibition 221 Pituitary anterior 221 Salivary gland 75 Two-electrode voltage clamp 453 Pituitary cells 221 Salt gland cells 231 Tyrosine kinase 254 Pituitary GH3 cells 12 Sarcomeres 542 Tyrosine residues 440 Plasma membrane transport Sarcoplasmic reticulum 276, 363 differentiation 110 Saturation binding analysis 516 PO> histogram 348 Secretagogues 462 U Polymyxin B 31 Selective permeability €3 Poorly selective cation channels 387 Sensory cells 446 Unweighting 155 Portal Vein 239 Sensory ciliated cells 446 Urea 387 Posterior hypothalamic lesions 371 SH-groups 552 Urea production 481 Post-ischaemic reperfusion 44 Short-chain fatty acids 472 Urethrane anaesthesia 371 Postnatal mice 161 Short-circuit current 396 Uridine triphosphate 534 Potassium 341 Single smooth muscle cells 239 Uridine 5’-triphosphate (UTP) 534 Potassium channel(s) 31, 139, 310, 440 Single sodium channels 360 Urinary bladder 304 Potassium clearance 52 Single-cell fura-2 microfluorometry 524 Urinary extract 357 Potassium conductance 44 Sinoatrial node cells 68 UTP 534 Potassium current 12, 139, 231, 247, 296 Skeletal muscle 360 Potassium current (Ix) 341 Skeletal muscle fibres 44 Precapillary arterioles 459 Skin blood flow 177 Vv Prefrontal cortex 183 Slow motor units 155 Proliferative activity 52 Slowpoke calcium-activated potassium Vasa recta 354 Proline 481 channels 440 Vasa recta blood 354 Protein kinase 146, 284 Small intestine 83 Vasoactive intestinal peptide 462 Protein kinase C 21, 31, 296, 333, 363 Smooth muscle 199, 363, 506 Velocity of shortening 542 Protein kinase C, inhibitors 296 Smooth muscle cells 239, 254, 433, 459 Ventricular cells 548 Protein kinase inhibitor 146 Sodium channels 61, 360 Ventricular Mz muscarinic receptors 516 Protein phosphorylation 472 Sodium current 146 Ventricular myocyte 146 Proximal tubule 333 Sodium nitroprusside 189, 419 Vesicle 276 Proximal-tubular S3 segments 5 Sodium/bicarbonate cotransport 267 Vestibular labyrinth 258 Pulmonary artery smooth-muscle cells Sodium/calcium exchange 199 Video imaging 89 433 Sodium/hydrogen exchanger 267 Voltage clamping 453 Purinoceptor subtypes 524 Soleus muscle 155 Voltage dependence 139 Purkinje neuron 402 Sperm maturation 396 Voltage-activated Ca?* currents 161 Pyramidal neocortical neurons 174 Sperm storage 396 Voitage-clamp 199, 239, 341 Spike firing adaptation 247 Voltage-dependent K* channels 52 Staurosporine 296 Voltage-dependent L-type Ca?* current Q Stomach control 491 239 Stretch 276 Voltage-gated K* currents 310 Qio 542 a-Subunit 360 Voltage-sensitive dye 548 Quisqualate 161 B,-subunit 360 Volume regulation 462 Sugar absorption 83 Sugar transport 491 R Sulphonylureas 284 Ww Surface electrodes 348 Renal inner medulla 354 Sympathetic activity 40 Whole-cell Ca?* current 214 Rb* 68 Sympathetic neurons 296 Whole-cell clamp technique 146 Reactive-oxygen-intermediates 548 System B°'* transport 121 Whole-cell patch clamp 247 Receptor activation 534 Whole-cell recording 61, 247 Receptors 433 Whole-cell voltage clamp 239 Recovery from inactivation 239 T Window current 239 Rectifying K* current 221, 320 Rectum 83 T lymphocytes 465 Relaxation 276 Temperature, influence of ... 542 Xx Renal cell lines 333 Tetraalkylammonium 320, 363 Renal S3 segment 5 Tetraethylammonium block 440 Xenopus laevis oocytes 453 Reperfusion post-ischaemic 44 Tetrahexylammonium ions 363 Xenopus oocytes 121, 139, 360, 440