Table Of Content

Vi Velussi C + Midrio M Woll E, Waldegger S, Lang F, Maly K, Xiong Z, Kitamura K, Kuriyama H: Evidence Vilella S, Guerra L, Helmle-Kolb C, Murer Grunicke H: Mechanism of intracellular for contribution of Ca** storage sites on H: Characterization of basolateral Na/H calcium oscillations in fibroblasts ex- unitary K* channel currents in inside- exchange (Na/H-1) in MDCK cells 275 pressing the ras oncogene 208 out membrane of rabbit portal vein 112 Woll E — Lang F Yakel JL: Inactivation of the Ba?* currentin Wojnowski L, GaBner B, Steigner W, dissociated Helix neurons: voltage de- Waldegger S — Woll E Oberleithner H: Endothelin-1 blunts pendence and the role of phosphoryla- Walton C > Dojat M transepithelial transport and differentiation 470 Watanabe M — Muraki K tion of Madin-Darby canine kidney Young JA — Cook DI Wegman EA — Cook DI cells 508 Weiss H — Lang F Zhu Y, Nosek TM: Ruthenium red affects Woledge RC — Phillips SK Wellens HJJ — Glatz JFC the contractile apparatus but not Whitaker M — Silver RA Wu G, Hamill OP: NPPB block of Ca* * - sarcoplasmic reticulum Ca?* release of Wietholter H — Brinkmeier H activated Cl~ currents in Xenopus skinned papillary muscle 255 Wittner M — Di Stefano A oocytes 227 Zou S-z — Neunlist M Subject index a ATP phosphorylation potential 359 Ca?*-dependent mechanism 515 ATP sensitivity 101 Ca?** -dependent stimuli 522 A6 cells 559 Atrial myocytes 410 *°Ca efflux 313 Acetylcholine 127, 223, 313, 336, 461 Autacoids 461 Ca?* entry blockers 566 Acetylcholine action 389 [Ca?*], 115 — receptors 479 Ca?* influx 297 Acid/base regulation 153 Ca?*-permeability 213 — transport 584 B2-type receptors 213 Ca?* reabsorption 566 Acidification 78 Ba?* 54, 83 Ca?* release 167 Acinar cells 297 Ba** current 470 Ca?* release process 603 Acridines 29 Barium 451 Ca?* -sensitive electrode 101 Action potential 172 Basolateral membrane 54, 319, 559 Ca?* sensitivity 187 Active NaCl transport 290 — — potential 290 Ca?* storage sites 112 Adenocarcinoma 46 BAYk8644 219 Ca?* tail currents 302 Adenosine 359, 522 BAY K8644-sensitive channel 200 Ca?* transport 566 — 3',5’-(cyclic)monophosphate BC3H-1 cells 479 Ca-channel subunits 413 16 Bepridil 566 Ca current(s) 94, 106, 413 Adenylate system 359 Bicarbonate 584 Ca-Dependent K channels 461 Adrenal chromaffin cells 61 — secretion 46 Ca-EGTA 101 B-Adrenergic agents 389 — transport 153 Caffeine 112,115, 213 B-Adrenergic system 223 Bladder 23 Calcitonin 16, 282 Aging 407 Blockade of BK channels 167 Calcium 23, 180, 522, 573, 595, 603 Aldohexoses 367 Blood flow 194 —, cellular 313 Aldosterone 508 Bradykinin 208, 213 —, intracellular 493 Aluminium 515 Brain perfusion 194 Calcium-activated potassium channels Amiloride 78, 275, 544, 559 Brainstem-spinal cord preparations 399 109 1,2-bis (2-aminophenoxy) ethane- 8-Bromo(8-Br)-cAMP 61 Calcium channel(s) 72, 146, 200, 470 N,N’,N’-tetraacetic acid (BAPTA) 493 Brush-border membrane 551 — current 9, 146 4-Aminopyridine (4-AP) 451 Bubble method 264 Calcium-dependent potassium current, Ammonium chloride 297 Bufo marinus 23 Ixicay 347 Angiotensin I| 127 Bumetanide 424 Calcium elevation 213 1,5-Anhydro-D-glucitol 367 Butyric acid 297 — intracellular 536 Anhydrosugars 367 — oscillation 208 Anilines 29 c “Calcium-potassium paradox” 428 Anion channels 46 Calcium stores 313 Anodal stimulation 611 Ca?* 101,515 Calmodulin antagonist melittin 329 Anti-connexin antibodies 87 Ca?* -activated Cl” currents 227 cAMP 9, 16, 61, 336, 389 Antifibrillatory drug 446 Ca** -activated K* channel(s) 54, 101, cAMP-dependent phosphorylation 413 Ant venom 239 167, 417 Capillary endothelial cells 200 Aortic smooth muscle cells 417 Ca?* -activated skinned single muscle Carbachol-induced membrane currents Apamin 54, 347, 417 fibres 434 297 Arachidonic acid 551 Ca?* antagonistic action 410 Carbamylcholine 479 Arginine-vasopressin 219 Ca?*-ATPase 566 Cardiac action potential(s) 223, 611 Arsenate 544 Ca?* /calmodulin-dependent protein assist devices 1 Arteries 536 Kinase I! 470 calcium channel 413 Atomic emission spectroscopy 106 Ca** channel(s) 61, 72, 219, 255 delayed rectifier K* currents 180 ATP 101, 146, 213, 359, 470 Ca?* channel current 529 K* channels 180 ATP-activated channel 213 Ca?* chelation 101 potassium channels 180 ATPase 187 Ca?* concentration(s) 46, 109, 248 ventricular cells 94 — activity 187 Ca?* -dependent K* current 112 Cardiomyoplasty 1 Vi Velussi C + Midrio M Woll E, Waldegger S, Lang F, Maly K, Xiong Z, Kitamura K, Kuriyama H: Evidence Vilella S, Guerra L, Helmle-Kolb C, Murer Grunicke H: Mechanism of intracellular for contribution of Ca** storage sites on H: Characterization of basolateral Na/H calcium oscillations in fibroblasts ex- unitary K* channel currents in inside- exchange (Na/H-1) in MDCK cells 275 pressing the ras oncogene 208 out membrane of rabbit portal vein 112 Woll E — Lang F Yakel JL: Inactivation of the Ba?* currentin Wojnowski L, GaBner B, Steigner W, dissociated Helix neurons: voltage de- Waldegger S — Woll E Oberleithner H: Endothelin-1 blunts pendence and the role of phosphoryla- Walton C > Dojat M transepithelial transport and differentiation 470 Watanabe M — Muraki K tion of Madin-Darby canine kidney Young JA — Cook DI Wegman EA — Cook DI cells 508 Weiss H — Lang F Zhu Y, Nosek TM: Ruthenium red affects Woledge RC — Phillips SK Wellens HJJ — Glatz JFC the contractile apparatus but not Whitaker M — Silver RA Wu G, Hamill OP: NPPB block of Ca* * - sarcoplasmic reticulum Ca?* release of Wietholter H — Brinkmeier H activated Cl~ currents in Xenopus skinned papillary muscle 255 Wittner M — Di Stefano A oocytes 227 Zou S-z — Neunlist M Subject index a ATP phosphorylation potential 359 Ca?*-dependent mechanism 515 ATP sensitivity 101 Ca?** -dependent stimuli 522 A6 cells 559 Atrial myocytes 410 *°Ca efflux 313 Acetylcholine 127, 223, 313, 336, 461 Autacoids 461 Ca?* entry blockers 566 Acetylcholine action 389 [Ca?*], 115 — receptors 479 Ca?* influx 297 Acid/base regulation 153 Ca?*-permeability 213 — transport 584 B2-type receptors 213 Ca?* reabsorption 566 Acidification 78 Ba?* 54, 83 Ca?* release 167 Acinar cells 297 Ba** current 470 Ca?* release process 603 Acridines 29 Barium 451 Ca?* -sensitive electrode 101 Action potential 172 Basolateral membrane 54, 319, 559 Ca?* sensitivity 187 Active NaCl transport 290 — — potential 290 Ca?* storage sites 112 Adenocarcinoma 46 BAYk8644 219 Ca?* tail currents 302 Adenosine 359, 522 BAY K8644-sensitive channel 200 Ca?* transport 566 — 3',5’-(cyclic)monophosphate BC3H-1 cells 479 Ca-channel subunits 413 16 Bepridil 566 Ca current(s) 94, 106, 413 Adenylate system 359 Bicarbonate 584 Ca-Dependent K channels 461 Adrenal chromaffin cells 61 — secretion 46 Ca-EGTA 101 B-Adrenergic agents 389 — transport 153 Caffeine 112,115, 213 B-Adrenergic system 223 Bladder 23 Calcitonin 16, 282 Aging 407 Blockade of BK channels 167 Calcium 23, 180, 522, 573, 595, 603 Aldohexoses 367 Blood flow 194 —, cellular 313 Aldosterone 508 Bradykinin 208, 213 —, intracellular 493 Aluminium 515 Brain perfusion 194 Calcium-activated potassium channels Amiloride 78, 275, 544, 559 Brainstem-spinal cord preparations 399 109 1,2-bis (2-aminophenoxy) ethane- 8-Bromo(8-Br)-cAMP 61 Calcium channel(s) 72, 146, 200, 470 N,N’,N’-tetraacetic acid (BAPTA) 493 Brush-border membrane 551 — current 9, 146 4-Aminopyridine (4-AP) 451 Bubble method 264 Calcium-dependent potassium current, Ammonium chloride 297 Bufo marinus 23 Ixicay 347 Angiotensin I| 127 Bumetanide 424 Calcium elevation 213 1,5-Anhydro-D-glucitol 367 Butyric acid 297 — intracellular 536 Anhydrosugars 367 — oscillation 208 Anilines 29 c “Calcium-potassium paradox” 428 Anion channels 46 Calcium stores 313 Anodal stimulation 611 Ca?* 101,515 Calmodulin antagonist melittin 329 Anti-connexin antibodies 87 Ca?* -activated Cl” currents 227 cAMP 9, 16, 61, 336, 389 Antifibrillatory drug 446 Ca** -activated K* channel(s) 54, 101, cAMP-dependent phosphorylation 413 Ant venom 239 167, 417 Capillary endothelial cells 200 Aortic smooth muscle cells 417 Ca?* -activated skinned single muscle Carbachol-induced membrane currents Apamin 54, 347, 417 fibres 434 297 Arachidonic acid 551 Ca?* antagonistic action 410 Carbamylcholine 479 Arginine-vasopressin 219 Ca?*-ATPase 566 Cardiac action potential(s) 223, 611 Arsenate 544 Ca?* /calmodulin-dependent protein assist devices 1 Arteries 536 Kinase I! 470 calcium channel 413 Atomic emission spectroscopy 106 Ca** channel(s) 61, 72, 219, 255 delayed rectifier K* currents 180 ATP 101, 146, 213, 359, 470 Ca?* channel current 529 K* channels 180 ATP-activated channel 213 Ca?* chelation 101 potassium channels 180 ATPase 187 Ca?* concentration(s) 46, 109, 248 ventricular cells 94 — activity 187 Ca?* -dependent K* current 112 Cardiomyoplasty 1 Catecholamines 16 D Felodipine 566 Cathodal stimulation 611 Ferret right ventricle 603 Cation channel(s) 83, 319 Decerebrate cats 376 Fever response of sheep 259 Cell-attached patch-clamp 231 Denervated soleus muscle 446 Fibre type transformation 359 B Cell Ca?* current 72 Denervation 446 Fibrillation 446 Cell culture 46, 417 Depolarization-secretion coupling 121 Fibroblasts 208 —, kidney cells 153 Desensitization 16, 479 Filament overlap 578 — differentiation 508 Dexamethasone 559 Filtration rate 159 — homeostasis 275 Dextran (MW 200000 Da) 434 Fish intestine 551 — membrane 78, 83, 584 Diacylglycerol 269 Fl cells 87 DIDS 46 — volume regulation 424 Flow ventilator 136 Central noradrenergic system 376 Differentiation 508 Fluid absorption and secretion 551 cGMP 9 Digital imaging microscopy 213 Flunarizine 566 Channel activation 319 2,6-Diisopropyiphenol 393 Fluorescence image microscopy 493 — activity 417 4,4'-diisothiocyanato-stilbene-2,2’-di- — microscope 595 — density 248 sulphonic acid (DIDS) 146 Fluorescent dyes (artefacts and limits to — kinetics 479 Dihydropyridine niguldipine 410 resolution) 595 Charybdotoxin 347,417 Diltiazem 566 — ratio indicators 595 Chelation of intracellular Ca?* 493 Dimethyl-amiloride 424 Fluoride 451 Chloride channels 46, 559 Dioctanoylglycerol 269 Fluorine 515 Diphenylamine-2-carboxylate 83 — current(s) 223, 297, 313 fMet-Leu-Phe 522 — secretion 515 Distal colon crypt cells 319 Force/pCa relationship 187 p-Chloromercuribenzoate 83 — tubule 275 Forskolin 9, 389 8-Chlorophenylthio cAMP 389 Disulphonic stilbene derivatives 46 Frog heart 611 Chronic electrical stimulation 1 Divalent ions 106 Fura-2 172,428, 493, 536, 595 — low-frequency stimulation 359 D-mannose 367 - fluorescence measurements 573 Citrate 347 Dopamine 269 Fura-2-patch-clamp 213 channel blocker 559 Dorsal root ganglion 590 Furosemide 290, 424 channels 46 Double whole-cell recording 87 conductance 551, 559 G /HCO; -exchanger 290 E /OH~ exchanger 551 GABA 302 transport 551 Eccentric exercise 354 Gap-junctional conductance 87 * 94 EDRF 140 Gap junctions 87 Cochlear outer hair cells 493 EDRF-mediated relaxation 140 Gating 180 Colon 54,515 EEG slow-wave activity 500 - mode(s) 219, 239 Colon crypt cells 319 EGTA 146 Gating properties 61, 470 Compensatory renal hypertrophy 159 Elastic properties 434 Gestation 259 Complicance 434 Electrical excitability of hypophyseal cells Giga-seal formation 248 Conductance 559 302 Glial cells 584 Connecting tubule 566 — stimulation 1 Glibenclamide charybdotoxin 54 Connexin-43 87 Electron microprobe analysis 159, 290 Glucagon 16 Connexin protein 87 Endocytosis 121 Glucose 359 Contractile apparatus 255 Endothelial cells 200 Glycagon 354 Contraction 255 Endothelin 508 Glycogon 359 Control of posture 376 A7r5 Endothelin 417 G proteins 72, 127 Copper 106 Endothelium 140 Granules lytic 172 Cortical collecting duct(s) 39, 566 Endothelium-derived relaxing factor 140 GTP [S] 72 — temperature 500 Endotoxin 259 Guanine nucleotides 354 Creatine 359 Energy metabolism 1 Guanosine 5’-triphosphate 461 — phosphate 354 Energy-rich phosphates 354 Crossbridge stiffness 434 Enhancement of I-, 146 H Crustacean muscle 187 Epithelia 282 Cs* 83,94 Equivalent circuit analysis 559 Haemodynamic pressure overload 603 Cultured mammalian cells 87 B-Escin 461 Hair cells 493 Current clamp 239 Excitation-concentration coupling 536 Heart 223, 255, 611 Current/voltage relationship 451 Excitation-contraction coupling 407 — muscle 94 Cyclic-adenosine-mono-phosphate- Excitatory postsynaptic potentials — transplant 172 dependent protein kinase 470 (EPSPs) 399 Heat rate 578 Cyclic AMP 61, 282 Exercise 354 Helix pomatia 146 — AMP-dependent phosphorylation Exhaustion 359 Henle’s loop 290 61 Exocytosis 121 Heparin 112, 127 Cyproheptadine 9 External calcium inotropy 603 HEPES -buffered saline 584 Cytoplasmic calcium 536 Heterocyclic compounds 29 — pH 78 iz High impedance mechanical ventilator Cytosol 536 136 Cytosolic Ca?* 109 Facilitatory influence 376 Hill plot 566 — calcium 428, 493 Fast perfusion system 573 Hodgkin-Huxiey parameters 248 — pH 54 Fast-twitch muscle 359 — type m? activation — sodium 493 Fatigue-prone muscle 1 process 61 Cytotoxic T lymphocytes 172 Fatigue resistant muscle 1 Hormonal regulation 282 Vill Hormone receptors 16 K Methiothepin 9 H * transport across plasma cell membrane Kare channels 118 Methoxyverapamil 566 78 K* channel 112 Microdissection 16 Human muscle cells 621 K channel blockers 231 Microelectrode “point” voltage clamp 407 — pancreas 46 K* channel blockers 83 Microelectrodes 559 Hydrogen ion 153 K* channels 54, 101, 167, 393 Microinjection 376 Hyperfiltration 159 K-Channels 461 Microscopy 213 Hyperpolarization 410 K* conductance 78 Miniature end plate potential 336 Hypertrophy 603 K* current 118, 302 Monoolein/hexadecane 264 Hypodermic needles 106 K* depolarization 428 Motion artifacts 611 Hypophysis 302 Ketanserine 9 Motoneurons 376 Hypoxia induced vasodilation 118 Kidney 16, 29 Motor endplate 231 Kidney, K transport 39 Multi-channel pipette 573 — cells 153, 508 Multiple solution exchanges 529 — collecting system 566 Muscarinically evoked secretion 167 K* reversal potential 109 Muscarinic receptors 313 Immunological rejection 172 K* secretion 23 Muscle 248, 428, 446, 578 Inactivation 470 , chronic stimulation 359 Indomethacin 515 L cells 461, 621 Induction of labour 259 contraction 187,damage 354 Inflammation 621 La** 493 fibers 407 Inhibitor of nitric oxide 194 La** 83 fibres 231, 239, 434 — — protein kinases 227 Lactate 359 — fibre types 187 Inner medullary collecting duct 544 Lanthanum sensitive calcium entry 208 Myoballs 248 Inophore 522 Leech 584 Myocardial electrophysiology 172 Inosine monophosphate 354 — glial cells 584 — perfusion 194 Inositol 1,4,5-triphosphate 112, 461 Lemakalim 118 Myocyte(s) 172, 180, 410 — phosphates 127 Lengthening, forced 354 Myofibrillar ATPase 187 — trisphosphate 313 Leukocytes 522 Myosin heavy chain (MHC) isoforms 446 Inotropic responsiveness 603 Li* 127 — isoforms 446 Insulin secretion 72 Lipid membranes 264 Integrating electronics 618 Lithium 551 N Intercellular communication 87 LLC-PK,/PKEz2, cells 282 Interleukin-2 621 Loading test 367 N' [*H]methyinicotinamide (MeN*) 29 Intermediate lobe cells 302 Lecus coeruleus 376 Na*, K* 2Cl~ cotransporter 424 Internal GTP [S] 72 Loudspeaker-driven system 529 Na*-Ca?** exchange 493, 566 — perfusion 87 L-type Ca?* channels 61, 219 Na channels 239 Interosseal skeletal muscle fibres 231 — calcium channels 72 Na current 94, 231 Intestinal transport 551 — channel 200 Na* current(s) 248, 302, 342, 590 Intestine 329 Lucifer yellow 399 Na* -dependent Cl” transport 551 Intracellular alkalinization 584 Lung function testing 136 Na* flux 584 Ca?* 522 Na*/H* antiporter 508 Ca?* availability 603 M Na*/H* exchange 153 Ca** concentrations 515 Na/H exchange 78, 275 calcium 115 Macro cell-attached patch-clamp 231 Na*/H* exchange activity 282 — oscillations 208 Madin-Darby canine kidney cells 269, Na*/H* exchanger 290, 424 citrate 347 508 Na*-K*-2Cl~ -cotransporter 551 ion imaging 595 Mag-!ndo-1/AM fluorescence 347 Na/K-ATPase 269 Mg?* 347 Magnesium 347 Na*/K* pump 493 pH 78, 297, 584 — withdrawal 140 Na reabsorption 159 — (pH,) 275, 282 Maxi K-channel 54 Nephron segments 16 lon channel gating 61 — K* channels 101 Nernst equation 231 lon channels 264 MDCK 269 Neural retina 451 IP3-activated Ixic,) 347 — cells 275, 508 Neuroblastoma X glioma hybrid cells 347 3-lsobutyl-1-methylxanthine IBMX 9 Mechanical threshold 407 Neurohypophyseal hormones 23 Isobuty!-1-methylxanthine (IBMX) — ventilation 136 Neuromuscular junction 336 389 — ventilator 136 Neuronal calcium currents 106 Isolated crypts 54 Medulla 399 Neurones 146 — endothelial cell 200 Melittin 329 — of Helix pomatia 9 — perfused hearts 255 Membrane, inside-out 112 Neurons from Helix aspersa 470 — — tubule 39, 290 capacitance 121 Neurotransmitters 486 — rabbit intestine 329 current(s) 172, 297 Neutrophils 522 Isometric exercise 354 hyperpolarizations 109 Newborn rat dorsal root ganglia 590 — force 359, 578 potential(s) 109, 399 — rats 399 — heat rate 578 proteins integral 94 NG108-15 cells 347 lsophosphatidylicholine 94 vesicles 551 N°-nitro-L-arginine methyl ester 194 lsoprenaline 223 Mesenteric artery 115, 118 NHZ 39 Isoproterenol 16 Mesotubarium smooth muscle 428 NH3/NH, permeation 83 [1 -(5-isoquinoline-sulphonyl) -2- Metabolic adaptation 1 NIH fibroblasts 208, 424 methylpiperazine hydrochloride} — inhibition 118 Nimodipine 146 146 Metabolites of energy supply 359 Nitric oxide 194 5-nitro-2-(3-phenylpropy!l- — myristate acetate 269 medulla 508 amino)benzoate 559 — — — (PMA) 522 NaCl transport 290 5-Nitro-2(4-phenylpropylamino) - Phosphatase 470 perfusion 194 benzoic 551 — inhibitor okadaic acid 470 Pog, transport 544 N-methyl-D-glucamine (NMDG*) 493 Phosphate transport 544 tissue culture 275 NO 194 Phosphocreatine 359 — tubular reabsorption 367 Non-selective cation channel 83 Phosphodiesterase 336 Respiratory neurons 399 Nonselective cation channels 319 Phospholipid bilayers 94 Rest periods 603 Noradrenaline 115, 536 Phosphorylation 9, 61, 413, 470 Retinal pigment epithelium 451 Noradrenergic system 376 — potential 359 Right ventricle 603 NPPB 227 pH-Sensitive fluorescent probe 2’7’ -bis- Risotilide 54 Nystatin-permeabilized patch 109 carboxyethy!-5,6-carboxyfluorescein Rostral ventrolateral medulla 399 275 (Rp)-cAMPS isomer 336 Oo pH-sensitive K* conductance 78 Ruthenium red 255 Piezoresistive sensor 264 Octanol/water distribution ration 29 Pig myocytes 180 S Okadaic acid 470 Pituitary thin slices 302 OK cells 153 PK-C inhibitors 146 Salivary gland 297 Oleoylacetylglycerol 269 Polyamine 329 Sarcolemma 248 Olfactory receptor neurons 342 Polymorphonuclear leukocytes 522 Sarcomere length 578 Omega-conotoxin-sensitive component Poneratoxin 239 Sarcoplasmic reticulum 255, 407, 603 486 Portal vein 112 Second messengers 461 Omohyoideus muscles 578 Posterior pituitary hormones 23 Secretion 167 Oncogene 208 Post-rest contractility 603 Sensory neuron 590 Oocyte cell membrane 83 Postsynaptic activity 399 Serotonin 9 Oocytes 127, 227 Posture 376 Serotonin receptors 9 Optical recordings 611 Potassium 180,428 Shortening velocity 187 Organic cations 29 — channels 23, 451 Short-term desensitization 16 Osteoblast-like cells 109 — conductance 39 Silicone oil 618 OQuabain 544, 566 — current 118, 297 Single cell assay 121 Quabain-inhibitable mechanism 329 Primary culture(s) 417, 566 - — physiology 573 Ovarian follicles 127 Principal cells 39 Single-channel activity for K” 393 Oxygen radical production 522 Procainamide 446 Single channels 618 Prophase-arrested oocytes 78 Single channel noise 618 P Propofol 393 - muscle fibres 434 Prostaglandin E, 319 Single-nephron glomerular filtration rate Pacemaker current 389 Protein kinase(s) 61, 227 (SNGFR) 159 Palmitate oxidation 1 — — A 336 Single smooth muscle cell 461 Paimitoylicarnitine 94 — — C 146,C 269,C 282 Sino-atrial node 223 Pancreatic cancer cell line (Capan-1) 46 — inhibitor 9 SITS 290, 551 — duct cells 46 Proteolytic enzymes 354 Skeletal muscle 248, 434, 446, 578, 621 — islet B cells 121 Proton transport 78 — — fibers 407 — Bcells 72 Proximal tubule 29 — fibres 231, 239 Papillary muscle 255 PTH Skinned papillary muscle 255 Paradoxical decrease in cytosolic calcium Purkinje fibers 389 single muscle fibres 434 428 Putrescine transport 329 Sleep deprivation 500 Parathyroid hormone 16, 146, 544 Pyridines 29 regulation 500 Parotid gland 167, 297 Pyrogens 259 Slow repetitive activity 239 Parturition 259 Pyruvate dehydrogenase complex 1 Slow-to-fast transformation 446 Patch-clamp 46, 94, 101, 106, 167, 213, Small intestine 329 219, 231, 248, 297, 342, 393, 470, 590, Q — K-channel 54 618, 621 Smooth muscle 118, 413, 417, 428 — analysis 302 Quanta 336 — — cell(s) 101, 115, 219, 461 — technique 451 Quartz 618 - — tone 140 PC 12 cells 213 Quaternary N compounds 29 Snail neurone(s) 9, 146 PC12 cells 393 Quinidine 42, 451 — neurons 470 Peanut lectin 508 Quinolines 29 Socium channel 239 Peptide inhibitor (CKIP) 470 Sodium, intracellular 493 Perfusion rapid 479 — arsenate 544 Peripartum period 259 Sodium-binding benzoforan isophthalate Permeabilization 461 Rabbit 223 (SBFI) 493 Pertussis-toxin 72, 127 Ras oncogene 208, 424 Sodium/calcium exchange 603 pH 544 Rb* 39 Sodium channel(s) 94, 231,248, 342, Phagocytic functions 451 B-Receptor-operated |<, 590, 621,— Intracellular 584 Phenylalkylamines (catecholamines) 29 Recovery 359 — transport 159 8-Phenylitheophylline 522 Rectifier K* currents 180 559 Pheochromocytoma cell line 393 Rectifying Ci” channels 46 Solution exchanges 529 — (PC 12) cells 213 Refractoriness 313 Sphingosine 269 pH Extracellular 153 Regional blood flow 194 Stainless steel hypodermic needies 106 Phorbol 12-myristate 13-acetate 146 Renal epithelia 282 Staphylococcus aureus 259 — ester(s) 146, 269, 282 — hypertrophy 159 Stereospecific requirements 367 x Stiffness 434 Tubuloglomerular feedback 159 Vertebrate muscles 187 Stripped rabbit descending colon 515 Type Il fibres 1 Vesicles 551 Structure/activity relationship 29 Vestibulospinal reflexes 376 Substance P 461, 573 U Vigilance state 500 b-Subunit expression 413 Voltage-clamp 61, 109, 146, 180, 248, Surface tension 264 Unidirectional fluxes 329 407, 529 Uninephrectomised animals 159 — conditions 239 T Up-regulation 9 Voltage-gated Ca 200 Upright microscope 573 — currents 302 TEA 39, 54, 167 Urinary bladder 219 Voltage sensitive dyes 611 Tension/[Ca?*], relationship 536 — Ca** 23 Tension transients 434 Ussing chamber 329, 515 w Tetraethylammonium 83, 167 — (TEA) 451 Vv Water/electrolyte balance 23 Tetrodotoxin 590 Water immersion objectives 573 — (TTX) 342 Valinomycin 551 Whole-cell currents 451 Thapsigargin 109, 115 Vanadate 515 — recordings 399 Thermoregulation 500 Vascular calcium channel 413 T lymphocytes 172 — smooth muscle 112, 140, 413, 417 x Toad bladder 23 — — — cells 115 Tolbutamide 9 Vasoconstrictors 417 Xenopus laevis oocyte 83 Tracer microspheres 194 Vasodilation 118 — — ovarian follicles 127 Transcellular Ca?* transport 566 Vasopressin 16, 219, 282, 376, 536, 536 Xenopus oocytes 227, 313, 413 Transepithelial NaCl net fluxes 290 Vasopressium 417 X-ray diffraction patterns 434 — transport 508 Vein wall 140 Triphosphate (ATP) 359 Ventilation 136 T-type Ca?* currents 410 Ventricular cells 94 — transient current 200 — myocytes 172, 529 Tubular sodium handling 159 Verapamil 39, 146