Table Of Content

PERSPECTIVES /ws io.ocy a AND MEDICINE Fd / / / THE UNIVERSITY OF CHICAGO PRESS VOLUME 35 © 1991, 1992 By THE UNIVERSITY OF CHICAGO ALL RIGHTS RESERVED PUBLISHED AUTUMN 1991 WINTER, SPRING, SUMMER 1992 PUBLISHED BY THE UNIVERSITY OF CHICAGO PRESS PERSPECTIVES IN BIOLOGY AND MEDICINE VOLUME 35 - CONTENTS EDITORIAL: Winners of the Seventh Dwight J. Ingle Memorial Writing Award Nina V. Fedoroff Maize Transposable Elements James S. Goodwin The Empirical Basis for the Discovery of New Therapies Bernard D. Davis Two Perspectives: On René Dubos, and on Anti- biotic Actions James V. Neel Priorities in the Application of Genetic Principles to the Human Condition: A Dissident View Jane C. Burns, Peter Canine Pain Syndrome Is a Model for the Study J. Felsburg, Harry of Kawasaki Disease Wilson, Fred S. Rosen, and Lawrence T. Glickman Alfred I. Tauber The Immunological Self: A Centenary Perspective Daniel X. Freedman Of Chairs and Stools:—or, What’s Academic about Academic Medicine? Plinio Prioreschi Does History of Medicine Teach Useful Lessons? Marilyn R. Chandler Supporters and Survivors: The People without AIDS Howard Gest Dr. Martin Arrowsmith: Scientist and Medical Hero Robert A. Gelfand, It Has Been Said editor Samuel H. Greenblatt The Development of Modern Neurological Thinking in the 1860s Jannifer Stromberg, Some Thoughts about Aging from a Nine- Joel D. Howell, and teenth-Century Connecticut Yankee W. Andrew Achenbaum J. M. Friedman Eugenics and the “New Genetics” BOOK REVIEWS: Human Genetic Information: Sci- ence, Law and Ethics, edited by D. Chadwick, G. Bock, and J. Whelen; Jn situ Hybridization: Ap- plication to Developmental Biology and Medicine, edited by N. Harris and D. G. Wilkinson; An Infor- mal History of W. B. Saunders Company, by John Dusseau MISCELLANY by Thomas R. Platt, Gloria Z. Wurst, and Nora Jacobson EDITORIAL: Co-winner of the 1991 Dwight J. Ingle Memorial Writing Award Scott A. Norton Salt Consumption in Ancient Polynesia Petr Skrabanek The Poverty of Epidemiology James S. McCormick The Abuse of Language and Logic in Epidemi- ology Stewart Wolf The Medicine of the Lateral Pass Michael O'Reilly falling on deaf ears Ralph L. Engle, Jr. Attempts to Use Computers as Diagnostic Aids in Medical Decision Making: A Thirty-Year Ex- perience Alfred I. Tauber and The Human Genome Project: Has Blind Reduc- Sahotra Sarkar tionism Gone too Far? Carl Elliott On Psychiatry and Souls: Walker Percy and the Ontological Lapsometer Nicholas Starkovsky, It Has Been Said Twice editor Velio Bocci The Neglected Organ: Bacterial Flora Has a Crucial Immunostimulatory Role DanielJ . McCarty, Equity in Physician Compensation: The Marsh- David L. Schieder- field Experiment mayer, G. Stanley Custer, Russell F. Lewis, and George Magnin Michael J. McNamara From Billings to Bigelow Jurgen Aschoff On the Dilatability of Subjective Time Richard P. Vance, Cultural Literacy of Medical Students Robert W. Prichard, Charles King, and Gwendie Camp Evelyn Fox Keller Between Language and Science: The Question of Directed Mutation in Molecular Genetics BOOK REVIEWS: Aztec Medicine, Health, and Nutri- tion by Bernard R. Ortiz de Montellano; The His- tory of Yellow Fever, an Essay on the Birth of Tropical Medicine, by Francois Delaporte; Understanding Medical Terminology 8th ed., by Sr. Agnes Clare Frenay and Sr. Rose Maureen Mahoney. LETTERS TO THE EDITOR: D. B. Tyler; Plinio Prior- eschi; and George V. Mann. MISCELLANY by Eric L. Dyer EDITORIAL: Introducing Students to Medicine by an Expanded Gross Anatomy Course Co-Winner of the 1991 DwightJ . Ingle Memorial Writing Award David A. Hyman Professional Profiteering? The Ethics of Physi- cian Entrepreneurship William Regelson RU 486: How Abortion Politics Have Impacted on a Potentially Useful Drug of Broad Medical Application James M. Gustafson Response to Van Rensselaer Potter, “Getting to the Year 3000: Can Global Bioethics Overcome Evolution’s Fatal Flaw?” Harold M. Mozar, Coronary Artery Disease: Diet-Associated Vi- Dileep G. Bal, Neal ruses as Initiators D. Kohatsu, and Alana J. Mozar Philip Dziuk Survival of Peas, Peaches, and Prenatal Pigs Steven L. Primack, One Hundred Years of Imaging: New Benefits, Caroline Chiles, and New Challenges Charles E. Putman Milton Wainwright The Sinkovics Hybridoma—The Discovery of the First “Natural Hybridoma” Michael Uhrin, editor It Has Been Said Barron H. Lerner The Perils of “X-ray Vision”: How Radiographic Images Have Historically Influenced Perception Richard E. Heller A Requiem for Aniline Dyes Emanuel M. Papper The Influence of Romantic Literature on the Medical Understanding of Pain and Suffering— The Stimulus to the Discovery of Anesthesia Francesco Pansera Regression in Renal Cell Carcinoma as Re- expression of Cell Death in Kidney Development Maura C. Flannery Biology Is Beautiful C. G. Pinter and A Search for the Certitude of Scientific Facts with Vera Pinter Giambattista Vico and Karl Popper: The Impor- tance of Integrative Physiology Roger T. Mulder Boundaries of Psychiatry BOOK REVIEWS: Inherited Eye Diseases, Diagnosis and Clinical Management, by Saul Merin; Guide to Flow Cytometry Methods, by W. McLean Grogan and James M. Collins; Cell Surface and Differentiation, by T. Muramatsu; Titles That May Interest You, selected by Ronald Singer LETTERS TO THE EDITOR: Plinio Prioreschi; Wolf- gang Jéchle; and Robert T. Muller MISCELLANY by William C. Campbell and Jacques Padawer Bruce Nathan Should Intracerebroventricular Nerve Growth Saffran Factor Be Used to Treat Alzheimer’s Disease? Walter Ehrlich The Discovery of the Cardiac Conduction Sys- tem: The Testimony of the Authors Philip W. Jackson On Learning to See What Is Not There Donald S. Burke Human HIV Vaccine Trials: Does Antibody- Dependent Enhancement Pose a Genuine Risk? Richard B. Dr. Horace Wells and the Conquest of Surgical Gunderman Pain: A Promethean Tale Laurence R. A Theory of the Mind/Brain Dichotomy with Tancredi and Nora Special Reference to the Contribution of Posi- D. Volkow tron Emission Tomography David B. Resnik Gaia: From Fanciful Notion to Research Pro- gram David Hamerman Responses of the Health Professions to the De- and Andrea Fox mographic Revolution: A Multidisciplinary Per- spective 594 Franklin M. Harold, It Has Been Said editor 596 Craig H. Steffee Penicillins and Staphylococci: A Historical Inter- action 609 Bernard M. Patten Myasthenia, Elise Borden, and Me 612 Richard U’Ren Psychiatric Diagnosis and the Market 617 Sanford Tweedie Whatever You Desire: For Richard Selzer— A Patient’s Point of View 620 BOOK REVIEW: The Genetic Revolution: Scientific Prospects and Public Perceptions, ed. by Bernard D. Davis LETTERS TO THE EDITOR: Milton B. Engel and Theodore B. Schwartz MISCELLANY by Thomas Peter Bennett