Peptides Biology and Chemistry: Proceedings of the 1996 Chinese Peptide Symposium July 21–25, 1996, Chengdu, China PDF
Preview Peptides Biology and Chemistry: Proceedings of the 1996 Chinese Peptide Symposium July 21–25, 1996, Chengdu, China
Peptides Biology and Chemistry Peptides Biology and Chemistry Proceedings of the 1996 Chinese Peptide Symposium July 21-25, 1996, Chengdu, China Edited by Xiao-Jie Xu Department of Chemistry Peking University Beijing 100871 , China Yun-Hua Ye Department of Chemistry Peking University Beijing 100871, China and James P. Tam Department of Microbiology and Immunology Vanderbilt University Nashville, TN 37232, U.S.A. Published under the KLUWER /ESCOM imprint by Kluwer Academic Publishers New York / Boston / Dordrecht / London / Moscow eBookISBN: 0-306-46859-X Print ISBN: 0-792-34963-6 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow All rights reserved No part of this eBook maybe reproducedor transmitted inanyform or byanymeans,electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: http://www.kluweronline.com and Kluwer's eBookstore at: http://www.ebooks.kluweronline.com Preface The fourth Chinese Peptide Symposium, hosted by Peking University, was held at Chengdu, China on July 21-25, 1996 with 164 participants, including 45 scientists from abroad, representing 12 countries. The four-day conference was both intense and spiritually rewarding. Our goal for CPS-96 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 10 sessions with 55 oral and 78 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry- biology-interface and challenging problems in peptides. Theenthusiasticcooperationandexcellentcontributionsweregratifying andtheactive response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. James P. Tam and Dr. Jie-Cheng Xu were the recipients of ‘The Cathay Award’ sponsored by the H. H. Liu Education Foundation, offered for their seminal contributions in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group). It is our pleasure to acknowledge Nobel Laureate Professor Bruce R. Merrifield for his kindness in supporting and serving as the chairman of the Awarding Committee for the ‘Cathay Award’, and all members of the program and organizing committee for their generous contributions to the successful symposium. Dr. John R. Martin and Kluwer Academic Publishers kindly agreed to publish the CPS-96 proceedings, and we thank them for their contributions and support of the symposium. We greatly appreciate the generous financial assistance of the sponsors and donors. On behalf of the organizing committee, we thank the administrative assistance by Peking University and Sichuan University as well as Vanderbilt University. Finally, we are grateful to our colleagues, especially Professor Yan-Ling Song, Professor Gui-Lin Tian, Dr. Jia-Xi Xu, Dr. Zhen-Wei Miao and Ms. Vicki Gates Bryant, who have devoted much time and effort to ensure the success of CPS-96. Xiao-Jie Xu Yun-Hua Ye James P. Tam v Chinese Peptide Symposium - 1996 July 2 1-25, 1996, Chengdu, China Peking University Sichuan University Chairpersons Dr.Xiao-JieXu, Peking University, Beijing, China Dr. Yun-Hua Ye, Peking University, Beijing, China Program Committee Yu-Cang Du, Chairman, Shanghai Institute of Biochemistry, Shanghai, China James P. Tam, Vanderbilt University, U.S.A. Xiao-Jie Xu, Peking University, Beijing, China Meng-Shen Cai, Beijing Medical University, Beijing, China Roger Epton, Mayflower Worldwide Ltd., U K. Yue-Ting Gong, Shanghai Institute of Biochemistry, Shanghai, China Victor J. Hruby, University of Arizona, U.S.A. Chong-Xi Li, Peking University, Beijing, China Jean Martinez, CNRS Faculte de Pharmacie, France Jean E. Rivier, The Salk Institute, U S.A. Peter W. Schiller, Clinical Research Institute o f Montreal, Canada Yasutsugu Shimonishi, Osaka University, Japan Akinori Suzuki, University of Tokyo, Japan John D. Wade, University of Melbourne, Australia Jie-Cheng Xu, Shanghai Institute of Organic Chemistry, Shanghai, China Organizing Committee Yun-Hua Ye, Chairman, Peking University, Beijing, China Gui-Shen Lu, Vice-chairman,Institute of Materia Medica, Beijing, China James P. Tam, Vice-chairman,Vanderbilt University, U.S.A. Saburo Aimoto, Osaka University, Japan Shu-Hua Chen, Sichuan University, Chengdu, China vi Zhen-Kai Ding, Chinese Institute of Military Medical Science, Beijing, China Xiao-Yu Hu, Lanzhou University, Lanzhou, China Wei Li, Jilin University, Changchun, China Robert Liu, H. H. Liu Education Foundation, U S.A. Bing-Gen Ru, Peking University, Beijing, China Arnold Satterthwait, The Scripps Research Institute, U. S.A. Shao-Bo Xiao, State Family Planning Commission, Beijing, China Awarding Committee of Cathay Award Bruce Merrifield, Chairman, The Rockefeller University, U.S.A. Victor J. Hruby, University of Arizona, U.S.A. Peter W. Schiller, Clinical Research Institute of Montreal, Canada Yu-Cang Du, Shanghai Institute of Biochemistry, Shanghai, China Gui-Shen Lu, Institute of Materia Medica, Beijing, China Zhen-Kai Ding, Chinese Institute of Military Medical Science, Chinu Xiao-Jie Xu, Peking University, Beijing, China Major Sponsors H. H. Liu Education Foundation National Natural Science Foundation of China Sponsors ASTA MEDICA Penninsula Laboratories, Inc. Pharmacia Biotech Beaufour Ipsen International China Office American Peptide Company, Inc. Eli Lilly and Company Torrey Pines Institute for Molecular Studies Amgen, Inc. Isochem Penta Biotech, Inc. Warner-Lambert Company Beijing Xingda Science System Co. vii Donors Chiron Corporation Waters Corporation World Ways Bio Electronics Co. Abbreviations Abbreviations used in the proceedings volume are defined below: 2D-NMR two dimensional NMR CGRP calcitonin gene-related AAA amino acid analysis peptide ACE angiotensin-converting Cha cyclohexylamine enzyme CPS Chinese peptide ACh acetylcholine symposium Acm acetamidomethyl CT carboxy terminus; ADP adenosine diphosphate calcitonin; Aib aminoisobutyric acid chymotrypsin; AIDS acquired immune cholera toxin d i f i c i e n c y CT L c y t o t o x i c s y n d r o me AM adrenomedullin AMD actinomycin D D diversity (as with Ig or AMP adenosine TCRgenes) monophosphate DAPaa N-(O,O-dialkyl)phos- Aoq α-amino-β-[4-(1,2- pho amino acid dihydro-2-oxo DCC dicyclohexyl-carbodiimide quinolinyl)]propionic DCM dichloromethane acid DDSi dichlorodimethylsilane APC antigen presenting cell DEPBT 3-diethoxyphosph- ATP adenosine triphosphate oryloxy-1,2,3-benzo- Atq 2-amino-3-( 1,2-dihy- triazin-4(3H)-one dro-2-thio-quinolinyl) DIEA diisopropylethylamine propionic acid DIPEA diisopropylethylamine AVP arginine-8-vasopressin DIPP N-(O,O-diisopropy1)- Boc tert-butyloxycarbonyl phosphoryl BSA bovine serum albumin DMF dimethylformamide Bu,But butyl DMSO dimethyl sulfoxide Bzl benzyl DOPC dioleoyl-sn-glycero- bZIP basicr egion-leucine zipper phosphocholine DTT dithiothreitol CaM calmodulin CaMKII Ca2'/CaM-dependent EDC 1- (3-dimethyl- protein kinase aminopropy1)-3- Cbz carbobenzoxy; ethylcarbodiimide benzyloxycarbonyl hydrochloride CCK cholecystokinin EDTA ethyienediamine- CD circular dichroism; tetraacetic acid complement domain ELISA enzyme-linked CE capillary electro-phoresis immunosorbent assay ix Abbreviations ERK extracellular signal- IPTG isopropy1-D- regulated kinases thiogalactoside IR infiared; FAB-MS fast atombombard- insulin receptor ment mass spectro- metry LH luteinizing hormone FD flexible docking LHRH luteinizing hormone Fmoc 9-fluoreny lmethoxy- releasing hormone carbonyl LTP long-term potentiation FSH follicle stimulating hormone MAb monoclonal antibody Ftase farnesyl transferase MALD-MS matrix-assisted laser FTIR Fourier transform infiared desorption mass GH growth hormone spectrometry GHR growth hormone MAP multiple antigen peptide; receptor mean arterial pressure GPCR G-protein coupled MAPK mitogen-activated protein receptor kinase GSTs glutathione s- MBHA methylbenzhydrylamine transferases MDP muramyl dipeptide ME mercaptoethanol HBTU O-benzotriazolyl- MHC major histocompatibility N,N,N’,N’-tetrameth- complex yluronium hexafluoro- MM molecular mechanics phosphate MP mastoparan; hCG human chorionic melting point gonadotropin MS mass spectrometry hCG-PP hCG-induced progesterone MT metallothionein production MTT 3-(2-yl)-2,Sdiphenyl- HCV hepatitis C virus tetrazolium bromide HEV hepatitis E virus MVD mouse vas deferens HIV human immuno -deficiency virus NGF nerve growth factor HLA human leukocyte Nle norleucine antigen NMDA N-methyl-D-aspartate HOBt N-hydroxybenzotriazole NMDA-R NMDA- receptor HOOBt N-hydroxyoxodihy- NMM N-methylmorpholine drobenzotriazine NMR nuclear magnetic HOSu N-hydroxysuccinimide resonance HPLC high performance liquid OEt O-ethyl ester chromatography OMe O-methyl ester OSU O-succinimide ester Ig immunoglobulin IL interleukin PACAP pituitary adenylatecyclase X Abbreviations activating polypeptide TASP template assembled PBMC peripheral blood synthetic protein mononuclear cell TCEP tris(2-carboxyethy1)- PBS phosphate buffered saline phosphine PCR polymerase chain reaction TCR T lymphocyte antigen PDB phorbol 12,13-dibutyrate; receptor PDB protein data bank TEA triethylamine PDGF platelet derived growth TFA trifluoroacetic acid factor TFE trifluoroethanol PDI protein disulfide isomerase TFMSA trifluoromethane-sulfonic PEG polyethylene glycol acid PfP pentafluorophenyl ester THF tetrahydrohran PLGA copolymer of lactic Tic 1,2,3,4-tetrahydro acid-co-glycolic acid quinoline-3-carboxylic PSPP papaver somniferum acid pollen peptide TIPP H-Tyr-Tic-Phe-Phe-OH PTH parathyroid hormone TIS triisopropyl silane PTX pertussis toxin TLC thin layer chromatography PY pyridine TLN thermolysin Tmob S-2,4,6-trimethoxybenzyl RBD rigid-body docking TMSBr trimethylsilyl bromide RP-HPLC reversed-phase high TNF tumornecro factor performance liquid TOF-MS Time of flight mass chromatography spectra RTK receptor tyrosine kinase Tris tris(hydroxymeth-yl) aminomethane SAg superantigen TSST Toxic shock syndrome SD soft docking toxin SDS sodium dodecyl sulfate SFD semiflexible docking UNCA N -urethane-protected Snm S-(N-methy1-N- carboxyanhydride phenylcarbamoy 1) UV ultraviolet sulfenyl VIP vasoactive intestinal SP substance P peptide SPPS solid phase peptide synthesis Z carbobenzoxy xi
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