Description:In Canada alone there are hundreds of neonates and children at risk for thrombotic complications related to interventions in cardiac and renal disease, treatments for leukemia and lupus, and ischemic stroke. The authors lay a foundation in the principles of hemostasis, congenital prethrombotic disorders, and the epidemiology of venous and arterial thromboembolism. The management protocols embrace heparin, oral anticoagulants, and thrombolytic therapy.