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VUmc Cancer Center Amsterdam
VUmc CCA

Annual Report 2012

Appendices
Address

VUmc Cancer Center Amsterdam (VUmc CCA)
VU University Medical Center
PK 7 Z 182
De Boelelaan 1117
1081 HV Amsterdam
The Netherlands

phone: [phone]
e-mail: [email protected]
website : www.vumc.nl/afdelingen/CCA-V-ICI

Appendix Annual Report 2012 VUmc CCA - 1
List of contents

Appendices

1. Organization 3

2. Scientific input 7

3. Newly started PhD projects 18

4. Scientific output 20

5. Indicators of esteem 62

6. Societal impact 108

7. Ongoing projects 113

8. International collaboration 145

9. Scientific Research Committee 153

10. Evening lectures 164

Appendix Annual Report 2012 VUmc CCA – List of contents - 2
Appendix 1. Organization

Management Board
Management Board (MB) members:
- P.C. Huijgens, oncology research, director of VUmc CCA
- G. Kraal, immunology research, deputy director of VUmc CCA
- H.J. Bonjer, regionalisation
- G.C.P.M. Hoskens, manager finances division I
- C.R. Leemans, education, chairman of internal advisory board
- G.A. Meijer, infrastructure
- B.J. Slotman, regionalisation
- H.M.W.Verheul, patient care/fundraising, member

Supportive staff
- J. van Diemen (board assistant)
- Y.M. Duiker (board assistant)
- E. van Kessel (project manager)
- M.A.J. Koelink (senior secretary)
- G.K. Kuipers (senior board assistant)
- H. Loeffen (communication advisor)
- E.M. Ruhé-Hoogervorst (senior board assistant)
- E. Takkenberg (fundraiser)
- B. Volman (project controller)
- J. Zweers (project controller)

Executive Board
The Executive Board (EB) of VUmc CCA consists of the program leaders. The EB meets every 2
months together with the MB, chaired by one of the MB directors. The EB advises the MB about:
- research projects
- long-term policy with respect to personnel and materials
- first money stream graduate students
Appendix Annual Report 2012 VUmc CCA – Organization - 3
- allocation of equipment for research of > € 12.000
- patient care projects
- clinical and translational research
- education
- fundraising for cancer research, care and education
- early diagnostics
- all matters concerning VUMC CCA whether on request or not.

The complete EB convenes regularly to discuss the long term policy of VUmc CCA.

Executive Board members:
Program 1: Oncogenesis:
- R.H. Brakenhoff
- P.J.F. Snijders
- J. de Winter

Program 2: Immunopathogenesis:
- R.H.J. Beelen
- T.D. de Gruijl
- E. Hooijberg
- Y. van Kooyk
- R. Mebius

Program 3: Disease profiling:
- G.A.M.S. van Dongen
- O.S. Hoekstra
- C. Jimenez
- C.L. Verweij
- T. Würdinger

Program 4: Innovative therapy:
- R. de Bree
- J. Janssen
- G.J. Peters
- S. Senan
- H. van der Vliet

Program 5: Quality of Life
- J. Dekker
- G.J.L. Kaspers
- B.D. Onwuteaka-Philipsen
- I.M. Verdonck-de Leeuw
- O. Visser

Internal Advisory Board
The members of the internal advisory board consist of 5 to 10 heads of departments involved in
cancer and immunology within the VUmc. The chairman is member of the MB. The board meets
twice a year.

Internal Advisory Board members:
- C.R. Leemans (Chair)
- M.A. Blankenstein
- J. Bonjer
- C.D. Dijkstra
- J.J. Heimans
- O.S. Hoekstra
- G.C.P.M. Hoskens
- P.C. Huijgens
- G.G. Kenter
Appendix Annual Report 2012 VUmc CCA – Organization - 4
- G. Kraal
- D. de Kruif
- G.A. Meijer
- H. Meijers-Heijboer
- C.J.J. Mulder
- B. Slotman
- E.F. Smit
- H.M.W. Verheul
- A. Voskuyl

Scientific Research Committee (CWO)
The CWO is divided into a section that advises merely animal related protocols and a section that
advises patient related protocols and other project proposals.

The CWO advises about the research policy and about the feasibility of new research projects upon
request of the MB. The CWO advises the MB specifically about the quality and the feasibility of all
research proposals that need permission of the ethical committees for patient related or animal
related research before they can be realized.

Research proposals made on behalf of (inter)nationally recognized joint ventures (EORTC, HOVON,
SIOP, SKION) and multi-center studies in which the VUMC is not the main judging committee, are
judged only marginally on local feasibility.

The CWO also advises on other research proposals for which judgment by the CWO is desired. The
CWO gives asked and unasked advice to the MB about the quality of research within VUMC CCA. The
CWO section for patient related protocols meets twice a month, the CWO section for animal related
protocols meets once a month.

The VUMC Management Regulations stipulate that the VUmc CCA CWO section for patients related
protocols is composed of 5 to 9 members. In view of the institute’s size and in order to have
sufficient expertise in the different research fields, the CWO has been extended to a maximum of 15
members.

Scientific Research Committee (CWO) members - Section for patient related protocols:
- A.A. van der Loosdrecht (chair)
- A.A. van Bodegraven
- B.J.M. Braakhuis
- A.J.M. van den Eertwegh
- M. van Egmond
- T.D. de Gruijl (till July 2012)
- N. Haasbeek (from August 2012)
- N.H. Hendrikse
- D. de Jong (from August 2012)
- M. Klein (from February 2012)
- G.K. Kuipers (secretary)
- R.D.M. Steenbergen (from August 2012)
- F.B.J.M. Thunnissen (till April 2012)
- W.J.J. Unger (from August 2012)
- Q. Waisfisz

Scientific Research Committee (CWO) members - Section for animal related protocols:
- R. Scheper (chair)
- B.J. Appelmelk
- V. van Beusechem
- G. Kraal
- G.K. Kuipers (secretary till September 2012)
- Y.M. Duiker (secretary from September 2012)

Appendix Annual Report 2012 VUmc CCA – Organization - 5
Committee for Education & Training
This committee supervises and advices about all training and education activities within VUmc CCA.
The graduate training is organized within the Oncology Graduate School Amsterdam (OOA) and the
Leiden Amsterdam Institute for Immunology (ALIFI).

More in detail, by means of subgroups, this committee organizes and advises about training in the
framework of the:
- oncology profile
- immunology profile
- masters education in oncology
- masters education in immunology
- graduate students education
- postgraduate education
- SMBWO (Foundation for the Training of Biomedical Scientists)
- NVVI (Dutch Society for Immunology)
- all other types of education within VUmc CCA.

Each of these subgroups is composed of the main teachers within the education involved. The
committee gives asked and unasked advice about the quality and quality maintenance of education
within VUmc CCA. The committee meets at least six times a year.

Members of the Committee for Education & Training:
- C.R Leemans (chair)
- R.H.J. Beelen
- M.M. van Duist
- G.A. Meijer
- E.M. Ruhé-Hoogervorst (secretary)

Subgroups:
Oncology profile committee members:
- B.J.M. Braakhuis
- E. Boven
- A.A. van de Loosdrecht
- N.C.T. van Grieken
- F.B.J.M Thunnissen
- E.M. Ruhé-Hoogervorst (profile coordinator)

Immunology and Infection committee members:
- B.J. Appelmelk
- I.E.M. Bultink
- K.A. Gelderman
- I.M.W. van Hoogstraten
- M.B.E. von Blomberg
- G.K. Kuipers (profile coordinator)

Directorate OOA (Oncology Graduate School Amsterdam)
- A.W. Griffioen from September
- G.A. Meijer till September
- E.M. Ruhé-Hoogervorst, secretary (VUmc)
- T. Sixma (NKI)
- M. Spaargaren (AMC)

Funding by Stichting VUmc CCA
The Stichting VUmc CCA supports VUmc and VUmc CCA in their cancer research and care for
patients with cancer.
Appendix Annual Report 2012 VUmc CCA – Organization - 6
Appendix 2. Scientific input

Program 1: Oncogenesis

Department Funding FTE
Full professor
Oudejans CBM Clinical Chemistry 1 0,05
Meijers-Heijboer HE Clinical Genetics 1 0,20
te Riele H Clinical Genetics 1 0,00
Kenter GG Obstetrics and Gynaecology 1 0,33
Bloemena E Oral and Maxillofacial Surgery and Pathology 1 0,20
Schulten EAJM Oral and Maxillofacial Surgery and Pathology 1 0,10
van der Waal I Oral and Maxillofacial Surgery and Pathology 1 0,20
Brakenhoff RH Otolaryngology/Head and Neck Surgery 1 0,85
Leemans CR Otolaryngology/Head and Neck Surgery 1 0,05
Meijer CJLM Pathology 3 0,17
Meijer GA Pathology 1 0,10
Middeldorp JM Pathology 1 0,50
Mooi WJ Pathology 1 0,10
Peeper DS Pathology 1 0,00
Snijders PJF Pathology 1 0,60
Associate professor
Berkhof J Clinical Epidemiology and Biostatistics 1 1,00
van de Wiel MA Clinical Epidemiology and Biostatistics 2 0,50
de Winter JP Clinical Genetics 1 1,00
Dorsman JC Clinical Genetics 1 1,00
Braakhuis BJM Otolaryngology/Head and Neck Surgery 1 0,85
Heideman DAM Pathology 1 0,50
Steenbergen RDM Pathology 1 0,50
van Kemenade F Pathology 1 0,10
Assistent professor
Menko FH Clinical Genetics 1 0,20
van Hest LP Clinical Genetics 1 0,10
Waisfisz Q Clinical Genetics 1 0,80
Karagozoglu KH Oral and Maxillofacial Surgery and Pathology 1 0,10
Bleeker MCG Pathology 1 0,20
Carvalho B Pathology 2 0,61
Cillessen SAGM Pathology 3 0,90
de Jong D Pathology 1 0,15
Hooijberg E Pathology 3 0,50
Pegtel M Pathology 3 0,83
Rozendaal L Pathology 1 0,10
van Criekinge WMR Pathology 2 0,11
van Hattum AH Pathology 1 0,04
Other tenured staff
Gille JJP Clinical Genetics 1 0,10
Heins YM Clinical Genetics 1 0,10
Holstege H Clinical Genetics 1 0,50
Poddighe J Clinical Genetics 1 0,10
Oudgenoeg G Laboratory Medical Oncology 1 1,00
Bremmer JF Otolaryngology/Head and Neck Surgery 4 0,23
Rekers N Pathology 3 0,38
Scheffer GL Pathology 3 0,25
Thunnissen FBJM Pathology 1 0,10
Total tenured staff 16,30
Non tenured staff
Ameziane N Clinical Genetics 1 1,00
de Lange J Clinical Genetics 3 1,00
de Wit M Laboratory Medical Oncology 1 0,75
Appendix Annual Report 2012 VUmc CCA – Scientific input - 7
Pham TV Laboratory Medical Oncology 3 1,00
van Beynum JR Laboratory Medical Oncology 3 1,00
Schaaij-Visser BM Medical Oncology 1 0,33
Jordanova ES Obstetrics and Gynaecology 1 0,70
Nagel R Otolaryngology/Head and Neck Surgery 2 1,00
Stoepker C Otolaryngology/Head and Neck Surgery 1 0,50
Hesselink AT Pathology 3 1,00
Lalic D Pathology 3 0,24
Wilting SM Pathology 3 1,00
PhD students
Adank M Clinical Genetics 1 0,20
Bakker JL Clinical Genetics 1 0,75
Corbin M Clinical Genetics 2 0,75
Dommering CJ Clinical Genetics 1 0,10
Faramarz A Clinical Genetics 2 0,75
Haitjema A Clinical Genetics 3 0,75
Kooi EI Clinical Genetics 3 0,75
Massink M Clinical Genetics 2 0,75
Mol BM Clinical Genetics 3 0,69
Roohollahi K Clinical Genetics 1 0,00
Stoepker C Clinical Genetics 1 0,53
de Leeuw DC Laboratory Hematology 3 0,37
Neerincx M Laboratory Medical Oncology 3 0,75
Paulis YWJ Laboratory Medical Oncology 3 0,75
Heusschen R Medical Oncology 3 0,38
Ferns D Obstetrics and Gynaecology 1 0,75
Dekker H Oral and Maxillofacial Surgery and Pathology 1 0,20
Dekker H Oral and Maxillofacial Surgery and Pathology 3 0,25
Matse JH Oral and Maxillofacial Surgery and Pathology 1 0,40
Ramawadh RS Oral and Maxillofacial Surgery and Pathology 1 0,30
de Boer DV Otolaryngology/Head and Neck Surgery 3 0,50
Graveland APJ Otolaryngology/Head and Neck Surgery 1 0,05
Martens-de Kemp SR Otolaryngology/Head and Neck Surgery 3 0,19
Rietbergen MM Otolaryngology/Head and Neck Surgery 3 0,75
van der Plas M Otolaryngology/Head and Neck Surgery 4 0,75
Bierkens M Pathology 3 0,00
Bosch LJW Pathology 2 0,50
Cordes M Pathology 3 0,34
de Strooper LMA Pathology 3 0,75
Hiemstra AC Pathology 1 0,75
Hubers J Pathology 3 1,00
Luttmer R Pathology 3 1,00
Miok V Pathology 3 0,75
Mollers M Pathology 3 0,75
Novalic Z Pathology 3 0,75
Ramayanti O Pathology 3 0,75
Scherpenisse M Pathology 3 0,75
Schütze DM Pathology 3 0,75
Snellenberg S Pathology 3 0,75
van Boerdonk R Pathology 3 0,75
Verweij FJ Pathology 3 0,75
Haloua JP Surgery 3 0,75
Total non tenured staff 33,77

Total research staff 50,07

Appendix Annual Report 2012 VUmc CCA – Scientific input - 8
Program 2: Immunopathogenesis

Department Funding FTE
Full professor
de Rie MA Dermatology 1 0,20
Gibbs S Dermatology 1 0,25
Starink TM Dermatology 1 0,10
Mulder CJJ Gastroenterology 1 0,06
Bitter W Medical Microbiology and Infection Control 1 0,35
Vandenbroucke-Grauls CMJE Medical Microbiology and Infection Control 1 0,12
Beelen RHJ Molecular Celbiology and Immunology 1 0,50
Dijkstra CD Molecular Celbiology and Immunology 1 0,05
Kraal G Molecular Celbiology and Immunology 1 0,60
Mebius RE Molecular Celbiology and Immunology 1 0,80
van Kooyk Y Molecular Celbiology and Immunology 1 0,60
Scheper RJ Pathology 1 0,01
van den Elsen PJ Pathology 1 0,10
Verweij CL Pathology 1 0,20
Verweij CL Pathology 2 0,30
Associate professor
Stoof TJ Dermatology 1 0,08
de Gruijl TD Laboratory Medical Oncology 1 1,00
Appelmelk BJ Medical Microbiology and Infection Control 1 0,70
van Die IM Molecular Celbiology and Immunology 1 0,60
van Egmond M Molecular Celbiology and Immunology 1 0,10
von Blomberg BME Pathology 1 0,09
van Egmond M Surgery 1 0,90
Assistent professor
Franken SM Dermatology 1 0,30
Kirtschig G Dermatology 1 0,05
Rustemeyer T Dermatology 1 0,30
van Montfrans C Dermatology 1 0,20
Felt-Bersma RJF Gastroenterology 1 0,20
van Bodegraven AA Gastroenterology 1 0,20
van Nieuwkerk CMJ Gastroenterology 1 0,20
Ang W Medical Microbiology and Infection Control 1 0,05
van der Sar AM Medical Microbiology and Infection Control 1 0,55
van den Eertwegh AJM Medical Oncology 1 0,05
den Haan JMM Molecular Celbiology and Immunology 2 0,60
Unger WWJ Molecular Celbiology and Immunology 2 0,69
Douma CE Nefrology 3 0,20
Farhat K Nefrology 1 0,15
Nurmohamed SA Nefrology 1 0,15
Mulder MF Paediatrics 1 0,10
van der Plas RN Paediatrics 1 0,00
Other tenured staff
Boks MA Molecular Celbiology and Immunology 2 0,58
van Rooijen N Molecular Celbiology and Immunology 1 0,00
van Vliet SJ Molecular Celbiology and Immunology 2 1,00
Ouburg S Pathology 3 0,17
Scheffer GL Pathology 3 0,25
van Hoogstraten IMW Pathology 1 0,10
Total tenured staff 13,80
Non tenured staff
Reinders J Dermatology 2 0,50
Santegoets SJAM Laboratory Medical Oncology 3 1,00
Geurtsen J Medical Microbiology and Infection Control 2 0,63
Houben E Medical Microbiology and Infection Control 1 0,70
Ambrosini M Molecular Celbiology and Immunology 3 1,00
Bakema JE Molecular Celbiology and Immunology 2 0,89
Appendix Annual Report 2012 VUmc CCA – Scientific input - 9