Pathophysiology: The Biologic Basis for Disease in Adults and Children Kathryn L McCance, Sue E. Huether 2019 8th ed PDF
Preview Pathophysiology: The Biologic Basis for Disease in Adults and Children Kathryn L McCance, Sue E. Huether 2019 8th ed
Pathophysiology THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN EIGHTH EDITION KATHRYN L. McCANCE, MS, PhD Professor Emeritus College of Nursing University of Utah Salt Lake City, Utah SUE E. HUETHER, MS, PhD Professor Emeritus College of Nursing University of Utah Salt Lake City, Utah SECTION EDITORS VALENTINA L. BRASHERS, MD, FACP, FNAP Professor of Nursing and Woodard Clinical Scholar Attending Physician in Internal Medicine University of Virginia Health System Charlottesville, Virginia NEAL S. ROTE, PhD Academic Vice-Chair and Director of Research, Department of Obstetrics and Gynecology University Hospitals Case Medical Center William H. Weir, MD Professor of Reproductive Biology and Pathology Case Western Reserve University, School of Medicine Cleveland, Ohio with more than 1200 illustrations Table of Contents Cover image Title Page What's New? About the Cover Image Copyright Contributors Reviewers Preface Organization and Content: What's New in the Eighth Edition Features to Promote Learning Art Program Ancillaries Acknowledgments Introduction to Pathophysiology References Part One Central Concepts of Pathophysiology: Cells and Tissues Unit I The Cell Chapter 1 Cellular Biology Prokaryotes and Eukaryotes Cellular Functions Structure and Function of Cellular Components Cell-to-Cell Adhesions Cellular Communication and Signal Transduction Cellular Metabolism Membrane Transport: Cellular Intake and Output Cellular Reproduction: the Cell Cycle Tissues Summary Review Key Terms References Chapter 2 Altered Cellular and Tissue Biology Cellular Adaptation Cellular Injury Manifestations of Cellular Injury Cellular Death Aging and Altered Cellular and Tissue Biology Somatic Death Summary Review Key Terms References Chapter 3 The Cellular Environment Distribution of Body Fluids Aging and Distribution of Body Fluids Alterations in Water Movement Sodium, Chloride, and Water Balance Alterations in Sodium, Water, and Chloride Balance Alterations in Potassium, Calcium, Phosphate, and Magnesium Balance Acid-Base Balance Summary Review Key Terms References Unit II Genes, Gene-Environment Interaction, and Epigenetics Chapter 4 Genes and Genetic Diseases DNA, RNA, and Proteins: Heredity at the Molecular Level Chromosomes Elements of Formal Genetics Transmission of Genetic Diseases Linkage Analysis and Gene Identification Summary Review Key Terms References Chapter 5 Genes, Environment-Lifestyle, and Common Diseases Factors Influencing Incidence of Disease in Populations Principles of Multifactorial Inheritance Nature and Nurture: Disentangling the Effects of Genes and Environment Genetics of Common Diseases Summary Review Key Terms References Chapter 6 Epigenetics and Disease Overview of Epigenetic Mechanisms Epigenetics and Human Development Genomic Imprinting Epigenetics in Cognitive Development and Mental Health Exploring the Possible Multigenerational Persistence of Epigenetic States That Arise in Response to Environmental Factors Epigenetic Change Over the Life Span Molecular and Computational Tools for Exploring Epigenetic States Epigenetics and Cancer Emerging Strategies for the Treatment of Epigenetic Disease Future Directions Summary Review Key Terms References Unit III Mechanisms of Self-Defense Chapter 7 Innate Immunity Human Defense Mechanisms First Line of Defense: Physical, Mechanical, and Biochemical Barriers and Normal Microbiome Second Line of Defense: Inflammation Local Manifestations of Inflammation Systemic Manifestations of Acute Inflammation Chronic Inflammation Wound Healing Pediatrics: Innate Immunity in the Newborn Child Aging: Innate Immunity in the Older Adult Population Summary Review Key Terms References Chapter 8 Adaptive Immunity General Characteristics of Adaptive Immunity Recognition and Response Generation of Clonal Diversity Induction of an Immune Response: Clonal Selection Effector Mechanisms Fetal and Neonatal Immune Function Aging and Immune Function Summary Review Key Terms References Chapter 9 Alterations in Immunity and Inflammation Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity References: Deficiencies in Immunity Summary Review Key Terms References
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