Pathology of laboratory rodents and rabbits PDF
Preview Pathology of laboratory rodents and rabbits
PATHOLOGY OF LABORATORY RODENTS AND RABBITS F O U R T H E D I T I O N PATHOLOGY OF LABORATORY RODENTS AND RABBITS Stephen W. Barthold, DVM, MS, PhD, Dipl. ACVP Distinguished Professor Emeritus Veterinary and Medical Pathology University of California Davis, CA Stephen M. Griffey, DVM, PhD Clinical Professor of Laboratory Animal Pathology Director of the Comparative Pathology Laboratory School of Veterinary Medicine University of California Davis, CA Dean H. Percy, DVM, MSc, PhD, Dipl. ACVP Professor Emeritus Pathobiology Department Ontario Veterinary College Guelph, Ontario This edition first published 2016 2016 by John Wiley & Sons, Inc. make no representations or warranties with respect to the accuracy First edition published 1993 Iowa State University Press. or completeness of the contents of this work and specifically Second edition published 2001 Iowa State University Press. disclaim all warranties, including without limitation any implied Third edition published 2007 Blackwell Publishing Professional. warranties of fitness for a particular purpose. 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The publisher and the author Contents Preface vii 2 Rat 119 Introduction, 119 About the companion website ix Anatomic Features, 119 Bibliography for Behavioral and Anatomic 1 Mouse 1 Features, 121 Introduction, 1 General References on Diseases of Rats, 121 Mouse Genetics and Genomics, 2 DNA Viral Infections, 121 Nomenclature, 2 RNA Viral Infections, 125 Common Inbred Strains, 3 Bibliography for Viral Infections, 130 Genomic Considerations for the Pathologist, 4 Bacterial Infections, 132 Anatomic Features, 5 Fungal Infections, 145 Immunologic Idiosyncracies, 10 Bibliography for Bacterial and Fungal Infections, 148 Bibliography for Introduction Through Anatomic Parasitic Diseases, 151 Features, 11 Bibliography for Parasitic Diseases, 154 General References on Diseases of Mice, 12 Age-Related Disorders, 154 Infections of Laboratory Mice: Effects on Miscellaneous Disorders, 159 Research, 12 Environmental Disorders, 161 Bibliography for Infections of Laboratory Mice: Drug-Related Disorders, 162 Effects on Research, 13 Bibliography for Age-, Miscellaneous-, Environmental- DNA Viral Infections, 14 and Drug-Related Disorders, 162 RNA Viral Infections, 23 Neoplasms, 164 Retroelements and Retrovirus Infections, 38 Bibliography for Neoplasms, 170 Bibliography for Viral Infections, 44 Bacterial Infections, 50 3 Hamster 173 Bibliography for Bacterial Infections, 72 Introduction, 173 Fungal Infections, 78 Anatomic Features, 173 Bibliography for Fungal Infections, 81 Bibliography for Introduction and Anatomic Parasitic Diseases, 82 Features, 174 Bibliography for Parasitic Diseases, 88 DNA Viral Infections, 175 Behavioral Disorders, 89 RNA Viral Infections, 178 Bibliography for Behavioral Disorders, 91 Bibliography for Viral Infections, 179 Aging, Degenerative, and Miscellaneous Disorders, 91 Bacterial and Fungal Infections, 180 Bibliography for Aging, Degenerative, and Bibliography for Bacterial and Fungal Infections, 186 Miscellaneous Disorders, 106 Parasitic Diseases, 188 Neoplasms, 108 Bibliography for Parasitic Diseases, 192 Bibliography for Neoplasms, 117 Nutritional and Metabolic Disorders, 193 v vi Contents Diseases Associated With Aging, 194 Bibliography for Nutritional, Metabolic, and Toxic Environomental, Genetic, and Other Disorders, 196 Disorders, 244 Bibliography for Noninfectious Diseases, 197 Miscellaneous Other Disorders, 245 Neoplasms, 197 Bibliography for Miscellaneous Disorders, 249 Bibliography for Neoplasms, 198 Neoplasms, 250 Bibliography for Neoplasms, 252 4 Gerbil 199 Introduction, 199 6 Rabbit 253 Anatomic Features, 199 Introduction, 253 Bibliography for Anatomic Features, 200 Behavioral, Physiologic, and Anatomic Features, 253 Viral Infections, 200 Bibliography for Behavioral, Physiologic, and Bibliography for Viral Infections, 201 Anatomic Features, 257 Bacterial Infections, 201 DNA Viral Infections, 257 Bibliography for Bacterial Infections, 204 RNA Viral Infections, 264 Parasitic Diseases, 204 Bibliography for Viral Infections, 269 Bibliography for Parasitic Diseases, 205 Bacterial Infections, 271 Genetic, Metabolic, and Other Disorders, 206 Bibliography for Bacterial Infections, 288 Bibliography for Genetic, Metabolic, and Other Fungal Infections, 292 Disorders, 209 Bibliography for Fungal Infections, 296 Neoplasms, 209 Parasitic Diseases, 297 Bibliography for Neoplasms, 211 Bibliography for Parasitic Diseases, 304 Noninfectious Gastrointestinal Disorders, 306 Bibiliography for Noninfectious Gastrointestinal 5 Guinea Pig 213 Disorders, 308 Behavioral, Physiologic, and Anatomic Features, 213 Aging and Miscellaneous Disorders, 308 Bibliography for Behavioral, Physiologic, and Bibliography for Aging and Miscellaneous Anatomic Features, 217 Disorders, 312 Viral Infections, 218 Nutritional, Metabolic and Toxic Disorders, 313 Bibliography for Viral Infections, 221 Bibliography for Nutritional, Metabolic, and Toxic Bacterial Infections, 222 Disorders, 316 Bibliography for Bacterial Infections, 231 Genetic Disorders, 318 Fungal Infections, 234 Bibliography for Genetic Disorders, 319 Bibliography for Fungal Infections, 235 Neoplasms, 320 Parasitic Diseases, 235 Bibliography for Neoplasms, 323 Bibliography for Parasitic Diseases, 239 Nutritional, Metabolic, and Toxic Disorders, 239 Index 325 Preface The Fourth Edition of Pathology of Laboratory Rodents and assistance of his friend and colleague, Stephen Griffey. Rabbits has been extensively revised in response to Reviewers suggested a third, younger author (Dr. Griffey) reviewers’ and colleagues’ comments, as well as addition to carry on the tradition of this text in future editions. of new material that has arisen since the Third edition Dr. Griffey, like Drs. Percy and Barthold, is a veterinary was published in 2007. In particular, the chapter on pathologist with extensive experience and expertise in rabbits has been significantly revised and expanded. A laboratory animal pathology. resounding message from reviewers and colleagues was Delving into the literature has been a thought- to publish this edition in color. Technology has provoking journey down memory lane. Many of the advanced such that color images are not only possible contributors to the laboratory animal pathology field but also cost-effective. The images in this text are non are deceased. Unfortunately, younger members of our pareil, and have been generously contributed by col profession must forego the privilege of personally know leagues, gleaned from the recent literature, and derived ing these giants upon whose shoulders our field has been from personal collections of the authors. built. Discovery of new diseases continues, but not at the Also notable in this edition is the change in author pace that took place in the 1970s and 1980s. ship. Dean Percy has fully retired as an active author of This book is dedicated to our families, our mentors, this text, but his significant input remains throughout our colleagues, and our students . . . past, present, and the text from previous editions. This book was his dream, future. It is especially dedicated to the subjects of this and its long-term success since publication of the First text: laboratory rodents and rabbits. They contribute Edition in 1993 can be largely attributed to his vision, enormously to biomedical and veterinary science, and energy, and perseverance. Stephen Barthold stepped up deserve our respect and full support. to the leadership for this edition, with the considerable vii
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