Pancreatic Disease: Protocols and Clinical Research PDF
Preview Pancreatic Disease: Protocols and Clinical Research
Colin D. Johnson Clement W. Imrie Editors Pancreatic Disease Protocols and Clinical Research 123 Pancreatic Disease Colin D. Johnson Clement W. Imrie • Editors Pancreatic Disease Protocols and Clinical Research Editors Colin D. Johnson, MChir FRCS Clement W. Imrie, BSc MB ChB FRCS University Surgical Unit West of Scotland Pancreatic Unit Southampton General Hospital Glasgow Royal Infirmary Southampton Glasgow UK UK ISBN 978-1-84882-117-0 e-ISBN 978-1-84882-118-7 DOI 10.1007/978-1-84882-118-7 Springer London Dordrecht Heidelberg New York British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Control Number: 2009932718 © Springer-Verlag London Limited 2010 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Printed on acid-free paper Springer Science+Business Media springer.com Contents Part I Potential Trials in Acute Pancreatitis 1 Acute Pancreatitis in Intensive Care ...................................................... 3 John Kinsella, Barry Clements, Euan Dickson, Thierry Dugernier, and Martin Hughes 2 Antibiotic Prophylaxis in Acute Severe Pancreatitis: Should We Have a Further Study? ........................................................ 11 Jens Werner, Kevin C.P. Conlon, Hjalmar C. van Santvoort, Caroline S. Verbeke, and Sakhawat H. Rahman 3 Designing an Optimal Study for the Management of Infected Pancreatic Necrosis .............................................................. 21 Marc G.H. Besselink, Hjalmar C. van Santvoort, Ross Carter, Richard M. Charnley, Damian J. Mole, and Hein G. Gooszen 4 Nutrition in Acute Pancreatitis ............................................................... 31 Hemant M. Kocher, Christos Dervenis, Attila Oláh, William R. Murray, Barry Clements, and Clement W. Imrie 5 An Optimal Randomized Study for Pain Control in Acute Pancreatitis ................................................................................ 41 Åke Andrén-Sandberg, Julia V. Mayerle, Ajith K. Siriwardena, David P. Berry, Gareth R. Kirk, and Markus M. Lerch Part II Potential Trials in Chronic Pancreatitis 6 Endoscopic Versus Surgical Drainage for Chronic Pancreatitis ......... 53 Stephen P. Pereira, Shivi S. Siva, and Colin D. Johnson v vi Contents 7 Duodenum-Preserving Pancreatic Resection with Pancreatic Duct Drainage: What Is the Role of Supraduodenal Biliary Drainage? ................................................... 67 Emre F. Yekebas, Christos Dervenis, Richard M. Charnley, Bettina M. Rau, Jens Werner, and Clement W. Imrie Part III Potential Trials in Pancreatic Cancer 8 Pain Management and Nutritional Support in Nonresectable Pancreatic Cancer .................................................................................. 73 David P. Berry, Richard M. Charnley, Christos Dervenis, Gareth R. Kirk, Francis Regan, Emre F. Yekebas, and Clement W. Imrie 9 Endoscopic Therapy in the Palliation of Nonresectable Pancreatic Cancer .................................................... 79 Attila Oláh, William R. Murray, Colin J. McKay, Åke Andrén-Sandberg, Sakhawat H. Rahman, and Colin D. Johnson 10 Pancreatic Endocrine Tumors .............................................................. 85 Damian J. Mole, Caroline S. Verbeke, and Nicholas S. Reed 11 The Role of the Systemic Inflammatory Response in Predicting Outcome in Patients with Pancreatic Cancer .............. 97 Donald C. McMillan Part IV Topic Reviews 12 Botulinum Toxin and the Sphincter of Oddi ....................................... 105 William R. Murray 13 The European Study Group for Pancreatic Cancer (ESPAC) Trials .......................................................................... 109 Paula Ghaneh, Khaled Dajani, Michael G.T. Raraty, Robert Suttton, and John P. Neoptolemos Index ................................................................................................................ 123 Contributors Åke Andrén-Sandberg, MD PhD Department of Surgery, Karolinska University Hospital, Stockholm, Sweden David P. Berry, MB BCh MD FRCS(Eng) FRCS(Gen) Department of Surgery, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK Marc G.H. Besselink, MD PhD Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands Ross Carter, MBChB FRCS MD FRCS(Gen) West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK Richard M. Charnley, MA MB BChir DM FRCS Department of Hepato-Pancreato-Biliary Surgery, Freeman Hospital, Newcastle Upon Tyne, UK Barry Clements, BSc(Hons) MD FRCS(Gen) FRCSI Department of Gastrointestinal Surgery, Royal Victoria Hospital, Belfast, UK Kevin C.P. Conlon, MA MCh MBA FRCSI FACS FRCS(Glas) FTCD Professorial Surgical Unit, University of Dublin, Trinity College, Tallaght, Dublin, Ireland Khaled Dajani, MBChB Department of Surgery, Royal Liverpool Hospital, Liverpool, UK Christos Dervenis, MD FRCS 1st Department of Surgery, Agia Olga Hospital, Athens, Greece Euan Dickson, MD Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK Thierry Dugernier, MD PhD Intensive Care Department, Clinique Saint Pierre, Ottignies, Belgium vii viii Contributors Paula Ghaneh, MD FRCS Department of Surgery, Royal Liverpool Hospital, Liverpool, UK Hein G. Gooszen, MD PhD Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, The Netherlands Martin Hughes, MB ChB BSc MRCP FRCA Intensive Care Unit, Glasgow Royal Infirmary, Glasgow, UK Clement W. Imrie, BSc MB ChB FRCS West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK Colin D. Johnson, MChir FRCS University Surgical Unit, Southampton General Hospital, Southampton, UK John Kinsella, MBBS MD FRCA Department of Anaesthesia, Pain and Critical Care, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK Gareth R. Kirk, MPhil MB FRCS(Glas.)(Gen. Surg.) Department of Surgery, Belfast City Hospital, Belfast, UK Hemant M. Kocher, MBBS MS MD FRCS Barts and the London HPB Centre, The Royal London Hospital, London, UK Markus M. Lerch Department of Medicine A, Ernst-Moritz-Arndt-Universität, Greifswald, Germany Julia V. Mayerle, MD Department of Gastroenterology, Endocrinology and Nutrition, Clinic for Internal Medicine, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany Colin J. McKay, MBChB MD FRCS West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK Donald C. McMillan, PhD University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK Damian J. Mole, BMedSci MBChB PhD MRCS MRC Centre for Inflammation Research and Department of Surgery, The University of Edinburgh, Edinburgh, UK William R. Murray, BSc(Hons), MBChB MD FRCS Lister Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK John P. Neoptolemos, MD FRCS Department of Surgery, Royal Liverpool Hospital, Liverpool, UK Attila Oláh, MD PhD Surgical Department, Petz Aladar County Teaching Hospital, Gyor, Hungary Contributors ix Stephen P. Pereira, BSc PhD FRCP Institute of Hepatology, University College London, London, UK Sakhawat H. Rahman, MBChB MD FRCS Centre for HPB Surgery and Liver Transplantation, Royal Free Hospital, London, UK Michael G.T. Raraty, MD FRCS Department of Surgery, Royal Liverpool Hospital, Liverpool, UK Bettina M. Rau, MD Department of Genearl, Thoracic, Vascular, and Transplantation Surgery, University of Rostock, Rostock, Germany Nicholas S. Reed, MBBS MRCP(UK) FRCR FRCP(Glas) Beatson Oncology Centre, Gartnavel General Hospital, Glasgow, UK Francis Regan Cancer Information Nurse Specialist, Glasgow Royal Infirmary, Glasgow, UK Hjalmar C. van Santvoort, MD Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands Ajith K. Siriwardena, MD FRCS Hepatobiliary Unit, Manchester Royal Infirmary, Manchester, UK Shivi S. Siva, BSc MBBS(Hon) MD ABIM MACP Department of Molecular Medicine, Institute of Cell and Molecular Science, London, UK Robert Sutton, MD FRCS Department of Surgery, Royal Liverpool Hospital, Liverpool, UK Caroline S. Verbeke, MD PhD FRCPath Department of Histopathology, St James’ University Hospital, Leeds, UK Jens Werner, MD MBA Department of General Surgery, University of Heidelberg, Heidelberg, Germany Emre F. Yekebas, MD Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany Introduction Clem Imrie and Colin Johnson This book stems from an unusual meeting held in The Royal College of Physicians and Surgeons of Glasgow in March 2007. Enthusiastic doctors in the diagnosis and treatment of pancreatic diseases were arranged in small groups to discuss specific unsolved/partially clinical problems and suggest the way forward. In some instances, the recommendations were initial improved longitudinal studies, while in others better double-blind randomized stud- ies. The recommendations were then presented on the second day before the total 40 plus participants who added their input. Finally, the mechanics of initiating the proposals were arranged. The editors are most thankful to the authors from the meeting, who have assem- bled the various contributions to this stimulating volume. xi
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