Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management

459 Pages·2015·27.001 MB·English

by  Hans G. Beger, Akimasa Nakao, John P. Neoptolemos, Shu You Peng, Michael G. Sarr

Pancreatic cancer,
cystic neoplasms,
and endocrine tumors

Pancreatic cancer,
cystic neoplasms,
and endocrine tumors
Diagnosis and management
EDITED BY
Hans G. Beger MD, FACS
Emeritus Professor of Surgery
Universitätsklinikum Ulm
Universität Ulm
Ulm, Germany
Akimasa Nakao MD, PhD, FACS
Professor Emeritus, Nagoya University
President, Nagoya Central Hospital
Nagoya, Japan
John P. Neoptolemos MA, MB, BChir, MD, FRCS, FMedSci
The Owen and Ellen Evans Chair of Surgery
NIHR Senior Investigator
NIHR Liverpool Pancreas Biomedical Research Unit
The Liverpool Clinical Trials Unit and Cancer Research UK Cancer Trails Unit Director
Department of Molecular and Clinical Cancer Medicine
Institute of Translational Medicine
University of Liverpool
Liverpool, UK
Shu You Peng MD, FACS, FRCSG, ESA
Professor
Department of Surgery
Second Affiliated Hospital, Zhejiang University
Sir Run Run Shaw Hospital, Zhejiang University
Hangzhou, China
Michael G. Sarr MD
J.C. Masson Professor of Surgery
Department of Surgery
Mayo Clinic
Rochester, Minnesota, USA
This edition first published 2015 © 2015 by John Wiley & Sons, Ltd.
Text illustrations for chapters 18, 25 and 27 © Mayo Clinic, unless stated otherwise.
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Library of Congress Cataloging-in-Publication Data
Pancreatic cancer, cystic neoplasms and endocrine tumors : diagnosis and management / edited by Hans
G. Beger, Akimasa Nakao, John P. Neoptolemos, Shu You Peng, Michael G. Sarr.
p. ; cm.
Includes index.
ISBN 978-0-470-67318-8 (cloth)
I. Beger, H. G. (Hans G.), editor. II. Nakao, Akimasa, editor. III. Neoptolemos, John, editor. IV. Peng,
Shu You, editor. V. Sarr, Michael G., 1950-, editor.
[DNLM: 1. Pancreatic Neoplasms—diagnosis. 2. Neoplasms, Cystic, Mucinous, and Serous—
diagnosis. 3. Neoplasms, Cystic, Mucinous, and Serous—therapy. 4. Neuroendocrine Tumors—
diagnosis. 5. Neuroendocrine Tumors—therapy. 6. Pancreatic Neoplasms—therapy. WI 810]
RC280.P25
616.99′437—dc23
2014048459
A catalogue record for this book is available from the British Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may
not be available in electronic books.
Cover images courtesy of the author
Cover design by Sarah Dickinson
Set in 8.5/12 pt MeridienLTStd by Toppan Best-set Premedia Limited
1 2015
Contents
Contributors, ix 11 Pancreatic cancer: the role of bypass
procedures, 83
Preface, xvii
J.A.M.G. Tol, O.R.C. Busch, T.M. van Gulik,
Abbreviations, xviii
and D.J. Gouma
12 Evidence of adjuvant chemotherapy of ductal
PART I: Ductal adenocarcinoma
pancreatic cancer, 94
of the pancreas
Asma Sultana, Christopher Halloran, Daniel Palmer,
1 Histologic classification and tumor staging of Paula Ghaneh, Trevor Cox, and John P. Neoptolemos
pancreatic cancer, 3
13 Neoadjuvant chemotherapy and
Akio Yanagisawa and Eiichi Konishi
radiochemotherapy: is there a survival advantage
2 What we know about carcinogenesis of ductal for pancreatic cancer patients?, 103
adenocarcinoma of the pancreas, 10 Susan Tsai, Ben George, Kathleen K. Christians,
C.J. Bruns, H. Niess, B. Schwarz, A. Kleespies, and Douglas B. Evans
M.K. Angele, and K.-W. Jauch
14 Standards of palliative chemotherapy and
3 Familial cancer of the pancreas, 15 chemoradiotherapy of local advanced pancreatic
Detlef K. Bartsch, Volker Fendrich, and Peter Langer cancer, side effects, and survival benefits, 120
Hana Algül and Roland M. Schmid
4 Clinical, laboratory, and radiologic presentation of
pancreatic cancer, 23 15 Management of local and distant recurrence after
Susumu Hijioka and Kenji Yamao pancreatic cancer resection, 126
Takuji Okusaka, Kenji Hashimoto,
5 Standards of oncologic pancreatic surgery, 29
Tomoko Katsui Taniyama, Hideki Ueno,
Zhi Ven Fong and Keith D. Lillemoe
Chigusa Morizane, Shunsuke Kondo, Shuichi Mitsunaga,
6 Extended resection for pancreatic cancer: risks and
Satoshi Shimizu, Izumi Ohno, Hideaki Takahashi,
benefits, 47
and Masafumi Ikeda
Akimasa Nakao
16 Survival 3, 5, and 10 years after adjuvant regional
7 Risk/benefit of total pancreatectomy for pancreatic and neoadjuvant chemotherapy in resectable
cancer: are there indications?, 54
pancreatic cancer patients: an institutional
Åke Andrén-Sandberg and Ralf Segersvärd
experience, 132
8 Is there a benefit from additional arterial resection Osamu Ishikawa, Hiroaki Ohhigashi,
of ductal cancer of the pancreas?, 59 Hidenori Takahashi, and Yuri Ito
Satoshi Hirano and Takahiro Tsuchikawa
17 Nonductal primary malignancies of the pancreas:
9 Who benefits from ultraradical pancreatic cancer acinus cell carcinoma, 138
resection?, 62 Marius Distler and Robert Grützmann
Akimasa Nakao
18 Nonductal primary malignancies of the pancreas:
10 Risk and results of pancreatic cancer metastatic malignancies, 142
resection, 69 Victor Zaydfudim, Michael B. Farnell,
Norbert Hüser, Volker Assfalg, and Helmut Friess and Michael G. Sarr
v
vi Contents
PART II: Periampullary cancers 31 What are the pathologic criteria that
justified observational management in
19 Histopathology of tumors of the ampulla of
patients with cystic neoplastic lesions of the
Vater, 153
pancreas?, 229
Lirong Chen
Klaus Sahora and Carlos Fernández-del Castillo
20 Clinical approach to periampullary cancer, 160
32 Indications for operative intervention of cystic
Xiujun Cai
neoplasms of the pancreas, 233
21 Adenoma of the papilla of Vater and endoscopic George H. Sakorafas and Vassileios Smyrniotis
management, 165
33 Surgical management of IPMN lesions of the
Takao Itoi and Shujiro Tsuji
pancreas, 238
22 Controversies about local or regional treatment of Marcus C.B. Tan and Peter J. Allen
adenoma of the papilla of Vater: the Japanese
34 Surgical management of mucinous cystic
experience, 179
neoplastic lesions of the pancreas, 243
Takehiro Ota, Masakazu Yamamoto, and
Klaus Sahora and Carlos Fernández-del Castillo
Ken Takasaki
35 Surgical management of serous cystic neoplasms of
23 Cancer of the papilla: surgical management, 183
the pancreas, 249
Hans G. Beger, Qilu Qiao, and Bertram Poch
Giuseppe Malleo, Claudio Bassi, and Roberto Salvia
24 Evidence of surgical management of distal
36 Surgical management of solid pseudopapillary
common bile duct cancer, 187
neoplasms of the pancreas, 254
Yingbin Liu and Wenguang Wu
Song Cheol Kim
25 Evidence of surgical management of duodenal
37 Limited oncologic resection or major surgery for
cancer, 194
cystic neoplasms of the pancreas?, 259
Rory L. Smoot and Florencia G. Que
Hans G. Beger, Yinmo Yang, and Akimasa Nakao
26 Survival and chance of cure after surgery, adjuvant
38 Enucleation of cystic neoplasia of the
chemotherapy, and palliative chemotherapy of
pancreas, 268
periampullary cancers, 197
Janak A. Parikh and C. Max Schmidt
Hao Ran Qian, Shu You Peng, and Zhi Fei Wang
39 Long-term outcome after observation and
surgical treatment of cystic neoplasms of the
PART III: Cystic neoplastic lesions pancreas, 275
of the pancreas Giuseppe Malleo, Roberto Salvia, and Claudio Bassi
27 Histologic classification and staging of cystic
neoplastic lesions of the pancreas, 207 PART IV: Endocrine neoplasms
Rondell Graham and Thomas C. Smyrk of the pancreas
28 Clinical presentation of cystic neoplastic lesions of 40 Classification of endocrine tumors of the
the pancreas, 216 pancreas, 283
Masao Tanaka J.J. Mukherjee and K.O. Lee
29 Endoscopic ultrasonography and cystic fluid 41 Clinical manifestation of endocrine tumors of the
analysis of the pancreas: evidence of diagnostic pancreas, 293
measures, 221 K.O. Lee
Won Jae Yoon and William R. Brugge
42 Evidence of hormonal, laboratory, biochemical,
30 Natural history of IPMN: adenoma–carcinoma and instrumental diagnostics of endocrine tumors
sequence in IPMN, 225 of the pancreas, 301
Masanori Sugiyama and Yutaka Suzuki David C.E. Ng, J.J. Mukherjee, and K.O. Lee
Contents vii
43 Evidence of medical and radionuclide-targeted 51 Autoimmune pancreatitis: how to recognize this
treatment of endocrine tumors of the entity and avoid surgical treatment, 364
pancreas, 310 Raghuwansh P. Sah and Suresh T. Chari
K.O. Lee, J.J. Mukherjee, and David C.E. Ng
52 What is the place of interventional endoscopic
44 Insulinoma: evidence of surgical treatment, 316 treatment in chronic pancreatitis with
Yiping Mou inflammatory tumor of the pancreatic head?, 373
Yoshiki Hirooka and Hidemi Goto
45 Gastrinoma: evidence of surgical treatment, 324
Renyi Qin 53 When to change from conservative to surgical
management in alcoholic chronic and tropical
46 Rare endocrine tumors of the pancreas: evidence
chronic pancreatitis, 378
of management, 328
Shailesh V. Shrikhande and Savio G. Barreto
Jiang Tao Li, Shu You Peng and De Fei Hong
54 Duodenum-preserving pancreatic head resection in
47 Long-term outcome after clinical management of
chronic pancreatitis with inflammatory mass, 386
endocrine tumors of the pancreas, 335
Hans G. Beger and Bertram Poch
Bin Xu, Jian Wei Wang, Hai Jun Li, and
Xi Yan Wang 55 Major resection for chronic pancreatitis, 392
John C. McAuliffe and John D. Christein
Part V: Chronic pancreatitis with 56 Short-term and long-term outcome after
inflammatory tumor of the pancreas interventional and surgical treatment of chronic
pancreatitis with inflammatory mass, 397
48 Chronic pancreatitis with inflammatory mass in
Volker Assfalg, Norbert Hüser, and Helmut Friess
the pancreatic head, 341
Ulrich F. Wellner and Tobias Keck
Index, 412
49 Chronic tropical pancreatitis: clinical syndromes,
natural course management principles, 347
Savio G. Barreto and Shailesh V. Shrikhande
50 Laboratory, endoscopic, and radiologic diagnostics
of chronic pancreatitis with inflammatory mass in
the head, 355
J. Enrique Domínguez-Muñoz, Julio Iglesias-Garcia,
and Jose Lariño-Noia