Pancreas : pathological practice and research

329 Pages·2007·13.949 MB·English

by  Koichi Suda

Pancreas – Pathological Practice and Research

Pancreas – Pathological
Practice and Research
Editor
Koichi Suda Tokyo
197 figures, and 17 tables, 2007
Basel·Freiburg·Paris·London·New York·
Bangalore·Bangkok·Singapore·Tokyo·Sydney
Koichi Suda, MD, PhD
Department of Human Pathology
Juntendo University
School of Medicine
Tokyo, Japan
Library of Congress Cataloging-in-Publication Data
Pancreas : pathological practice and research / volume editor, Koichi Suda.
p. ; cm.
Includes bibliographical references and indexes.
ISBN-13: 978-3-8055-8240-7 (hard cover : alk. paper)
ISBN-10: 3-8055-8240-4 (hard cover : alk. paper)
1. Pancreas–Pathophysiology. 2. Pancreas–Diseases. I. Suda, Koichi.
[DNLM: 1. Pancreas–physiopathology. 2. Disease Models, Animal. 3.
Pancreatic Diseases–physiopathology. WI 800 P18838 2007]
RC857.P3675 2007
616.3(cid:1)7–dc22
2006101489
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Index Medicus.
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© Copyright 2007 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free paper by Reinhardt Druck, Basel
ISBN: 978–3–8055–8240–7
Contents
IX Preface
Suda, K. (Tokyo)
1 Development of the Pancreas with Relation to Its
Paired Ventral Anlagen
Nobukawa, B. (Tokyo)
8 Vascular Anatomy of the Pancreas
Nobukawa, B. (Tokyo)
12 Anomalous Lesions of the Pancreatic Head and
Vaterian System, Related to Their Structures
Suda, K.; Nobukawa, B. (Tokyo); Suzuki, F. (Chiba); Fujii, H. (Yamanashi);
Matsumoto, M. (Shizuoka); Matsumoto, Y. (Yamanashi); Miyano, T. (Tokyo)
25 Normal Structure/Shape and Distended Glands of Papilla of Vater
Suda, K.; Matsubara, K.; Takei, K.; Sonoue, H.; Yamasaki, S. (Tokyo);
Ohtaka, M. (Yamanashi)
36 Pancreatic Ischemic Lesions
Matsukuma, S.; Suda, K. (Tokyo)
45 Repair/Reparative Change in Acute Pancreatitis and the
Role of Fat Necrosis
Suda, K. (Tokyo); Tsukahara, M. (Tochigi); Takase, M.; Arakawa, A.;
Izumi, H.; Mizutani, Y. (Tokyo)
V
56 Pancreatic Ductal Myofibroblasts
Izumi, M.; Suda, K. (Tokyo)
67 Distribution, Pathogenesis and Progression of
Human Pancreatic Fibrosis
Suda, K. (Tokyo)
80 Electron-Microscopic Aspect of Pancreatic Fibrosis:
Pancreatic Periacinar Collagenization at the Initial Stage
Kuroda, J. (Nagano); Suda, K.; Hosokawa, Y. (Tokyo)
94 Paracrine and Autocrine Mechanisms of Pancreatic Fibrosis
Kumasaka, T.; Fukumura, Y.; Hayashi, T. (Tokyo)
105 Experimental Animal Models of Pancreatic Fibrosis
Kakinuma, C.; Abe, H.; Suda, K. (Tokyo)
135 Experimental Pancreatitis in Animal Models
Yamamura, A. (Tokyo)
146 Histological Characteristics of Chronic Pancreatitis,
Based upon Etiology
Fukumura, Y. (Tokyo)
154 Groove Pancreatitis
Jimi, A. (Fukuoka)
164 Complications of Chronic Inflammation
Takase, M. (Tokyo)
171 Autoimmune Pancreatitis
Takase, M.; Kashiwagi, S. (Tokyo)
178 Regeneration of the Pancreas
Eguchi, M. (Tokyo)
188 Pathology of Pancreas in Collagen Diseases
Matsumoto, T. (Tokyo)
192 Multinucleated Giant Cells in Various Pancreatic Diseases
Miyake, T.; Suda, K.; Yamamura, A. (Tokyo)
199 Age-Related Lesions of the Pancreas, Relevant to Branch
Duct Type IPMT/IPMN and Differential Diagnosis of MCT/MCN
Suda, K. (Tokyo); Komatsu, K. (Kagawa); Nobukawa, B.; Abe, K.;
Ogura, K.; Ueda, A. (Tokyo)
Contents VI
209 Mucinous Cystic Neoplasms of the Pancreas: A Morphological
and Immunohistochemical Study
Shiono, S. (Chiba); Suda, K. (Tokyo)
216 The Spectrum of Serous Cystic Tumors of the Pancreas
Yamasaki, S.; Suda, K. (Tokyo)
228 Intraductal Adenoma and Epithelial Hyperplasia of the
Pancreatic Ducts
Abe, K.; Suda, K.; Sonoue, H. (Tokyo)
237 Carcinoma in situ, Invasive Ductal Carcinoma of the
Pancreas, and Intraductal Papillary-Mucinous Neoplasm
Nobukawa, B. (Tokyo)
246 Intraductal Components of Invasive Ductal
Carcinoma of the Pancreas
Yamasaki, S.; Suda, K. (Tokyo)
257 Fine Needle Aspiration Cytology of Noninvasive
Ductal Carcinomas of the Pancreas.
Differences from Invasive Ductal Carcinoma
Hara, H. (Yamanashi); Suda, K. (Tokyo)
282 Genetic Alterations in Pancreatic Cancer
Nobukawa, B. (Tokyo)
289 Islets of Langerhans in Various States of Glucose Intolerance
Suda, K.; Takei, K.; Matsubara, K.; Itoh, H. (Tokyo); Yamane, T.;
Mogaki, M. (Yamanashi); Kamano, T. (Tokyo)
300 Solid Pseudopapillary Tumor of the Pancreas: Report of Four Cases
Suzuki, F.; Ishi, K. (Chiba); Shiono, S. (Chiba/Tokyo); Arakawa, A.;
Izumi, H. (Tokyo)
310 Author Index
311 Subject Index
Contents VII

Preface
The pancreas lies deep in the
body. It is a calm, silent organ located
behind the stomach, with much hope
and possibilities for solving the physi-
ological and pathological problems of
its behavior. Because the pancreas is a
complicated organ, it is important in
an anatomical and embryological
sense, and because of its frequent age-
related lesions. It develops from two
buds fused into a single organ with a
ductal system, close to the biliary tract
and duodenum. Both mucous-cell
hyperplasia, which corresponds to
PanIN-1, and cystic dilatation of the
branch pancreatic duct, relevant to
branch-duct-type intraductal papillary-
mucinous tumors, frequently occur in
elderly persons, resulting in the modi-
fication of the tissue surrounding it, i.e. atrophy. Moreover, pathological
changes in the pancreas are focal or patchy in nature (i.e. normal tissue is found
adjacent to the affected foci), especially in non-tumorous lesions, but not homo-
geneous and diffuse in the case in the liver.
IX