Paediatric Endocrinology in Clinical Practice PDF
Preview Paediatric Endocrinology in Clinical Practice
PAEDIATRIC ENDOCRINOLOGY IN CLINICAL PRACTICE P AEDIAT RIC ENDOCRINOLOGY IN CLINICAL PRACTICE Edited by A. AYNSLEY-GREEN James Spence Professor of Child Health The Children's Clinic Royal Victoria Infirmary Newcastle upon Tyne England Proceedings of the Royal College oj Pfrysicians' Paediatric Endocrinology Conference held in London 20-21 October 1983 ~c_~ MTP PRESS LIMITED d a member of the KLUWER ACADEMIC PUBLISHERS GROUP • LANCASTER / BOSTON / THE HAGUE / DORDRECHT Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Paediatric endocrinology in clinical practice 1. Pediatric endocrinology I. Aynsley-Green, A. 618.92'4 RJ418 ISBN-13 :978-94-01 0-8974-6 e-ISBN-13 :978-94-009-561 0-0 DOl: 10.1 007/978-94-009-5610-0 Published in the USA by MTP Press A division of Kluwer Boston Inc 190 Old Derby Street Hingham, MA 02043, USA Library of Congress Cataloging in Publication Data Paediatric Endocrinology Conference (1983: London, England) Paediatric endocrinology in clinical practice Includes bibliographical references and index. 1. Pediatric endocrinology-Congresses. I. Aynsley-Green, A. II. Royal College of Physicians of. III. Title. [DNLM: 1. Endocrine Diseases-in infancy & childhood-congresses. 2. Endocrine Glands-physiology-congresses. WS 330 Pl265c 1983] RJ418.P34 1983 618.92'4 84-11275 Copyright © 1984 MTP Press Limited Softcover reprint of the hardcover 1s t edition 1984 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. CONTENTS Page Preface IX List of Chairmen X List of Contributors Xl SECTION 1 NEONATAL ENDOCRINOLOGY Chairman: THE PRESIDENT The effects of maternal endocrine disease on the fetus and neonate 3 J. A. H. WASS 2 Normal and abnormal pancreatic endocrine function in the fetus and neonate 19 A. AYNSLEy-GREEN SECTION 2 THE THYROID GLAND Chairman: DR D. I. JOHNSTON 3 Congenital hypothyroidism: pathogenesis, screenmg and prognosIs 45 D. B. GRANT 4 Clinical aspects of acquired thyroid disease in childhood 55 N. D. BARNES v PAEDIATRIC ENDOCRINOLOGY IN CLINICAL PRACTICE Page SECTION 3 DISORDERS OF SEXUAL DEVELOPMENT Chairman: DR D. A. PRICE 5 Pathogenesis and investigation of ambiguous genitalia 75 M. O. SAVAGE 6 Medical and psychological management of congenital adrenal hyperplasia 83 I. A. HUGHES 7 Surgical management of intersex in childhood 117 J. DEWHURST 8 The Teale Lecture 1983 Fetal growth: the role of insulin and related pep tides 125 R. D. G. MILNER SECTION 4 NORMAL AND ABNORMAL GROWTH Chairman: DR P. H. W. RAYNER 9 Normal growth in infancy, childhood and adolescence 149 M. A. PREECE 10 Investigation and management of abnormal growth 161 M. A. PREECE SECTION 5 NORMAL AND ABNORMAL PUBERTY Chairman: DR C. C. FORSYTH 11 Endocrine aspects of normal pubertal development 175 P. C. SIZONENKO 12 The effects of chemotherapy and radiotherapy for malignant disease on growth and sexual development 183 S.M. SHALET VI CONTENTS Page SECTION 6 MISCELLANEOUS DISORDERS Chairman: PROFESSOR J. W. F ARQ.UHAR 13 Some aspects of the genetics of paedia tric endocrinology 203 R. HARRIS 14 HLA-DR expression on endocrine cells: a new way to look at autoimmunity 219 G. F. BOTTAZZO and D. DONIACH 15 Controversies in diabetes mellitus 227 J. D. BAUM 16 Practical management of disorders of calcium homeostasis 241 J. ALLGROVE Index 265 VII PREFACE This book is made up of 16 papers delivered during the Paediatric Conference convened by the Royal College of Physicians of London on 20th and 21st October 1983. The main intention oft he conference was to allow each contributor to deliver a personal review of his own field, indicating recent develop- ments and current practice. This volume, representing the proceedings of that meeting, is not intended as a comprehensive textbook of paedi- atric endocrinology but rather as a series of personal narratives. I wish to express my thanks to the Chairmen, who so ably stimulated discussion, and to Miss Gillian Andrew, Conference Secretary of the Royal College of Physicians, and her colleagues, for providing invalu- able help in the organization of the conference. I am also grateful to the staff ofMTP Press Limited for their help in producing the book. A. Aynsley-Green IX LIST OF CHAIRMEN Professor R. Hoffenburg PRCP Dr D. I. Johnston MD FRCP President Queen's Medical Centre Royal College of Physicians Nottingham London Dr D. A. Price FRCP Professor J. W. Farquhar MD Royal Manchester Children's FRCP(Ed) Hospital Department of Child Life and Health Pendlebury University of Edinburgh Manchester Edinburgh Dr P. H. W. Rayner FRCP Dr C. C. Forsyth MD FRCP Institute of Child Health Department of Child Health University of Birmingham University of Dundee Birmingham Dundee x LIST OF CONTRIBUTORS Dr J. Allgrove MRCP Dr D. B. Grant MD FRCP East Birmingham Hospital The Hospital for Sick Children Birmingham Great Ormond Street London Professor A. Aynsley-Green DPhil FRCP Professor R. Harris MD FRCP Department of Child Health Department of Medical Genetics University of Newcastle upon Tyne St Mary's Hospital Newcastle upon Tyne Manchester Dr N. D. Barnes FRCP Department of Paediatrics Dr I. A. Hughes MD FRCP Addenbrooke's Hospital Department of Child Health Cambridge Welsh National School of Medicine Cardiff Dr J. D. Baum. MD FRCP Department of Paediatrics Professor R. D. G. Milner MD University of Oxford FRCP Oxford Departmen t of Paediatrics University of Sheffield Dr G. F. Bottazzo MD MRCP Sheffield Department of Immunology ( Teale Lecturer) The Middlesex Hospital London Dr M. A. Preece MD FRCP Institute of Child Health Professor Sir John Dewhurst FRCOG 30 Guilford Street London Queen Charlotte's Maternity Hospital London Dr M. O. Savage MD MRCP Professor D. Doniach MD FRCP Department of Child Health Department of Immunology St Bartholomew's Hospital The Middlesex Hospital Medical Queen Elizabeth Hospital for School Children London London xi PAEDIATRIC ENDOCRINOLOGY IN CLINICAL PRACTICE Dr S. M. Shalet MD MRCP Dr J. A. H. WassMDMRCP Christie Hospital and Holt Radium Department of Endocrinology Institute St Bartholomew's Hospital Withington London Manchester Professor P. C. Sizonenko MD Division de Biologie de la Croissance et de la Reproduction Hopital Cantonal Universitaire Geneva Switzerland XII
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