Oxidative Stress in Lung Diseases: Volume 1

488 Pages·2019·11.896 MB·English

by  Sajal Chakraborti, Tapati Chakraborti, Salil Kumar Das, Dhrubajyoti Chattopadhyay

Sajal Chakraborti · Tapati Chakraborti 
Salil Kumar Das 
Dhrubajyoti Chattopadhyay E ditors
Oxidative
Stress in Lung
Diseases
Volume 1
Oxidative Stress in Lung Diseases
Sajal Chakraborti
Tapati Chakraborti
Salil Kumar Das
Dhrubajyoti Chattopadhyay
Editors
Oxidative Stress in Lung
Diseases
Volume 1
Editors
Sajal Chakraborti Tapati Chakraborti
Department of Biochemistry and Biophysics Department of Biochemistry and Biophysics
University of Kalyani University of Kalyani
Kalyani, West Bengal, India Kalyani, West Bengal, India
Salil Kumar Das Dhrubajyoti Chattopadhyay
Department of Biochemistry Amity University
and Cancer Biology Kolkata, West Bengal, India
Meharry Medical College
Nashville, TN, USA
ISBN 978-981-13-8412-7 ISBN 978-981-13-8413-4 (eBook)
https://doi.org/10.1007/978-981-13-8413-4
© Springer Nature Singapore Pte Ltd. 2019
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Singapore
This book is dedicated to Prof. Padmanabhan
Balaram, who was born on 19 February,
1949. Professor Padmanabhan Balaram is
an outstanding Indian biochemist, an
exceptional academic administrator, and a
former director of the Indian Institute of
Science (IISc), Bangalore, India.
vi
He is currently the distinguished professor of
Molecular Biophysics at the IISc, Bangalore,
India. His main research interests are in
bioorganic chemistry and molecular
biophysics. He is the author of over 580
research papers with more than 16, 800
citations.
Prof. Balaram received his bachelor’s degree
in Chemistry from Fergusson College,
Savitribai Phule Pune University, M.Sc. from
the Indian Institute of Technology-Kanpur
(1969), and PhD in Chemistry with Prof.
Aksel A. Bothner-By from Carnegie Mellon
University, Pittsburgh, USA (1972). During
his PhD, he studied the use of negative
nuclear Overhauser effect signals as probes
of macromolecular conformations. He did
his postdoctoral research at Harvard
University with Nobel laureate Prof. Robert
Burns Woodward. As a postdoc with Prof.
Woodword, he worked on the synthesis of the
antibiotic erythromycin.
Prof. Balaram is a fellow of the Indian
Academy of Sciences, the Indian National
Science Academy, and the Third World
Academy of Sciences, Trieste, Italy. He has
received many awards/honors in recognition
of his work, of which mention must be made
of the Shanti Swarup Bhatnagar Prize of the
CSIR (1986), Alumni Award for Excellence
in Research of the IISc (1991), G.D. Birla
Award for Scientific Research (1994),
Distinguished Alumnus Award of the IIT
Kanpur (2000), and Padma Shri by the
Government of India (2002). He also
received the third highest Indian civilian
honor of Padma Bhushan (2014). He has
vii
served on many committees like CSIR, DST,
DBT, DAE, DRDO, ICMR, and UGC of the
Government of India and is currently a
member of the Science Advisory Committee
to the Union Cabinet and Scientific Advisory
Council to the Prime Minister, among others.
He has been the editor of Current Science
since 1995. He is currently serving in the
editorial board of the following journals:
ChemBioChem, Biopolymers, and Protein
Engineering, Design and Selection.
Prof. Balaram undoubtedly is a legendary
figure in Indian Science. He has excellent
ability to inspire and motivate young
researchers. We feel honored to dedicate this
book to him and wish him good health and
success in his long fruitful activities.
Preface
“The aim of science is not to open
the door to infinite wisdom,
but to set a limit to infinite error.”
Bertolt Brecht: Life of Galileo
The number of diseases in which detrimental oxidative stress has been proposed to
play a causative or exacerbating role has grown steadily over the past two decades.
Among them, the most prevalent one is the oxidant-mediated lung diseases.
As the lungs lie in the interface between environment and oxidative processes of
tissues, it must possess several mechanisms to prevent excessive degree of stress.
Enzymatic and nonenzymatic antioxidant systems can quench a wide range of ROS.
Diseases like asthma, chronic obstructive pulmonary disease (COPD), and acute
respiratory distress syndrome (ARDS) occur from a number of sources, including
greater exposure to environmental prooxidants, airway infiltration of inflammatory
cells, metabolic dysregulation, and reduced levels of antioxidants.
The oxidant burden in the lung is enhanced in smokers by the release of ROS
from macrophages and neutrophils. Oxidants present in cigarette smoke can stimu-
late alveolar macrophages to produce ROS and to release a host of mediators, some
of which attract neutrophils and other inflammatory cells in the lungs, thereby gen-
erating ROS via NADPH oxidase system. A marked increase in the numbers of
neutrophils and macrophages was observed in the lungs of cigarette smokers com-
pared with those of the non-smokers. Moreover, the lungs of smokers with airway
obstruction have more neutrophils than smokers without airway obstruction.
Circulating neutrophils from cigarette smokers and patients with exacerbations of
COPD release more O−. Cigarette smoke is associated with a marked increase in
2
the production of myeloperoxidase (MPO) in neutrophils, which can be correlated
with the degree of pulmonary dysfunction.
This book contains 23 state-of-the-art chapters contributed by established inves-
tigators working on the different oxidative stress-induced aspects of lung diseases.
Each chapter of the book summarizes information from basic research that hints to
possible pharmacological intervention. We hope that this book will be useful for the
postgraduate students and biomedical researchers to better understand the
ix
x Preface
mechanisms associated with oxidant-induced lung diseases and to identify targets
for drug development for different types of lung diseases.
Our sincere gratitude goes to all contributors for their considerable energy, time,
and effort to accomplish a complete chapter with no quid pro quo benefit. We are
thankful to Dr. Madhurima Kahali and Raagai Priya Chandrasekaran (Springer
Nature) for their cooperation and support during the preparation of this book.
Kalyani, West Bengal, India Sajal Chakraborti
Contents
Part I General Implications of Oxidative Stress on Lungs
1 Nutrition in Inflammatory Lung Diseases . . . . . . . . . . . . . . . . . . . . . . 3
Daisy Karina Aguilar-López, Carlos Olvera-Sandoval,
Diego Estrada-Luna, Jeannett Alejandra Izquierdo-Vega,
Ashutosh Sharma, and Gabriel Betanzos-Cabrera
2 Oxidative Stress and Smoke-Related Lung Diseases:
A Tentative Approach Through the Blood, Lungs, and Gut . . . . . . . . 27
Francesco Marotta, Jaganath Arunachalam, Antara Banerjee,
Roberto Catanzaro, Sudhir Adalti, Aparimita Das,
Alexander Kolyada, and Surajit Pathak
3 Oxidative Stress in Neonatal Lung Diseases . . . . . . . . . . . . . . . . . . . . . 51
Ru-Jeng Teng
4 DNA Repair Protein OGG1 in Pulmonary Infection
and Other Inflammatory Lung Diseases . . . . . . . . . . . . . . . . . . . . . . . . 85
Ping Lin, Qinqin Pu, Shugang Qin, Jacob Schettler,
Mariah Thoemke, Guoping Li, Jianxin Jiang, and Min Wu
5 The Dual Role of Oxidative Stress in Lung Cancer . . . . . . . . . . . . . . . 99
Asmaa M. Ahmed
6 Cigarette Smoke-Induced Oxidative Stress in Type I
and Type II Lung Epithelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
Subodh Kumar, Phulen Sarma, Bikash Medhi,
and Krishan L. Khanduja
7 Infectious Lung Diseases and Endogenous Oxidative Stress . . . . . . . 125
Kasturi Sarkar and Parames C. Sil
8 Role of MMPs and Oxidants in Lung Diseases . . . . . . . . . . . . . . . . . . 149
Nilanjana Deb, Sudipta Mallick, Ashish Jaiswal, Anirban Manna,
Ulaganathan Mabalirajan, and Snehasikta Swarnakar
xi