Oxford Textbook of Cancer Biology

500 Pages·2019·157.095 MB·English

by  Francesco Pezzella (editor), Mahvash Tavassoli (editor), David J. Kerr (editor)

Oxford Textbook of
Cancer Biology

Oxford Textbook of
Cancer Biology
EDITED BY
Francesco Pezzella
Nuffield Division of Clinical Laboratory Sciences,
Radcliffe Department of Medicine,
University of Oxford, Oxford, UK
Mahvash Tavassoli
Department Mucosal and Salivary Biology,
King’s College London,
London, UK
David J. Kerr
Nuffield Division of Clinical Laboratory Sciences,
Radcliffe Department of Medicine,
University of Oxford, Oxford, UK;
Weill Cornell College of Medicine,
New York, USA
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Preface
The textbook is dead. Long live the textbook! With increased output understand that without novel basic science and the generation of
of rapidly published new data and availability of teaching material new knowledge, there cannot be sustainable innovations in cancer
on the web, it has often been predicted that the textbook will be- diagnosis and therapy. We have structured this book logically and
come extinct. However, in our experience, it has also become in- trust that the inquisitive reader will select which chapters to explore
creasingly difficult to find a comprehensive text which enables us in greater depth.
to catch up with the current state of art in multiple fields, within There is a difference between the textbooks of today and yes-
a wider contextual framework. While the high number of research terday: before, publication was the terminus or end of the work for
and review papers provide a continuous update on increasingly its authors; now, because of the integration between the printed
narrow and specialized topics in cancer biology, we think there will book and online resources, this is no longer the case. This will allow
be always a need for concise, coherent descriptions of the funda- us to annually review, revise, and update the chapters on the online
mentals on areas like cell cycle or cell death. This is particularly im- version of the book to reflect recent developments in the field.
portant for students who require a platform of basic information Finally, as this is a cancer textbook, we would like to remember
before venturing more deeply into the literature. We have assembled our parents, relatives, friends and, of course, patients whose lives
a fantastic cast of authors, each of whom are outstanding in their have been affected and in many cases, ended too soon by this dis-
field, and have attempted, when relevant, to make the translational ease. We hope this book is another small step forward in the right
link to the application of cancer biology for patient benefit. We must direction.

Acknowledgements
We would like to thank our friends Sandor Paku, Balazs Dome, and of creating this book: Andrea, Caroline, Janine, Sree, and Anya.
Andrew Reynolds for granting us permission to use the picture on We also would like to thank all the authors for their work and their
the cover of the book, illustrating a non- angiogenic tumour growing willingness and commitment to write.
in a mouse model.
We would also like to acknowledge the help and support by
Oxford University Press staff that guided us through the process

Contents
Abbreviations xi SECTION III
Contributors xv
How the cancer cell works
9. Growth factors and associated signalling
SECTION I pathways in tumour progression and in cancer
treatment 105
The multicellular organism
Nadège Gaborit and Yosef Yarden
1. The multicellular organism and cancer 3 10. Hormones and cancer 123
Francesco Pezzella, David J. Kerr, and Mahvash Tavassoli Balkees Abderrahman and V. Craig Jordan
2. DNA repair and genome integrity 13 11. Oncogenesis and tumour suppression 136
Giacomo Buscemi Mahvash Tavassoli and Francesco Pezzella
3. Evolution and cancer 33 12. The signalling pathways in cancer 155
Tom Donnem, Kingsley Micklem, and Francesco Pezzella Jiangting Hu and Francesco Pezzella
13. Cell cycle control 178
Simon Carr and Nicholas La Thangue
SECTION II
14. Cancer and cell death 196
The aetiology of cancer
Jessica Bullenkamp and Mahvash Tavassoli
4. Genetics and genetic instability in cancer 43 15. Telomerase and immortalization 209
Mark A. Glaire and David N. Church Laura Collopy and Kazunori Tomita
5. Epigenetics 56 16. Cancer metabolism 221
Edward Hookway, Nicholas Athanasou, Almut Schulze, Karim Bensaad, and Adrian L. Harris
and Udo Oppermann
17. Chaperones and protein quality control in the
6. Viral carcinogenesis—an overview 71 neoplastic process 239
Dirk P. Dittmer and Blossom Damania Andrea Rasola
7. Chemical carcinogens 79 18. Oxygen and cancer: The response to hypoxia 255
David H. Phillips Adrian L. Harris and Margaret Ashcroft
8. Radiation as a carcinogen 91 19. Invasion, metastasis, and tumour dormancy 270
Yan- Qun Xiang and Chao- Nan Qian Andrey Ugolkov and Andrew P. Mazar
20. Cancer stem cells 283
Connor Sweeney, Lynn Quek, Betty Gration, and Paresh Vyas