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Oxford Handbook of Neonatology PDF

575 Pages·2017·8.603 MB·English
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i OXFORD MEDICAL PUBLICATIONS Oxford Handbook of Neonatology ii Published and forthcoming Oxford Handbooks Oxford Handbook for the Foundation Oxford Handbook of General Programme 4e Practice 4e Oxford Handbook of Acute Oxford Handbook of Genetics Medicine 3e Oxford Handbook of Genitourinary Oxford Handbook of Anaesthesia 4e Medicine, HIV, and Sexual Health 2e Oxford Handbook of Applied Dental Oxford Handbook of Geriatric Sciences Medicine 2e Oxford Handbook of Cardiology 2e Oxford Handbook of Infectious Oxford Handbook of Clinical and Diseases and Microbiology 2e Healthcare Research Oxford Handbook of Key Clinical Oxford Handbook of Clinical and Evidence 2e Laboratory Investigation 3e Oxford Handbook of Medical Oxford Handbook of Clinical Dermatology 2e Dentistry 6e Oxford Handbook of Medical Imaging Oxford Handbook of Clinical Oxford Handbook of Medical Sciences 2e Diagnosis 3e Oxford Handbook of Medical Statistics Oxford Handbook of Clinical Oxford Handbook of Neonatology 2e Examination and Practical Skills 2e Oxford Handbook of Nephrology and Oxford Handbook of Clinical Hypertension 2e Haematology 4e Oxford Handbook of Neurology 2e Oxford Handbook of Clinical Oxford Handbook of Nutrition and Immunology and Allergy 3e Dietetics 2e Oxford Handbook of Clinical Oxford Handbook of Obstetrics and Medicine—Mini Edition 9e Gynaecology 3e Oxford Handbook of Clinical Oxford Handbook of Occupational Medicine 9e Health 2e Oxford Handbook of Clinical Pathology Oxford Handbook of Oncology 3e Oxford Handbook of Clinical Oxford Handbook of Operative Pharmacy 2e Surgery 3e Oxford Handbook of Clinical Oxford Handbook of Ophthalmology 3e Rehabilitation 2e Oxford Handbook of Oral and Oxford Handbook of Clinical Maxillofacial Surgery Specialties 10e Oxford Handbook of Orthopaedics Oxford Handbook of Clinical Surgery 4e and Trauma Oxford Handbook of Complementary Oxford Handbook of Paediatrics 2e Medicine Oxford Handbook of Pain Management Oxford Handbook of Critical Care 3e Oxford Handbook of Palliative Care 2e Oxford Handbook of Dental Oxford Handbook of Practical Drug Patient Care Therapy 2e Oxford Handbook of Dialysis 4e Oxford Handbook of Pre-Hospital Care Oxford Handbook of Emergency Oxford Handbook of Psychiatry 3e Medicine 4e Oxford Handbook of Public Health Oxford Handbook of Endocrinology Practice 3e and Diabetes 3e Oxford Handbook of Reproductive Oxford Handbook of ENT and Head Medicine and Family Planning 2e and Neck Surgery 2e Oxford Handbook of Respiratory Oxford Handbook of Epidemiology for Medicine 3e Clinicians Oxford Handbook of Rheumatology 3e Oxford Handbook of Expedition and Oxford Handbook of Sport and Exercise Wilderness Medicine 2e Medicine 2e Oxford Handbook of Forensic Handbook of Surgical Consent Medicine Oxford Handbook of Tropical Oxford Handbook of Gastroenterology Medicine 4e and Hepatology 2e Oxford Handbook of Urology 3e iii Oxford Handbook of Neonatology Second Edition Dr Grenville Fox Consultant Neonatologist, Evelina London Children’s Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK Dr Nicholas Hoque Consultant Neonatologist, Queen Charlotte’s and St Mary’s Hospitals, Imperial College Healthcare NHS Trust, UK and Dr Timothy Watts Consultant Neonatologist, Evelina London Children’s Hospital, Guy’s & St Thomas’ NHS Foundation Trust, London, UK 1 iv 1 Great Clarendon Street, Oxford, OX2 6DP, United Kingdom Oxford University Press is a department of the University of Oxford. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries © Oxford University Press 2017 The moral rights of the authors have been asserted First Edition published in 2010 Second Edition published in 2017 Impression: 1 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by licence or under terms agreed with the appropriate reprographics rights organization. Enquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above You must not circulate this work in any other form and you must impose this same condition on any acquirer Published in the United States of America by Oxford University Press 198 Madison Avenue, New York, NY 10016, United States of America British Library Cataloguing in Publication Data Data available Library of Congress Control Number: 2016945507 ISBN 978– 0– 19– 870395– 2 Printed and bound in China by C&C Offset Printing Co., Ltd. Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up-t o- date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-p regnant adult who is not breast- feeding Links to third party websites are provided by Oxford in good faith and for information only. Oxford disclaims any responsibility for the materials contained in any third party website referenced in this work. v v Preface The original idea for this handbook arose from files of clinical guidelines from our own neonatal unit. Our ethos in developing these guidelines was that they should avoid dogma and provide practical guidance rather than rigid rules and regulations. These have been rewritten to provide much of the practical advice given in this handbook, with succinct background notes added to each topic. We hope this will provide enough detail to inform medical and nursing staff at all levels and act as an aide-memoire to those with more experience in the specialty. Practical guidance and a suggested approach to different clinical situations have been written using the best available evidence, but we have relied on consensus of opinion where evi- dence is lacking. This second edition has a revised chapter order and a new chapter on neonatal endocrinology, with updates to all other sections reflecting recent changes and evidence in the specialty. Grenville Fox Nicholas Hoque Timothy Watts vi vii vii Acknowledgements We are grateful to our consultant colleagues, trainees, senior nursing staff, and subspecialty teams at the Evelina London Children’s Hospital Neonatal Unit at St.Thomas’ Hospital, who have contributed to the guidelines which formed the original idea for this handbook. We are particularly grateful to Michael Champion from the Evelina London Children’s Hospital for his con- tribution to the metabolic section; and to Julia Phillips from King’s College Hospital, and Tony Hulse from the Evelina London Children’s Hospital for the new endocrinology chapter. We are also grateful to Victoria Barr for rendering of selected illustrations. viii ix ix Contents Symbols and abbreviations xi 1 Antenatal care, obstetrics, and fetal medicine  1 2 Management at birth and routine postnatal care  19 3 Problems on the postnatal ward  31 4 Admission, discharge, and outcome  51 5 Fluids and electrolytes  71 6 Nutrition  87 7 Respiratory problems  105 8 Respiratory support  149 9 Cardiovascular problems  169 10 Gastrointestinal problems  235 11 Neurological problems  275 12 Infection  323 13 Metabolic problems and jaundice  371 14 Haematological problems  393 15 Nephrological and urological problems  423 16 Endocrinology  439 17 Iatrogenic problems  457 18 Neonatal transport  465 19 Family support, consent, and end of life care  483 20 Practical procedures  493 21 Normal values, therapeutic drug levels, and useful formulae  531 Index 543

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