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Optimization of Care Strategies PDF

239 Pages·2016·11.52 MB·English
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ptimization Car Strat gi s in mophilia Jansk oc ptimiz tion C r Jansk oc Str t gi s in mophili Optmizaton of Care Strategies in Hemophilia Janske Lock Colofon Printing of this thesis was kindly supported by: Bayer HealthCare, CSL Behring, Erasmus MC, Novo Nordisk, and Pfzer. Cover lay-out: J.D. Lock. Cover photo: stocksolutions / 123RF Stockfoto. Lay-out and Printing: Optima Grafsche Communicatie, Rotterdam, the Netherlands. ISBN: 978-94-6169-918-3 © Janske Lock, 2016 All rights reserved. No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any electronic, mechanical, or other means, now known, or hereafter invented, including photocopying and recoding, or in any information storage and retrieval system without prior written permission of the author or, when appropriate, of the publishers of the publications. Optimization of Care Strategies in Hemophilia Optimaliseren van behandelstrategieën bij hemoflie Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnifcus prof.dr. H.A.P. Pols en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 26 oktober 2016 om 13:30 uur door Jannetje Lock geboren te Ede PROMOTIECOMMISSIE Promotoren: Prof. dr. F.W.G. Leebeek Prof. dr. H.A. Moll Overige leden: Prof. dr. R.A.A. Mathôt Dr. M. Peters Prof. dr. H. Raat Copromotor: Dr. M.H. Cnossen Old ways won’t open new doors. TabLE Of COnTEnTS Chapter 1 General introduction, aims and outline 9 PaRT I IMPROVEMEnT Of PaTIEnT OUTCOME bY OPTIMIZaTIOn Of HEMOPHILIa CaRE Chapter 2 Optimization of home treatment in hemophilia: efects of 23 transmural support by a hemophilia nurse on adherence and quality of life Haemophilia. 2016; Accepted for publication. Chapter 3 Adherence to treatment in a Western European pediatric 47 population with hemophilia: reliability and validity of the VERITAS-Pro scale Haemophilia. 2014 Sep;20(5):616-23. Chapter 4 Reliability and validity of a novel Hemophilia-specifc 67 Self-Efcacy Scale Haemophilia. 2014 Jul;20(4):e267-74. Chapter 5 The Group Medical Appointment in hemophilia and von 87 Willebrand’s disease: a new development in pediatric outpatient care Haemophilia. 2012 Sep;18(5):766-72. PaRT II IMPROVEMEnT Of PaTIEnT OUTCOME bY OPTIMIZaTIOn Of HEMOPHILIa TREaTMEnT Chapter 6 Perioperative treatment of hemophilia A patients: blood 103 group O patients are at risk of bleeding complications J Thromb Haemost. 2016 Mar;14(3):468-78. Chapter 7 A population pharmacokinetic model for perioperative 129 dosing of factor VIII in hemophilia A patients Haematologica. 2016 Jul; Epub. Chapter 8 Facilitating implementation of pharmacokinetic-guided 153 dosing of prophylaxis in hemophilia care by discrete choice experiment Haemophilia. 2016 Jan;22(1):e1-e10. Chapter 9 General discussion and future perspectives 181 Chapter 10 Summary/ Samenvatting 201 aPPEnDICES I List of Abbreviations 220 II List of Publications 222 III Authors and Afliations 224 IV Word of Thanks/ Dankwoord 227 V PhD Portfolio 233 VI About the Author 236

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