Oncogenes and Tumor Suppressor Genes in Human Malignancies

389 Pages·1993·21.054 MB·English

by  Edison Liu, Bernard Weissman (auth.), Christopher C. Benz, Edison T. Liu (eds.)

Oncogenes and Tumor Suppressor Genes in Human
Malignancies
Cancer Treatment and Research
Livingston R.B. (ed): LungCancer1. 1981. ISBN90-247-2394-9
HumphreyG.B., DehnerL.P.,GrindeyG.B.,ActonR.T. (eds): PediatricOncology1. ISBN90-274-2408-2
DeCosseJ.J.,SherlockP.(eds):GastrointestinalCancer1. 1981. ISBN90-247-2461-9
BennettJ.M. (ed): Lymphomas I,includingHodgkin'sDisease. 1981. ISBN90-247-2479-1
BloomfieldCe. (ed): Adult Leukemias 1. 1982. ISBN90-247-2478-3
PaulsonD.F. (ed):GenitourinaryCancer1. 1982. ISBN90-247-2480-5
Muggia F.M.(ed):CancerChemotherapy I. 1983. ISBN90-247-2713-8
HumphreyG.B., GrindeyG.B. (eds): PancreaticTumorsinChildren. 1982. ISBN90-247-2702-2
CostanziJ.J. (ed): Malignant Melanoma 1. 1983. ISBN90-247-2706-5
GriffithsCT., FullerA.F. (eds): GynecologicOncology. 1983. ISBN0-89838-555-5
GrecoA.F. (ed): BiologyandManagementofLungCancer. 1983. ISBN0-89838-554-7
WalkerM.D. (ed):OncologyoftheNervousSystem. 1983. ISBN0-89838-567-9
Higby D.J. (ed):SupportiveCareinCancerTherapy. 1983. ISBN0-89838-569-5
Herberman R.B. (ed): BasicandClinicalTumorImmunology. 1983. ISBN0-89838-579-2
BakerL.H. (ed):SoftTissueSarcomas. 1983. ISBN0-89838-584-9
BennettJ.M. (ed):Controversiesinthe ManagementofLymphomas. 1983. ISBN0-89838-586-5
HumphreyG.B.,GrindeyG.B.(eds):AdrenalandEndocrineTumorsinChildren. 1983.ISBN0-89838-590-3
DeCosseJ.J., Sherlock P. (eds): Clinical Management ofGastrointestinal Cancer. 1984. ISBN 0-89838
601-2
CatalonaWJ., RatliffT.L. (eds): UrologicOncology. 1984. ISBN0-89838-628-4
Santen R.J., Manni A. (eds): Diagnosis and Management of Endocrine-Related Tumors. 1984. ISBN
0-89838-636-5
CostanziJ.J. (ed):ClinicalManagementofMalignant Melanoma. 1984. ISBN0-89838-656-X
WolfG.T. (ed): Headand NeckOncology. 1984. ISBN0-89838-657-8
AlbertsD.S.,SurwitE.A. (eds): OvarianCancer. 1985. ISBN0-89838-676-4
MuggiaF.M. (ed): ExperimentalandClinical ProgressinCancerChemotherapy. 1985. ISBN0-89838-679-9
Higby DJ. (ed): IssuesinSupportiveCareofCancerPatients. 1986. ISBN0-89838-816-3
SurwitE.A., AlbertsD.S. (eds):CervixCancer. 1987. ISBN0-89838-822-8
JacobsC (cd):Cancersofthe Headand Neck. 1987. ISBN0-89838-825-2
MacDonaldJ.S. (ed):Gastrointestinal Oncology. 1987. ISBN0-89838-829-5
RatliffT.L.,CatalonaW.J. (cds): GenitourinaryCancer. 1987. ISBN0-89838-830-9
Nathanson L. (cd): BasicandClinicalAspectsofMalignantMelanoma. 1987. ISBN0-89838-856-2
Muggia F.M. (ed): Concepts, Clinical Developments,andTherapeuticAdvances inCancerChemotherapy.
1987. ISBN0-89838-879-5
FrankelA.E. (ed): Immunotoxins. 1988. ISBN0-89838-984-4
Bennett J.M., Foon K.A. (eds): Immunologic Approaches to the Classification and Management of
Lymphomasand Leukemias. 1988. ISBN0-89838-355-2
OsborneC.K. (ed): EndocrineTherapiesin Breastand ProstateCancer. 1988. ISBN0-89838-365-X
LippmanM.E.,DicksonR. (eds):BreastCancer:CellularandMolecularBiology. 1988.ISBN0-89838-368-4
Kamps W.A., Humphrey G.B., Poppema S. (eds): Hodgkin's Disease in Children: Controversies and
CurrentPractice. 1988. ISBN0-89838-372-2
Muggia F.M. (ed): Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances.
1988. ISBN0-89838-381-1
Nathanson L. (ed): MalignantMelanoma: Biology,Diagnosis,andTherapy. 1988. ISBN0-89838-384-6
PinedoH.M., VerweijJ. (eds):TreatmentofSoftTissueSarcomas. 1989. ISBN0-89838-391-9
Hansen H.H. (ed): BasicandClinicalConceptsofLungCancer. 1989. ISBN0-7923-0153-6
LeporH., RatliffTL(eds): UrologicOncology. 1989. ISBN0-7923-0161-7
BenzC,LiuE. (eds): Oncogenes. 1989. ISBN0-7923-0237-0
OzolsR.F. (ed): Drug ResistanceinCancerTherapy. 1989. ISBN0-7923-0244-3
SurwitE.A., AlbertsD.S. (cds): EndometrialCancer. 1989. ISBN0-7923-0286-9
ChamplinR. (ed): BoneMarrowTransplantation. 1990. ISBN0-7923-0612-0
GoldenberllD. (ed):CancerImagingWIth Radiolabeled Antibodies. 1990. ISBN0-7923-0631-7
JacobsC (ed):Carcinomasofthe Headand Neck. 1990. ISBN0-7923-0668-6
Lippman M.E., Dickson R. (eds): Regulatory Mechanisms in Breast Cancer: Advances in Cellular and
MolecularBiologyofBreastCancer. 1990. ISBN0-7923-0868-9
Nathanson L. (ed): Maligant Melanoma: Genetics, Growth Factors, Metastases,and Antigens. 1991. ISBN
0-7923-0895-6
SugarbakerP.H. (ed): ManallementofGastricCancer. 1991. ISBN0-7923-1102-7
PinedoH.M.,VerweijJ.,SUItH.D.(eds):SoftTissueSarcomas:NewDevelopmentsintheMultidisciplinary
ApproachtoTreatment. ISBN0-7923-1139-6
OzolsR.F. (ed): MolecularandClinicalAdvancesinAnticancerDrugResistance. 1991. ISBN0-7923-1212-0
MuggiaF.M. (cd): NewDrugs,Conceptsand ResultsinCancerChemotherapy. 1991. ISBN0-7923-1253-8
Dickson R.B., Lippman, M.E. (eds): Genes, Oncogenes and Hormones: Advances in Cellular and
MolecularBiologyofBreastCancer. ISBN0-7923-1748-3
Humphrey G. Bennett, Schraffordt Koops H., Molenaar W.M.. Postma A. (cds): Osteosarcoma in
Adolescentsand YoungAdults: NewDevelopmentsandControversies. ISBN0-7923-1905-2
Benz Christopher C, Liu Edison T. (eds): Oncogenes and Tumor Suppressor Genes in Human
Malignancies.
Oncogenes and Turnor
Suppressor Genes in
Human Malignancies
edited by
Christopher c. Benz
Cancer Research Institute
University of California, San Francisco
and
Edison T. Lin
Lineberger Cancer Research Center
The University of North CaroUna at Chapel Hill
~.
"
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publicalion Data
Oncogcncs and lumor supprcssor gcnes in human m~lignancie<; I cdilcd by
ChriSlopher C. Benz and Edison T. Liu.
p. cm. - (Cancer treatment and rcscareh; eTAR 63)
Indudcs bibliographical referenees aod index.
ISBN 978-1-4613-6349-1 ISBN 978-1-4615-3088-6 (eBook)
DOI 10.1007/978-1-4615-3088-6
1. Onoogcncs. 2. Anlionoo8encs. 3. Cancer- Genetic aspccts.
1. Benz. Christophcr. Il. Liu. Edison T. 111. Scrics: Cancer
1rcalmenl and rescareh; Y. 63.
IDNLM: 1. Cell Transformation. Ncoplastic- gcnetics. 2. Gencs.
SupprCS'iOr, Tumor. 3. Onoogeocs. WI CA69J v. 63 f QZ 202 054451
RC268.42.OS28 I9'JJ
616.\I9'207I-dc20
DNLMIDLC
for Library of Congrcss 92-49212
CIP
Copyright 1993 by Springer Science+Business Media New York
Originally published by Kluwer AC3demic Publishers in 1993
Softcover reprint ofthe hardcover Ist edition t 993
AII rights reserved. No part of this publication may be reproduced, stored in
a retrieval system ar transmitted in anyf orm ar by any means, mechanical,
photocopying. recording, or otherwise, without the prior written permsision
of the p ublisher, Springer Science+Business Media, LLC.
Dedication
William L. McGuire, M.D.
(1937-1992)
Professsor ofMedicine
Chiefof Medical Oncology
University ofTexas Health Science Center
San Antonio, Texas
Series Editor
Cancer Treatment
We dedicate this volume to the memory and achievements (both scientific
and academic) of one of the most influential cancer researchers of this
century, particularly relating to the biology and treatment of breast cancer.
He will be greatly missed both personally and professionally.
Table of Contents
ListofContributors. ............................................ IX
Preface. ........................ ..... ... ..... .................. xv
1. Oncogenes and TumorSuppressor Genes. ...................... 1
E. LIU AND B. WEISSMAN
2. Activated Oncogenes and PutativeTumorSuppressorGenes
Involved in Human Breast Cancers ............................ 15
c.c.
D. TRIPATHY AND BENZ
3. Oncogenes in Human LungCancer. ................ ........... 61
R.A. KRATZKE, E. SHIMIZU, AND FJ. KAYE
4. Thyroid Growth Factorsand Oncogenes. ....................... 87
O.H. CLARK AND Q.-Y. DUH
5. Growth Regulation ofHuman Neuroblastoma 105
O.M. EL-BADRY AND M.A. ISRAEL
6. Kaposi Sarcoma: A Cytokine Responsive Neoplasia? 129
S.A. MILES
7. BCL-2: Physiology and Role in Neoplasia 141
A. BAGG ANDJ. COSSMAN
8. MalignantTransformation byabland BCR/ABL 167
R.A. VAN ETTEN
9. The Biological and Clinical RolesofIncreased Insulin Receptorsin
Human Breast Cancer 193
R. VIGNERI AND I.D. GOLDFINE
10. The Role ofFibroblast Growth Factors and Related Oncogenes in
Tumor Growth 211
H. BREM AND M. KLAGSBRUN
vii
11. TransformingGrowth Factor-alpha and its Role in Neoplastic
Progression 233
D.C. LEE, N.C. LUETTEKE, AND L.A. PETCH
12. Growth Regulation byTransforming Growth Factor-~. ........... 255
B.A. ARRICK AND R. DERYNCK
13. Signal Transduction by ReceptorTyrosine Kinases , 265
D.R. KAPLAN, A. PERKINS, AND O.K. MORRISON
14. InvolvementofG Proteins, CytoplasmicCalcium, Phospholipases,
Phospholipid-DerivedSecond Messengers, and Protein Kinases in
Signal Transduction from Mitogenic Cell Surface Receptors 281
R.A. FRYE
15. Fos andfun: InducibleTranscription Factors RegulatingGrowth of
Normal and Transformed Cells. ............................... 301
J. HOLT
16. DNA Binding by the myc Oncoproteins ........................ 313
G.J. KATO, D.S. WECHSLER, AND C.V. DANG
17. Normal and Malignant Growth Control by p53 327
C.A. FINLAY
18. Nucleoside Diphosphate Kinases, nm23, and TumorMetastasis:
Possible Biochemical Mechanisms ............................. 345
A. GOLDEN, M. BENEDICT, A. SHEARN, N. KIMURA, A.
LEONE, L. LIOTTA, AND P.S. STEEG
19. Angiogenesis: A Mechanism byWhich Oncogenes and
Tumor SuppressorGenes Regulate Tumorigenesis ............... 359
N. BOUCK
Index , 373
viii
List of contributors
(Primary authors in bold)
Bradley Arrick, M.D., Ph.D.
Section ofHematology and Oncology
Dartmouth-HitchcockMedical Center
2Maynard St.
Hanover, NH 03756
(603-646-5347)
Adam Bagg, M.D.
Department ofPathology
Georgetown University Medical Center
3900 Reservoir Rd., N.W.
Washington, DC20007
(202-687-1704)
Mary Benedict
Laboratory ofPathology, N.C.1.
Bldg. 10, Room 2A33, N.I.H.
9000 Rockville Pike
Bethesda, MD 20892
(301-496-9753)
ChristopherBenz, M.D.
Cancer Research Institute
University ofCalifornia San Francisco
San Francisco, CA 94143-0128
(415-476-4149)
Noel P. Bouck, Ph.D.
DepartmentofMicrobiology-Immunologyand CancerCenter
Northwestern University MedicalSchool
303East ChicagoAve.
Chicago, III60611
(312-503-5934)
ix
Harold Brem, M.D.
Boston Children's Hospital
300Longwood Avenue
Boston, MA02115
(617-735-7503)
OrloH. Clark, M.D.
DepartmentofSurgery
U.C.S.F.- Mt. ZionMedical Center
1600DivisaderoSt.
San Francisco, CA94120
(415·885·7616)
JeffreyCossman, M.D.
DepartmentofPathology
Georgetown University MedicalCenter
3900Reservoir Rd., N.W.
Washington, DC 20007
(202-687-1704)
Chi V. Dang, M.D., Ph.D.
DepartmentsofMedicine, Cell Biologyand Anatomy, and theJohns Hopkins
Oncology Center
TheJohn Hopkins UniversitySchoolofMedicine
720 N. RutlandSt. Ross 1012
Baltimore, MD 21205
(410-955-2773)
Rik Derynck, Ph.D.
Departments ofGrowth and Development and Anatomy
University ofCalifornia, San Francisco
San Francisco, CA 94143·0640
(415·476·3018)
Quan-Yang Duh, M.D.
Department of Surgery
V.C.S.F. - Mt. Zion Medical Center
1600 Divisadero St.
San Francisco, CA 94120
(415-885-7616)
Osama EI-Badry
Training Center
Life Technologies, Inc.
20271 Goldenrod Lane, Suite 100
Germantown, MD 20876
(301-921-2245)
x
Cathy A. Finley, Ph.D.
Department ofMolecular Biology
Lewis Thomas Lab
Princeton University
Washington Rd.
Princeton, NJ 08544-1014
(609-258-6785)
Roy A. Frye, M.D.
Department ofPathology
University ofPittsburgh
Pittsburgh, PA 15261
(412-647-6592)
Adam Golden
Laboratory of Pathology, N.C.I.
Bldg. 10, Room 2A33, N.I.H.
9000 Rockville Pike
Bethesda, MD 20892
(301-496-9753)
Ira Goldfine, M.D.
Division ofDiabetes and Endocrine Research
U.C.S.F. - Mt. Zion Medical Center
1600 Divisadero St.
San Francisco, CA 94115
(415-885-7429)
Jeffrey Holt, M.D.
Department ofCell Biology and Pathology
Vanderbilt University
Nashville, TN 37232
(615-343-4730)
Mark Israel, M.D.
Preuss Laboratory, Department ofNeurosurgery,
Brain Tumor Research Center
University ofCalifornia San Francisco
San Francisco, CA 94143-0520
(415-476-6662)
David Kaplan, Ph.D.
ABL-Basic Research Program
N.C.I. - Frederick Cancer Research and Development Center
Frederick, MD 21702
(301-846-5497)
xi