VOLUME 4 Obsessive-Compulsive Disorder Second Edition WPA Series Evidence and Experience in Psychiatry Obsessive-CompulsiveDisorder,SecondEdition. EditedbyMarioMaj,NormanSartorius,AhmedOkashaand JosephZohar. #2002JohnWiley&SonsLtd.ISBN:0-470-84966-5 Other Titles in the WPA Series Evidence and Experience in Psychiatry Volume 1—Depressive Disorders, Second Edition Mario Maj and Norman Sartorius Volume 2—Schizophrenia, Second Edition Mario Maj and Norman Sartorius Volume 3—Dementia, Second Edition Mario Maj and Norman Sartorius Volume 5—Bipolar Disorder Mario Maj, Hagop S. Akiskal, Juan Jose´ Lo´pez-Ibor and Norman Sartorius VOLUME 4 Obsessive-Compulsive Disorder Second Edition Edited by Mario Maj University of Naples, Italy Norman Sartorius University of Geneva, Switzerland Ahmed Okasha Ain Shams University, Cairo, Egypt Joseph Zohar Tel Aviv University, Israel WPA Series Evidence and Experience in Psychiatry Copyright#2002JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester, WestSussexPO198SQ,England Telephone(+44)1243779777 Email(forordersandcustomerserviceenquiries):[email protected] VisitourHomePageonwww.wileyeurope.comorwww.wiley.com FirstEditionprintedin2000. 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Contents List of ReviewContributors xi Preface xiii CHAPTER1 DIAGNOSISOF OBSESSIVE-COMPULSIVE DISORDER 1 Diagnosis of Obsessive-CompulsiveDisorder: AReview 1 A.Okasha COMMENTARIES 1.1 Obsessive-Compulsive Disorder:Towardsa Diagnosisby Etiology 20 G.Nestadt 1.2 Assessment and Management of Obsessive-Compulsive Disorder 22 A.Rothenberg 1.3 Subtypesof Obsessive-CompulsiveDisorder? 25 M.A. Riddle 1.4 DissectingObsessive-CompulsiveDisorder into Subtypes 26 M.L. Berthier 1.5 The Diagnosisof Obsessive-Compulsive Disorder and ItsSubtypes 29 E.C. Migueland A.G. Hounie 1.6 Obsessive-Compulsive Symptoms: Implications for Treatment 32 L. Ravizza, U.Albert,G.Mainaand F. Bogetto 1.7 Insightand PsychologicalAspects of Obsessive-Compulsive Disorder 34 Y.G.Papakostas and G.N. Christodoulou 1.8 The Role of Overvalued Ideas andBiological Markersinthe Diagnosisof Obsessive-Compulsive Disorder 37 F. Neziroglu vi CONTENTS 1.9 Research on DiagnosisofObsessive-Compulsive Disorder in Latin America 39 H. Nicolini CHAPTER 2 PHARMACOLOGICAL TREATMENTOF OBSESSIVE-COMPULSIVE DISORDER 43 PharmacologicalTreatment of Obsessive-CompulsiveDisorder: A Review 43 J. Zohar, Y. Sasson, M.Chopra, D. Amital and I. Iancu COMMENTARIES 2.1 Pharmacotherapy ofObsessive-Compulsive Disorder: Accomplishment, Unanswered Questions andNew Directions 62 T.A.Pigott 2.2 Beyond SerotoninReuptake Inhibitors: DoWe HaveOur Second Wind? 65 C.J.McDougle 2.3 Future Pharmacotherapy for Obsessive-Compulsive Disorder: 5-HT Agonists and Beyond 68 2 P.L. Delgado 2.4 Commentson the Pharmacological Treatment ofObsessive-CompulsiveDisorder 71 M.R.Mavissakalian 2.5 The Expanding Obsessive-Compulsive Disorder Evidence Base 73 L.M.Koran 2.6 The Heterogeneity ofObsessive-Compulsive Disorder and ItsImplications for Treatment 76 L. Bellodi 2.7 Pharmacotherapy ofObsessive-Compulsive Disorder: Questionsfor theNext Decade 79 M. Arato 2.8 Recent ProgressandOpenIssues in the Pharmacological Approach toObsessive- CompulsiveDisorder 82 J.A.Yaryura-Tobias 2.9 Treatmentand Neurobiology of Obsessive- CompulsiveDisorder 84 J.A.den Boer CONTENTS vii 2.10 Obsessive-Compulsive Disorder:Pharmacological Decision 86 J.Ananth 2.11 Serotonergic Antidepressants inObsessive- Compulsive Personality Disorder 89 M.Ansseau 2.12 Drug Treatmentof Obsessive-Compulsive Disorder: Dark Past,BrightPresent, but Glowing Future 91 P. Blier CHAPTER3 PSYCHOTHERAPIES FOR OBSESSIVE- COMPULSIVE DISORDER 93 Psychotherapies for Obsessive-Compulsive Disorder: AReview 93 E.B. Foa and M.E. Franklin COMMENTARIES 3.1 EffectiveBehavioural Therapy Constrained: Dissemination isthe Issue 116 J.H. Greist 3.2 Can We Enhance theEffectsof Cognitive-Behavioural Therapy in Obsessive-Compulsive Disorder? 119 P.M.G. Emmelkamp 3.3 Obsessive-Compulsive Disorder:Symptom-directed Behavioural Techniques and Beyond 122 I.Hand 3.4 Is theCombination of Antidepressants with Cognitive-Behavioural Therapy the Most Potent Treatment Possibility in Obsessive-Compulsive Disorder? 125 A.J.L.M. van Balkom 3.5 CognitiveTherapy and Behavioural Therapy in Obsessive-Compulsive Disorder:in Searchof the Process 129 J.Cottraux 3.6 Obsessional Problems: NewerCognitive-Behavioural Approaches Are a Workin Progress 131 P.M. Salkovskis 3.7 CurrentIssues in theUse of Behavioural Therapy for Obsessive-CompulsiveDisorder 134 K.A.Kobak and B.C. Riemann viii CONTENTS 3.8 Cognitive-BehaviouralTherapy andIntegrated Approaches in theTreatment of Obsessive- CompulsiveDisorder 136 F. Hohagen 3.9 Mindful Awareness:the Key to Successful Self-directed Treatment Strategies 139 J.M. Schwartz 3.10 The Role of Cognitive Therapy inthe Treatment ofObsessive-CompulsiveDisorder 142 L.M.Drummond 3.11 Psychodynamic Treatment of Obsessive-Compulsive Conditions 144 D. Shapiro CHAPTER 4 CHILD AND ADOLESCENTOBSESSIVE- COMPULSIVE DISORDER 147 Child and Adolescent Obsessive-Compulsive Disorder: AReview 147 M.F.Flament and D.Cohen COMMENTARIES 4.1 Theoretical andClinical Implicationsof the Spectrum of Childhood Obsessionality 184 R.A. King 4.2 Developmental Perspectivesin PediatricOnset Obsessive-Compulsive Disorder 187 D.A.Geller 4.3 AConcept of Disorder in Some Disorder 190 D. Bolton 4.4 Obsessive-Compulsive Disorder: a Model for Closing the ‘‘Gap’’betweenAdultand Pediatric Psychiatry 192 J. DeVeaugh-Geiss 4.5 The Spectrum of Obsessive-Compulsive Symptoms inChildren and Adolescents 195 P.H.Thomsen 4.6 Obsessive-Compulsive Disorder in Children and Adolescents: Narrowing theGap between Knowledgeand Clinical Practice 196 J.G.Simeon 4.7 Obsessive-Compulsive Disorder in Children and Adolescents: Data from a Developing Country 198 C.E. Berganza CONTENTS ix CHAPTER5 OBSESSIVE-COMPULSIVE SPECTRUM DISORDERS 203 Obsessive-CompulsiveSpectrum Disorders: AReview 203 E. Hollander and J. Rosen COMMENTARIES 5.1 The Obsessive-Compulsive Spectrum: Promisesand Pitfalls 225 K.A.Phillips 5.2 Understandingthe Obsessive-Compulsive Spectrum: a Four-factor Modelof Obsessive-Compulsive Symptoms 228 D.Watsonand K. Wu 5.3 Extremesof ImpulseControl and Serotonin/Frontal Lobe Pathophysiology 230 W.Kaye 5.4 The Obsessive-Compulsive Spectrum: Fact or Fancy? 233 D.W. Black 5.5 BlurrySpectrum Disorders 235 N.R.Swerdlow 5.6 Spectrum Disorders:Utilitarian Concepts or Utopian Fantasies? 238 J.W. Jefferson 5.7 Carving Natureat ItsJoints: Different Approaches to theObsessive-CompulsiveSpectrum of Disorders 241 D.J. Stein 5.8 The Challenge of Deconvolving the Obsessive-Compulsive DisorderSpectrum into ItsComponent Diseases 244 M.George 5.9 Obsessive-Compulsive Spectrum Disorders: are Opposites Related? 246 R. Crino 5.10 The Spectrum of Obsessive-Compulsive-Related Disorders: Stateof theArt 249 D.Marazziti CHAPTER6 COSTS OFOBSESSIVE-COMPULSIVE DISORDER 253 Costs of Obsessive-CompulsiveDisorder: AReview 253 M.Knapp,J. Henderson and A.Patel x CONTENTS COMMENTARIES 6.1 Consideringthe Full EconomicBurden 276 M.M. Weissman 6.2 The Economics of Obsessive-Compulsive Disorder: Achievingthe Potential Benefit 278 M. Aveline 6.3 In Search of Data on Costs of Obsessive-Compulsive Disorder 281 G. Steketee 6.4 Obsessive Slownessin Creating aCost-Effectiveness Evidence Basefor Obsessive-CompulsiveDisorder 283 G. Thornicroft 6.5 Evaluationsof TreatmentsforObsessive-Compulsive Disorder: the Need for HealthEconomics Input 286 P. McCrone 6.6 Obsessive-Compulsive Disorder: a Psychiatric Disorder in Economic No Man’s Land 288 P. Tyrer 6.7 NotExpensive and Cheap to Treat: New Evidence Leads to Different Conclusions 290 G. Andrews 6.8 Economics of Obsessive-Compulsive Disorder: onSafeGrounds? 293 W. Ro¨ssler 6.9 Obsessive-Compulsive Disorder: theHidden Costs ofa HiddenEpidemic 295 L. Salvador-Carulla 6.10 Obsessive-Compulsive Disorder: anUnderestimated Disorder 297 M. Berger,U. Voderholzer andF. Hohagen Acknowledgementsfor the First Edition 301 Index 303