Nutrition in Epigenetics

358 Pages·2011·14.377 MB·English

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Nutrition in Epigenetics
P1:SBT Color:1C
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Nutrition in Epigenetics
Edited By
Mihai D. Niculescu
Paul Haggarty
A John Wiley & Sons, Ltd., Publication
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Thiseditionfirstpublished2011(cid:2)C 2011byBlackwellPublishing,Ltd.
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Nutritioninepigenetics/editedbyMihaiD.Niculescu,PaulHaggarty.
p.cm.
Includesbibliographicalreferencesandindex.
ISBN978-0-8138-1605-0(hardcover:alk.paper)
1.Nutrition–Geneticaspects. 2.Epigenesis. 3.Geneticregulation. 4.Geneexpression.
I.Niculescu,MihaiD. II.Haggarty,Paul.
QP144.G45N8882011
612.3–dc22
2010047816
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1 2011
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Contents
Contributors vii
1. Introduction 1
MihaiD.NiculescuandPaulHaggarty
PARTI: FundamentalPrinciplesinEpigenetics
SECTIONA: EpigeneticMechanisms
2. DNAMethylation 13
NataliaV.Cucu
3. ChromatinModifications 47
SandraB.Hake
4. RolesofRNAiandOtherMicro-RNAsintheRegulationof
EpigeneticProcesses 73
MullerFabbri
5. EpigeneticInheritance:BothMitoticandMeiotic 87
NinaJ.Kaminen-Ahola,ArttuI.Ahola,andEmmaWhitelaw
SECTIONB: DevelopmentEpigenetics
6. DevelopmentalEpigenetics:RolesinEmbryonicDevelopment 107
LilianaBurlibas¸aandLucianGavrila˘
SECTIONC: EpigeneticMechanismsinDisease
7. Epigenetics,Nutrition,andCancer 129
AmyR.Johnson
8. MetabolicSyndrome,Obesity,andDiabetes 145
KarenD.Corbin
v
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vi Contents
9. Autoimmunity 165
DonnaRayandRaymondYung
10. CardiovascularDiseases 173
AurelianBidulescuandMethodeBacanamwo
PARTII: NutritionalStatusandSpecificNutrients
SECTIONA: MaternalNutritionandFetalDevelopment
11. MaternalNutritionandDevelopmentalOutcomes 193
ShannonL.Haley,LaurieJ.Moyer-Mileur,RobertH.Lane,andLisaA.Joss-Moore
SECTIONB: RoleofSpecificNutrients
12. Folate,VitaminB ,andVitaminB 211
12 6
PatrickJ.Stover
13. DietaryCholine,Betaine,Methionine,andEpigeneticMechanisms
InfluencingBrainDevelopment 225
StevenH.Zeisel
14. EpigeneticRegulationbyRetinoids 241
AmandioVieira
15. WeAreWhatWeEat:HowNutritionalCompoundsSuchAsIsoflavones
ShapeOurEpigenome 249
CarlosM.Guerrero-BosagnaandSusanJ.Clark
16. IsothiocyanatesandPolyphenols 263
NigelJ.BelshawandIanT.Johnson
SECTIONC: MacronutrientIntakes
17. TheEffectofMaternalMacronutrientIntakeonPhenotypeInduction
andEpigeneticGeneRegulation 275
KarenA.Lillycrop,MarkA.Hanson,andGrahamC.Burdge
SECTIOND: EnvironmentalExposures
18. EpigeneticManifestationofEnvironmentalExposures 289
DanaC.Dolinoy,OliviaS.Anderson,andLauraS.Rozek
SECTIONE: EpidemiologyofNutritionalEpigenetics
19. Epigenetics,Nutrition,andReproduction:Short-and
Long-TermConsequences 311
PaulHaggarty
20. Nutrition,Epigenetics,andCancer:AnEpidemiologicalPerspective 329
AudreyJungandEllenKampman
Index 345
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Contributors
ArttuI.Ahola
DivisionofGeneticsandPopulationHealth
QueenslandInstituteofMedicalResearch
Queensland
Australia;
DepartmentofBiologicalandEnvironmentalSciences
UniversityofHelsinki
Finland
OliviaS.Anderson
DepartmentofEnvironmentalHealthSciences
UniversityofMichiganSchoolofPublicHealth
AnnArbor,MI
USA
MethodeBacanamwo
CardiovascularResearchInstitute
MorehouseSchoolofMedicine
Atlanta,GA
USA
NigelJ.Belshaw
InstituteofFoodResearch
NorwichResearchPark
Colney,Norwich
UK
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viii Contributors
AurelianBidulescu
CardiovascularResearchInstitute
MorehouseSchoolofMedicine
Atlanta,GA
USA
GrahamC.Burdge
DOHaDResearchDivision
UniversityofSouthampton
Southampton
UK
LilianaBurlibas¸a
GeneticsDepartment
BucharestUniversity
Romania
SusanJ.Clark
EpigeneticsLaboratory
CancerProgram
GarvanInstituteofMedicalResearch
Sydney
Australia
KarenD.Corbin
TheUniversityofNorthCarolinaatChapelHillNutritionResearchInstitute
ChapelHill,NC
USA
NataliaV.Cucu
EpigeneticsLaboratory
DepartmentofGenetics
FacultyofBiology
UniversityofBucharest
Romania
DanaC.Dolinoy
DepartmentofEnvironmentalHealthSciences
UniversityofMichiganSchoolofPublicHealth
AnnArbor,MI
USA
MullerFabbri
DepartmentofMolecularVirology,Immunology,andMedicalGenetics
TheOhioStateUniversity
Columbus,OH
USA
LucianGavrila˘
GeneticsDepartment
BucharestUniversity
Romania
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Contributors ix
CarlosM.Guerrero-Bosagna
CenterforReproductiveBiology
SchoolofBiologicalSciences
WashingtonStateUniversity
Pullman,WA
USA
PaulHaggarty
Nutrition&EpigeneticsGroup
RowettInstituteofNutrition&Health
UniversityofAberdeen
Aberdeen,Scotland
UK
SandraB.Hake
Adolf-ButenandtInstituteandCenterforIntegratedProteinScienceMunich(CIPSM)
DepartmentofMolecularBiology
Ludwig-MaximiliansUniversity
Munich
Germany
MarkA.Hanson
DOHaDResearchDivision
UniversityofSouthampton
Southampton
UK
ShannonL.Haley
DivisionofNeonatology
UniversityofUtah
SaltLakeCity,UT
USA
AmyR.Johnson
DepartmentofNutrition
UniversityofNorthCarolinaatChapelHill
ChapelHill,NC
USA
IanT.Johnson
InstituteofFoodResearch
NorwichResearchPark
Colney,Norwich
UK
LisaA.Joss-Moore
DivisionofNeonatology
UniversityofUtah
SaltLakeCity,UT
USA
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x Contributors
AudreyJung
DepartmentofEpidemiology
Biostatistics,andHealthTechnologyAssessment
RadboudUniversityNijmegenMedicalCentre
Nijmegen
TheNetherlands
NinaJ.Kaminen-Ahola
DivisionofGeneticsandPopulationHealth
QueenslandInstituteofMedicalResearch
Queensland
Australia
EllenKampman
DepartmentofEpidemiology
Biostatistics,andHealthTechnologyAssessment
RadboudUniversityNijmegenMedicalCentre
Nijmegen
TheNetherlands;
DivisionofHumanNutrition
WageningenUniversity
Wageningen
TheNetherlands
RobertH.Lane
DivisionofNeonatology
UniversityofUtah
SaltLakeCity,UT
USA
KarenA.Lillycrop
SchoolofBiologicalSciences
UniversityofSouthampton
Southampton
UK
LaurieJ.Moyer-Mileur
DivisionofNeonatology
UniversityofUtah
SaltLakeCity,UT
USA
MihaiD.Niculescu
DepartmentofNutritionandNutritionResearchInstitute
UniversityofNorthCarolinaatChapelHill
Kannapolis,NC
USA
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Contributors xi
DonnaRay
DepartmentofInternalMedicine
UniversityofMichigan
AnnArbor,MI
USA
LauraS.Rozek
DepartmentofEnvironmentalHealthSciences
UniversityofMichiganSchoolofPublicHealth
AnnArbor,MI
USA
PatrickJ.Stover
DivisionofNutritionalSciences
CornellUniversity
Ithaca,NY
USA
AmandioVieira
NutritionandMetabolicRL
BiomedicalPhysiology&Kinesiology
SimonFraserUniversity
Burnaby,BC
Canada
EmmaWhitelaw
DivisionofGeneticsandPopulationHealth
QueenslandInstituteofMedicalResearch
Queensland
Australia
RaymondYung
DepartmentofInternalMedicine
UniversityofMichigan
AnnArbor,MI
USA
StevenH.Zeisel
NutritionResearchInstituteandDepartmentsofNutritionandPediatrics
UniversityofNorthCarolinaatChapelHill
Kannapolis,NC
USA